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85 Trials

   

Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Aggrastat (tirofiban) / Correvio, Medicure
ChiCTR-TRC-08000060: A multicenter, single-blind, randomized controlled clinical trial: the influence of salvianolate injection for the myocardial perfusion and prognosis of primary PCI after acute myocardial infarction

Completed
4
300
 
Start using tirofiban 30 minutes before the operation. Intravenous injection 10ug/kg within 3 minutes, and then continuous intravenous drip 0.15 ug/kg/min for 36 hours ;Placebo group: routine treatment for emergency PCI after acute myocardial infarction is given. No uses of studied agents mentioned above or intravenous use of TCM and calcium antagonists ;Start using salvianotlate 30 minutes before the operation (400mg + NS 100ml, 50mL/h), and then continue intravenous use of salvianotlate, Qd.
The 6th people's hospital of Shanghai; Science and Technology Commission of Shanghai Municipality, Science and Technology Commission of Shanghai Municipality
Acute myocardial infarction
 
 
ChiCTR-TRC-10000777: Early Administration of Tirofiban in High-risk Patients with Non-ST Elevation Acute Coronary Syndrome Referred for Percutaneous Coronary Intervention

Completed
4
500
 
Early administration of tirofiban ;Downstream tirofiban
The First Hospital, Peking University; Wuhan Grand pharmaceutical group CO. LTD., Wuhan Grand pharmaceutical group CO. LTD.
high-risk non–ST-segment elevation acute coronary syndrome
 
 
ETN-STEP Trail, ChiCTR-TRC-12002699: Early Administration of Tirofiban in High-risk Patients with Non-ST Elevation Acute Coronary Syndrome Referred for Percutaneous Coronary Intervention

Completed
4
478
 
early administration of tirofiban at least 12 hour ;administration of tirofiban during PCI operation
Peking University First Hospital; Peking University First Hospital, Wuhan Yuanda Pharmaceutical Company Market Department
Non-ST Elevation Acute Coronary Syndrome
 
 
ChiCTR-TRC-10000809: Benefits and Safety of Early Tirofiban in the Treatment of Patients with Acute Coronary Syndrome: a Prospective, Multicenter and Randomized controlled trial

Completed
4
852
 
Group one, conservation treatment group, tirofiban was used in the study group whereas it was not in the control group.its use was according to the instruction book. ;group two, PCI group, for patients with NSTEACS, tirofiban was used in the study group at least 4 hours before operation and for patients with STEMI, tirofiban was used just before PCI, whereas tirofibn was not used before coronary angiography but the provisional use during or after PCI in the control one; its use was according to the instruction book. ;group three, post-PCI group, tirofiban was used after operation in the study group whereas it was not in the control group. its use was according to the instruction book.
Henan Provincial People’Hospital; Wuhan Grand Pharmaceutical Group Co., Ltd, Wuhan Grand Pharmaceutical Group Co., Ltd.
acute coronary syndrome
 
 
ChiCTR-TRC-14004226: Effect of tirofiban on coronary microcirculation of PCI operation and research on the mechanism

Completed
4
119
 
Oral aspirin 300mg and clopidogrel + tirofiban + directly perform PCI inter-coronary artery ;Oral aspirin 300mg and clopidogrel + directly perform PCI inter-coronary artery
Tianjin Tifth Central Hospital; Tianjin Tifth Central Hospital, Health bureau of Tianjin City
Acute myocardial infarction
 
 
ChiCTR-TRC-14004630: The safety and effectiveness of early administration of tirofiban in patients treated with alteplase for acute ischemic stroke

Completed
4
160
 
rt-PA 0.9mg/kg ;rt-PA 0.9mg/Kg combined with tirofiban 0.4ug/kg load i.v., 30', after then, 0.1ug/kg in 24 hours
Department of Neurology, Daping Hospital, the Third Military Medical University; Chongqing Three Gorges Central Hospital, Self-financing
Acute ischemic stroke
 
 
ChiCTR-IPR-17010745: A Randomized, Parallel-controlled, Multi-center Study of the Effects of Intracoronary Recombinant HUman Prourokinase or TIrofiban on the Coronary Flow during Primary PCI for the Acute Myocardial InfartiON,ERUPTION

Recruiting
4
360
 
the Coronary Flow ;the Coronary Flow ;the Coronary Flow
Zhongshan Hospital Affiliated to Fudan University; Zhongshan Hospital Affiliated to Fudan University, Shanghai tasly pharmaceutical co., LTD
STEMI
 
 
ChiCTR1900027700: Efficacy and safety of tirofiban in patients with progressive stroke

Not yet recruiting
4
66
 
tirofiban
The People's Hospital Liaoning Province; The People's Hospital Liaoning Province, Lunan Better Pharmaceutical Co.,Ltd.
PIS
 
 
ChiCTR1900025466: Efficacy and safety of tirofiban in the treatment of acute non-thrombolytic ischemic stroke: a randomized controlled trial.

Recruiting
4
268
 
Saline+Tirofiban ;Aspirin +Clopidogrel or oral anticoagulant
The Affiliated Weihai Central Hospital of Qingdao University; The Affiliated Weihai Central Hospital of Qingdao University, National Natural Science Foundation and self raised fund
acute ischemic stroke
 
 
ChiCTR2000031297: Clinical efficacy and safety of tirofiban in patients with acute ischemic stroke

Recruiting
4
400
 
Tirofiban plus standard management ;Standard management
The Affiliated Hospital of Qingdao University; The Affiliated Hospital of Qingdao University, The National Key Research and Development Program of China
acute ischemic stroke
 
 
ChiCTR1900022321: Efficacy and safety of tirofiban in bridging treatment of acute intracranial atherosclerotic vascular occlusion: a randomized controlled trial

Not yet recruiting
4
168
 
tirofiban hydrochloride injection ;Placebo injection
Shanghai General Hospital; Shanghai General Hospital, Shanghai General Hospital Clinical Research Innovation team Project (CTCCR-2018BP05)
acute intracranial atherosclerotic vascular occlusion
 
 
POST-DES, ChiCTR1900022351: A prospective, multi-center, randomized controlled clinical trial for perioperative optimal bridge strategy on antithrombotic therapy of patients with a recently implanted coronary drug-eluting stent undergoing non-cardiac surgery

Not yet recruiting
4
1600
 
tirofiban ;enoxaparin
Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine; Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine
coronary artery disease
 
 
2021-003874-30: ATILA Project: Aspirin vs Tirofiban in endovascular treatment for patients with acute ischemic stroke due to Tandem Lession. Proyecto ATILA: Aspirina vs Tirofibán en el tratamiento endovascular para pacientes con Ictus isquémico agudo por Lesión en tAndem

