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88 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Acetavance (acetaminophen) / Mallinckrodt
NCT03020875: IV vs Oral Acetaminophen in Spine Fusion Perioperative Care

Enrolling by invitation
4
166
US
Ofirmev, Intravenous Acetaminophen, Per Os Acetaminophen
Hospital for Special Surgery, New York, Mallinckrodt
Multimodal Analgesic Approach
03/26
03/26
POPCORN, NCT03677830: Postoperative Pain Control & Relief in Neonates

Terminated
4
11
US
Acetaminophen, Ofirmev 10 MG/ML Injectable Solution, Saline
St. Louis University
Pain, Postoperative, Premature Infant, Opioid Use
03/24
03/24
PANDORA, NCT04093219: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients

Active, not recruiting
3
900
US
IV acetaminophen, ofirmev, Placebo
Beth Israel Deaconess Medical Center, National Institute on Aging (NIA)
Delirium in Old Age, Delirium, Coronary Artery Disease
03/25
03/26
NCT01391962: Sunitinib or Cediranib for Alveolar Soft Part Sarcoma

Active, not recruiting
2
34
US
Cediranib, AZD2171 maleate, Recentin, AXD2171, Sunitinib, Sutent, SU11248, SU011248, Prochlorperazine, Compro, Promethazine, Phenadoz, Phenergan, Promethegan, Benzodiazepine, Valium, Diazepam, Estazolam, ProSom, Flurazepam, Dalmane, Lorazepam, Ativan, Filgrastim, Neupogen, Sargramostim, Leukine, Lomotil, Diphenoxylate hydrochloride (HCL)/atropine, Loperamide, Imodium, Diamode, Anti-Diarrheal (loperamide), Vitamin B6, Pyridoxine, Aquaphor, Acetaminophen, Tylenol, Ofirmev, FeverAll, Levothyroxine, Synthroid, Tirosint, Unithroid, Warfarin, Coumadin
National Cancer Institute (NCI)
Sarcoma, Alveolar Soft Part
11/23
03/26
NCT06043323: A Phase II Study of Axicabtagene Ciloleucel, an Anti-CD19 Chimeric Antigen Receptor (CAR) Tcell Therapy, in Combination With Radiotherapy (RT) in Relapsed/Refractory Follicular Lymphoma

Recruiting
2
20
US
Axicabtagene Ciloleucel, Cyclophosphamide, Cytoxan®, Neosar®, Fludarabine phosphate, Prednisone, Diphenhydramine, Benadryl®, Acetaminophen, Tylenol®, Dorcol®, Feverall, Panadol, APAP, N-Acetyl-P-Aminophenol, Paracetamo, Ofirmev™
M.D. Anderson Cancer Center
Follicular Lymphoma
09/26
09/28
NCI-2022-02215, NCT05285813: A Phase II Study of Vibecotamab (XmAb14045) for MRD- Positive AML and MDS After Hypomethylating Agent Failure

Active, not recruiting
2
42
US
Vibecotamab, XmAb14045, Dexamethasone, Decadron, Acetaminophen, Tylenol®, Dorcol®, Feverallâ"¢, Panadol®, APAP, N-Acetyl-P-Aminophenol, Paracetamol, Ofirmevâ"¢, Diphenhydramine, Benadryl®
M.D. Anderson Cancer Center
AML, MDS
12/26
12/26
QuEST1, NCT03493945: Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine, M7824, N-803 and Epacadostat

Completed
1/2
59
US
M7824, Bintrafusp alfa, N-803, Anktiva, MVA-BN-Brachyury, modified vaccinia Ankara Bavarian Nordic Brachyury, FPV-Brachyury, Fowlpox Virus Brachyury, Epacadostat, IDO1, Acetaminophen, Tylenol, Ofirmev, FeverAll, Ibuprofen, Advil, Advil Migraine, Naproxen, Aleve, Naprosyn, Anaprox DS, Benadryl, Diphenhydramine, EKG, Electrocardiogram, Bone scan, Bone scintigraphy, CT chest, abdomen and pelvis, Computed tomography chest, abdomen and pelvis, MRI, Magnetic resonance imaging
National Cancer Institute (NCI)
Metastatic Castration-resistant Prostate Cancer, Prostate Cancer, Prostate Neoplasm, Advanced Solid Tumor, Solid Tumor, Non-metastatic Castration-resistant Prostate Cancer
10/24
10/24
NCT02356159: Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

Completed
1/2
34
US
Rituximab, Rituxan, Riabni, Ruxience, Truxima, Conditioning chemotherapy, Fludarabine, Cyclophosphamide, Mesna, Furosemide, TMS, Tacrolimus, FLAG, Cytarabine, Filgrastim, EPOCH-F, Etoposide phosphate, Prednisone, Vincristine sulfate, Doxorubicin hydrochloride, Hematopoietic stem cell transplant, HSCT, Palifermin, Kepivance, Acetaminophen, Tylenol, Ofirmev, FeverAll, Diphenhydramine, Benadryl, Banophen, Nytol, Rayos, Deltasone, Prednisone Intensol, Epinephrine, Adrenaline, IV Saline, Intravenous saline, ECG, Electrocardiogram, ECHO, Echocardiogram, MUGA, Multigated acquisition, DEXA, Dual-energy X-ray absorptiometry, CT chest, Computed tomography chest, PET, Positron-emission tomography, MRI, Magnetic resonance imaging, BM aspirate, Bome marrow aspirate, BM biopsy, Bone marrow biopsy, Lumbar puncture, LP
National Cancer Institute (NCI)
Myelodysplastic Syndromes, Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma, Acute Leukemia, Multiple Myeloma
12/24
03/25
NCT03554473: M7824 and Topotecan or Temozolomide in Relapsed Small Cell Lung Cancers

Completed
1/2
37
US
M7824, MSB0011359C, Topotecan, Hycamtin, Temozolomide, Temodar, EKG, Electrocardiogram, CT scan, Computed tomography scan, PET scan, Positron emission tomography scan, Acetaminophen, Tylenol, Ofirmev, FeverAll, Antihistamines, Diphenhydramine, Benadryl, Banophen, Nytol, Dexamethasone, Maxidex, Ozurdex, DexPak 10 day, Epinephrine, Adrenaline
National Cancer Institute (NCI)
Carcinoma, Small Cell, Lung Cancer, Small Cell Lung Cancer
06/22
03/25
19-C-0042, NCT03805932: Moxetumomab Pasudotox-tdfk (Lumoxiti(TM)) and Either Rituximab (Rituxan(R)) or Ruxience for Relapsed Hairy Cell Leukemia

Active, not recruiting
1
18
US
Moxetumomab Pasudotox-tdfk, Lumoxiti, Rituximab, Rituxan, Ruxience, Rituximab-pvvr, Dexamethasone, Ozurdex, Maxidex, DexPak 6 Day, Acetaminophen, Tylenol, Ofirmev, FeverAll, Diphenhydramine, Benadryl, Nytol, Banophen, Famotidine, Pepcid AC, Pepcid, Acid Controller, Aspirin, Ecotrin, Enteric Coated Aspirin, Buffered Aspirin
National Cancer Institute (NCI)
Hairy Cell Leukemia
07/23
06/25
NCT05211336: Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid (VIPOR) for Diffuse Large B-cell Lymphoma Involving the Central Nervous System

Active, not recruiting
1
14
US
Obinutuzumab, Gazyva, Prednisone, Rayos, Deltasone, Prednisone Intensol, Lenalidomide, REVLIMID, Venetoclax, Venclexta, Venclyxto, Ibrutinib, Imbruvica, Acetaminophen, Tylenol, Ofirmev, FeverAll, Diphenhydramine, Benadryl, Banophen, Nytol, Peg-filgrastim, Neulasta, CT Scan (chest, abdomen, and pelvis), Computed tomography scan, MRI, Magnetic resonance imaging, 18f-FDG-PET, F18-fluorodeoxyglucose-positron emission tomography, PET, Lumbar puncture/Ommaya tap, Bone marrow aspiration/biopsy, EKG, Electrocardiogram
National Cancer Institute (NCI)
Primary Diffuse Large B-cell Lymphoma of the Central Nervous System (CNS), Aggressive B-cell Lymphoma With Secondary Involvement of the CNS
06/24
06/29
NCT03448393: CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies

Completed
1
54
US
CD19/CD22 CAR T-Cells, cluster of differentiation 19 chimeric antigen receptor T-cells, cluster of differentiation 22 chimeric antigen receptor T-cells, Fludarabine, Fludara, Cyclophosphamide, Cytoxan, Apheresis, Anti-emetic, Diphenhydramine, Benadryl, Banophen, Nytol, Acetaminophen, Tylenol, ofirmev, FeverAll, ECG, Electrocardiogram, ECHO, Echocardiogram, MRI Brain, Magnetic resonance imaging, Bone marrow biopsy, BM biopsy, Cardiac MRI, Cardiac magnetic resonance imaging
National Cancer Institute (NCI)
Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, B Cell, B-Cell Lymphoma, B-Cell Leukemia, Acute Lymphoid Leukemia, B-Non Hodgkin Lymphoma, B-NHL, B-All, Acute Lymphoblastic Leukemia, Acute Lymphocytic Leukemia
07/24
01/25
NCT04599634: Venetoclax With Obinutuzumab and Magrolimab (VENOM) in Relapsed and Refractory Indolent B-cell Malignancies

Completed
1
11
US
Obinutuzumab, Gazyna, Afutuzumab, GA101, Venetoclax, GDC-0199, ABT-199, RG-7601, Magrolimab, 5F9, GS-4721, ONO-7913, Acetaminophen, Tylenol, Ofirmev, FeverAll, Diphenhydramine, Benadryl, Banophen, Nytol, Prednisone/prednisolone, Rayos, Deltasone, Prednisone Intensol, Methylprednisolone, Solu-Medrol, Depo-Medrol, Medrol, CT Scan chest/abdomen/pelvis, Computed tomography scan chest/abdomen/pelvis, MRI, Magnetic resonance imaging, 18-FDG-PET, 18F-fluorodeoxyglucose positron emission tomography, Bone Marrow Biopsy, BM Bx, Bone Marrow Aspiration, BM aspiration
National Cancer Institute (NCI)
Follicular Lymphoma, Marginal Zone Lymphoma, Mantle Cell Lymphoma, Chronic Lymphocytic Lymphoma, B-Cell Lymphoma
03/24
06/24
NCT02700451: Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes

Completed
N/A
178
US
Ketorolac, Toradol, Acetaminophen, Tylenol, Ofirmev, Placebo, Normal Saline
Hospital for Special Surgery, New York
Lumbar Osteoarthritis, Spondylosis, Lumbar Disc Disease, Spinal Stenosis
12/21
03/23
NCT06326983: Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery

