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15 Companies |
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15 Products |
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8 Mechanisms of Action |
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1 Trial |
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145 News |
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- New P2 trial: Fluid Therapy During Brain Tumor Resection in Children (clinicaltrials.gov) - Mar 14, 2016
P2, N=48, Recruiting, Sponsor: Federal University of S
- Trial primary completion date: Resuscitation Fluid Choice and Clinical Outcomes (clinicaltrials.gov) - Mar 4, 2016
P=N/A, N=65800, Active, not recruiting, Sponsor: University of Pittsburgh
Trial primary completion date: Jan 2016 --> Jan 2017
- || New P3 trial: Perioperative Fluid Therapy With Balanced Crystalloids (clinicaltrials.gov) - Feb 25, 2016
P3, N=112, Completed, Sponsor: University Hospital Olomouc
- Norditropin (somatropin) / Novo Nordisk, Insuman Rapid (recombinant human insulin) / Sanofi
Trial completion, Trial primary completion date: Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection. (clinicaltrials.gov) - Feb 24, 2016
P=N/A, N=9, Completed, Sponsor: University of Aarhus
Trial primary completion date: Jan 2016 --> Jan 2017 Active, not recruiting --> Completed | Trial primary completion date: Feb 2016 --> Sep 2015
- || Phase classification, Trial primary completion date, Claims database: Study on Incidence of Diabetic Ketoacidosis Among Participants With Type 2 Diabetes Mellitus Treated With Sodium-glucose Co-transporter 2 (SGLT2) Inhibitors or Other Antihyperglycemic Agents (clinicaltrials.gov) - Feb 17, 2016
P=N/A, N=400000, Active, not recruiting, Sponsor: Janssen Research & Development, LLC
Active, not recruiting --> Completed | Trial primary completion date: Feb 2016 --> Sep 2015 Phase classification: P4 --> P=N/A | Trial primary completion date: Dec 2015 --> Aug 2016
- Trial completion: Neonatal Acid-Base Status After C Section With Maternal Tilt vs. Supine (clinicaltrials.gov) - Jan 26, 2016
P=N/A, N=100, Completed, Sponsor: Columbia University
Phase classification: P4 --> P=N/A | Trial primary completion date: Dec 2015 --> Aug 2016 Recruiting --> Completed
- Kineret (anakinra) / SOBI
Trial primary completion date: Anti-IL-1 Treatment in Children Diabetic Keto-Acidosis (DKA) at Diagnosis of Type 1 Diabetes (clinicaltrials.gov) - Jan 17, 2016
P2, N=21, Recruiting, Sponsor: University of Colorado, Denver
Recruiting --> Completed Trial primary completion date: Dec 2015 --> Mar 2016
- New trial: Resuscitation Fluid Choice and Clinical Outcomes (clinicaltrials.gov) - Dec 29, 2015
P=N/A, N=65800, Active, not recruiting, Sponsor: University of Pittsburgh
- ||||| New P4 trial, Claims database: Study on Incidence of Diabetic Ketoacidosis Among Participants With Type 2 Diabetes Mellitus Treated With Sodium-glucose Co-transporter 2 (SGLT2) Inhibitors or Other Antihyperglycemic Agents (clinicaltrials.gov) - Dec 21, 2015
P4, N=400000, Active, not recruiting, Sponsor: Janssen Research & Development, LLC
- fludrocortisone / Generic mfg., furosemide / Generic mfg.
