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37 Companies |
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35 Products |
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35 Products |
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54 Mechanisms of Action |
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3 Trials |
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404 News |
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- | NN1213 / Novo Nordisk
Enrollment change: Pilot Study of Startle-response Test to Assess Transcranial Direct Current Stimulation-induced Modulation of Hyperphagia in Prader-Willi Syndrome (clinicaltrials.gov) - Apr 26, 2019
P=N/A, N=31, Completed, Sponsor: University of Kansas Medical Center
N=52 --> 31
- | Trial completion: Morphee: Down Syndrome and Continuous Positive Pressure Therapy (clinicaltrials.gov) - Apr 20, 2019
P=N/A, N=31, Completed, Sponsor: Institut Jerome Lejeune
N=52 --> 31 Recruiting --> Completed
- | NN1213 / Novo Nordisk
Trial completion, Trial completion date, Trial primary completion date: RCT/DD: DIR/ Floortime (clinicaltrials.gov) - Mar 7, 2019
P=N/A, N=48, Completed, Sponsor: Kingkaew Pajareya
Recruiting --> Completed Recruiting --> Completed | Trial completion date: Oct 2017 --> Dec 2016 | Trial primary completion date: Mar 2017 --> Dec 2016
- | Trial completion, Enrollment change, Trial completion date, Trial primary completion date: Gait Parameters of Persons With Down Syndrome With and Without Orthotics Using GaitRite (clinicaltrials.gov) - Feb 16, 2019
P=N/A, N=23, Completed, Sponsor: Oregon Health and Science University
Recruiting --> Completed | Trial completion date: Oct 2017 --> Dec 2016 | Trial primary completion date: Mar 2017 --> Dec 2016 Recruiting --> Completed | N=300 --> 23 | Trial completion date: Jun 2020 --> Aug 2018 | Trial primary completion date: Jun 2015 --> Aug 2018
- | Trial completion, Trial primary completion date: OT2SUITE: Follow-up of Prader Willi Syndrome Infants Treated by Oxytocin and Comparison With Not-treated Infants. (clinicaltrials.gov) - Jan 30, 2019
P=N/A, N=34, Completed, Sponsor: University Hospital, Toulouse
Recruiting --> Completed | N=300 --> 23 | Trial completion date: Jun 2020 --> Aug 2018 | Trial primary completion date: Jun 2015 --> Aug 2018 Recruiting --> Completed | Trial primary completion date: Dec 2018 --> May 2018
- Odomzo (sonidegib) / Sun Pharma, buparlisib (AN2025) / Adlai Nortye
Trial termination, Metastases: Pilot Study of Sonidegib and Buparlisib in Treating Patients With Advanced or Metastatic Basal Cell Carcinoma (clinicaltrials.gov) - Jan 29, 2019
P2, N=10, Terminated, Sponsor: Anne Chang
Recruiting --> Completed | Trial primary completion date: Dec 2018 --> May 2018 Completed --> Terminated; Business Decision
- | NN1213 / Novo Nordisk
Trial completion, Trial completion date: Assessing the Feasibility of the Use of Visual Aids in Patient Education in Adults With Down Syndrome (DS) (clinicaltrials.gov) - Jan 23, 2019
P=N/A, N=40, Completed, Sponsor: Advocate Health Care
Completed --> Terminated; Business Decision Active, not recruiting --> Completed | Trial completion date: Oct 2018 --> Oct 2017
- | Enrollment change, Trial termination: Evaluation of Autonomic Function in Individuals With Cornelia de Lange Syndrome (CdLS) (clinicaltrials.gov) - Dec 6, 2018
P=N/A, N=1, Terminated, Sponsor: Mayo Clinic
Active, not recruiting --> Completed | Trial completion date: Oct 2018 --> Oct 2017 N=10 --> 1 | Recruiting --> Terminated; Difficulty in recruitment, Funding has run out.