Recruiting
N/A
58
US
Dexmedetomidine, Precedex, Acetaminophen, Ofirmev, Ketorolac, Toradol, Morphine
Boston Children's Hospital
Tonsillitis, Post-operative Nausea and Vomiting (PONV), Emergence Delirium, Opioid Analgesic Adverse Reaction, Anesthesia, Pain
12/25
04/26
H.P. Acthar Gel (repository corticotropin injection) / Mallinckrodt
FACT, NCT05546047: A Study of Acthar Gel Alone or With Tacrolimus to Reduce Proteinuria in Fibrillary Glomerulopathy Patients

Active, not recruiting
4
34
US
Acthar Gel 80 UNT/ML Injectable Solution, Tacrolimus 1.0 mg
NephroNet, Inc., Mallinckrodt
Fibrillary Glomerulonephritis
10/23
10/24
NCT02541955: Use of Acthar in Rheumatoid Arthritis (RA) Related Flares

Recruiting
4
40
US
Acthar, Repository corticotropin injection
Veena Ranganath, MD, MS
Rheumatoid Arthritis (RA)
12/25
12/25
NCT02226341: ACTHar in the Treatment of Lupus Nephritis

Terminated
4
8
US
CellCept, Mycophenolate Mofetil, ACTHar gel, ACTHar, H.P. ACTHar Gel, Repository corticotropin
Columbia University
Lupus Nephritis
01/24
01/24
MNK, NCT06964269: Use of Acthar Gel Single-Dose Pre-Filled SelfJectTM Injector in Patients With Moderate-Severe Keratitis and Autoimmune Disease

Recruiting
4
20
US
Acthar Gel 80 UNT/ML Injectable Solution
Toyos Clinic
Autoimmune Diseases, Dry Eye, Neurotrophic Keratitis
02/28
02/28
NCT02523092: Use of CXCL9 as a Biomarker of Acthar Efficacy

Recruiting
4
14
US
Acthar gel, Acthar
University of California, San Francisco, Mallinckrodt
Sarcoidosis
12/25
12/26
NCT03511625: The Effects of Acthar on Synovial Inflammation in Rheumatoid Arthritis

Active, not recruiting
3
6
US
Acthar Injectable Product, repository corticotropin injection, H.P. Acthar Gel, Depo medrol, methylprednisolone acetate injectable suspension
Attune Health Research, Inc., Mallinckrodt
Rheumatoid Arthritis
02/20
12/24
NCT01950234: ACTH in Progressive Forms of MS

Terminated
2
59
US
ACTH, Acthar gel, Placebo
University of Minnesota, Mallinckrodt
Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis, Progressive Relapsing Multiple Sclerosis
12/22
12/22
ATLAS , NCT03465111: A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis

Recruiting
2
30
US
ACTH (adrenocorticotropic hormone) gel, H.P. Acthar® Gel
Metropolitan Eye Research & Surgery Institute, Mallinckrodt, Stanford University, Ocular Imaging Research and Reading Center, Foresight Studies, LLC
Scleritis
12/24
12/24
NCT03727776: Adrenocorticotropic Hormone (ACTH) for Post-op Inflammation in Proliferative Vitreoretinopathy (PVR)

Completed
1
11
US
Adrenocorticotropic Hormone, H.P. Acthar Gel, Repository Corticotropin Injection
Johns Hopkins University, Mallinckrodt
Proliferative Vitreoretinopathy
07/23
07/23
NCT04086992: Decreasing Parental Stress of Caregivers of Infants With Infantile Spasms by Using Telemedicine Technology

Recruiting
N/A
40
US
Remote monitoring
University of Colorado, Denver, Mallinckrodt
Infantile Spasms, Non-Intractable
10/23
10/23
Ryoncil (remestemcel-L) / Mallinckrodt, Mesoblast
Mesoblast_COVID-19: Remestemcel-L Looks Promising in COVID-19 Patients With Moderate to Severe ARDS

Not yet recruiting
3
0
US
Ryoncil (remestemcel-L) - Mallinckrodt, Mesoblast, JCR Pharma
Mesoblast, JCR Pharma, Mallinckrodt
Moderate to Severe ARDS
 
 
NCT04548583: Study of Mesenchymal Stem Cells for the Treatment of Medically Refractory Crohn's Colitis

Recruiting
1/2
24
US
Remestemcel-L, Placebo
The Cleveland Clinic, Mesoblast, Inc.
Crohn Colitis
10/23
10/23
NCT04543994: Study of Mesenchymal Stem Cells for the Treatment of Medically Refractory Ulcerative Colitis (UC)

Recruiting
1/2
24
US
Remestemcel-L, Placebo
The Cleveland Clinic, Mesoblast, Inc.
Ulcerative Colitis
11/23
11/23
NCT00759018: Prochymal Expanded Access Treatment for Pediatric Patients Who Have Failed Steroids for Acute GVHD

Checkmark In pediatric patients with GVHD at BMT Tandem 2016
Feb 2016 - Feb 2016: In pediatric patients with GVHD at BMT Tandem 2016
No Longer Available
N/A
Canada, US
remestemcel-L, Prochymal®, Ex-vivo Cultured Adult Human Mesenchymal Stem Cells
Mesoblast, Inc.
Graft vs Host Disease, Graft-Versus-Host Disease
 
 
NCT00826046: Prochymal® Expanded Access for Adults Who Have Failed Steroid Treatment for Acute Graft Versus Host Disease (GVHD)

No Longer Available
N/A
US
Prochymal®, Ex-vivo Cultured Adult Human Mesenchymal Stem Cells
Mesoblast, Inc.
Graft-Versus-Host Disease
 
 
NCT01510431: Safety and Treatment Outcome Study of PROCHYMAL® (Remestemcel-L) Intravenous Infusion in Subjects With Treatment-resistant Crohn's Disease

No Longer Available
N/A
US
PROCHYMAL (remestemcel-L)
Mesoblast, Inc.
Crohn's Disease
 
 
NCT04366830: Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19 Infection

No Longer Available
N/A
US
Remestemcel-L
Mesoblast International Sàrl
Moderate to Severe Acute Respiratory Distress Syndrome Associated With COVID-19
 
 
NCT04456439: Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With Coronavirus Disease (COVID-19)

Available
N/A
NA
Remestemcel-L, Hydrocortisone, Diphenhydramine, Benadryl®
Mesoblast International Sàrl
Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With Coronavirus Disease (COVID-19)
 
 
Terlivaz (terlipressin) / Mallinckrodt
ACTRN12619000891123: The impact of continuous terlipressin infusion on complications of end-stage liver disease

Completed
3
30
 
Austin Health, Mallinckrodt Pharmaceuticals
Cirrhosis, Sarcopaenia, Inflammation, Malnutrition, Ascites, Infection, Immune function, Hepatic encephalopathy
 
 
Uvadex/Therakos Photopheresis (methoxsalen/ECP) / Mallinckrodt
2019-000894-22: Phase II multicenter study of UV irradiation with UvadexTM outside of the body plus standard steroid treatment for high risk acute Graft-versus-Host Disease Multizentrische Phase-II-Studie zur UV-Bestrahlung mit UvadexTM außerhalb des Körpers plus Standardbehandlung mit Steroiden bei akuter Spender-gegen-Empfänger-Erkrankung mit hohem Risiko

Not yet recruiting
2
72
Europe
Solution for blood fraction modification, UVADEX
Department of Stem Cell Transplantation - University Medical Center Hamburg-Eppendorf, Therakos, Inc.
New onset high risk acute GvHD following allogeneic SCT Neu auftretende akute GvHD mit hohem Risiko nach allogener SCT, New onset high risk acute Graft-versus-Host-Disease following allogeneic (of nonself origin) Stem Cell Transplantation Neu auftretende akute Spender-gegen-Empfänger-Erkrankung mit hohem Risiko nach Transplantation von Stammzellen, die nicht vom Patienten selbst stammen, Diseases [C] - Immune System Diseases [C20]
 
 
COPAVEHDI, NCT06133192: Steroids Versus ECP and Steroids as First-line Treatment of Grade II Acute GVHD

Not yet recruiting
2
42
Europe
Uvadex, Steroids
Central Hospital, Nancy, France
Graft Vs Host Disease
09/25
01/26
NCT05157581: Extracorporeal Photopheresis in Sezary Syndrome

Recruiting
2
15
US
Extracorporeal photopheresis (ECP), ECP, photopheresis, Methoxsalen Injection, Uvadex
Oleg E. Akilov, MD, PhD, Mallinckrodt
Sezary Syndrome
12/25
12/26
NCT04986605: Extracorporeal Photopheresis in Early Diffuse Cutaneous Systemic Sclerosis

Not yet recruiting
2
15
Canada
Extracorporeal Photopheresis (ECP), ECP, 8-mop, UVADEX
London Health Sciences Centre OR Lawson Research Institute of St. Joseph's, Mallinckrodt
Diffuse Cutaneous Systemic Sclerosis
07/26
07/27
NCT05680558: Photopheresis in Early-stage Mycosis Fungoides

Recruiting
2
74
US
UVADEX® (methoxsalen) Sterile Solution in conjunction with the THERAKOS® CELLEX Photopheresis, UVADEX® with THERAKOS® CELLEX Photopheresis, THERAKOS® CELLEX photopheresis system
Columbia University, Mallinckrodt, Inc.
Cutaneous T Cell Lymphoma, Mycosis Fungoides
12/25
07/26
EPIC, NCT06646016: - Extracorporeal Photopheresis (ECP) for Immune-related Colitis

Suspended
2
30
US
Methoxsalen, UVADEX®, 20 micrograms per milliliter (mcg/mL), Infliximab, REMICADE®, INFLECTRA®, IXIFI®, RENFLEXIS®, AVSOLA®, Vedolizumab, ENTYVIO®
Therakos LLC
Immune-related Colitis
02/26
02/27
2021-002073-26: Extracorporeal photopheresis as treatment for immune related adverse events after immunotherapy Extrakorporale Photopherese zur Behandlung von immunvermittelten unerwünschten Ereignissen nach einer Immuntherapie

Not yet recruiting
1/2
14
Europe
UVADEX, Sterile concentrate, UVADEX
Medical Center - University of Freiburg, University of Freiburg, Faculty of Medicine, Therakos EMEA Ltd
Immune related adverse events induced by treatment with immune checkpoint inhibitors (monoclocanl antibodies against PD-1, PD-L1 or CTLA-4) Immunvermittelte unerwünschte Ereignisse, die durch eine Behandlung mit Immun-Checkpoint-Inhibitoren (monoklonale Antikörper gegen PD-1, PD-L1 oder CTLA-4) induziert wurden, Immune related adverse events induced by treatment with immunotherapy Immunvermittelte unerwünschte Ereignisse durch eine Behandlung mit einer Immuntherapie, Diseases [C] - Cancer [C04]
 
 
Synacthen Depot (cosyntropin) / Novartis, Mallinckrodt, Alliance
2006-000788-27: International Collaborative Infantile Spasms Study (ICISS)

Ongoing
4
200
Europe
SABRIL SACHETS, SYNACTHEN DEPOT, SOLUBLE PREDNISOLONE TABLETS, SABRIL SACHETS, SYNACTHEN DEPOT, SOLUBLE PREDNISOLONE TABLETS
Royal United Hospital Bath NHS Trust, , Castang Foundation, NIHR, Bath Unit for Research in Paediatrics, Bronner/Bender Stiftung
Infantile spasms are a rare severe form of epilepsy affecting approx 1 in 2,250 infants, usually under the age of 1 year. Affected infants have a very abnormal EEG and a poor prognosis for subsequent epilepsy and neuro-development. There is a high risk of underlying neurological disease that independently causes delayed development and other seizure disorders. There is a high risk of a poor outcome even when there is no other detectable underlying neurological disorder.
 