Trial primary completion date: Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis (clinicaltrials.gov) - Dec 16, 2015
P=N/A, N=300, Recruiting, Sponsor: University Hospital Inselspital, Berne
Trial primary completion date: Dec 2015 --> Mar 2016 Trial primary completion date: Sep 2015 --> Sep 2016
- New trial: VNI Versus: Efficacy and Safety of Non-invasive Ventilation by Calibrated Leak in the Treatment of Respiratory Acidosis in ICU (clinicaltrials.gov) - Dec 15, 2015
P=N/A, N=20, Recruiting, Sponsor: University Hospital, Grenoble
- Trial completion: A Study of Intracellular Signaling in Muscle and Fat Cells During Ketosis (clinicaltrials.gov) - Dec 4, 2015
P=N/A, N=9, Completed, Sponsor: University of Aarhus
Trial primary completion date: Sep 2015 --> Sep 2016 Active, not recruiting --> Completed
- || New P2/3 trial: FIRST-line Support for Assistance in Breathing in Children (FIRST-ABC) Feasibility Study (clinicaltrials.gov) - Nov 24, 2015
P2/3, N=120, Not yet recruiting, Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust
- Enrollment open, Trial initiation date: CAMP: Carglumic Acid in Methylmalonic Acidemia and Propionic Acidemia (clinicaltrials.gov) - Nov 17, 2015
P3, N=44, Recruiting, Sponsor: King Abdullah International Medical Research Center
Active, not recruiting --> Completed Not yet recruiting --> Recruiting | Initiation date: May 2015 --> Nov 2015
- Norditropin (somatropin) / Novo Nordisk, Insuman Rapid (recombinant human insulin) / Sanofi
Enrollment closed: Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection. (clinicaltrials.gov) - Sep 25, 2015
P=N/A, N=10, Active, not recruiting, Sponsor: University of Aarhus
Not yet recruiting --> Recruiting | Initiation date: May 2015 --> Nov 2015 Recruiting --> Active, not recruiting
- dichloroacetate (SL-1009) / Saol Therap
Trial primary completion date: CLA: Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Expanded Access (clinicaltrials.gov) - Sep 24, 2015
P1, N=4, Active, not recruiting, Sponsor: University of Florida
Recruiting --> Active, not recruiting Trial primary completion date: Jun 2016 --> Jun 2017
- Enrollment change, Trial primary completion date: The Effect of Irrigation Solution Volume on Electrolytes and Acid-Base Balance (clinicaltrials.gov) - Sep 9, 2015
P=N/A, N=1, Terminated, Sponsor: Rambam Health Care Campus
Trial primary completion date: Jun 2016 --> Jun 2017 N=200 --> 1 | Trial primary completion date: Jun 2015 --> Sep 2015
- New trial: Enhanced vs. Routine Clear Liquid Intake in Labor (clinicaltrials.gov) - Aug 14, 2015
P=N/A, N=400, Recruiting, Sponsor: Temple University
- Trial completion: Effects of Zeolite + Dolomite on Performance and Acidosis (clinicaltrials.gov) - Aug 11, 2015
P=N/A, N=56, Completed, Sponsor: Green Beat
N=200 --> 1 | Trial primary completion date: Jun 2015 --> Sep 2015 Active, not recruiting --> Completed
- Mircera (methoxy polyethylene glycol-epoetin beta) / Roche
New trial: A Study Of Mircera In Patients With Kidney Disease Who Are Not On Dialysis (clinicaltrials.gov) - Jul 6, 2015
P=N/A, N=153, Completed, Sponsor: Hoffmann-La Roche
- New trial: Whole Body Periodic Acceleration on Blood Lactate and Recovery (clinicaltrials.gov) - Jun 26, 2015
P0, N=10, Recruiting, Sponsor: New York Institute of Technology
- Januvia (sitagliptin) / Merck (MSD)
Biomarker, Trial completion: Ketosis-Prone Diabetes Mellitus (KPDM): Metformin Versus Sitagliptin Treatment (clinicaltrials.gov) - Jun 18, 2015
P4, N=48, Completed, Sponsor: Dawn Smiley MD
Active, not recruiting --> Completed Active, not recruiting --> Completed
- Kineret (anakinra) / SOBI
Trial primary completion date: Anti-IL-1 Treatment in Children Diabetic Keto-Acidosis (DKA) at Diagnosis of Type 1 Diabetes (clinicaltrials.gov) - Jun 11, 2015
P2, N=21, Recruiting, Sponsor: University of Colorado, Denver
Active, not recruiting --> Completed Trial primary completion date: Nov 2014 --> Nov 2015
- Trial primary completion date: Randomized Control Trial of Fluid Therapy for Pediatric Diabetic Ketoacidosis (clinicaltrials.gov) - Jun 11, 2015
P3, N=1510, Recruiting, Sponsor: University of California, Davis
Trial primary completion date: Nov 2014 --> Nov 2015 Trial primary completion date: Mar 2015 --> Jul 2016
- Trial completion, Enrollment change: Pilot Study For Hypothermia Treatment In Hyperammonemic Encephalopathy In Neonates And Very Young Infants (clinicaltrials.gov) - Jun 1, 2015
P2, N=5, Completed, Sponsor: Uta Lichter-Konecki
Trial primary completion date: Mar 2015 --> Jul 2016 Recruiting --> Completed | N=24 --> 5
- New trial: DKA-Cog: Diabetic Ketoacidosis: Brain Morphology and Cognition (clinicaltrials.gov) - May 13, 2015
P=N/A, N=40, Recruiting, Sponsor: Emory University
- New P3 trial: CAMP: Carglumic Acid in Methylmalonic Acidemia and Propionic Acidemia (clinicaltrials.gov) - Apr 27, 2015
P3, N=44, Not yet recruiting, Sponsor: King Abdullah International Medical Research Center
- dichloroacetate (SL-1009) / Saol Therap
Trial completion, Trial completion date: Prevention of Dichloroacetate Toxicity (clinicaltrials.gov) - Mar 25, 2015
P=N/A, N=30, Completed, Sponsor: University of Florida
Recruiting --> Completed | N=24 --> 5 Recruiting --> Completed | Trial completion date: Aug 2004 --> Sep 2005
- dichloroacetate (SL-1009) / Saol Therap
Trial completion: Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis (clinicaltrials.gov) - Mar 25, 2015
P3, N=45, Completed, Sponsor: University of Florida
Recruiting --> Completed | Trial completion date: Aug 2004 --> Sep 2005 Active, not recruiting --> Completed
- | dichloroacetate topical / Generic mfg.
