Esperion Therap 
Welcome,         Profile    Billing    Logout  
 2 Products   12 Diseases  2 Products   12 Trials   1797 News 
23 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Nexletol (bempedoic acid) / Esperion Therap
NCT06431763: A Study to Investigate LDL-cholesterol Lowering With Inclisiran Compared to Bempedoic Acid in Patients With Atherosclerotic Cardiovascular Disease.

Recruiting
4
400
Europe
Inclisiran sodium, PCSK9 inhibitor, siRNA, BPA, small molecule, ACL inhibitor
Novartis Pharmaceuticals
Hypercholesterolemia
09/25
09/25
CLEAR Taiwan, NCT06925100: A Multicenter, Prospective, Phase IV, Interventional Study to Investigate the Effectiveness and Safety of Bempedoic Acid in Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia in Taiwan

Not yet recruiting
4
180
RoW
Bempedoic acid 180 mg tablet
Daiichi Sankyo Taiwan Ltd.
Primary Hypercholesterolemia or Mixed Hyperlipidemia
12/25
12/25
2021-005602-10: Study which will investigate, if the treatment with Inclisiran, Bempedoic acid and monoclonal antibodies Alirocumab or Evolocumab has other than lipid-lowering effects such as change in platelet activity and inflammation markers.

Not yet recruiting
3
60
Europe
Inclisiran, Nilemdo, Repatha, Rosuvastatin, Atorvastatin, Solution for injection in pre-filled syringe, Film-coated tablet, Leqvio, Nilemdo, Repatha, Rosuvastatin, Atorvastatin
Verein zur Förderung der Forschung auf dem Gebiet der Arteriosklerose, Thrombose und vaskulären Biologie (ATVB), Verein zur Fördferung der Forschung auf dem Gebiet der Arteriosklerose, Thrombose und vaskulären Biologie (ATVB)
platelet activity and inflammation markers in patients with coronary artery disease, platelet activity and inflammation markers in patients with coronary artery disease, Diseases [C] - Cardiovascular Diseases [C14]
 
 
2022-003526-50: Clinical study to evaluate the effectiveness of the active ingredient Bempedoic acid in patients following myocardial infarctions insufficiently treated with the drugs atorvastatin plus ezetimibe.

Not yet recruiting
3
135
Europe
Film-coated tablet, Nilemdo®
Hannover Medical School, Daiichi-Sankyo Germany GmbH
Patients following acute percutaneous coronary intervention for STEMI or NSTEMI insufficiently treated with high-intensity oral lipid lowering therapy, patients following myocardial infarctions insufficiently treated with high-intensity oral lipid lowering therapy, Diseases [C] - Cardiovascular Diseases [C14]
 
 
NCT05683340: A Confirmatory Trial of ETC-1002 in Patients With Hyper-LDL Cholesterolemia

Completed
3
96
Japan
180mg of ETC-1002(bempedoic acid), Placebo
Otsuka Pharmaceutical Co., Ltd.
Hyper-low-density Lipoprotein (LDL) Cholesterolemia
02/24
03/24
NCT05687071: A Long-term Trial of ETC-1002 in Patients With Hyper-LDL Cholesterolemia

Completed
3
130
Japan
180mg of ETC-1002(bempedoic acid)
Otsuka Pharmaceutical Co., Ltd.
Hyper-low-density Lipoprotein (LDL) Cholesterolemia
10/24
11/24
NCT06780410: A Clinical Study to Evaluate the Efficacy, Tolerability, and Safety of Bempedoic Acid

Recruiting
3
240
RoW
Bempedoic Acid Tablet, Placebo
Gan & Lee Pharmaceuticals.
Primary Hyperlipidemia
10/25
10/25
CLEAR Path 1, NCT05694260 / 2018-004084-31: A Clinical Study in Children With Heterozygous Familial Hypercholesterolemia (HeFH) Aged 6 to 17 Treated Once Daily With Bempedoic Acid Oral Dosing

Recruiting
2
54
Europe, Canada, US
Bempedoic acid, ETC-1002
Esperion Therapeutics, Inc., Esperion Therapeutics, Inc.
Hypercholesterolemia
06/25
08/25
CLEAR HIV, NCT05488431: Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial ( Trial)

Recruiting
2
121
US
Bempedoic acid, BA, Placebo
Priscilla Hsue, MD, University of California, Los Angeles, Massachusetts General Hospital
Dyslipidemias, Cardiovascular Diseases, HIV Infections, Atherosclerosis
03/28
03/28
NCT06923956: Single Dose Oral Bioequivalence Study of Bempedoic Acid 180 mg Film Coated Tablet and Nilemdo® (Bempedoic Acid) 180 mg Film-coated Tablets in Healthy Adult Human Subjects Under Fasting Conditions.