Not yet recruiting
4
240
Europe
Tirofiban Agrastat ®, INYESPRIN®, Solution for infusion, Powder for solution for injection/infusion, AGGRASTAT® (50 micrograms/ml) solution for infusion, INYESPRIN®
Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla (FISEVI)., Instituto de Salud Carlos III (Ministerio de Ciencia e Innovación)
Acute Ischemic Stroke Ictus isquémico agudo de circulación anterior secundario a lesión en tándem, Acute Ischemic Stroke Accidente cerebrovascular isquémico agudo, Diseases [C] - Cardiovascular Diseases [C14]
 
 
RESCUE BT, ChiCTR-INR-17014167: Revascularization pretreated with tirofiban for acute ischemic stroke

Recruiting
4
930
 
IV tirofiban and endovascular treatment ;IV placebo and endovascular treatment
Xinqiao Hospital, the Third Military Medical University; Xinqiao Hospital, the Third Military Medical University, self-financing
acute ischemic stroke
 
 
ChiCTR2000031935: The safety and efficacy of tirofiban prior to stenting for intracranial atherosclerotic stenosis

Not yet recruiting
4
180
 
give tirofiban ;not give tirofiban
The First Affiliated Hospital of Shandong First Medical University; The First Affiliated Hospital of Shandong First Medical University, self-collected
intracranial atherosclerotic disease
 
 
RESCUE BT 2, ChiCTR2000029502: A prospective, multicenter, randomized controlled trial for tirofiban in the early treatment of acute ischemic stroke

Completed
4
1158
 
Tirofiban ;Placebo+Standard medical treatment
The Second Affiliated Hospital of the Army Medical University; The Second Affiliated Hospital of the Army Medical University, Self-financing
Acute ischemic stroke
 
 
ChiCTR2300075648: Safety and efficacy of prophylactic tirofiban in treating intracranial aneurysms

Completed
4
495
 
N/A; N/A
Qilu Hospital of Shandong University; Qilu Hospital of Shandong University, self-funded
intracranial aneurysms
 
 
NCT05841147: Reduction of Microembolism After the Intervention Surgery of Intracranial Aneurysms by Administration of Tirofiban

Recruiting
4
70
RoW
Tirofiban, normal saline
Lu Hua
Intracranial Aneurysm
07/23
08/23
ChiCTR2000031383: Efficacy and safety of tirofiban in the prevention of thrombus during stent assisted embolization of intracranial aneurysms

Recruiting
4
40
 
tirofiban0.15μg/(kg·min) ;Intravenously push 10μg/kg for 3-5min, then 0.15μg/(kg·min) intravenously
Gansu Provincial People's Hospital; Gansu Provincial Hospital, None
Intracranial aneurysms
 
 
ChiCTR2200067188: Preliminary exploratory study on the antithrombotic effect of tirofiban in stent assisted embolization of ruptured aneurysms

Not yet recruiting
4
150
 
Oral loading dose double antibody before interventional embolization of ruptured intracranial aneurysm. ;Interventional embolization of ruptured intracranial aneurysms perioperative use of tirofiban. ;Intravenous application of tirofiban in perioperative period
The First Affiliated Hospital of Army Medical University, PLA; The First Affiliated Hospital of Army Medical University, PLA, Chongqing Science and Health Joint Project
Ruptured intracranial aneurysm
 
 
ChiCTR2100042184: An observational registry study of early tirofiban treatment in acute ischemic non-large vessel occlusive stroke

Recruiting
4
1000
 
Nil ;Nil
The Second Affiliated Hospital of the Army Medical University; The Second Affiliated Hospital of the Army Medical University, Self-financing
Acute ischemic stroke
 
 
ChiCTR2100044191: Effectiveness and safety of tirofiban in the treatment of ischemic stroke

Not yet recruiting
4
100
 
do not use tirofiban ;full dose tirofiban ;2/3 full dose tirofiban ;1/3 full dose tirofiban
Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine; Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Medical and Health Science and Technology Program of Zhejiang Province
Ischemic Stroke
 
 
ChiCTR2200061110: Prospective study of tirofiban in the prevention of early progression of acute non-large vessel occlusions cerebral infarction

Recruiting
4
204
 
Tirofiban ;Aspirin/ Clopidogrel
The Sixth Affiliated Hospital of Jinan University; The Sixth Affiliated Hospital of Jinan University, Self-financing
Acute ischemic stroke
 
 
ATILA, NCT05225961: Project: Aspirin Versus Tirofiban in Endovascular Treatment for Patients With Acute Ischemic Stroke Due to Tandem Lesion

Recruiting
4
240
Europe
Tirofiban, Acetylsalicylic acid
Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Acute Ischemic Stroke
06/25
12/25
STRATEGY, NCT05310968: Study on Tirofiban With Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction

Recruiting
4
970
RoW
Tirofiban hydrochloride sodium chloride injection, Tirofiban hydrochloride sodium chloride injection placebo, Aspirin
Beijing Tiantan Hospital, GrandPharma (China) Co., Ltd.
Branch Atheromatous Disease
06/24
09/24
ChiCTR2100049825: Efficacy and safety of agatreban versus tirofiban in the treatment of progressive stroke

Not yet recruiting
4
125
 
Agartreban is administered intravenously ;Intravenous use of tirofiban ;aspirin+clopidogrel
Nanfang Hospital of Southern Medical University; Zengcheng Branch of Nanfang Hospital, Zengcheng Branch of Nanfang Hospital
Progressive stroke
 
 
ChiCTR2200055421: Clinical randomized trial of tirofiban combined with aspirin in the treatment of moderate and severe perforator atherosclerotic cerebral infarction

Recruiting
4
140
 
Tirofiban + Antiplatelet therapy ;Antiplatelet therapy
The Second People's Hospital of Chengdu; The Second People's Hospital of Chengdu, self-funded
Acute Ischemia Stroke
 
 
H2-THROMBUS, NCT06769256: Intracoronary rhTNK-tPA Versus Tirofiban in Patients With STEMI and High Thrombus Burden

Recruiting
4
300
RoW
rhTNK-tPA, 4-8 mg, Tirofiban
Henan Institute of Cardiovascular Epidemiology
ST-segment Elevation Myocardial Infarction (STEMI)
12/25
12/26
ATTIS, NCT05604638: Early Administration of Tirofiban in Patients Treated With Tenecteplase for Acute Ischemic Stroke

Not yet recruiting
4
600
NA
Tenecteplase plus Tirofiban, Tenecteplase plus Placebo
Second Affiliated Hospital of Guangxi Medical University, CSPC Pharmaceutical Group Limited
Acute Ischemic Stroke
03/25
12/25
ChiCTR2200062760: Efficacy of tirofiban sequential DAPT in the treatment of perforator atherosclerosis