- | Trial completion: Characterization of Pulmonary Artery Stenoses in Alagille Syndrome - a Medical Record Review (clinicaltrials.gov) - Sep 28, 2018
P=N/A, N=25, Completed, Sponsor: Stanford University
N=10 --> 1 | Recruiting --> Terminated; Difficulty in recruitment, Funding has run out. Recruiting --> Completed
- | NN1213 / Novo Nordisk
Trial completion: The Effect of Conservative Interventions on the Signs and Symptoms of Diastasis Recti (clinicaltrials.gov) - Sep 25, 2018
P=N/A, N=32, Completed, Sponsor: Queen's University
Recruiting --> Completed Active, not recruiting --> Completed
- | fezagepras (PBI-4050) / Liminal BioSci
Biomarker, Trial completion: Safety and Tolerability of PBI-4050 and Its Effects on the Biomarkers in Subjects With Alstr (clinicaltrials.gov) - Aug 29, 2018
P2, N=12, Completed, Sponsor: ProMetic BioSciences Inc.
Active, not recruiting --> Completed Active, not recruiting --> Completed
- | Trial completion: Natural History of Amyloid Deposition in Adults With Down Syndrome (clinicaltrials.gov) - Aug 10, 2018
P=N/A, N=81, Completed, Sponsor: University of Pittsburgh
Active, not recruiting --> Completed Active, not recruiting --> Completed
- | NN1213 / Novo Nordisk
Trial completion, Enrollment change: Obstructive Sleep Apnea and Down Syndrome: Clinical Examination Issue (clinicaltrials.gov) - Jul 30, 2018
P=N/A, N=17, Completed, Sponsor: Fondation Lenval
Active, not recruiting --> Completed Recruiting --> Completed | N=150 --> 17
- | Erivedge (vismodegib) / Roche
Trial completion, Trial completion date: PDT-Vismo: Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas (clinicaltrials.gov) - Jul 18, 2018
P1, N=4, Completed, Sponsor: University of Arizona
Recruiting --> Completed | N=150 --> 17 Active, not recruiting --> Completed | Trial completion date: Jun 2018 --> Nov 2017
- | NN1213 / Novo Nordisk
Trial completion, Trial primary completion date: Phenotypic Specific Communication Intervention for Children With Down Syndrome (clinicaltrials.gov) - Jul 12, 2018
P=N/A, N=78, Completed, Sponsor: Vanderbilt University
Active, not recruiting --> Completed | Trial completion date: Jun 2018 --> Nov 2017 Recruiting --> Completed | Trial primary completion date: Dec 2017 --> Aug 2017
- | NN1213 / Novo Nordisk
Trial completion, Enrollment change, Trial completion date, Trial primary completion date: Tracking Neurodegeneration in Early Wolfram Syndrome (clinicaltrials.gov) - Jul 11, 2018
P=N/A, N=101, Completed, Sponsor: Washington University School of Medicine
Recruiting --> Completed | Trial primary completion date: Dec 2017 --> Aug 2017 Active, not recruiting --> Completed | N=150 --> 101 | Trial completion date: Apr 2018 --> Jul 2017 | Trial primary completion date: Apr 2018 --> Jul 2017
- | NN1213 / Novo Nordisk
Trial completion, Trial completion date: Growth Arrest in Focal Dermal Hypoplasia (clinicaltrials.gov) - Jun 18, 2018
P=N/A, N=16, Completed, Sponsor: University of Colorado, Denver
Active, not recruiting --> Completed | N=150 --> 101 | Trial completion date: Apr 2018 --> Jul 2017 | Trial primary completion date: Apr 2018 --> Jul 2017 Active, not recruiting --> Completed | Trial completion date: May 2019 --> May 2018
- | Trial completion, Enrollment change: Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome (clinicaltrials.gov) - Jun 18, 2018
P=N/A, N=13, Completed, Sponsor: Advocate Health Care
Active, not recruiting --> Completed | Trial completion date: May 2019 --> May 2018 Active, not recruiting --> Completed | N=30 --> 13
- | NN1213 / Novo Nordisk
Trial completion date: Growth Arrest in Focal Dermal Hypoplasia (clinicaltrials.gov) - Jun 14, 2018
P=N/A, N=16, Active, not recruiting, Sponsor: University of Colorado, Denver
Active, not recruiting --> Completed | N=30 --> 13 Trial completion date: Mar 2018 --> May 2019
- ||| SP-002 / Stamford Pharma
Trial completion, Enrollment change, Trial completion date, Combination therapy: ASN-002-001: A Study of the Efficacy and Safety of ASN-002 in Adult Patients With Low-risk Nodular Basal Cell Carcinoma (clinicaltrials.gov) - Jun 6, 2018