Completed
1
14
RoW
Bempedoic Acid Film Coated Tablet, Nilemdo® (Bempedoic Acid) Film-coated tablets
Humanis Saglık Anonim Sirketi
Hypercholesterolaemia, Mixed Dyslipidaemia, Cardiovascular Diseases
12/24
02/25
NCT06742853: A Study to Investigate the Pharmacokinetics, Safety, Tolerability, and Efficacy of AZD0780 With Ezetimibe Combinations in Healthy Adults With Elevated LDL-C.

Recruiting
1
120
Europe, US
AZD0780, Ezetimibe, Rosuvastatin, Bempedoic Acid, Placebo
AstraZeneca
Dyslipidemia
08/25
08/25
B-LIFT, NCT06035874: Effect of Bempedoic Acid on Liver Fat in Individuals With Nonalcoholic Fatty Liver Disease and Type 2 Diabetes

Recruiting
N/A
100
RoW
Bempedoic acid
Medanta, The Medicity, India, Diabetes & Endocrinology Foundation
Type 2 Diabetes, Non Alcholic Fatty Liver Disease
11/24
10/25
NCT06960655: Improving Lipid Optimization Quality and Treatment Options in ASCVD

Not yet recruiting
N/A
300
US
Referral to Pharmacist-Driven Medication Management Program, Best-Practice Alert
Brigham and Women's Hospital, Merck Sharp & Dohme LLC
Hypercholesterolemia, ASCVD
04/26
11/26
MILOS, NCT04579367: Treatment With Bempedoic Acid and/or Its Fixed-dose Combination With Ezetimibe in Primary Hypercholesterolemia or Mixed Dyslipidemia

Recruiting
N/A
5000
Europe
Bempedoic acid and/or its fixed-dose combination with ezetimibe
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Hypercholesterolemia, Mixed Dyslipidemia
09/25
09/25
JaZ, NCT05587621: Intensive Lipid-lowering in Patients With STEMI and NSTEMI (Germany on Target)

Not yet recruiting
N/A
300
Europe
statins, ezetimibe, bempedoic acid, evolocumab, alirocumab, inclisiran, dietary advice
Jena University Hospital
ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction, LDL-cholesterol
04/26
12/26
MILOS-Spain, NCT05798390: Treatment With Bempedoic Acid And/Or Its Fixed-dose Combination With Ezetimibe in Routine Clinical Practice in Patients With Primary Hypercholesterolemia Or Mixed Dyslipidemia

Withdrawn
N/A
1100
NA
Bempedoic acid and/or its fixed dose combination with ezetimibe
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Primary Hypercholesterolemia, Mixed Dyslipidemia
04/26
04/26
NCT05103254: Bempedoic Acid Pregnancy Surveillance Program

Recruiting
N/A
20
US
Bempedoic Acid, Nexletol, Bempedoic Acid / Ezetimibe, Nexlizet
Esperion Therapeutics, Inc.
Pregnancy, Hyperlipidemias
05/32
05/32
Nexlizet (bempedoic acid/ezetimibe) / Esperion Therap
2021-006550-31: BempeDoic acid in Acute Coronary Syndrome Ácido bempedoico en el síndrome coronario agudo

Not yet recruiting
4
206
Europe
Bempedoic Acid / Ezetimibe, SUB183128, Film-coated tablet, NUSTENDI
SPANISH SOCIETY OF CARDIOLOGY, SPANISH SOCIETY OF CARDIOLOGY
Acute coronary syndrome with poor LDL-cholesterol control Síndrome coronario agudo con mal control de colesterol LDL, Acute coronary syndrome Síndrome coronario agudo, Diseases [C] - Cardiovascular Diseases [C14]
 
 
NCT05263778: Cholesterol Lowering Via Bempedoic Acid/Ezetimibe, an ACL-Inhibiting Regimen in Acute Coronary Syndrome Study

Not yet recruiting
4
500
US
Bempedoic Acid / Ezetimibe Oral Tablet, Nexlizet, Placebo
Kaiser Permanente, Esperion Therapeutics, Inc.
Cardiovascular Diseases, NSTEMI, STEMI
06/23
12/23
NCT06021951: Milk-Only Lactation Study to Evaluate the Concentration of Bempedoic Acid and Bempedoic Acid/Ezetimibe Fixed Combination Drug Product (FCDP) in the Breast Milk of Healthy Lactating Women