Not yet recruiting
4
94
 
Tirofiban sequential dual antiplatelet ;Dual antiplatelet
The First Hospital of Putian; the First Hospital of Putian, Science and Technology Project of Putian University
perforator atherosclerotic disease
 
 
ChiCTR2400086525: Registration study of early administration of tirofiban in patients treated with intravenous thrombolysis for acute ischemic stroke

Not yet recruiting
4
1000
 
None; None
The Second Affiliated Hospital of Guangxi Medical University; The Second Affiliated Hospital of Guangxi Medical University, Guangxi medical key specialty funds
acute ischemic stroke
 
 
ChiCTR2400087813: A randomized clinical trial of early administration of tirofiban in patients treated with intravenous thrombolysis for acute ischemic stroke

Recruiting
4
406
 
Intravenous thrombolysis + tirofiban + standard medication; Intravenous thrombolysis + standard medication
The Second Affiliated Hospital of Guangxi Medical University; The Second Affiliated Hospital of Guangxi Medical University, Guangxi Medical Key Specialty Funds
acute ischemic stroke
 
 
ChiCTR2300075991: Efficacy of tirofiban for acute cerebral infarction presenting beyond the time window for intravenous thrombolytic therapy

Not yet recruiting
4
128
 
Treatment with tirofiban after imaging examination; Intensive lipid-lowering therapy
Tianjin TEDA hospital; Tianjin TEDA hospital, Self-financing
acute cerebral infarction
 
 
REVIVE-FLOW, ChiCTR2400080004: no Reflow after EndoVascular therapy for acute large artery occlusIVe strokE FolLOWed by early use of tirofiban: An efficacy and safety study

Not yet recruiting
4
370
 
tirofiban hydrochloride sodium chloride injection (tirofiban hydrochloride 5mg and sodium chloride 0.9g), intravenous loading dose of 0.4ug/kg/min for 30min (total dose does not exceed 1mg), followed by 0.1ug/kg/min continuous pump for 23.5h, and then combined with other anti-thrombotic therapy.; aspirin 100mg Qd orally/nasogastric tube, and then combined with other anti-thrombotic therapy.
Traditional Chinese and Western Medicine Hospital of Wuhan (Wuhan NO. 1 Hospital); Traditional Chinese and Western Medicine Hospital of Wuhan (Wuhan NO. 1 Hospital), The second Medical Leading Talents Project of Hubei Province
Ischemic stroke
 
 
RESCUE BT3, ChiCTR2400080653: A study on the effectiveness and safety of early combined treatment with tirofiban following intravenous thrombolysis in acute ischemic stroke

Recruiting
4
1314
 
Tirofiban+Standard medical treatment; Placebo+Standard medical treatment
The Second Affiliated Hospital of the Army Medical University; The Second Affiliated Hospital of the Army Medical University, The funding for this project was provided by three sources:(1) Project "Basic and clinical translation research on new strategies for reperfusion therapy in acute ischemic stroke", project number:2022XKRC002. (2) Project "Clinical research on new strategies for recanalization therapy in acute ischemic stroke", project number:2023GGXM007. (3) Project "Basic research on the mechanism of neuronal injury and repair strategies in ischemic stroke", project number:82090040.
Acute ischemic stroke
 
 
ChiCTR2500095812: Efficacy and safety of Tirofiban after PCI in patients with non-emergency coronary complex high-risk characteristics

Not yet recruiting
4
468
 
Patients in the experimental group received intravenous tirofiban immediately after PCI; Patients in the control group received intravenous 0.9% sodium chloride solution (normal saline) immediately after PCI
Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology; Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology, Self-selected project (self-funded)
Coronary atherosclerotic heart disease
 
 
ChiCTR2100052029: Safety and efficacy of thrombolysis combined with tirofiban in acute ischemic stroke

Not yet recruiting
3
584
 
rtPA(recombinant tissue plasminogenactivator) and tirofiban ;rtPA
The First Affiliated Hospital of Bengbu Medical College; The First Affiliated Hospital of Bengbu Medical College, Special Fund of Bengbu Medical College
Acute ischemic stroke
 
 
ASSET-IT, NCT06134622: Advancing Stroke Safety and Efficacy Through Early Tirofiban Administration After Intravenous Thrombolysis

Completed
3
832
RoW
Intravenous thrombolysis plus tirofiban, Intravenous thrombolysis plus placebo
The First Affiliated Hospital of University of Science and Technology of China
Acute Ischemic Stroke
09/24
12/24
NCT06319846: Tirofiban for Patients With intraCranial Artery Stenosis and High-risk Acute Non-disabling Cerebrovascular Events(CHANCE-4)

Recruiting
3
4674
RoW
Tirofiban, Placebo
Beijing Tiantan Hospital
Ischemic Stroke, Acute, TIA, Symptomatic Intracranial Artery Stenosis
10/25
12/26
BRANT, NCT06037889: Efficacy and Safety of Tirofiban for Patients With BAD

Recruiting
3
516
RoW
Tirofiban, Tirofiban Hydrochloride and Sodium Chloride Injection, Aspirin tablet, Clopidogrel tablet
Peking Union Medical College Hospital, Pharmaron (Chengdu) Clinical Services Co., Ltd.
Branch Atheromatous Disease
07/25
10/25
PICASSO, NCT05611242: Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial

Recruiting
3
404
US
MT+CAS with IV-AP, Thrombectomy, MT+CAS with PO-AP, MT+CAT with PO-AP
Mercy Health Ohio
Acute Ischemic Stroke
03/26
05/27
TREND, NCT04491695: Tirofiban for the Prevention of Neurological Deterioration in Acute Ischemic Stroke

Recruiting
2/3
420
RoW
Tirofiban Hydrochloride, Oral antiplatelet
Capital Medical University
Acute Stroke
12/22
03/23
TEAR, NCT06238115: Tirofiban for Reduction of Thromboembolic Events in Endovascular Unruptured Aneurysm Repair

Recruiting
2/3
190
RoW
Tirofiban, aspirin, clopidogrel
Beijing Tiantan Hospital
Unruptured Intracranial Aneurysm, Flow Diverter, Stent-assisted Coiling, Thromboembolic Events
12/24
06/25
ATTRACTION, NCT06265051: Tirofiban After Successful MT Recanalization in AIS