 
2012-001682-33: Rescue of Addison’s disease 2

Ongoing
2
30
Europe
Mabthera Infusion, Solu-Medrone, Synacthen Depot, Rituximab, Methylprednisolone, Tetracosactide acetate, Mabthera infusion, Solu-Medrone, Synacthen Depot, Mabthera infusion, Solu-Medrone, Synacthen Depot
Newcastle upon Tyne Hospitals NHS Foundation Trust, Medical Research Council
Autoimmune Addison\'s disease: autoimmune primary adrenal insufficiency
 
 
ESYBRECHE, NCT02813655 / 2015-003357-17: Evaluation of the Effectiveness and Tolerance of Tetracosactide Synacthen® in the Treatment of Post Dural Puncture Headaches

Terminated
2
46
Europe
Tetracosactide (Synacthène®), placebo saline (0.9% NaCl)
Hospices Civils de Lyon
Post-dural Puncture Headache
11/22
11/22
NeSST2, NCT03514589 / 2012-003241-15: The Development of a Noninvasive Short Synacthen Test

Recruiting
2
12
Europe
nasal Tetracosactide, cosyntropin, Synacthen, IV tetracosactide, synacthen
Sheffield Children's NHS Foundation Trust
Adrenal Suppression
12/25
12/25
2012-003241-15: A study to develop a non-invasive version of the diagnostic test of the body's ability to produce enough stress hormone.

Not yet recruiting
1
258
Europe
100mcg tetracosactide (in a 1:1 mix with chitosan), 500 mcg tetracosactide, 500 mcg tetracosactide (in a mix 1:1 with chitosan), 1 mcg Synacthen, Nasal spray, solution, Suspension for injection, Synacthen
Sheffield Children's NHS Foundation Trust
In stages 1+2 of the study healthy volunteers will be used to determine the bioequivalence of nasal Synacthen with 1 microgram of intravenous synacthen. Stage 3 will use healthy children to establish normal ranges for the adrenal response to a low-dose synacthen test. In stage 4 adrenal function in asthmatic individuals on inhaled corticosteroids will be studied., Inability to produce the stress hormone, cortisol, is known as adrenal insufficiency. It can cause serious illness and even death. Inhaled steroids taken for asthma can cause adrenal insufficiency., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Diagnosis [E01]
 
 
NCT03142893: Hormonal Mechanisms of Sleep Restriction - Axis Study

Active, not recruiting
1
80
US
Ketoconazole Pill, Nizoral, Ganirelix, Dexamethasone, Dexamethasone Injection, Cosyntropin Injectable Product, Recombinant Human Luteinizing Hormone, Luveris, Hydrocortisone Injection, solu-cortef, Gonadorelin, Lutrepulse, Corticorelin, Acthrel, Placebo oral capsule, Saline Solution, Saline Solution for Injection
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Sleep Restriction
10/20
03/25
NCT04037605: Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women

Active, not recruiting
1
5
US
Ketoconazole Pill (also known as nizoral), Ganirelix, Dexamethasone Pill, Dexamethasone injection, Cosyntropin Injectable Product, Recombinant Human Luteinizing Hormone (also known as luveris), Hydrocortisone Injection (also known as solu-cortef), Gonadorelin (also known as Lutrepulse), Corticorelin (also known as Acthrel), Placebo oral tablet, Saline Solution, Saline solution for injection
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Sleep Restriction
07/22
07/24
NCT04546126: Positron Emission Tomography (PET) Imaging of Cholesterol Trafficking: Clinical Evaluation of [18F]FNP-59 in Normal Human Subjects (Groups 2, 3 & 4)

Recruiting
1
24
US
Dexamethasone (Group 2), Cosyntropin (Group 3), PET/CT Scan with FNP-59
Benjamin Viglianti
Radiotracer, Hypertension, Cholesterol
12/25
12/25
NCT03905603: Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS

Recruiting
1
144
US
ACTH, Cosyntropin, rhCG, Ovidrel
University of Virginia
Polycystic Ovary Syndrome
04/26
05/26
NCT02339506: Stress and the Nervous System

Active, not recruiting
N/A
23
US
Cosyntropin, ACTH, Placebo, Normal Saline
Brigham and Women's Hospital, Beth Israel Deaconess Medical Center
Autonomic Nervous System, Baroreflex, Stress, Physiological
10/16
12/23
NCT01421797: Evaluation of Adrenal Androgens in Normal and Obese Girls After Suppression and Stimulation

Active, not recruiting
N/A
84
US
Dexamethasone, Cortrosyn, ACTH
University of Virginia, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), University of California, San Diego
Hyperandrogenemia, Polycystic Ovary Syndrome, Obesity
08/24
12/24
NCT04642391: Defining the Mechanisms Underlying Adrenal Insufficiency in Cirrhosis

Completed
N/A
76
US
Cosyntropin
University of Virginia, American Association for the Study of Liver Diseases
Cirrhosis, Adrenal Insufficiency
06/23
06/24
Inomax (nitric oxide) / Mallinckrodt
2017-000421-13: Treatment of high blood pressure in the lungs in newborns with a defect in the diaphragm; inhaled Nitric Oxide compared to intravenous Sildenafil.

Ongoing
3/4
330
Europe
Solution for injection/infusion, Medicinal gas, compressed, revatio 0.8mg/ml solution for injection, INOmax 800ppm mol/mol inhalatiegas, Neophyr 1000ppm mol/mol
Erasmus MC, SSWO, CDH UK Sparks
Congenital diaphragmatic hernia with pulmonary hypertension Hernia diafragmatica met pulmonale hypertensie, Defect in diaphragm resulting in high blood pressure in the lungs Defect in het middenrif resulterend in hoge bloeddruk in de longen, Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
 
 
2017-004684-12: Nitric oxide administration in the heart-lung machine during surgery for heart defects Toediening van stikstofmonoxide in de hartlongmachine bij kinderen met congenitale hartafwijkingen

Not yet recruiting
3
1470
Europe
Nitric oxide, Medicinal gas, compressed, INOmax
Lady Cilento Children's Hospital, Stichting Hart4Onderzoek
Congenital heart disease ranks still within the top causes of infant mortality in industrialized countries. Despite considerable advances over the past decade, the exposure to cardiopulmonary bypass (CPB), which is needed for most heart surgeries, remains responsible for major side effects: The exposure of patient blood to large artificial surfaces in the CPB circuit triggers a very strong systemic inflammatory syndrome, which leads in a third of patients to low cardiac output syndrome (LCOS)., Cardiac surgery often requires cardiopulmonary bypass. Children often develop an inflammatory response to bypass and this contributes to complications after surgery and delayed recovery., Body processes [G] - Immune system processes [G12]
 
 
NORISC, NCT06702553: Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass

Recruiting
3
3650
US, RoW
Nitric Oxide Gas, Nitric Oxide inhalation, Standard Care Arm, Nitrogen inhalation
Xijing Hospital, Nikolay O. Kamenshchikov., M.D., Tomsk National Research Medical Center of the Russian Academy of Sciences, Lorenzo Berra., M.D., Massachusetts General Hospital, Jiange Han, Tianjin Chest Hospital, Tianjin, China, Qingping Wu, Wuhan Union Hospital, Wuhan, China, Evgeniy Grigoriev, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation, Vladimir Boboshko, E. Meshalkin National Medical Research Center, Novosibirsk, Russian Federation, Andrei Bautin, The Almazov National Medical Research Centre, St. Petersburg, Russian Federation, Vladimir Pichugin, Specialized Cardiac Surgery Clinical Hospital named after Academician B.A. Korolev, Nizhny Novgorod, Russian Federation, Evgeniy Rosseykin, Federal Center of Cardiovascular Surgery, Khabarovsk, Russian Federation, Sheng Wang, Anzhen Hospital, Beijing, China
Nitric Oxide, Cardiac Surgery, Cardiopulmonary Bypass, Adult Patients Undergoing Cardiovascular Surgery With Cardiopulmonary Bypass
03/28
03/29
2008-006776-29: NO som behandling vid knäproteskirurgi.Studie med avseende på anti-inflammatorisk modulation hos patienter som genomgår operation med ryggbedövning.

Ongoing
2
45
Europe
INOmax, INOmax
Karolinska Institutet
Patienter som skall genomgå knäprotesoperation och skall ha bedövning i form av ryggbedövning (spinalanestes/epiduralanestesi).
 
 
2005-001525-28: INFLUENCE OF THE ANTIOXIDANT N-ACETYLCYSTEINE ON INHALED NITRIC OXIDE INDUCED PULMONARY RESPONSES FOLLOWING HUMAN LUNG ISCHAEMIA-REPERFUSION INJURY

Ongoing
2
43
Europe
INOmax® (nitric oxide), ACETYLCYSTEINE 200MG/ML INJECTION,
Imperial College London
heart-lung transplantation
 
 
2020-001490-68: Inhaled Nitric Oxide Gas Therapy in Respiratory Treated Patients with COVID-19 infection

Ongoing
2
40
Europe
Nitric oxide, Inhalation vapour, INOmax 800 ppm mol/mol, inhalation gas
Stockholm County Council; Danderyd Hospital, Unrestricted grant, Linde Healthcare
COVID-19 infection caused by SARS-CoV-2, COVID-19 is an infection caused by the virus SARS-CoV-2. Some of the patients develop a severe acute respiratory syndrome and need mechanical ventilation., Diseases [C] - Respiratory Tract Diseases [C08]
 
 
2020-001656-18: The aim of this trial is to see how we can increase the amount of oxygen in the blood of a patient who may suffer from Covid-19 and severe breathing difficulties. Such patient often need intubation and mechanical ventilation, and we will compare twi ways of preparing for such intubation. The first is todays normal treatment with the patient breathing 100% oxygen on a bag/mask with some resistance. The other is that oxygen treatment combined with inhaled nitric oxide.