P1/2, N=16, Completed, Sponsor: Ascend Biopharmaceuticals Ltd
Trial completion date: Mar 2018 --> May 2019 Recruiting --> Completed | N=36 --> 16 | Trial completion date: May 2018 --> Nov 2017
- | Trial completion, Enrollment change, Trial completion date: Treatment of Sleep Disturbances in School-age Children With Down Syndrome (clinicaltrials.gov) - Jun 4, 2018
P=N/A, N=34, Completed, Sponsor: Children's Hospital Medical Center, Cincinnati
Recruiting --> Completed | N=36 --> 16 | Trial completion date: May 2018 --> Nov 2017 Recruiting --> Completed | N=80 --> 34 | Trial completion date: Aug 2018 --> May 2018
- | Trial completion, Enrollment change: Thoracic Aortic Dilatation Syndromes (clinicaltrials.gov) - May 2, 2018
P=N/A, N=120, Completed, Sponsor: University of Aarhus
Recruiting --> Completed | N=80 --> 34 | Trial completion date: Aug 2018 --> May 2018 Active, not recruiting --> Completed | N=300 --> 120
- | Enrollment closed, Trial completion date, Trial primary completion date: Tracking Neurodegeneration in Early Wolfram Syndrome (clinicaltrials.gov) - May 1, 2018
P=N/A, N=150, Active, not recruiting, Sponsor: Washington University School of Medicine
Active, not recruiting --> Completed | N=300 --> 120 Recruiting --> Active, not recruiting | Trial completion date: Apr 2017 --> Apr 2018 | Trial primary completion date: Apr 2017 --> Apr 2018
- | Odomzo (sonidegib) / Sun Pharma, buparlisib (AN2025) / Novartis, Adlai Nortye
Trial completion, Phase classification, Metastases: Pilot Study of Sonidegib and Buparlisib in Treating Patients With Advanced or Metastatic Basal Cell Carcinoma (clinicaltrials.gov) - Apr 17, 2018
P2, N=11, Completed, Sponsor: Anne Chang
Recruiting --> Active, not recruiting | Trial completion date: Apr 2017 --> Apr 2018 | Trial primary completion date: Apr 2017 --> Apr 2018 Active, not recruiting --> Completed | Phase classification: PN/A --> P2
- | topiramate / Generic mfg.
Trial termination: TOPRADER: Study of the Efficacy of Topiramate in Patients With Prader Willi Syndrome Over 8 Weeks (clinicaltrials.gov) - Apr 11, 2018
P3, N=69, Terminated, Sponsor: Assistance Publique - H
Active, not recruiting --> Completed | Phase classification: PN/A --> P2 Completed --> Terminated
- | fezagepras (PBI-4050) / Liminal BioSci
Biomarker, Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date: Safety and Tolerability of PBI-4050 and Its Effects on the Biomarkers in Subjects With Alstr (clinicaltrials.gov) - Apr 11, 2018
P2, N=12, Active, not recruiting, Sponsor: ProMetic BioSciences Inc.
Completed --> Terminated Recruiting --> Active, not recruiting | N=18 --> 12 | Trial completion date: Mar 2017 --> Jun 2018 | Trial primary completion date: Jan 2017 --> Sep 2017
- | Phase classification, Enrollment change: Studies of Heritable Disorders of Connective Tissue (clinicaltrials.gov) - Apr 6, 2018
P, N=929, Completed, Sponsor: National Institute on Aging (NIA)
Recruiting --> Active, not recruiting | N=18 --> 12 | Trial completion date: Mar 2017 --> Jun 2018 | Trial primary completion date: Jan 2017 --> Sep 2017 Phase classification: P=N/A --> P | N=1335 --> 929
- | Phase classification: Informed Consent for Whole Genome Sequencing: Ideals and Norms Referenced by Early Participants (clinicaltrials.gov) - Apr 6, 2018
P, N=30, Completed, Sponsor: National Human Genome Research Institute (NHGRI)
Phase classification: P=N/A --> P | N=1335 --> 929 Phase classification: P=N/A --> P
- | Phase classification, Enrollment change: dbGaP Protocol: Genetic Variants Associated With Pentalogy of Cantrell (clinicaltrials.gov) - Apr 5, 2018
P, N=3280, Completed, Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Phase classification: P=N/A --> P Phase classification: P=N/A --> P | N=9999 --> 3280
- | Trial completion date: Assessing the Feasibility of the Use of Visual Aids in Patient Education in Adults With Down Syndrome (DS) (clinicaltrials.gov) - Mar 30, 2018
P=N/A, N=40, Active, not recruiting, Sponsor: Advocate Health Care