Recruiting
2/3
1360
RoW
Tirofiban, trade name: Xinweining; Wuhan Grand Pharmaceutical Group Co., LTD. (China), Saline placebo
Xiang Luo, Wuhan Central Hospital, Zhongnan Hospital of Wuhan University, Renmin Hospital of Wuhan University, Second Affiliated Hospital of Soochow University, The First Affiliated Hospital of Zhengzhou University, Wuhan Hospital of Traditional Chinese Medicine, The Central Hospital of Enshi Tujia And Miao Autonomous Prefecture, Huangshi Central Hospital, China, The First Affiliated Hospital of Yangtze University, The Fifth Hospital of Wuhan, Wuhan Puren Hospital, Xiangyang No.1 People's Hospital, Xianning Central Hospital, Wuhan Hanyang Hospital, Wuhan Third Hospital, Yichang Central People's Hospital, Affiliated Hospital of Chengde Medical University, Beijing Tiantan Hospital, Nanyang Central Hospital, Jingzhou Central Hospital, Taihe Hospital, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Acute Ischemic Stroke, Vessel Occlusion
03/27
09/27
ADJUVANT-2, NCT06373042: Tirofiban for Successful Endovascular Stroke Thrombectomy

Not yet recruiting
2/3
712
NA
Intraarterial and intravenous tirofiban, Tirofiban, Intraarterial and intravenous placebo, Placebo
Zhongming Qiu, Mianyang Central Hospital, The Second Affiliated Hospital of Chongqing Medical University, The Second Hospital of Jiaozuo, Chongzhou People's Hospital, Xihua People's Hospital, Xingguo People's Hospital
Stroke, Acute Ischemic
07/26
10/26
TREND-2, NCT06587347: Tirofiban for the Prevention of Early Neurological Deterioration After Intravenous Thrombolysis in Acute Ischemic Stroke

Not yet recruiting
2/3
302
RoW
Tirofiban Hydrochloride, Standard medical treatment (SMT)
Capital Medical University
Acute Stroke, Ischemic Stroke, Acute, Cerebral Infarction
06/26
06/26
ADJUVANT, NCT05728333: Intravenous Tirofiban Versus Alteplase Before Mechanical Thrombectomy in Stroke

Recruiting
2/3
800
RoW
Tirofiban, Tirofiban & EVT, Alteplase, Alteplase & EVT
Xinqiao Hospital of Chongqing, Zhejiang University
Stroke, Acute Ischemic
03/27
06/27
ChiCTR-OIN-17013510: Safety and Efficacy of Intravenous Tirofiban in Acute Ischemic Stroke Patient without Large Arterial Occlusion

Recruiting
2
100
 
intravenous tirofiban ;Simple expansion, antiplatelet or anticoagulant therapy
Daping Hospital,Third Military Medical University; Daping Hospital, Third Military Medical University, Chongqing Science & Technology Grant (CSTC2015shmszx120089)
Acute Ischemic Stroke
 
 
ChiCTR1800014666: the study of Clinical efficacy of low-dose rt-PA combined with tirofiban in the treatment of non-cardiac acute cerebral infarction

Recruiting
2
100
 
Low-dose alteplase and tirofiban ;standard single-dose rt-PA treatment
Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University; Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Self-financing,Yantai Science and Technology Development Project,Hospital project
Cerebrovascular disease
 
 
OPTIMISTIC, NCT04851457: One Pass Tirofiban In Management of Ischemic Stroke Thrombectomy In China

Completed
2
200
RoW
Intravenous tirofiban combination therapy, Tirofiban
Shanghai East Hospital, Shanghai 6th People's Hospital, Ningbo No. 1 Hospital, Zhangzhou Municipal Hospital of Fujian Province, Shanghai 7th People's Hospital, Jinan Central Hospital, Xuchang Central Hospital
Ischemic Stroke
07/23
10/23
RESET, NCT05188417: A Study Evaluating the Safety and Efficacy of Tirofiban in Combination With Alteplase in Acute Ischemic Stroke

Active, not recruiting
2
266
RoW
Tirofiban 0.05 MG/ML, Alteplase, 0.9% sodium chloride solution
GrandPharma (China) Co., Ltd.
Acute Ischemic Stroke
03/23
06/23
ChiCTR-TRC-08000168: A Clinical Research of the Timing of Tirofiban for High-Risk non-ST-segment Elevation Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention

Completed
1
160
 
Received tirofiban with the guidewire crossing the coronary lesion. Tirofiban was administrated as a bolus dose of 10ug/kg per 3 min, following by an infusion of 0.15ug/kg/min up to 24-36h after PCI. ;Received tirofiban within 4-6h before coronary angiography. Tirofiban was administrated as a bolus dose of 10ug/kg per 3 min, following by an infusion of 0.15ug/kg/min up to 24-36h after PCI.
Beijing Anzhen Hospital, Capital University of Medical Science; Foundation for Beijing Health-Care Project, Specific Foundation for Beijing Health-Care Project
high-risk non-ST-segment elevation acute coronary syndromes (NSTE-ACS)
 
 
ChiCTR-IOR-14005295: The safety and efficiency of selectively early combination with tirofiban based on the monitoring of thromboelastography after thrombolysis in acute ischemic stroke patients

Recruiting
N/A
150
 
rt-PA combination with tirofiban ;only rt-PA
Department of Neurology, Research Institute of Surgery and Daping Hospital, Third Military Medical University; Department of Neurology, Research Institute of Sur, self-raised fund
acute ischemic stroke
 
 
ChiCTR-ICR-15006964: A randomized, controlled, open, single center clinical trial of application of thrombus aspiration and injection of urokinase, tirofiban and nitroglycerin in emergency PCI for patients with ST segment elevation myocardial infarction

Recruiting
N/A
40
 
PCI Operation + thrombus aspiration combined with coronary artery thrombus local injection of fixed dose urokinase,tirofiban and nitroglycerin ;PCI Operation + tirofiban and nitroglycerin + implant stent
Nanjing drum tower hospital; Nan jing Drum Tower Hospital, Nan jing university
acute myocardial infarction
 
 
ATTACK, ChiCTR-ONN-17013512: Safety and Efficacy of Intravenous Tirofiban in Patients with Recurrent Transient Ischemic Attack

Recruiting
N/A
80
 
intravenous tirofiban ;expansion only, oral antiplatelet or anticoagulant therapy
Da Ping Hospital of Third Military Medical University; Daping hospital, Third Military Medical University, Chongqing Science & Technology Grant (CSTC2015shmszx120089)
Transient Ischemic Attack
 
 
ChiCTR1900025936: Clinical efficacy and safety of clofibroxaol in the treatment of non-thrombolytic cerebral infarction and transient ischemic attack: a real-world retrospective study based on case database

Not yet recruiting
N/A
440
 
Tirofiban ;Aspirin and/or Clopidogrel
The Affiliated Weihai Central Hospital of Qingdao University; The Affiliated Weihai Central Hospital of Qingdao University, Self-financing
acute ischemic stroke
 