Completed
4
16
US
Bempedoic Acid 180 MG Oral Tablet, Nexletol, Bempedoic Acid/Ezetimibe 180 MG-10 MG Oral Tablet, Nexlizet 180 mg-10 mg
Esperion Therapeutics, Inc.
Healthy Lactating Women
02/24
03/24
ARTCAP, NCT06280976: Aggressive Risk-Prevention Therapies for Coronary Atherosclerotic Plaque (ART-CAP)

Withdrawn
4
200
US
Statin, atorvastatin, Aspirin tablet, aspirin 81 mg, Nexlizet, bempedoic acid-ezetimibe, LEQVIO, inclisiran, Vascepa, icosapent ethyl, Jardiance, empagliflozin, Colchicine
University of Louisville
Coronary Artery Disease, Atherosclerosis, Heart Attack
01/25
01/25
BESAFE, NCT06381947: Efficacy and Safety of Bempedoic Acid in Association With Anti-PCSK9 and Ezetimibe in Statin-intolerant Patients

Not yet recruiting
4
130
NA
Lipid-lowering therapy combination with PCSK9 inhibitors, bempedoic acid and ezetimibe, PCSK9 inhibitors, bempedoic acid, ezetimibe, Praluent, Repatha, Nilemdo, Nustendi, Absorcol, Lipid-lowering therapy combination with PCSK9 inhibitors and ezetimibe, PCSK9 inhibitors, ezetimibe, Praluent, Repatha, Absorcol
University of Salerno
Dyslipidemias, Statin Adverse Reaction, Cardiovascular Diseases, Lipid Metabolism Disorders
06/25
06/25
NCT05543122: Drug Concentrations in Breast Milk and Prediction of Blood Levels of the Breastfed Infants

Completed
N/A
39
Canada
either of Atenolol, Bupropion, Brivaracetam, Escitalopram, Fluconazole, Lacosamide, Lamotrigine, Levetiracetam, Methotrexate or Ezetimibe, Typical brand names include, but not limited to: Tenoretic, Wellbutrin, Zyban, Briviact, Cipralex, Lexapro, Diflucan, Vimpat, Lamictal, Keppra, Trexall, Xatmep, Ezetrol, Nexlizet
The Hospital for Sick Children, St. Justine's Hospital, University of Waterloo
Breast Feeding
12/23
03/24
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Nexletol (bempedoic acid) / Esperion Therap
NCT06431763: A Study to Investigate LDL-cholesterol Lowering With Inclisiran Compared to Bempedoic Acid in Patients With Atherosclerotic Cardiovascular Disease.

Recruiting
4
400
Europe
Inclisiran sodium, PCSK9 inhibitor, siRNA, BPA, small molecule, ACL inhibitor
Novartis Pharmaceuticals
Hypercholesterolemia
09/25
09/25
CLEAR Taiwan, NCT06925100: A Multicenter, Prospective, Phase IV, Interventional Study to Investigate the Effectiveness and Safety of Bempedoic Acid in Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia in Taiwan

Not yet recruiting
4
180
RoW
Bempedoic acid 180 mg tablet
Daiichi Sankyo Taiwan Ltd.
Primary Hypercholesterolemia or Mixed Hyperlipidemia
12/25
12/25
2021-005602-10: Study which will investigate, if the treatment with Inclisiran, Bempedoic acid and monoclonal antibodies Alirocumab or Evolocumab has other than lipid-lowering effects such as change in platelet activity and inflammation markers.

Not yet recruiting
3
60
Europe
Inclisiran, Nilemdo, Repatha, Rosuvastatin, Atorvastatin, Solution for injection in pre-filled syringe, Film-coated tablet, Leqvio, Nilemdo, Repatha, Rosuvastatin, Atorvastatin
Verein zur Förderung der Forschung auf dem Gebiet der Arteriosklerose, Thrombose und vaskulären Biologie (ATVB), Verein zur Fördferung der Forschung auf dem Gebiet der Arteriosklerose, Thrombose und vaskulären Biologie (ATVB)
platelet activity and inflammation markers in patients with coronary artery disease, platelet activity and inflammation markers in patients with coronary artery disease, Diseases [C] - Cardiovascular Diseases [C14]
 
 
2022-003526-50: Clinical study to evaluate the effectiveness of the active ingredient Bempedoic acid in patients following myocardial infarctions insufficiently treated with the drugs atorvastatin plus ezetimibe.