Phase classification: P=N/A --> P | N=9999 --> 3280 Trial completion date: Dec 2017 --> Oct 2018
- | Trial completion date: Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome (clinicaltrials.gov) - Mar 3, 2018
P=N/A, N=30, Active, not recruiting, Sponsor: Advocate Health Care
Trial completion date: Dec 2017 --> Oct 2018 Trial completion date: Feb 2018 --> Mar 2018
- ||| Trial completion, Trial completion date, Trial primary completion date: Study of the Efficacy of New Non-invasive Prenatal Tests for Screening for Fetal Trisomies Using Maternal Blood (clinicaltrials.gov) - Feb 22, 2018
P=N/A, N=3819, Completed, Sponsor: CHU de Quebec-Universite Laval
Trial completion date: Feb 2018 --> Mar 2018 Active, not recruiting --> Completed | Trial primary completion date: Sep 2017 --> Jun 2017 | Trial completion date: Dec 2017 --> Jun 2017
- | Trial completion, Enrollment change, Trial completion date, Trial primary completion date: FaSchi22: Perception of Facial Emotions in Schizophrenia and 22q11 Deletion Syndrome (clinicaltrials.gov) - Feb 8, 2018
P=N/A, N=70, Completed, Sponsor: H
Active, not recruiting --> Completed | Trial primary completion date: Sep 2017 --> Jun 2017 | Trial completion date: Dec 2017 --> Jun 2017 Active, not recruiting --> Completed | N=120 --> 70 | Trial primary completion date: Oct 2018 --> Oct 2017 | Trial completion date: Nov 2018 --> Dec 2017
- | Metopirone (metyrapone) / Perrigo Company
Trial completion, Trial primary completion date: Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome (clinicaltrials.gov) - Jan 29, 2018
P=N/A, N=23, Completed, Sponsor: Nationwide Children's Hospital
Active, not recruiting --> Completed | N=120 --> 70 | Trial primary completion date: Oct 2018 --> Oct 2017 | Trial completion date: Nov 2018 --> Dec 2017 Recruiting --> Completed | Trial primary completion date: Dec 2015 --> Aug 2016
- | Enrollment closed: Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome (clinicaltrials.gov) - Jan 10, 2018
P=N/A, N=30, Active, not recruiting, Sponsor: Advocate Health Care
Recruiting --> Completed | Trial primary completion date: Dec 2015 --> Aug 2016 Recruiting --> Active, not recruiting
- | Trial completion, Trial primary completion date: Pilot Study of Startle-response Test to Assess Transcranial Direct Current Stimulation-induced Modulation of Hyperphagia in Prader-Willi Syndrome (clinicaltrials.gov) - Dec 28, 2017
P=N/A, N=52, Completed, Sponsor: University of Kansas Medical Center
Recruiting --> Active, not recruiting Recruiting --> Completed | Trial primary completion date: Jul 2017 --> Oct 2016
- | gaboxadol (OV101) / Ovid Therapeutics, Angelini Group, Healx
Trial completion: Single Dose Pharmacokinetic (PK) Study (clinicaltrials.gov) - Nov 30, 2017
P1, N=12, Completed, Sponsor: Ovid Therapeutics Inc.
Recruiting --> Completed | Trial primary completion date: Jul 2017 --> Oct 2016 Active, not recruiting --> Completed
- Erivedge (vismodegib) / Roche
Enrollment closed, Enrollment change: PDT-Vismo: Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas (clinicaltrials.gov) - Nov 20, 2017
P1, N=4, Active, not recruiting, Sponsor: University of Arizona
Active, not recruiting --> Completed Recruiting --> Active, not recruiting | N=12 --> 4
- | Humira (adalimumab) / AbbVie
Trial completion: Clinical Trial Using Humira in Netherton Syndrome (clinicaltrials.gov) - Oct 18, 2017
P2, N=11, Completed, Sponsor: Assistance Publique - H
Recruiting --> Active, not recruiting | N=12 --> 4 Active, not recruiting --> Completed
- | Trial primary completion date: Treatment of Sleep Disturbances in School-age Children With Down Syndrome (clinicaltrials.gov) - Oct 5, 2017
P=N/A, N=80, Recruiting, Sponsor: Children's Hospital Medical Center, Cincinnati
Active, not recruiting --> Completed Trial primary completion date: Jun 2017 --> Jun 2018
- gaboxadol (OV101) / Ovid Therapeutics, Angelini Group, Healx
Enrollment closed: Single Dose Pharmacokinetic (PK) Study (clinicaltrials.gov) - Sep 15, 2017
P1, N=12, Active, not recruiting, Sponsor: Ovid Therapeutics Inc.