 
TITOCNI, ChiCTR1800014908: Comparison the efficacy and safety of ticagrelor and TEG-optimized clopidogrel on emergency PCI for patients with acute non-ST segment-elevation myocardial infarction

Not yet recruiting
N/A
2000
 
180mg loading dose of ticagrelor, followed by 90mg q12h.; 600mg loading dose of clopidogrel, with TEG-guided upstream tirofiban, followed by clopidogrel 75mg/day ;Rosuvastatin of 20mg are given twice in the first 24 hours, followed by 20mg/day ;Rosuvastatin are given 5mg/day
Tianjin Cardiogy Institue; Level of the institution:, Health and Family Planning Commision of Tianjin
acute non-ST-elevation myocardial infarction
 
 
ChiCTR-ONN-17013511: Safety and Efficacy of Intervention of Tirofiban during Perioperative period of Endovascular Therapy in Patients with Acute Ischemic Stroke

Recruiting
N/A
160
 
intravenous or intra-arterial tirofiban ;Mechanical thrombectomy and drug treatment programs include expansion, control of blood pressure, blood sugar, moderate sedation, etc.
Daping Hospital of Third Military Medical University; DaPing Hospital of Third Military Medical University, Livelihood project of Chongqing science and technology commission (CSTC2015-shmszx120089)
acute ischemic stroke
 
 
ChiCTR2000029556: Clinical safety and efficacy of low dose RT-PA combined with Tirofiban in the treatment of acute non-cardiac cerebral infarction with unknown onset time of DWI-Flair mismatch

Not yet recruiting
N/A
80
 
试验组 ;对照组
Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University; Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Self-Financing, Yantai Science and Technology Development Project, Hospital Project
Cerebrovascular disease
 
 
ChiCTR1800018167: Application of ERAS in cardiovascular surgery

Recruiting
N/A
750
 
early ambulation ;Respiratory exercise ;acupuncture ;Video visitation ;Leosimendan ;tirofiban ;esmolol ;Improved extracorporeal circulation perfusion
Shandong Provincial Hospital; Shandong Provincial Hospital, self-financing
cardiovascular diseases
 
 
NCT06260969: Endovascular Treatment of Acute Ischemic Stroke With Underlying Intracranial Artery Stenosis

Recruiting
N/A
470
RoW
balloon dilatation, endovascular stenting, aspiration catheter, stent retriever, Tirofiban, intracranial stenting, normal saline
Tianjin Huanhu Hospital
Large Vessel Occlusion, Intracranial Artery Occlusion With Cerebral Infarction, Endovascular Treatments, Acute Ischemic Stroke
09/25
09/25
ChiCTR2200058513: Clinical application of multimodal evaluation and individualized treatment in patients with acute cerebral infarction after ineffective intravenous thrombolysis or arterial thrombectomy

Not yet recruiting
N/A
200
 
Tirofiban was used after intravenous thrombolysis ;Routine treatment after intravenous thrombolysis
Kunshan First People's Hospital; Kunshan First People's Hospital, Grant, Suzhou Science and Technology Bureau Financial Grant
stroke
 
 
ChiCTR2100045661: One Pass Tirofiban In Management of Ischemic Stroke Thrombectomy In China

Recruiting
N/A
200
 
intravenous tirofiban plus MT therapy ;MT therapy with no antiplatelet drugs (intravenous or intra-arterial) are administered
East Hospital, Tongji University School of Medicine; East Hospital, Tongji University School of Medicine, Stroke and Dementia Special Committee of Shanghai Science & Technology Development Foundation
Acute Ischemic Stroke
 
 
ChiCTR2100046570: The study of clinical efficacy of platelet GPII b / III a receptor antagonist in the treatment of acute non-cardiac stroke which screened by imaging

Recruiting
N/A
80
 
intravenous infusion of tirofiban ;Standard antiplatelet therapy
Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University; Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Self-Financed, Yantai Science and Technology Development Project, Hospital Project
Cerebrovascular disease
 
 
ChiCTR2200055661: An ambispective study of the efficacy and safety of tirofiban and heparin in 30 days after coronary artery bypass grafting combined with coronary endarterectomy

Recruiting
N/A
390
 
;
Capital Medical University Affiliated Beijing Anzhen Hospital; Capital Medical University Affiliated Beijing Anzhen Hospital, The capital health research and development of special
coronary heart disease
 
 
ChiCTR1900024123: Effect of thrombolytic therapy on prognosis in acute stage of large artery occlusive cerebral infarction

Not yet recruiting
N/A
574
 
rtPA + tirofiban ;rtPA
The First Affiliated Hospital of Bengbu Medical College; Daping Hospital, Army Medical University, Bengbu Medical College Special Fund
Cardia-cerebrovascular Disease
 
 
TITACIPPI, NCT05733507: Tirofiban Plus Intravenous Thrombolysis in Acute Anterior Choroidal Infarction or Paramedian Pontine Infarction

Completed
N/A
48
Europe
IVT with tenecteplase or alteplase, Intervention Name : Tirofiban and IVT with tenecteplase or alteplase
Centre Hospitalier Sud Francilien
Acute Anterior Choroidal Infarction (ACI), Paramedian Pontine Infarction (IPP)
09/23
09/23
AIS ICAS-MT, NCT06702657: A Randomized Clinical Trial on Urgent Angioplasty for IntraCranial Atherosclerotic Stenosis-related Large-Vessel Occlusion After Mechanical Thrombectomy

Not yet recruiting
N/A
612
NA
balloon dilatation and/or stenting, medication
Changhai Hospital, The First People's Hospital of Changzhou
AIS, ICAS - Intracranial Atherosclerosis, Stroke
11/26
08/27
NCT06836531: POCT Detection for Blood Concentration of Tirofiban in Acute Myocardial Infarction Based on Azo-POP Probe.