Not yet recruiting
3
135
Europe
Film-coated tablet, Nilemdo®
Hannover Medical School, Daiichi-Sankyo Germany GmbH
Patients following acute percutaneous coronary intervention for STEMI or NSTEMI insufficiently treated with high-intensity oral lipid lowering therapy, patients following myocardial infarctions insufficiently treated with high-intensity oral lipid lowering therapy, Diseases [C] - Cardiovascular Diseases [C14]
 
 
NCT05683340: A Confirmatory Trial of ETC-1002 in Patients With Hyper-LDL Cholesterolemia

Completed
3
96
Japan
180mg of ETC-1002(bempedoic acid), Placebo
Otsuka Pharmaceutical Co., Ltd.
Hyper-low-density Lipoprotein (LDL) Cholesterolemia
02/24
03/24
NCT05687071: A Long-term Trial of ETC-1002 in Patients With Hyper-LDL Cholesterolemia

Completed
3
130
Japan
180mg of ETC-1002(bempedoic acid)
Otsuka Pharmaceutical Co., Ltd.
Hyper-low-density Lipoprotein (LDL) Cholesterolemia
10/24
11/24
NCT06780410: A Clinical Study to Evaluate the Efficacy, Tolerability, and Safety of Bempedoic Acid

Recruiting
3
240
RoW
Bempedoic Acid Tablet, Placebo
Gan & Lee Pharmaceuticals.
Primary Hyperlipidemia
10/25
10/25
CLEAR Path 1, NCT05694260 / 2018-004084-31: A Clinical Study in Children With Heterozygous Familial Hypercholesterolemia (HeFH) Aged 6 to 17 Treated Once Daily With Bempedoic Acid Oral Dosing

Recruiting
2
54
Europe, Canada, US
Bempedoic acid, ETC-1002
Esperion Therapeutics, Inc., Esperion Therapeutics, Inc.
Hypercholesterolemia
06/25
08/25
CLEAR HIV, NCT05488431: Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial ( Trial)

Recruiting
2
121
US
Bempedoic acid, BA, Placebo
Priscilla Hsue, MD, University of California, Los Angeles, Massachusetts General Hospital
Dyslipidemias, Cardiovascular Diseases, HIV Infections, Atherosclerosis
03/28
03/28
NCT06923956: Single Dose Oral Bioequivalence Study of Bempedoic Acid 180 mg Film Coated Tablet and Nilemdo® (Bempedoic Acid) 180 mg Film-coated Tablets in Healthy Adult Human Subjects Under Fasting Conditions.

Completed
1
14
RoW
Bempedoic Acid Film Coated Tablet, Nilemdo® (Bempedoic Acid) Film-coated tablets
Humanis Saglık Anonim Sirketi
Hypercholesterolaemia, Mixed Dyslipidaemia, Cardiovascular Diseases
12/24
02/25
NCT06742853: A Study to Investigate the Pharmacokinetics, Safety, Tolerability, and Efficacy of AZD0780 With Ezetimibe Combinations in Healthy Adults With Elevated LDL-C.

Recruiting
1
120
Europe, US
AZD0780, Ezetimibe, Rosuvastatin, Bempedoic Acid, Placebo
AstraZeneca
Dyslipidemia
08/25
08/25
B-LIFT, NCT06035874: Effect of Bempedoic Acid on Liver Fat in Individuals With Nonalcoholic Fatty Liver Disease and Type 2 Diabetes

Recruiting
N/A
100
RoW
Bempedoic acid
Medanta, The Medicity, India, Diabetes & Endocrinology Foundation
Type 2 Diabetes, Non Alcholic Fatty Liver Disease
11/24
10/25
NCT06960655: Improving Lipid Optimization Quality and Treatment Options in ASCVD

Not yet recruiting
N/A
300
US
Referral to Pharmacist-Driven Medication Management Program, Best-Practice Alert
Brigham and Women's Hospital, Merck Sharp & Dohme LLC
Hypercholesterolemia, ASCVD
04/26
11/26
MILOS, NCT04579367: Treatment With Bempedoic Acid and/or Its Fixed-dose Combination With Ezetimibe in Primary Hypercholesterolemia or Mixed Dyslipidemia

Recruiting
N/A
5000
Europe
Bempedoic acid and/or its fixed-dose combination with ezetimibe
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Hypercholesterolemia, Mixed Dyslipidemia
09/25
09/25
JaZ, NCT05587621: Intensive Lipid-lowering in Patients With STEMI and NSTEMI (Germany on Target)