Not yet recruiting
2
54
Europe
INOmax, Medicinal gas, compressed, INOmax 800 ppm mol/mol
Oslo University Hospital, Oslo University Hospital
Severe respiratory failure in patients with confirmed, suspected or probable Covid- 19 disease, Patients that are, or may be, infected with the new corona virus and have difficulties breathing., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
NOpreventCOVID, NCT04312243: NO Prevention of COVID-19 for Healthcare Providers

Active, not recruiting
2
24
US
Inhaled nitric oxide gas
Massachusetts General Hospital
Coronavirus Infections, Healthcare Associated Infection
04/23
04/23
DOMINO, NCT03023449: Diffuse Optical Monitoring with Inhaled Nitric Oxide

Active, not recruiting
2
40
US
Nitric Oxide, iNO, NO2
Steven Messe, Mallinckrodt
Stroke
07/25
07/25
iNOCAPA, NCT05868109: Inhaled Nitric Oxide for Cardiac Arrest in Pediatrics and Adults

Recruiting
2
40
Canada
inhaled nitric oxide (iNO), INOMAX, Sham, Sham intervention with no flow of inhaled nitric oxide to the patient
The Hospital for Sick Children, Heart and Stroke Foundation of Canada
Cardiac Arrest
01/25
01/26
NoCovid, NCT04305457: Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19

Active, not recruiting
2
70
US
Nitric Oxide, Nitric Oxide inhalation
Massachusetts General Hospital, University of Alabama at Birmingham
Coronavirus Infections, Pneumonia, Viral, Acute Respiratory Distress Syndrome
04/25
04/25
NCT03576885: Inhaled Nitric Oxide for Pulmonary Hypertension and Bronchopulmonary Dysplasia

Terminated
1/2
32
US
inhaled nitric oxide, iNO, Placebo
AdventHealth, Mallinckrodt, Thrasher Research Fund
Pulmonary Hypertension, Bronchopulmonary Dysplasia
10/23
10/23
NCT06249633: Inhaled Nitric Oxide for ARDS-related Pulmonary Hypertension

Not yet recruiting
1
20
US
Nitric Oxide, iNOMAX
Yuri Matusov, Mallinckrodt
Acute Respiratory Distress Syndrome, Pulmonary Hypertension
02/26
02/26
iNO, NCT05871606: Inhaled Nitric Oxide in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy

Not yet recruiting
1
27
US
iNO, Inhaled Nitrous Oxide
Wake Forest University Health Sciences, Mallinckrodt
Cerebrovascular Disorders, Acute Cerebrovascular Disease
05/28
09/28
NCT05612074: Methemoglobin Concentration in High Dose Inhaled Nitric Oxide

Active, not recruiting
1
10
US
Inhaled Nitric Oxide, Nitric Oxide, Gaseous Nitric Oxide
Massachusetts General Hospital
Healthy Subjects
06/25
12/25
iNO300, NCT06950294: Therapy in Critically Ill Patients With Pneumonia

Not yet recruiting
1
34
NA
High dose inhaled nitric oxide, Sham treatment, standard therapy
Massachusetts General Hospital
Critical Illness, Pneumonia
06/26
10/26
NCT06675435: Inhaled Nitric Oxide in Severe Obesity

Not yet recruiting
N/A
60
US
Nitric oxide
Massachusetts General Hospital
Obesity, Respiratory Insufficiency, Hypoxemic Respiratory Failure, Nitric Oxide
10/27
12/27
NCT05801224: Vascular ARDS Recruitment After Inhaled Nitric Oxide

Suspended
N/A
70
US
Nitric Oxide, inhaled nitric oxide (iNO)
Massachusetts General Hospital
Acute Respiratory Distress Syndrome, Ventilation Perfusion Mismatch
12/28
12/28
Amitiza (lubiprostone) / Takeda, Mallinckrodt
NCT04985669: Study of Comparative Effectiveness of Prucalopride and Lubiprostone in Constipation Predominant Irritable Bowel Syndrome

Recruiting
4
140
RoW
Prucalopride 2mg, calopride
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Patient Satisfaction
02/22
03/22
ChiCTR2400088155: Evaluating lubiprostone for effective in colonoscopic bowel preparation

Not yet recruiting
4
244
 
Use of rupiprostenone before bowel preparation; Use of rupiprostenone before bowel preparation; control group 1 ; control group 12
The Affiliated People’s Hospital of Ningbo University; The Affiliated People’s Hospital of Ningbo University, self-finance
Bowel Preparation
 
 
ChiCTR2400090921: A Randomized Controlled Study of the Efficacy and Safety of a Bowel Preparation Regimen of 1L Polyethylene Glycol Combined with Lubiprostone Versus 2L Polyethylene Glycol

Not yet recruiting
4
284
 
1L Polyethylene Glycol (PEG) + Lubiprostone; 2L Polyethylene Glycol (PEG)
The First Affiliated Hospital Of Guangzhou Medical University; The First Affiliated Hospital Of Guangzhou Medical University, Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd
Bowel preparation protocol before colonoscopy
 
 
ChiCTR2400090127: Efficacy and Safety of Lubiprostone Compared to Lactulose in Elderly Patients with Chronic Constipation: A Randomized, Controlled, Open-Label, Multicenter Clinical Study

Not yet recruiting
4
190
 
Subjects will take Lubiprostone capsules orally for 4 consecutive weeks, 24 μg per capsule, 1 capsule per dose, twice daily; Subjects will take lactulose solution orally for 4 consecutive weeks, starting with an initial dose of 30 mL per day. The maintenance dose will be 10-25 mL per day, administered orally, for a total duration of 4 weeks.
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School; Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Corporate Sponsorship
Chronic constipation
 
 
ChiCTR1800015360: The efficacy and safety of Lubiprostone capsule in the treatment of functional constipation: a randomized, double-blind, multi-center, placebo-parallel-controlled Confirmatory clinical trial

Not yet recruiting
3
260
 
lubiprostone capsules ;Placebo capsules
The First Affiliated Hospital of Sun Yat-sen University; Nanjing ChiaTai TianQing Pharmaceuticals LP, self-raised
functional constipation
 
 
NCT05768334: Efficacy and Tolerability of Lubiprostone in Patients With Nonalcoholic Fatty Liver Disease

Completed
3
116
RoW
Lubiprostone 24Mcg Oral twice daily
Helwan University
NAFLD
02/23
02/23
NCT06543979: Anorectal Manometery in Pediatric Chronic Refractory Constipation

Recruiting
1/2
60
RoW
lubiprostone , single arm, lubicont, biofeed back sessions, botox injection
Ain Shams University
Chronic Constipation
09/25
10/25
NCT04861233: A Study of Lubiprostone to Treat Constipation

Recruiting
N/A
3000
RoW
No Intervention
Jeil Pharmaceutical Co., Ltd.
Constipation
05/24
11/24
ChiCTR2500096667: Evaluation study on the effectiveness and safety of Lubiprostone combined with magnesium sulfate in bowel preparation for elderly patients with constipation

Recruiting
N/A
100
 
Lubiprostone; placebo
Shanghai Geriatric Medical Center; Shanghai Geriatric Medical Center, Self-financing
elderly constipation
 
 
ChiCTR2500098149: Efficacy and safety of a polyethylene glycol electrolyte solution combined with lubiprostone for bowel preparation in type 2 diabetes patients using GLP-1 receptor agonists: a prospective, multicenter, randomized, open-label, blinded endpoint trial

Not yet recruiting
N/A
216
 
3 L PEG fractional lavage + lubiprostone; 3 L PEG for bowel wash
West China Hospital, Sichuan University; West China Hospital, Sichuan University, GCP Clinical Trial of Lubiprostone
Diabetes
 
 
NCT03720613: Risk of Major Adverse Cardiovascular Events for Naldemedine & Other Medications for Opioid Induced Constipation

Recruiting
N/A
34532
US
Naldemedine, Symproic®, Lubiprostone, Amitiza®, Naloxegol, Movantik®
BioDelivery Sciences International, HealthCore, Inc.
Opioid-induced Constipation
11/30
11/30
ornithine phenylacetate oral (MNK-6106) / Yaqrit
NCT01634230: Emergency Use of OCR-002 in Acute Liver Failure (ALF)

No Longer Available
N/A
US
OCR-002, ornithine phenylacetate
Ocera Therapeutics, Inc.
Acute Liver Failure
 
 
Stratagraft (regenerative skin tissue) / Mallinckrodt
StrataSTEPS, NCT05517902: StrataGraft Safety, Tolerability and Efficacy in Pediatric Subjects

Completed
3
1
US
StrataGraft
Stratatech, a Mallinckrodt Company, Biomedical Advanced Research and Development Authority
Skin Wound, Burns, Trauma-related Wound
05/24
05/24
StrataSOMA, NCT04765202: StrataGraft Overlay of Meshed Autograft in Full-thickness Thermal Burns

Terminated
1/2
13
US
AG Tx, Meshed Autograft, SOMA Tx, StrataGraft skin tissue Overlay of Meshed Autograft (SOMA)
Stratatech, a Mallinckrodt Company
Full Thickness Thermal Burn
06/24
06/24
NCT04896346: Scarring in Stratagraft-treated vs. Autograft-treated Burn Wounds: a Clinical and Histological Investigation

Active, not recruiting
N/A
5
US
Punch biopsy, non-invasive photography, assessments, and measurements
Medstar Health Research Institute
Burn Scar, Scar
10/22
06/23
adrabetadex (VTS-270) / Mandos Health
NCT02534844 / 2015-002548-15: VTS-270 to Treat Niemann-Pick Type C1 (NPC1) Disease

Completed
2b
56
Europe, US, RoW
Parts A/B: Adrabetadex, 2-hydroxypropyl-β-cyclodextrin, Cyclodextrin, VTS-270, Adrabetadex, Parts A/B: Sham Control, Procedure Control, Skin prick
Mandos LLC
Niemann-Pick Disease, Type C
03/18
03/18
NCT03471143: Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease, Type C

Active, not recruiting
1/2
12
US
adrabetadex (2-Hydroxypropyl-Beta-Cyclodextrin), VTS-270, HP-Beta-CD
Washington University School of Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Niemann-Pick Disease, Type C
10/25
10/25
recombinant human serum albumin (RU-10) / Mallinckrodt
No trials found
SLN501 / Silence Therap, Mallinckrodt
No trials found
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Acetavance (acetaminophen) / Mallinckrodt
NCT03020875: IV vs Oral Acetaminophen in Spine Fusion Perioperative Care