Enrolling by invitation
N/A
100
RoW
First Affiliated Hospital of Ningbo University
Acute Myocardial Infarction (AMI)
07/25
07/25
NCT06966674: No-Reflow in Patients With STEMI After Intracoronary Tirofiban After Opening of the Track

Recruiting
N/A
60
RoW
Intracoronary tirofiban, Aggrastat, Saline 0.9%
Kafrelsheikh University
No-Reflow, STEMI, Intracoronary, Tirofiban
10/25
10/25
ANGEL-DRUG, NCT07026318: Endovascular Therapy Combined With Tirofiban for Intracranial Atherosclerotic Acute Ischemic Stroke

Not yet recruiting
N/A
716
RoW
Tirofiban, Placebo
Beijing Anzhen Hospital
Acute Ischemic Stroke
03/27
04/27
ChiCTR2200055697: Tirofiban versus heparin bridged with antiplatelet for the prevention of major cardiovascular and cerebrovascular events in patients undergoing coronary endarterectomy combined with coronary artery bypass grafting

Recruiting
N/A
726
 
heparin ;tirofiban
Capital Medical University Affiliated Beijing Anzhen Hospital; Capital Medical University Affiliated Beijing Anzhen Hospital, The capital health research and development of special
coronary heart disease
 
 
ChiCTR2400081394: The therapeutic effect of tirofiban on acute perforating artery infarct: a real-world study

Not yet recruiting
N/A
117
 
atiplatelet Agents was administrated orally; tirofiban was administrated intravenously
Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.; The First Medical Center, Chinese PLA General Hospital., No funding is required
stroke
 
 
TAIS, ChiCTR2000038771: Tirofiban for the Treatment of Acute Ischemic Stroke

Not yet recruiting
N/A
1000
 
Tirofiban
Xuanwu Hosptial, Capital Medical University; Xuanwu Hosptial, Capital Medical University, Beijing Municipal Science & Technology Commission; Ministry of Science and Technology, PRC.
Acute ischemic stroke
 
 
NCT06045156: Early Tirofiban Administration After Intravenous Thrombolysis in Acute Ischemic Stroke

Recruiting
N/A
1084
RoW
Tirofiban, Tirofiban simulant
The First Hospital of Jilin University
Acute Ischemic Stroke
01/26
12/26
TACT, ChiCTR2500099293: A randomized controlled study on the effect of thrombus aspiration combined with continuous intracoronary injection of tirofiban on IMR in STEMI patients with high thrombus burden

Not yet recruiting
N/A
60
 
Conventional thrombus aspiration, tirofiban intravenous loading dose in coronary artery and intravenous pump were used according to kg body weight for 24 hours, and 1/3 of the loading dose in coronary artery was added before stent implantation.; After conventional thrombus aspiration, stent implantation (pre expansion and post expansion if necessary) was performed. Tirofiban was given intravenous load according to kg body weight and maintained dose by intravenous pump 24 hours after operation
Zhoupu Hospital, Pudong New Area, Shanghai; Zhoupu Hospital, Pudong New Area, Shanghai, Shanghai Songjiang District Science and Technology Research Project
coronary heart disease
 
 
ChiCTR2400089572: Efficacy and safety of tirofiban after intravenous thrombolysis with tenecteplase in acute ischemic stroke: a multicenter randomized controlled trial

Not yet recruiting
N/A
310
 
Teneplase thrombolysis was followed by intravenous tirofiban antiplatelet therapy; Patients in this group received intravenous placebo
ganzhou people's hospital; ganzhou people's hospital, no funding
acute ischemic stroke
 
 
ChiCTR2400087048: Clinical study of tirofiban combined with oxiracetam in the treatment of acute progressive cerebral infarction

Not yet recruiting
N/A
114
 
conventional therapy; Conventional treatment combined with tirofiban and oxiracetam
Hebei Cangzhou Integrated Traditional Chinese and Western Medicine Hospital; Hebei Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Hebei Cangzhou Integrated Traditional Chinese and Western Medicine Hospital
Acute ischemic cerebrovascular disease
 
 
ChiCTR2400090049: Early tirofiban administration after intra-arterial thrombolysis in central retinal artery occlusion: Study protocol of a prospective, multicenter, placebo-controlled

Not yet recruiting
N/A
334
 
None; None
Xi’an No.1 Hospital; Xi’an No.1 Hospital, The Science and Technology Program of Xi’an City(2023YXYJ0005)
Center retinal artery occlusion
 
 
ChiCTR2300073104: Multicenter Clinical study of low-dose rt-PA combined with tirofiban in the treatment of non-cardiac ischemic stroke screened by MRI within 12 h of stroke onset

Recruiting
N/A
400
 
low-dose rt-PA (0.6 mg/kg) + tirofiban ;standard dose rt-PA (0.9 mg/kg)
Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University; Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Self-financing,Yantai Science and Technology Development Project,Hospital project
Cerebrovascular disease
 
 
CHANCE-4, ChiCTR2400086742: Tirofiban for patients with intraCranial artery stenosis and High-risk Acute Non-disabling Cerebrovascular Events

Not yet recruiting
N/A
4674
 
Tirofiban; 0.9% normal saline
Beijing Tiantan Hospital, Capital Medical University; Beijing Tiantan Hospital, Capital Medical University, Beijing Hospitals Authority
Mild ischemic stroke or transient ischemic attack with symptomatic intracranial artery stenosis
 
 
ChiCTR2500103163: Effect of aspiration thrombectomy combined with tirofiban on microvascular obstruction in STEMI patients: a prospective, randomised controlled cardiac magnetic resonance trail

Not yet recruiting
N/A
80
 
Aspiration thrombectomy; None
Changzhou Second People's Hospital; Changzhou Second People's Hospital, Self-selected project (self-raised)
Acute ST-segment elevation myocardial infarction
 
 
ChiCTR2500101820: A Clinical Study on the Interventional Clinical Efficacy of Shexiang Baoxin Pills in Patients with STEMI (Qi-Stagnation and Blood-Stasis Syndrome) After PCI.

Not yet recruiting
N/A
80
 
Preoperative medication:Aspirin: 300 mg for all patients;P2Y12 inhibitors: Patients <75 years: Clopidogrel 600 mg?or?Ticagrelor 180 mg or Patients ≥75 years: Clopidogrel 300 mg. Intraoperative medication:Heparin: Intravenous injection (100 IU/kg);High thrombus burden (thrombus score ≥3):Tirofiban: Initial bolus of 10 μg/kg, followed by continuous intravenous infusion at 0.15 μg/kg/min for 24 hours.Adjusted heparin dose: 50–70 IU/kg. Long-term postoperative medication:Aspirin: 75–100 mg once daily (lifelong). P2Y12 inhibitors:Patients <75 years: Clopidogrel 75 mg once daily?or?Ticagrelor 90 mg twice daily (for at least 1 year). Other medications: Administered according to established guidelines: ACE inhibitors (ACEI)?or?angiotensin receptor blockers (ARB) or ARNI;Beta-blockers;Statins.; Standard Western medical treatment + Shexiang Baoxin Pills;Shexiang Baoxin Pills administration:Pre-PCI: 90 mg sublingually before percutaneous coronary intervention (PCI).Post-PCI: 45 mg orally three times daily, taken with warm water, for 28 days.
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Self-funded
Acute ST-Elevation Myocardial Infarction
 