Trial completion: Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia (clinicaltrials.gov) - Mar 23, 2015
P2, N=75, Completed, Sponsor: University of California, San Diego
Active, not recruiting --> Completed Recruiting --> Completed
- Clinical: Renal Tubular Acidosis is Highly Prevalent in Critically Ill Patients (clinicaltrials.gov) - Mar 18, 2015
P=N/A, N=100, Completed, Sponsor: Medical University of Vienna
- | acetazolamide / Generic mfg.
Trial completion: TRAMA study: Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation. (clinicaltrials.gov) - Mar 17, 2015
P3, N=140, Completed, Sponsor: Hospital Son Llatzer
Recruiting --> Completed Recruiting --> Completed
- Enrollment change, Trial termination, Trial primary completion date: Long-term Outcome of N-Carbamylglutamate Treatment in Propionic Acidemia and Methylmalonic Acidemia (clinicaltrials.gov) - Feb 5, 2015
P2, N=1, Terminated, Sponsor: Mendel Tuchman
Recruiting --> Completed N=34 --> 1 | Recruiting --> Terminated | Trial primary completion date: Mar 2016 --> Feb 2015; insufficient enrollment
- Trial completion, Phase classification: Anaplerotic Therapy in Propionic Acidemia (clinicaltrials.gov) - Jan 22, 2015
P1, N=3, Completed, Sponsor: Nicola Longo
N=34 --> 1 | Recruiting --> Terminated | Trial primary completion date: Mar 2016 --> Feb 2015; insufficient enrollment Active, not recruiting --> Completed | Phase classification: P1/2 --> P1
- Enrollment open: Neonatal Acid-Base Status After C Section With Maternal Tilt vs. Supine (clinicaltrials.gov) - Jan 5, 2015
P=N/A, N=100, Recruiting, Sponsor: Columbia University
Active, not recruiting --> Completed | Phase classification: P1/2 --> P1 Not yet recruiting --> Recruiting
- acetazolamide / Generic mfg.
Trial completion, Trial primary completion date: DIABOLO: Effectiveness of Acetazolamide for Reversal of Metabolic Alkalosis in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients (clinicaltrials.gov) - Dec 10, 2014
P4, N=380, Completed, Sponsor: Assistance Publique - H
Not yet recruiting --> Recruiting Recruiting --> Completed | Trial primary completion date: Nov 2014 --> Jul 2014
- Enrollment closed: A Study of Intracellular Signaling in Muscle and Fat Cells During Ketosis (clinicaltrials.gov) - Sep 19, 2014
P=N/A, N=9, Active, not recruiting, Sponsor: University of Aarhus
Recruiting --> Completed | Trial primary completion date: Nov 2014 --> Jul 2014 Recruiting --> Active, not recruiting
- Enrollment change, Trial termination: Two Bag System for Hydration in Diabetes (clinicaltrials.gov) - Sep 4, 2014
P=N/A, N=12, Terminated, Sponsor: Hospital General de Ni
Recruiting --> Active, not recruiting N=36 --> 12 | Recruiting --> Terminated; Monitoring Committee found significant & meaningful difference on main outcome
- entecavir / Generic mfg., lamivudine HBV / Generic mfg.