Enrolling by invitation
4
166
US
Ofirmev, Intravenous Acetaminophen, Per Os Acetaminophen
Hospital for Special Surgery, New York, Mallinckrodt
Multimodal Analgesic Approach
03/26
03/26
POPCORN, NCT03677830: Postoperative Pain Control & Relief in Neonates

Terminated
4
11
US
Acetaminophen, Ofirmev 10 MG/ML Injectable Solution, Saline
St. Louis University
Pain, Postoperative, Premature Infant, Opioid Use
03/24
03/24
PANDORA, NCT04093219: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients

Active, not recruiting
3
900
US
IV acetaminophen, ofirmev, Placebo
Beth Israel Deaconess Medical Center, National Institute on Aging (NIA)
Delirium in Old Age, Delirium, Coronary Artery Disease
03/25
03/26
NCT01391962: Sunitinib or Cediranib for Alveolar Soft Part Sarcoma

Active, not recruiting
2
34
US
Cediranib, AZD2171 maleate, Recentin, AXD2171, Sunitinib, Sutent, SU11248, SU011248, Prochlorperazine, Compro, Promethazine, Phenadoz, Phenergan, Promethegan, Benzodiazepine, Valium, Diazepam, Estazolam, ProSom, Flurazepam, Dalmane, Lorazepam, Ativan, Filgrastim, Neupogen, Sargramostim, Leukine, Lomotil, Diphenoxylate hydrochloride (HCL)/atropine, Loperamide, Imodium, Diamode, Anti-Diarrheal (loperamide), Vitamin B6, Pyridoxine, Aquaphor, Acetaminophen, Tylenol, Ofirmev, FeverAll, Levothyroxine, Synthroid, Tirosint, Unithroid, Warfarin, Coumadin
National Cancer Institute (NCI)
Sarcoma, Alveolar Soft Part
11/23
03/26
NCT06043323: A Phase II Study of Axicabtagene Ciloleucel, an Anti-CD19 Chimeric Antigen Receptor (CAR) Tcell Therapy, in Combination With Radiotherapy (RT) in Relapsed/Refractory Follicular Lymphoma

Recruiting
2
20
US
Axicabtagene Ciloleucel, Cyclophosphamide, Cytoxan®, Neosar®, Fludarabine phosphate, Prednisone, Diphenhydramine, Benadryl®, Acetaminophen, Tylenol®, Dorcol®, Feverall, Panadol, APAP, N-Acetyl-P-Aminophenol, Paracetamo, Ofirmev™
M.D. Anderson Cancer Center
Follicular Lymphoma
09/26
09/28
NCI-2022-02215, NCT05285813: A Phase II Study of Vibecotamab (XmAb14045) for MRD- Positive AML and MDS After Hypomethylating Agent Failure

Active, not recruiting
2
42
US
Vibecotamab, XmAb14045, Dexamethasone, Decadron, Acetaminophen, Tylenol®, Dorcol®, Feverallâ"¢, Panadol®, APAP, N-Acetyl-P-Aminophenol, Paracetamol, Ofirmevâ"¢, Diphenhydramine, Benadryl®
M.D. Anderson Cancer Center
AML, MDS
12/26
12/26
QuEST1, NCT03493945: Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine, M7824, N-803 and Epacadostat

Completed
1/2
59
US
M7824, Bintrafusp alfa, N-803, Anktiva, MVA-BN-Brachyury, modified vaccinia Ankara Bavarian Nordic Brachyury, FPV-Brachyury, Fowlpox Virus Brachyury, Epacadostat, IDO1, Acetaminophen, Tylenol, Ofirmev, FeverAll, Ibuprofen, Advil, Advil Migraine, Naproxen, Aleve, Naprosyn, Anaprox DS, Benadryl, Diphenhydramine, EKG, Electrocardiogram, Bone scan, Bone scintigraphy, CT chest, abdomen and pelvis, Computed tomography chest, abdomen and pelvis, MRI, Magnetic resonance imaging
National Cancer Institute (NCI)
Metastatic Castration-resistant Prostate Cancer, Prostate Cancer, Prostate Neoplasm, Advanced Solid Tumor, Solid Tumor, Non-metastatic Castration-resistant Prostate Cancer
10/24
10/24
NCT02356159: Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

Completed
1/2
34
US
Rituximab, Rituxan, Riabni, Ruxience, Truxima, Conditioning chemotherapy, Fludarabine, Cyclophosphamide, Mesna, Furosemide, TMS, Tacrolimus, FLAG, Cytarabine, Filgrastim, EPOCH-F, Etoposide phosphate, Prednisone, Vincristine sulfate, Doxorubicin hydrochloride, Hematopoietic stem cell transplant, HSCT, Palifermin, Kepivance, Acetaminophen, Tylenol, Ofirmev, FeverAll, Diphenhydramine, Benadryl, Banophen, Nytol, Rayos, Deltasone, Prednisone Intensol, Epinephrine, Adrenaline, IV Saline, Intravenous saline, ECG, Electrocardiogram, ECHO, Echocardiogram, MUGA, Multigated acquisition, DEXA, Dual-energy X-ray absorptiometry, CT chest, Computed tomography chest, PET, Positron-emission tomography, MRI, Magnetic resonance imaging, BM aspirate, Bome marrow aspirate, BM biopsy, Bone marrow biopsy, Lumbar puncture, LP
National Cancer Institute (NCI)
Myelodysplastic Syndromes, Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma, Acute Leukemia, Multiple Myeloma
12/24
03/25
NCT03554473: M7824 and Topotecan or Temozolomide in Relapsed Small Cell Lung Cancers

Completed
1/2
37
US
M7824, MSB0011359C, Topotecan, Hycamtin, Temozolomide, Temodar, EKG, Electrocardiogram, CT scan, Computed tomography scan, PET scan, Positron emission tomography scan, Acetaminophen, Tylenol, Ofirmev, FeverAll, Antihistamines, Diphenhydramine, Benadryl, Banophen, Nytol, Dexamethasone, Maxidex, Ozurdex, DexPak 10 day, Epinephrine, Adrenaline
National Cancer Institute (NCI)
Carcinoma, Small Cell, Lung Cancer, Small Cell Lung Cancer
06/22
03/25
19-C-0042, NCT03805932: Moxetumomab Pasudotox-tdfk (Lumoxiti(TM)) and Either Rituximab (Rituxan(R)) or Ruxience for Relapsed Hairy Cell Leukemia

Active, not recruiting
1
18
US
Moxetumomab Pasudotox-tdfk, Lumoxiti, Rituximab, Rituxan, Ruxience, Rituximab-pvvr, Dexamethasone, Ozurdex, Maxidex, DexPak 6 Day, Acetaminophen, Tylenol, Ofirmev, FeverAll, Diphenhydramine, Benadryl, Nytol, Banophen, Famotidine, Pepcid AC, Pepcid, Acid Controller, Aspirin, Ecotrin, Enteric Coated Aspirin, Buffered Aspirin
National Cancer Institute (NCI)
Hairy Cell Leukemia
07/23
06/25
NCT05211336: Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid (VIPOR) for Diffuse Large B-cell Lymphoma Involving the Central Nervous System

Active, not recruiting
1
14
US
Obinutuzumab, Gazyva, Prednisone, Rayos, Deltasone, Prednisone Intensol, Lenalidomide, REVLIMID, Venetoclax, Venclexta, Venclyxto, Ibrutinib, Imbruvica, Acetaminophen, Tylenol, Ofirmev, FeverAll, Diphenhydramine, Benadryl, Banophen, Nytol, Peg-filgrastim, Neulasta, CT Scan (chest, abdomen, and pelvis), Computed tomography scan, MRI, Magnetic resonance imaging, 18f-FDG-PET, F18-fluorodeoxyglucose-positron emission tomography, PET, Lumbar puncture/Ommaya tap, Bone marrow aspiration/biopsy, EKG, Electrocardiogram
National Cancer Institute (NCI)
Primary Diffuse Large B-cell Lymphoma of the Central Nervous System (CNS), Aggressive B-cell Lymphoma With Secondary Involvement of the CNS
06/24
06/29
NCT03448393: CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies

Completed
1
54
US
CD19/CD22 CAR T-Cells, cluster of differentiation 19 chimeric antigen receptor T-cells, cluster of differentiation 22 chimeric antigen receptor T-cells, Fludarabine, Fludara, Cyclophosphamide, Cytoxan, Apheresis, Anti-emetic, Diphenhydramine, Benadryl, Banophen, Nytol, Acetaminophen, Tylenol, ofirmev, FeverAll, ECG, Electrocardiogram, ECHO, Echocardiogram, MRI Brain, Magnetic resonance imaging, Bone marrow biopsy, BM biopsy, Cardiac MRI, Cardiac magnetic resonance imaging
National Cancer Institute (NCI)
Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, B Cell, B-Cell Lymphoma, B-Cell Leukemia, Acute Lymphoid Leukemia, B-Non Hodgkin Lymphoma, B-NHL, B-All, Acute Lymphoblastic Leukemia, Acute Lymphocytic Leukemia
07/24
01/25
NCT04599634: Venetoclax With Obinutuzumab and Magrolimab (VENOM) in Relapsed and Refractory Indolent B-cell Malignancies

Completed
1
11
US
Obinutuzumab, Gazyna, Afutuzumab, GA101, Venetoclax, GDC-0199, ABT-199, RG-7601, Magrolimab, 5F9, GS-4721, ONO-7913, Acetaminophen, Tylenol, Ofirmev, FeverAll, Diphenhydramine, Benadryl, Banophen, Nytol, Prednisone/prednisolone, Rayos, Deltasone, Prednisone Intensol, Methylprednisolone, Solu-Medrol, Depo-Medrol, Medrol, CT Scan chest/abdomen/pelvis, Computed tomography scan chest/abdomen/pelvis, MRI, Magnetic resonance imaging, 18-FDG-PET, 18F-fluorodeoxyglucose positron emission tomography, Bone Marrow Biopsy, BM Bx, Bone Marrow Aspiration, BM aspiration
National Cancer Institute (NCI)
Follicular Lymphoma, Marginal Zone Lymphoma, Mantle Cell Lymphoma, Chronic Lymphocytic Lymphoma, B-Cell Lymphoma
03/24
06/24
NCT02700451: Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes

Completed
N/A
178
US
Ketorolac, Toradol, Acetaminophen, Tylenol, Ofirmev, Placebo, Normal Saline
Hospital for Special Surgery, New York
Lumbar Osteoarthritis, Spondylosis, Lumbar Disc Disease, Spinal Stenosis
12/21
03/23
NCT06326983: Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery

Recruiting
N/A
58
US
Dexmedetomidine, Precedex, Acetaminophen, Ofirmev, Ketorolac, Toradol, Morphine
Boston Children's Hospital
Tonsillitis, Post-operative Nausea and Vomiting (PONV), Emergence Delirium, Opioid Analgesic Adverse Reaction, Anesthesia, Pain
12/25
04/26
H.P. Acthar Gel (repository corticotropin injection) / Mallinckrodt
FACT, NCT05546047: A Study of Acthar Gel Alone or With Tacrolimus to Reduce Proteinuria in Fibrillary Glomerulopathy Patients

Active, not recruiting
4
34
US
Acthar Gel 80 UNT/ML Injectable Solution, Tacrolimus 1.0 mg
NephroNet, Inc., Mallinckrodt
Fibrillary Glomerulonephritis
10/23
10/24
NCT02541955: Use of Acthar in Rheumatoid Arthritis (RA) Related Flares

Recruiting
4
40
US
Acthar, Repository corticotropin injection
Veena Ranganath, MD, MS
Rheumatoid Arthritis (RA)
12/25
12/25
NCT02226341: ACTHar in the Treatment of Lupus Nephritis

Terminated
4
8
US
CellCept, Mycophenolate Mofetil, ACTHar gel, ACTHar, H.P. ACTHar Gel, Repository corticotropin
Columbia University
Lupus Nephritis
01/24
01/24
MNK, NCT06964269: Use of Acthar Gel Single-Dose Pre-Filled SelfJectTM Injector in Patients With Moderate-Severe Keratitis and Autoimmune Disease

Recruiting
4
20
US
Acthar Gel 80 UNT/ML Injectable Solution
Toyos Clinic
Autoimmune Diseases, Dry Eye, Neurotrophic Keratitis
02/28
02/28
NCT02523092: Use of CXCL9 as a Biomarker of Acthar Efficacy

Recruiting
4
14
US
Acthar gel, Acthar
University of California, San Francisco, Mallinckrodt
Sarcoidosis
12/25
12/26
NCT03511625: The Effects of Acthar on Synovial Inflammation in Rheumatoid Arthritis

Active, not recruiting
3
6
US
Acthar Injectable Product, repository corticotropin injection, H.P. Acthar Gel, Depo medrol, methylprednisolone acetate injectable suspension
Attune Health Research, Inc., Mallinckrodt
Rheumatoid Arthritis
02/20
12/24
NCT01950234: ACTH in Progressive Forms of MS

Terminated
2
59
US
ACTH, Acthar gel, Placebo
University of Minnesota, Mallinckrodt
Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis, Progressive Relapsing Multiple Sclerosis
12/22
12/22
ATLAS , NCT03465111: A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis

Recruiting
2
30
US
ACTH (adrenocorticotropic hormone) gel, H.P. Acthar® Gel
Metropolitan Eye Research & Surgery Institute, Mallinckrodt, Stanford University, Ocular Imaging Research and Reading Center, Foresight Studies, LLC
Scleritis
12/24
12/24
NCT03727776: Adrenocorticotropic Hormone (ACTH) for Post-op Inflammation in Proliferative Vitreoretinopathy (PVR)

Completed
1
11
US
Adrenocorticotropic Hormone, H.P. Acthar Gel, Repository Corticotropin Injection
Johns Hopkins University, Mallinckrodt
Proliferative Vitreoretinopathy
07/23
07/23
NCT04086992: Decreasing Parental Stress of Caregivers of Infants With Infantile Spasms by Using Telemedicine Technology

Recruiting
N/A
40
US
Remote monitoring
University of Colorado, Denver, Mallinckrodt
Infantile Spasms, Non-Intractable
10/23
10/23
Ryoncil (remestemcel-L) / Mallinckrodt, Mesoblast
Mesoblast_COVID-19: Remestemcel-L Looks Promising in COVID-19 Patients With Moderate to Severe ARDS

Not yet recruiting
3
0
US
Ryoncil (remestemcel-L) - Mallinckrodt, Mesoblast, JCR Pharma
Mesoblast, JCR Pharma, Mallinckrodt
Moderate to Severe ARDS
 
 
NCT04548583: Study of Mesenchymal Stem Cells for the Treatment of Medically Refractory Crohn's Colitis

Recruiting
1/2
24
US
Remestemcel-L, Placebo
The Cleveland Clinic, Mesoblast, Inc.
Crohn Colitis
10/23
10/23
NCT04543994: Study of Mesenchymal Stem Cells for the Treatment of Medically Refractory Ulcerative Colitis (UC)

Recruiting
1/2
24
US
Remestemcel-L, Placebo
The Cleveland Clinic, Mesoblast, Inc.
Ulcerative Colitis
11/23
11/23
NCT00759018: Prochymal Expanded Access Treatment for Pediatric Patients Who Have Failed Steroids for Acute GVHD

Checkmark In pediatric patients with GVHD at BMT Tandem 2016
Feb 2016 - Feb 2016: In pediatric patients with GVHD at BMT Tandem 2016
No Longer Available
N/A
Canada, US
remestemcel-L, Prochymal®, Ex-vivo Cultured Adult Human Mesenchymal Stem Cells
Mesoblast, Inc.
Graft vs Host Disease, Graft-Versus-Host Disease
 
 
NCT00826046: Prochymal® Expanded Access for Adults Who Have Failed Steroid Treatment for Acute Graft Versus Host Disease (GVHD)

No Longer Available
N/A
US
Prochymal®, Ex-vivo Cultured Adult Human Mesenchymal Stem Cells
Mesoblast, Inc.
Graft-Versus-Host Disease
 
 
NCT01510431: Safety and Treatment Outcome Study of PROCHYMAL® (Remestemcel-L) Intravenous Infusion in Subjects With Treatment-resistant Crohn's Disease

No Longer Available
N/A
US
PROCHYMAL (remestemcel-L)
Mesoblast, Inc.
Crohn's Disease
 
 
NCT04366830: Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19 Infection

No Longer Available
N/A
US
Remestemcel-L
Mesoblast International Sàrl
Moderate to Severe Acute Respiratory Distress Syndrome Associated With COVID-19
 
 
NCT04456439: Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With Coronavirus Disease (COVID-19)

Available
N/A
NA
Remestemcel-L, Hydrocortisone, Diphenhydramine, Benadryl®
Mesoblast International Sàrl
Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With Coronavirus Disease (COVID-19)
 
 
Terlivaz (terlipressin) / Mallinckrodt
ACTRN12619000891123: The impact of continuous terlipressin infusion on complications of end-stage liver disease

Completed
3
30
 
Austin Health, Mallinckrodt Pharmaceuticals
Cirrhosis, Sarcopaenia, Inflammation, Malnutrition, Ascites, Infection, Immune function, Hepatic encephalopathy
 
 
Uvadex/Therakos Photopheresis (methoxsalen/ECP) / Mallinckrodt
2019-000894-22: Phase II multicenter study of UV irradiation with UvadexTM outside of the body plus standard steroid treatment for high risk acute Graft-versus-Host Disease Multizentrische Phase-II-Studie zur UV-Bestrahlung mit UvadexTM außerhalb des Körpers plus Standardbehandlung mit Steroiden bei akuter Spender-gegen-Empfänger-Erkrankung mit hohem Risiko

Not yet recruiting
2
72
Europe
Solution for blood fraction modification, UVADEX
Department of Stem Cell Transplantation - University Medical Center Hamburg-Eppendorf, Therakos, Inc.
New onset high risk acute GvHD following allogeneic SCT Neu auftretende akute GvHD mit hohem Risiko nach allogener SCT, New onset high risk acute Graft-versus-Host-Disease following allogeneic (of nonself origin) Stem Cell Transplantation Neu auftretende akute Spender-gegen-Empfänger-Erkrankung mit hohem Risiko nach Transplantation von Stammzellen, die nicht vom Patienten selbst stammen, Diseases [C] - Immune System Diseases [C20]
 
 
COPAVEHDI, NCT06133192: Steroids Versus ECP and Steroids as First-line Treatment of Grade II Acute GVHD

Not yet recruiting
2
42
Europe
Uvadex, Steroids
Central Hospital, Nancy, France
Graft Vs Host Disease
09/25
01/26
NCT05157581: Extracorporeal Photopheresis in Sezary Syndrome

Recruiting
2
15
US
Extracorporeal photopheresis (ECP), ECP, photopheresis, Methoxsalen Injection, Uvadex
Oleg E. Akilov, MD, PhD, Mallinckrodt
Sezary Syndrome
12/25
12/26
NCT04986605: Extracorporeal Photopheresis in Early Diffuse Cutaneous Systemic Sclerosis

Not yet recruiting
2
15
Canada
Extracorporeal Photopheresis (ECP), ECP, 8-mop, UVADEX
London Health Sciences Centre OR Lawson Research Institute of St. Joseph's, Mallinckrodt
Diffuse Cutaneous Systemic Sclerosis
07/26
07/27
NCT05680558: Photopheresis in Early-stage Mycosis Fungoides

Recruiting
2
74
US
UVADEX® (methoxsalen) Sterile Solution in conjunction with the THERAKOS® CELLEX Photopheresis, UVADEX® with THERAKOS® CELLEX Photopheresis, THERAKOS® CELLEX photopheresis system
Columbia University, Mallinckrodt, Inc.
Cutaneous T Cell Lymphoma, Mycosis Fungoides
12/25
07/26
EPIC, NCT06646016: - Extracorporeal Photopheresis (ECP) for Immune-related Colitis

Suspended
2
30
US
Methoxsalen, UVADEX®, 20 micrograms per milliliter (mcg/mL), Infliximab, REMICADE®, INFLECTRA®, IXIFI®, RENFLEXIS®, AVSOLA®, Vedolizumab, ENTYVIO®
Therakos LLC
Immune-related Colitis
02/26
02/27
2021-002073-26: Extracorporeal photopheresis as treatment for immune related adverse events after immunotherapy Extrakorporale Photopherese zur Behandlung von immunvermittelten unerwünschten Ereignissen nach einer Immuntherapie

Not yet recruiting
1/2
14
Europe
UVADEX, Sterile concentrate, UVADEX
Medical Center - University of Freiburg, University of Freiburg, Faculty of Medicine, Therakos EMEA Ltd
Immune related adverse events induced by treatment with immune checkpoint inhibitors (monoclocanl antibodies against PD-1, PD-L1 or CTLA-4) Immunvermittelte unerwünschte Ereignisse, die durch eine Behandlung mit Immun-Checkpoint-Inhibitoren (monoklonale Antikörper gegen PD-1, PD-L1 oder CTLA-4) induziert wurden, Immune related adverse events induced by treatment with immunotherapy Immunvermittelte unerwünschte Ereignisse durch eine Behandlung mit einer Immuntherapie, Diseases [C] - Cancer [C04]
 
 
Synacthen Depot (cosyntropin) / Novartis, Mallinckrodt, Alliance
2006-000788-27: International Collaborative Infantile Spasms Study (ICISS)

Ongoing
4
200
Europe
SABRIL SACHETS, SYNACTHEN DEPOT, SOLUBLE PREDNISOLONE TABLETS, SABRIL SACHETS, SYNACTHEN DEPOT, SOLUBLE PREDNISOLONE TABLETS
Royal United Hospital Bath NHS Trust, , Castang Foundation, NIHR, Bath Unit for Research in Paediatrics, Bronner/Bender Stiftung
Infantile spasms are a rare severe form of epilepsy affecting approx 1 in 2,250 infants, usually under the age of 1 year. Affected infants have a very abnormal EEG and a poor prognosis for subsequent epilepsy and neuro-development. There is a high risk of underlying neurological disease that independently causes delayed development and other seizure disorders. There is a high risk of a poor outcome even when there is no other detectable underlying neurological disorder.
 