Not yet recruiting
N/A
300
Europe
statins, ezetimibe, bempedoic acid, evolocumab, alirocumab, inclisiran, dietary advice
Jena University Hospital
ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction, LDL-cholesterol
04/26
12/26
MILOS-Spain, NCT05798390: Treatment With Bempedoic Acid And/Or Its Fixed-dose Combination With Ezetimibe in Routine Clinical Practice in Patients With Primary Hypercholesterolemia Or Mixed Dyslipidemia

Withdrawn
N/A
1100
NA
Bempedoic acid and/or its fixed dose combination with ezetimibe
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Primary Hypercholesterolemia, Mixed Dyslipidemia
04/26
04/26
NCT05103254: Bempedoic Acid Pregnancy Surveillance Program

Recruiting
N/A
20
US
Bempedoic Acid, Nexletol, Bempedoic Acid / Ezetimibe, Nexlizet
Esperion Therapeutics, Inc.
Pregnancy, Hyperlipidemias
05/32
05/32
Nexlizet (bempedoic acid/ezetimibe) / Esperion Therap
2021-006550-31: BempeDoic acid in Acute Coronary Syndrome Ácido bempedoico en el síndrome coronario agudo

Not yet recruiting
4
206
Europe
Bempedoic Acid / Ezetimibe, SUB183128, Film-coated tablet, NUSTENDI
SPANISH SOCIETY OF CARDIOLOGY, SPANISH SOCIETY OF CARDIOLOGY
Acute coronary syndrome with poor LDL-cholesterol control Síndrome coronario agudo con mal control de colesterol LDL, Acute coronary syndrome Síndrome coronario agudo, Diseases [C] - Cardiovascular Diseases [C14]
 
 
NCT05263778: Cholesterol Lowering Via Bempedoic Acid/Ezetimibe, an ACL-Inhibiting Regimen in Acute Coronary Syndrome Study

Not yet recruiting
4
500
US
Bempedoic Acid / Ezetimibe Oral Tablet, Nexlizet, Placebo
Kaiser Permanente, Esperion Therapeutics, Inc.
Cardiovascular Diseases, NSTEMI, STEMI
06/23
12/23
NCT06021951: Milk-Only Lactation Study to Evaluate the Concentration of Bempedoic Acid and Bempedoic Acid/Ezetimibe Fixed Combination Drug Product (FCDP) in the Breast Milk of Healthy Lactating Women

Completed
4
16
US
Bempedoic Acid 180 MG Oral Tablet, Nexletol, Bempedoic Acid/Ezetimibe 180 MG-10 MG Oral Tablet, Nexlizet 180 mg-10 mg
Esperion Therapeutics, Inc.
Healthy Lactating Women
02/24
03/24
ARTCAP, NCT06280976: Aggressive Risk-Prevention Therapies for Coronary Atherosclerotic Plaque (ART-CAP)

Withdrawn
4
200
US
Statin, atorvastatin, Aspirin tablet, aspirin 81 mg, Nexlizet, bempedoic acid-ezetimibe, LEQVIO, inclisiran, Vascepa, icosapent ethyl, Jardiance, empagliflozin, Colchicine
University of Louisville
Coronary Artery Disease, Atherosclerosis, Heart Attack
01/25
01/25
BESAFE, NCT06381947: Efficacy and Safety of Bempedoic Acid in Association With Anti-PCSK9 and Ezetimibe in Statin-intolerant Patients

Not yet recruiting
4
130
NA
Lipid-lowering therapy combination with PCSK9 inhibitors, bempedoic acid and ezetimibe, PCSK9 inhibitors, bempedoic acid, ezetimibe, Praluent, Repatha, Nilemdo, Nustendi, Absorcol, Lipid-lowering therapy combination with PCSK9 inhibitors and ezetimibe, PCSK9 inhibitors, ezetimibe, Praluent, Repatha, Absorcol
University of Salerno
Dyslipidemias, Statin Adverse Reaction, Cardiovascular Diseases, Lipid Metabolism Disorders
06/25
06/25
NCT05543122: Drug Concentrations in Breast Milk and Prediction of Blood Levels of the Breastfed Infants

Completed
N/A
39
Canada
either of Atenolol, Bupropion, Brivaracetam, Escitalopram, Fluconazole, Lacosamide, Lamotrigine, Levetiracetam, Methotrexate or Ezetimibe, Typical brand names include, but not limited to: Tenoretic, Wellbutrin, Zyban, Briviact, Cipralex, Lexapro, Diflucan, Vimpat, Lamictal, Keppra, Trexall, Xatmep, Ezetrol, Nexlizet
The Hospital for Sick Children, St. Justine's Hospital, University of Waterloo
Breast Feeding
12/23
03/24

Download Options