 
ChiCTR2400089090: Early combination treatment with tirofiban following intravenous thrombolysis in acute ischemic stroke: a multicenter, prospective, cohort study

Not yet recruiting
N/A
454
 
NA; NA
Second Affiliated Hospital of Army Medical University, PLA; Second Affiliated Hospital of Army Medical University, PLA, 2023 General Program of the National Natural Science Foundation of China (NSFC)
Ischemic stroke
 
 
ChiCTR2500101044: The efficacy and safety of early Tirofiban adjunctive to endovascular treatment in acute basilar artery occlusive stroke (BASILAR-2)

Not yet recruiting
N/A
378
 
Treated with tirofiban. Dosage of tirofiban: Arterial administration of tirofiban, intravenous continuation until 24 hours of onset. Antithrombotic drugs were administered according to guidelines after the 24th hour of onset and continued until 90 days after randomization.; Placebo treatment with tirofiban, the usage is the same as that of tirofiban. Antithrombotic drugs were administered according to guidelines after the 24th hour of onset and continued until 90 days after randomization.
The Second Affiliated Hospital of the Army Medical University; Xinqiao Hospital, Self-funded
Acute ischemic stroke
 
 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Aggrastat (tirofiban) / Correvio, Medicure
ChiCTR-TRC-08000060: A multicenter, single-blind, randomized controlled clinical trial: the influence of salvianolate injection for the myocardial perfusion and prognosis of primary PCI after acute myocardial infarction

Completed
4
300
 
Start using tirofiban 30 minutes before the operation. Intravenous injection 10ug/kg within 3 minutes, and then continuous intravenous drip 0.15 ug/kg/min for 36 hours ;Placebo group: routine treatment for emergency PCI after acute myocardial infarction is given. No uses of studied agents mentioned above or intravenous use of TCM and calcium antagonists ;Start using salvianotlate 30 minutes before the operation (400mg + NS 100ml, 50mL/h), and then continue intravenous use of salvianotlate, Qd.
The 6th people's hospital of Shanghai; Science and Technology Commission of Shanghai Municipality, Science and Technology Commission of Shanghai Municipality
Acute myocardial infarction
 
 
ChiCTR-TRC-10000777: Early Administration of Tirofiban in High-risk Patients with Non-ST Elevation Acute Coronary Syndrome Referred for Percutaneous Coronary Intervention

Completed
4
500
 
Early administration of tirofiban ;Downstream tirofiban
The First Hospital, Peking University; Wuhan Grand pharmaceutical group CO. LTD., Wuhan Grand pharmaceutical group CO. LTD.
high-risk non–ST-segment elevation acute coronary syndrome
 
 
ETN-STEP Trail, ChiCTR-TRC-12002699: Early Administration of Tirofiban in High-risk Patients with Non-ST Elevation Acute Coronary Syndrome Referred for Percutaneous Coronary Intervention

Completed
4
478
 
early administration of tirofiban at least 12 hour ;administration of tirofiban during PCI operation
Peking University First Hospital; Peking University First Hospital, Wuhan Yuanda Pharmaceutical Company Market Department
Non-ST Elevation Acute Coronary Syndrome
 
 
ChiCTR-TRC-10000809: Benefits and Safety of Early Tirofiban in the Treatment of Patients with Acute Coronary Syndrome: a Prospective, Multicenter and Randomized controlled trial

Completed
4
852
 
Group one, conservation treatment group, tirofiban was used in the study group whereas it was not in the control group.its use was according to the instruction book. ;group two, PCI group, for patients with NSTEACS, tirofiban was used in the study group at least 4 hours before operation and for patients with STEMI, tirofiban was used just before PCI, whereas tirofibn was not used before coronary angiography but the provisional use during or after PCI in the control one; its use was according to the instruction book. ;group three, post-PCI group, tirofiban was used after operation in the study group whereas it was not in the control group. its use was according to the instruction book.
Henan Provincial People’Hospital; Wuhan Grand Pharmaceutical Group Co., Ltd, Wuhan Grand Pharmaceutical Group Co., Ltd.
acute coronary syndrome
 
 
ChiCTR-TRC-14004226: Effect of tirofiban on coronary microcirculation of PCI operation and research on the mechanism

Completed
4
119
 
Oral aspirin 300mg and clopidogrel + tirofiban + directly perform PCI inter-coronary artery ;Oral aspirin 300mg and clopidogrel + directly perform PCI inter-coronary artery
Tianjin Tifth Central Hospital; Tianjin Tifth Central Hospital, Health bureau of Tianjin City
Acute myocardial infarction
 
 
ChiCTR-TRC-14004630: The safety and effectiveness of early administration of tirofiban in patients treated with alteplase for acute ischemic stroke

Completed
4
160
 
rt-PA 0.9mg/kg ;rt-PA 0.9mg/Kg combined with tirofiban 0.4ug/kg load i.v., 30', after then, 0.1ug/kg in 24 hours
Department of Neurology, Daping Hospital, the Third Military Medical University; Chongqing Three Gorges Central Hospital, Self-financing
Acute ischemic stroke
 
 
ChiCTR-IPR-17010745: A Randomized, Parallel-controlled, Multi-center Study of the Effects of Intracoronary Recombinant HUman Prourokinase or TIrofiban on the Coronary Flow during Primary PCI for the Acute Myocardial InfartiON,ERUPTION

Recruiting
4
360
 
the Coronary Flow ;the Coronary Flow ;the Coronary Flow
Zhongshan Hospital Affiliated to Fudan University; Zhongshan Hospital Affiliated to Fudan University, Shanghai tasly pharmaceutical co., LTD
STEMI
 
 
ChiCTR1900027700: Efficacy and safety of tirofiban in patients with progressive stroke

Not yet recruiting
4
66
 
tirofiban
The People's Hospital Liaoning Province; The People's Hospital Liaoning Province, Lunan Better Pharmaceutical Co.,Ltd.
PIS
 
 
ChiCTR1900025466: Efficacy and safety of tirofiban in the treatment of acute non-thrombolytic ischemic stroke: a randomized controlled trial.