 
2012-001682-33: Rescue of Addison’s disease 2

Ongoing
2
30
Europe
Mabthera Infusion, Solu-Medrone, Synacthen Depot, Rituximab, Methylprednisolone, Tetracosactide acetate, Mabthera infusion, Solu-Medrone, Synacthen Depot, Mabthera infusion, Solu-Medrone, Synacthen Depot
Newcastle upon Tyne Hospitals NHS Foundation Trust, Medical Research Council
Autoimmune Addison\'s disease: autoimmune primary adrenal insufficiency
 
 
ESYBRECHE, NCT02813655 / 2015-003357-17: Evaluation of the Effectiveness and Tolerance of Tetracosactide Synacthen® in the Treatment of Post Dural Puncture Headaches

Terminated
2
46
Europe
Tetracosactide (Synacthène®), placebo saline (0.9% NaCl)
Hospices Civils de Lyon
Post-dural Puncture Headache
11/22
11/22
NeSST2, NCT03514589 / 2012-003241-15: The Development of a Noninvasive Short Synacthen Test

Recruiting
2
12
Europe
nasal Tetracosactide, cosyntropin, Synacthen, IV tetracosactide, synacthen
Sheffield Children's NHS Foundation Trust
Adrenal Suppression
12/25
12/25
2012-003241-15: A study to develop a non-invasive version of the diagnostic test of the body's ability to produce enough stress hormone.

Not yet recruiting
1
258
Europe
100mcg tetracosactide (in a 1:1 mix with chitosan), 500 mcg tetracosactide, 500 mcg tetracosactide (in a mix 1:1 with chitosan), 1 mcg Synacthen, Nasal spray, solution, Suspension for injection, Synacthen
Sheffield Children's NHS Foundation Trust
In stages 1+2 of the study healthy volunteers will be used to determine the bioequivalence of nasal Synacthen with 1 microgram of intravenous synacthen. Stage 3 will use healthy children to establish normal ranges for the adrenal response to a low-dose synacthen test. In stage 4 adrenal function in asthmatic individuals on inhaled corticosteroids will be studied., Inability to produce the stress hormone, cortisol, is known as adrenal insufficiency. It can cause serious illness and even death. Inhaled steroids taken for asthma can cause adrenal insufficiency., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Diagnosis [E01]
 
 
NCT03142893: Hormonal Mechanisms of Sleep Restriction - Axis Study

Active, not recruiting
1
80
US
Ketoconazole Pill, Nizoral, Ganirelix, Dexamethasone, Dexamethasone Injection, Cosyntropin Injectable Product, Recombinant Human Luteinizing Hormone, Luveris, Hydrocortisone Injection, solu-cortef, Gonadorelin, Lutrepulse, Corticorelin, Acthrel, Placebo oral capsule, Saline Solution, Saline Solution for Injection
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Sleep Restriction
10/20
03/25
NCT04037605: Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women

Active, not recruiting
1
5
US
Ketoconazole Pill (also known as nizoral), Ganirelix, Dexamethasone Pill, Dexamethasone injection, Cosyntropin Injectable Product, Recombinant Human Luteinizing Hormone (also known as luveris), Hydrocortisone Injection (also known as solu-cortef), Gonadorelin (also known as Lutrepulse), Corticorelin (also known as Acthrel), Placebo oral tablet, Saline Solution, Saline solution for injection
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Sleep Restriction
07/22
07/24
NCT04546126: Positron Emission Tomography (PET) Imaging of Cholesterol Trafficking: Clinical Evaluation of [18F]FNP-59 in Normal Human Subjects (Groups 2, 3 & 4)

Recruiting
1
24
US
Dexamethasone (Group 2), Cosyntropin (Group 3), PET/CT Scan with FNP-59
Benjamin Viglianti
Radiotracer, Hypertension, Cholesterol
12/25
12/25
NCT03905603: Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS

Recruiting
1
144
US
ACTH, Cosyntropin, rhCG, Ovidrel
University of Virginia
Polycystic Ovary Syndrome
04/26
05/26
NCT02339506: Stress and the Nervous System

Active, not recruiting
N/A
23
US
Cosyntropin, ACTH, Placebo, Normal Saline
Brigham and Women's Hospital, Beth Israel Deaconess Medical Center
Autonomic Nervous System, Baroreflex, Stress, Physiological
10/16
12/23
NCT01421797: Evaluation of Adrenal Androgens in Normal and Obese Girls After Suppression and Stimulation

Active, not recruiting
N/A
84
US
Dexamethasone, Cortrosyn, ACTH
University of Virginia, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), University of California, San Diego
Hyperandrogenemia, Polycystic Ovary Syndrome, Obesity
08/24
12/24
NCT04642391: Defining the Mechanisms Underlying Adrenal Insufficiency in Cirrhosis

Completed
N/A
76
US
Cosyntropin
University of Virginia, American Association for the Study of Liver Diseases
Cirrhosis, Adrenal Insufficiency
06/23
06/24
Inomax (nitric oxide) / Mallinckrodt
2017-000421-13: Treatment of high blood pressure in the lungs in newborns with a defect in the diaphragm; inhaled Nitric Oxide compared to intravenous Sildenafil.

Ongoing
3/4
330
Europe
Solution for injection/infusion, Medicinal gas, compressed, revatio 0.8mg/ml solution for injection, INOmax 800ppm mol/mol inhalatiegas, Neophyr 1000ppm mol/mol
Erasmus MC, SSWO, CDH UK Sparks
Congenital diaphragmatic hernia with pulmonary hypertension Hernia diafragmatica met pulmonale hypertensie, Defect in diaphragm resulting in high blood pressure in the lungs Defect in het middenrif resulterend in hoge bloeddruk in de longen, Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
 
 
2017-004684-12: Nitric oxide administration in the heart-lung machine during surgery for heart defects Toediening van stikstofmonoxide in de hartlongmachine bij kinderen met congenitale hartafwijkingen

Not yet recruiting
3
1470
Europe
Nitric oxide, Medicinal gas, compressed, INOmax
Lady Cilento Children's Hospital, Stichting Hart4Onderzoek
Congenital heart disease ranks still within the top causes of infant mortality in industrialized countries. Despite considerable advances over the past decade, the exposure to cardiopulmonary bypass (CPB), which is needed for most heart surgeries, remains responsible for major side effects: The exposure of patient blood to large artificial surfaces in the CPB circuit triggers a very strong systemic inflammatory syndrome, which leads in a third of patients to low cardiac output syndrome (LCOS)., Cardiac surgery often requires cardiopulmonary bypass. Children often develop an inflammatory response to bypass and this contributes to complications after surgery and delayed recovery., Body processes [G] - Immune system processes [G12]
 
 
NORISC, NCT06702553: Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass

Recruiting
3
3650
US, RoW
Nitric Oxide Gas, Nitric Oxide inhalation, Standard Care Arm, Nitrogen inhalation
Xijing Hospital, Nikolay O. Kamenshchikov., M.D., Tomsk National Research Medical Center of the Russian Academy of Sciences, Lorenzo Berra., M.D., Massachusetts General Hospital, Jiange Han, Tianjin Chest Hospital, Tianjin, China, Qingping Wu, Wuhan Union Hospital, Wuhan, China, Evgeniy Grigoriev, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation, Vladimir Boboshko, E. Meshalkin National Medical Research Center, Novosibirsk, Russian Federation, Andrei Bautin, The Almazov National Medical Research Centre, St. Petersburg, Russian Federation, Vladimir Pichugin, Specialized Cardiac Surgery Clinical Hospital named after Academician B.A. Korolev, Nizhny Novgorod, Russian Federation, Evgeniy Rosseykin, Federal Center of Cardiovascular Surgery, Khabarovsk, Russian Federation, Sheng Wang, Anzhen Hospital, Beijing, China
Nitric Oxide, Cardiac Surgery, Cardiopulmonary Bypass, Adult Patients Undergoing Cardiovascular Surgery With Cardiopulmonary Bypass
03/28
03/29
2008-006776-29: NO som behandling vid knäproteskirurgi.Studie med avseende på anti-inflammatorisk modulation hos patienter som genomgår operation med ryggbedövning.

Ongoing
2
45
Europe
INOmax, INOmax
Karolinska Institutet
Patienter som skall genomgå knäprotesoperation och skall ha bedövning i form av ryggbedövning (spinalanestes/epiduralanestesi).
 
 
2005-001525-28: INFLUENCE OF THE ANTIOXIDANT N-ACETYLCYSTEINE ON INHALED NITRIC OXIDE INDUCED PULMONARY RESPONSES FOLLOWING HUMAN LUNG ISCHAEMIA-REPERFUSION INJURY

Ongoing
2
43
Europe
INOmax® (nitric oxide), ACETYLCYSTEINE 200MG/ML INJECTION,
Imperial College London
heart-lung transplantation
 
 
2020-001490-68: Inhaled Nitric Oxide Gas Therapy in Respiratory Treated Patients with COVID-19 infection

Ongoing
2
40
Europe
Nitric oxide, Inhalation vapour, INOmax 800 ppm mol/mol, inhalation gas
Stockholm County Council; Danderyd Hospital, Unrestricted grant, Linde Healthcare
COVID-19 infection caused by SARS-CoV-2, COVID-19 is an infection caused by the virus SARS-CoV-2. Some of the patients develop a severe acute respiratory syndrome and need mechanical ventilation., Diseases [C] - Respiratory Tract Diseases [C08]
 
 
2020-001656-18: The aim of this trial is to see how we can increase the amount of oxygen in the blood of a patient who may suffer from Covid-19 and severe breathing difficulties. Such patient often need intubation and mechanical ventilation, and we will compare twi ways of preparing for such intubation. The first is todays normal treatment with the patient breathing 100% oxygen on a bag/mask with some resistance. The other is that oxygen treatment combined with inhaled nitric oxide.