Trial primary completion date: Jun 2017 --> Jun 2018 Recruiting --> Active, not recruiting
- ||| Trial completion, Trial primary completion date: ECP-015: Natural History and Outcomes in X-Linked Hypohidrotic Ectodermal Dysplasia (clinicaltrials.gov) - Sep 5, 2017
P=N/A, N=150, Completed, Sponsor: Edimer Pharmaceuticals
Recruiting --> Active, not recruiting Active, not recruiting --> Completed | Trial primary completion date: Oct 2019 --> Dec 2016
- | donepezil / Generic mfg.
Trial completion, Trial primary completion date: A Double-blind, Placebo-controlled Comparative Study and Open-label Extension Study to Confirm the Efficacy and Safety of E2020 in Subjects With Down Syndrome Having Regression Symptoms and Disabled Activities of Daily Living. (clinicaltrials.gov) - Aug 22, 2017
P2, N=36, Completed, Sponsor: Eisai Co., Ltd.
Active, not recruiting --> Completed | Trial primary completion date: Oct 2019 --> Dec 2016 Active, not recruiting --> Completed | Trial primary completion date: Apr 2017 --> Sep 2016
- | Trial completion: DEPOSA: T21,18 and 13 Screening by Cell Free Fetal DNA in Low Risk Patients (clinicaltrials.gov) - Aug 15, 2017
P=N/A, N=933, Completed, Sponsor: Assistance Publique - H
Active, not recruiting --> Completed | Trial primary completion date: Apr 2017 --> Sep 2016 Active, not recruiting --> Completed
- | Trial primary completion date: Natural History of Amyloid Deposition in Adults With Down Syndrome (clinicaltrials.gov) - Jul 26, 2017
P=N/A, N=81, Active, not recruiting, Sponsor: University of Pittsburgh
Active, not recruiting --> Completed Trial primary completion date: Apr 2017 --> Apr 2018
- | BMS-833923 / BMS
Trial completion, Trial primary completion date: Study of BMS-833923 in Two Specific Patients With Basal Cell Nevus Syndrome (clinicaltrials.gov) - Jul 11, 2017
P=N/A, N=2, Completed, Sponsor: University Health Network, Toronto
Trial primary completion date: Apr 2017 --> Apr 2018 Active, not recruiting --> Completed | Trial primary completion date: Feb 2019 --> May 2017
- |||| Erivedge (vismodegib) / Roche
Trial completion, Trial primary completion date: A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas (clinicaltrials.gov) - Jul 2, 2017
P2, N=229, Completed, Sponsor: Hoffmann-La Roche
Active, not recruiting --> Completed | Trial primary completion date: Feb 2019 --> May 2017 Active, not recruiting --> Completed | Trial primary completion date: Aug 2016 --> Aug 2015
- | NN1213 / Novo Nordisk
Trial completion: Velocardiofacial (VCFS; 22q11.2; DiGeorge) Syndrome Study (clinicaltrials.gov) - Jun 30, 2017
P=N/A, N=0, Completed, Sponsor: National Institute of Mental Health (NIMH)
Active, not recruiting --> Completed | Trial primary completion date: Aug 2016 --> Aug 2015 Recruiting --> Completed
- | Trial completion, Trial primary completion date: French Kabuki Syndrome Network. Epidemiology, Management of Patients and Research by Array-CGH (clinicaltrials.gov) - May 16, 2017
P=N/A, N=110, Completed, Sponsor: Assistance Publique - H
Recruiting --> Completed Recruiting --> Completed | Trial primary completion date: Sep 2013 --> Mar 2015
- | Trial completion, Enrollment change: Heterotaxy Syndrome and Intestinal Rotation Abnormalities - A Prospective Study (clinicaltrials.gov) - May 9, 2017
P=N/A, N=40, Completed, Sponsor: University of Alberta
Recruiting --> Completed | Trial primary completion date: Sep 2013 --> Mar 2015 Recruiting --> Completed | N=50 --> 40