Trial primary completion date: Lactic Acidosis During Entecavir(ETV)Treatment (clinicaltrials.gov) - Jun 27, 2014
P4, N=5, Terminated, Sponsor: Asan Medical Center
N=36 --> 12 | Recruiting --> Terminated; Monitoring Committee found significant & meaningful difference on main outcome Trial primary completion date: May 2013 --> Sep 2013
- entecavir / Generic mfg., lamivudine HBV / Generic mfg.
Trial termination: Lactic Acidosis During Entecavir(ETV)Treatment (clinicaltrials.gov) - Jun 27, 2014
P4, N=5, Terminated, Sponsor: Asan Medical Center
Trial primary completion date: May 2013 --> Sep 2013 Not yet recruiting --> Terminated; Tenofovir has become available in Korea.
- entecavir / Generic mfg., lamivudine HBV / Generic mfg.
Enrollment change, Trial termination, Trial primary completion date: Lactic Acidosis During Entecavir(ETV)Treatment (clinicaltrials.gov) - Jun 27, 2014
P4, N=5, Terminated, Sponsor: Asan Medical Center
Not yet recruiting --> Terminated; Tenofovir has become available in Korea. N=90 --> 5 | Not yet recruiting --> Terminated | Trial primary completion date: May 2013 --> Sep 2013; Tenofovir has become available in Korea.
- Clinical: A Study of Intracellular Signaling in Muscle and Fat Cells During Ketosis (clinicaltrials.gov) - Jun 3, 2014
P=N/A, N=9, Enrolling by invitation, Sponsor: University of Aarhus
- Trial primary completion date: Increasing Ureagenesis in Inborn Errors of Metabolism With N-Carbamylglutamate (clinicaltrials.gov) - May 27, 2014
P2, N=0, Withdrawn, Sponsor: Children's Hospital of Philadelphia
N=90 --> 5 | Not yet recruiting --> Terminated | Trial primary completion date: May 2013 --> Sep 2013; Tenofovir has become available in Korea. Trial primary completion date: Jun 2016 --> Aug 2012
- Trial withdrawal: Increasing Ureagenesis in Inborn Errors of Metabolism With N-Carbamylglutamate (clinicaltrials.gov) - May 27, 2014
P2, N=0, Withdrawn, Sponsor: Children's Hospital of Philadelphia
Trial primary completion date: Jun 2016 --> Aug 2012 Recruiting --> Withdrawn
- Trial completion date: Increasing Ureagenesis in Inborn Errors of Metabolism With N-Carbamylglutamate (clinicaltrials.gov) - May 27, 2014
P2, N=0, Withdrawn, Sponsor: Children's Hospital of Philadelphia
Recruiting --> Withdrawn Trial completion date: Jun 2016 --> Aug 2012
- Enrollment change: Increasing Ureagenesis in Inborn Errors of Metabolism With N-Carbamylglutamate (clinicaltrials.gov) - May 27, 2014
P2, N=0, Withdrawn, Sponsor: Children's Hospital of Philadelphia
Trial completion date: Jun 2016 --> Aug 2012 N=80 --> 0
- Januvia (sitagliptin) / Merck (MSD)
Biomarker, Trial completion date: Ketosis-Prone Diabetes Mellitus (KPDM): Metformin Versus Sitagliptin Treatment (clinicaltrials.gov) - May 23, 2014
P4, N=48, Active, not recruiting, Sponsor: Dawn Smiley MD
N=80 --> 0 Trial completion date: Feb 2014 --> Aug 2014
- Januvia (sitagliptin) / Merck (MSD)
Biomarker, Enrollment closed: Ketosis-Prone Diabetes Mellitus (KPDM): Metformin Versus Sitagliptin Treatment (clinicaltrials.gov) - May 23, 2014
P4, N=48, Active, not recruiting, Sponsor: Dawn Smiley MD
Trial completion date: Feb 2014 --> Aug 2014 Recruiting --> Active, not recruiting
- sevoflurane / Generic mfg.
Trial completion: PRISKIKO: Substitution of Propofol by Sevoflurane During Pediatric Cardiopulmonary Bypass (clinicaltrials.gov) - May 20, 2014
P=N/A, N=200, Completed, Sponsor: University of Schleswig-Holstein
Recruiting --> Active, not recruiting Recruiting --> Completed
- Norditropin (somatropin) / Novo Nordisk, Insuman Rapid (recombinant human insulin) / Sanofi
Trial initiation date: Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection. (clinicaltrials.gov) - May 14, 2014
P=N/A, N=10, Recruiting, Sponsor: University of Aarhus
Recruiting --> Completed Initiation date: Apr 2014 --> May 2014