Not yet recruiting
2
54
Europe
INOmax, Medicinal gas, compressed, INOmax 800 ppm mol/mol
Oslo University Hospital, Oslo University Hospital
Severe respiratory failure in patients with confirmed, suspected or probable Covid- 19 disease, Patients that are, or may be, infected with the new corona virus and have difficulties breathing., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
NOpreventCOVID, NCT04312243: NO Prevention of COVID-19 for Healthcare Providers

Active, not recruiting
2
24
US
Inhaled nitric oxide gas
Massachusetts General Hospital
Coronavirus Infections, Healthcare Associated Infection
04/23
04/23
DOMINO, NCT03023449: Diffuse Optical Monitoring with Inhaled Nitric Oxide

Active, not recruiting
2
40
US
Nitric Oxide, iNO, NO2
Steven Messe, Mallinckrodt
Stroke
07/25
07/25
iNOCAPA, NCT05868109: Inhaled Nitric Oxide for Cardiac Arrest in Pediatrics and Adults

Recruiting
2
40
Canada
inhaled nitric oxide (iNO), INOMAX, Sham, Sham intervention with no flow of inhaled nitric oxide to the patient
The Hospital for Sick Children, Heart and Stroke Foundation of Canada
Cardiac Arrest
01/25
01/26
NoCovid, NCT04305457: Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19

Active, not recruiting
2
70
US
Nitric Oxide, Nitric Oxide inhalation
Massachusetts General Hospital, University of Alabama at Birmingham
Coronavirus Infections, Pneumonia, Viral, Acute Respiratory Distress Syndrome
04/25
04/25
NCT03576885: Inhaled Nitric Oxide for Pulmonary Hypertension and Bronchopulmonary Dysplasia

Terminated
1/2
32
US
inhaled nitric oxide, iNO, Placebo
AdventHealth, Mallinckrodt, Thrasher Research Fund
Pulmonary Hypertension, Bronchopulmonary Dysplasia
10/23
10/23
NCT06249633: Inhaled Nitric Oxide for ARDS-related Pulmonary Hypertension

Not yet recruiting
1
20
US
Nitric Oxide, iNOMAX
Yuri Matusov, Mallinckrodt
Acute Respiratory Distress Syndrome, Pulmonary Hypertension
02/26
02/26
iNO, NCT05871606: Inhaled Nitric Oxide in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy

Not yet recruiting
1
27
US
iNO, Inhaled Nitrous Oxide
Wake Forest University Health Sciences, Mallinckrodt
Cerebrovascular Disorders, Acute Cerebrovascular Disease
05/28
09/28
NCT05612074: Methemoglobin Concentration in High Dose Inhaled Nitric Oxide

Active, not recruiting
1
10
US
Inhaled Nitric Oxide, Nitric Oxide, Gaseous Nitric Oxide
Massachusetts General Hospital
Healthy Subjects
06/25
12/25
iNO300, NCT06950294: Therapy in Critically Ill Patients With Pneumonia

Not yet recruiting
1
34
NA
High dose inhaled nitric oxide, Sham treatment, standard therapy
Massachusetts General Hospital
Critical Illness, Pneumonia
06/26
10/26
NCT06675435: Inhaled Nitric Oxide in Severe Obesity

Not yet recruiting
N/A
60
US
Nitric oxide
Massachusetts General Hospital
Obesity, Respiratory Insufficiency, Hypoxemic Respiratory Failure, Nitric Oxide
10/27
12/27
NCT05801224: Vascular ARDS Recruitment After Inhaled Nitric Oxide

Suspended
N/A
70
US
Nitric Oxide, inhaled nitric oxide (iNO)
Massachusetts General Hospital
Acute Respiratory Distress Syndrome, Ventilation Perfusion Mismatch
12/28
12/28
Amitiza (lubiprostone) / Takeda, Mallinckrodt
NCT04985669: Study of Comparative Effectiveness of Prucalopride and Lubiprostone in Constipation Predominant Irritable Bowel Syndrome

Recruiting
4
140
RoW
Prucalopride 2mg, calopride
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Patient Satisfaction
02/22
03/22
ChiCTR2400088155: Evaluating lubiprostone for effective in colonoscopic bowel preparation

Not yet recruiting
4
244
 
Use of rupiprostenone before bowel preparation; Use of rupiprostenone before bowel preparation; control group 1 ; control group 12
The Affiliated People’s Hospital of Ningbo University; The Affiliated People’s Hospital of Ningbo University, self-finance
Bowel Preparation
 
 
ChiCTR2400090921: A Randomized Controlled Study of the Efficacy and Safety of a Bowel Preparation Regimen of 1L Polyethylene Glycol Combined with Lubiprostone Versus 2L Polyethylene Glycol

Not yet recruiting
4
284
 
1L Polyethylene Glycol (PEG) + Lubiprostone; 2L Polyethylene Glycol (PEG)
The First Affiliated Hospital Of Guangzhou Medical University; The First Affiliated Hospital Of Guangzhou Medical University, Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd
Bowel preparation protocol before colonoscopy
 
 
ChiCTR2400090127: Efficacy and Safety of Lubiprostone Compared to Lactulose in Elderly Patients with Chronic Constipation: A Randomized, Controlled, Open-Label, Multicenter Clinical Study

Not yet recruiting
4
190
 
Subjects will take Lubiprostone capsules orally for 4 consecutive weeks, 24 μg per capsule, 1 capsule per dose, twice daily; Subjects will take lactulose solution orally for 4 consecutive weeks, starting with an initial dose of 30 mL per day. The maintenance dose will be 10-25 mL per day, administered orally, for a total duration of 4 weeks.
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School; Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Corporate Sponsorship
Chronic constipation
 
 
ChiCTR1800015360: The efficacy and safety of Lubiprostone capsule in the treatment of functional constipation: a randomized, double-blind, multi-center, placebo-parallel-controlled Confirmatory clinical trial

Not yet recruiting
3
260
 
lubiprostone capsules ;Placebo capsules
The First Affiliated Hospital of Sun Yat-sen University; Nanjing ChiaTai TianQing Pharmaceuticals LP, self-raised
functional constipation
 
 
NCT05768334: Efficacy and Tolerability of Lubiprostone in Patients With Nonalcoholic Fatty Liver Disease

Completed
3
116
RoW
Lubiprostone 24Mcg Oral twice daily
Helwan University
NAFLD
02/23
02/23
NCT06543979: Anorectal Manometery in Pediatric Chronic Refractory Constipation

Recruiting
1/2
60
RoW
lubiprostone , single arm, lubicont, biofeed back sessions, botox injection
Ain Shams University
Chronic Constipation
09/25
10/25
NCT04861233: A Study of Lubiprostone to Treat Constipation

Recruiting
N/A
3000
RoW
No Intervention
Jeil Pharmaceutical Co., Ltd.
Constipation
05/24
11/24
ChiCTR2500096667: Evaluation study on the effectiveness and safety of Lubiprostone combined with magnesium sulfate in bowel preparation for elderly patients with constipation

Recruiting
N/A
100
 
Lubiprostone; placebo
Shanghai Geriatric Medical Center; Shanghai Geriatric Medical Center, Self-financing
elderly constipation
 
 
ChiCTR2500098149: Efficacy and safety of a polyethylene glycol electrolyte solution combined with lubiprostone for bowel preparation in type 2 diabetes patients using GLP-1 receptor agonists: a prospective, multicenter, randomized, open-label, blinded endpoint trial

Not yet recruiting
N/A
216
 
3 L PEG fractional lavage + lubiprostone; 3 L PEG for bowel wash
West China Hospital, Sichuan University; West China Hospital, Sichuan University, GCP Clinical Trial of Lubiprostone
Diabetes
 
 
NCT03720613: Risk of Major Adverse Cardiovascular Events for Naldemedine & Other Medications for Opioid Induced Constipation

Recruiting
N/A
34532
US
Naldemedine, Symproic®, Lubiprostone, Amitiza®, Naloxegol, Movantik®
BioDelivery Sciences International, HealthCore, Inc.
Opioid-induced Constipation
11/30
11/30
ornithine phenylacetate oral (MNK-6106) / Yaqrit
NCT01634230: Emergency Use of OCR-002 in Acute Liver Failure (ALF)

No Longer Available
N/A
US
OCR-002, ornithine phenylacetate
Ocera Therapeutics, Inc.
Acute Liver Failure
 
 
Stratagraft (regenerative skin tissue) / Mallinckrodt
StrataSTEPS, NCT05517902: StrataGraft Safety, Tolerability and Efficacy in Pediatric Subjects

Completed
3
1
US
StrataGraft
Stratatech, a Mallinckrodt Company, Biomedical Advanced Research and Development Authority
Skin Wound, Burns, Trauma-related Wound
05/24
05/24
StrataSOMA, NCT04765202: StrataGraft Overlay of Meshed Autograft in Full-thickness Thermal Burns

Terminated
1/2
13
US
AG Tx, Meshed Autograft, SOMA Tx, StrataGraft skin tissue Overlay of Meshed Autograft (SOMA)
Stratatech, a Mallinckrodt Company
Full Thickness Thermal Burn
06/24
06/24
NCT04896346: Scarring in Stratagraft-treated vs. Autograft-treated Burn Wounds: a Clinical and Histological Investigation

Active, not recruiting
N/A
5
US
Punch biopsy, non-invasive photography, assessments, and measurements
Medstar Health Research Institute
Burn Scar, Scar
10/22
06/23
adrabetadex (VTS-270) / Mandos Health
NCT02534844 / 2015-002548-15: VTS-270 to Treat Niemann-Pick Type C1 (NPC1) Disease

Completed
2b
56
Europe, US, RoW
Parts A/B: Adrabetadex, 2-hydroxypropyl-β-cyclodextrin, Cyclodextrin, VTS-270, Adrabetadex, Parts A/B: Sham Control, Procedure Control, Skin prick
Mandos LLC
Niemann-Pick Disease, Type C
03/18
03/18
NCT03471143: Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease, Type C

Active, not recruiting
1/2
12
US
adrabetadex (2-Hydroxypropyl-Beta-Cyclodextrin), VTS-270, HP-Beta-CD
Washington University School of Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Niemann-Pick Disease, Type C
10/25
10/25
recombinant human serum albumin (RU-10) / Mallinckrodt
No trials found
SLN501 / Silence Therap, Mallinckrodt
No trials found

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