Recruiting
4
268
 
Saline+Tirofiban ;Aspirin +Clopidogrel or oral anticoagulant
The Affiliated Weihai Central Hospital of Qingdao University; The Affiliated Weihai Central Hospital of Qingdao University, National Natural Science Foundation and self raised fund
acute ischemic stroke
 
 
ChiCTR2000031297: Clinical efficacy and safety of tirofiban in patients with acute ischemic stroke

Recruiting
4
400
 
Tirofiban plus standard management ;Standard management
The Affiliated Hospital of Qingdao University; The Affiliated Hospital of Qingdao University, The National Key Research and Development Program of China
acute ischemic stroke
 
 
ChiCTR1900022321: Efficacy and safety of tirofiban in bridging treatment of acute intracranial atherosclerotic vascular occlusion: a randomized controlled trial

Not yet recruiting
4
168
 
tirofiban hydrochloride injection ;Placebo injection
Shanghai General Hospital; Shanghai General Hospital, Shanghai General Hospital Clinical Research Innovation team Project (CTCCR-2018BP05)
acute intracranial atherosclerotic vascular occlusion
 
 
POST-DES, ChiCTR1900022351: A prospective, multi-center, randomized controlled clinical trial for perioperative optimal bridge strategy on antithrombotic therapy of patients with a recently implanted coronary drug-eluting stent undergoing non-cardiac surgery

Not yet recruiting
4
1600
 
tirofiban ;enoxaparin
Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine; Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine
coronary artery disease
 
 
2021-003874-30: ATILA Project: Aspirin vs Tirofiban in endovascular treatment for patients with acute ischemic stroke due to Tandem Lession. Proyecto ATILA: Aspirina vs Tirofibán en el tratamiento endovascular para pacientes con Ictus isquémico agudo por Lesión en tAndem

Not yet recruiting
4
240
Europe
Tirofiban Agrastat ®, INYESPRIN®, Solution for infusion, Powder for solution for injection/infusion, AGGRASTAT® (50 micrograms/ml) solution for infusion, INYESPRIN®
Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla (FISEVI)., Instituto de Salud Carlos III (Ministerio de Ciencia e Innovación)
Acute Ischemic Stroke Ictus isquémico agudo de circulación anterior secundario a lesión en tándem, Acute Ischemic Stroke Accidente cerebrovascular isquémico agudo, Diseases [C] - Cardiovascular Diseases [C14]
 
 
RESCUE BT, ChiCTR-INR-17014167: Revascularization pretreated with tirofiban for acute ischemic stroke

Recruiting
4
930
 
IV tirofiban and endovascular treatment ;IV placebo and endovascular treatment
Xinqiao Hospital, the Third Military Medical University; Xinqiao Hospital, the Third Military Medical University, self-financing
acute ischemic stroke
 
 
ChiCTR2000031935: The safety and efficacy of tirofiban prior to stenting for intracranial atherosclerotic stenosis

Not yet recruiting
4
180
 
give tirofiban ;not give tirofiban
The First Affiliated Hospital of Shandong First Medical University; The First Affiliated Hospital of Shandong First Medical University, self-collected
intracranial atherosclerotic disease
 
 
RESCUE BT 2, ChiCTR2000029502: A prospective, multicenter, randomized controlled trial for tirofiban in the early treatment of acute ischemic stroke

Completed
4
1158
 
Tirofiban ;Placebo+Standard medical treatment
The Second Affiliated Hospital of the Army Medical University; The Second Affiliated Hospital of the Army Medical University, Self-financing
Acute ischemic stroke
 
 
ChiCTR2300075648: Safety and efficacy of prophylactic tirofiban in treating intracranial aneurysms

Completed
4
495
 
N/A; N/A
Qilu Hospital of Shandong University; Qilu Hospital of Shandong University, self-funded
intracranial aneurysms
 
 
NCT05841147: Reduction of Microembolism After the Intervention Surgery of Intracranial Aneurysms by Administration of Tirofiban

Recruiting
4
70
RoW
Tirofiban, normal saline
Lu Hua
Intracranial Aneurysm
07/23
08/23
ChiCTR2000031383: Efficacy and safety of tirofiban in the prevention of thrombus during stent assisted embolization of intracranial aneurysms

Recruiting
4
40
 
tirofiban0.15μg/(kg·min) ;Intravenously push 10μg/kg for 3-5min, then 0.15μg/(kg·min) intravenously
Gansu Provincial People's Hospital; Gansu Provincial Hospital, None
Intracranial aneurysms
 
 
ChiCTR2200067188: Preliminary exploratory study on the antithrombotic effect of tirofiban in stent assisted embolization of ruptured aneurysms

Not yet recruiting
4
150
 
Oral loading dose double antibody before interventional embolization of ruptured intracranial aneurysm. ;Interventional embolization of ruptured intracranial aneurysms perioperative use of tirofiban. ;Intravenous application of tirofiban in perioperative period
The First Affiliated Hospital of Army Medical University, PLA; The First Affiliated Hospital of Army Medical University, PLA, Chongqing Science and Health Joint Project
Ruptured intracranial aneurysm
 
 
ChiCTR2100042184: An observational registry study of early tirofiban treatment in acute ischemic non-large vessel occlusive stroke

Recruiting
4
1000
 
Nil ;Nil
The Second Affiliated Hospital of the Army Medical University; The Second Affiliated Hospital of the Army Medical University, Self-financing
Acute ischemic stroke
 
 
ChiCTR2100044191: Effectiveness and safety of tirofiban in the treatment of ischemic stroke

Not yet recruiting
4
100
 
do not use tirofiban ;full dose tirofiban ;2/3 full dose tirofiban ;1/3 full dose tirofiban
Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine; Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Medical and Health Science and Technology Program of Zhejiang Province
Ischemic Stroke
 
 
ChiCTR2200061110: Prospective study of tirofiban in the prevention of early progression of acute non-large vessel occlusions cerebral infarction

Recruiting
4
204
 
Tirofiban ;Aspirin/ Clopidogrel
The Sixth Affiliated Hospital of Jinan University; The Sixth Affiliated Hospital of Jinan University, Self-financing
Acute ischemic stroke
 
 
ATILA, NCT05225961: Project: Aspirin Versus Tirofiban in Endovascular Treatment for Patients With Acute Ischemic Stroke Due to Tandem Lesion

Recruiting
4
240
Europe
Tirofiban, Acetylsalicylic acid
Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Acute Ischemic Stroke
06/25
12/25
STRATEGY, NCT05310968: Study on Tirofiban With Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction

Recruiting
4
970
RoW
Tirofiban hydrochloride sodium chloride injection, Tirofiban hydrochloride sodium chloride injection placebo, Aspirin
Beijing Tiantan Hospital, GrandPharma (China) Co., Ltd.
Branch Atheromatous Disease
06/24
09/24
ChiCTR2100049825: Efficacy and safety of agatreban versus tirofiban in the treatment of progressive stroke

Not yet recruiting
4
125
 
Agartreban is administered intravenously ;Intravenous use of tirofiban ;aspirin+clopidogrel
Nanfang Hospital of Southern Medical University; Zengcheng Branch of Nanfang Hospital, Zengcheng Branch of Nanfang Hospital
Progressive stroke
 
 
ChiCTR2200055421: Clinical randomized trial of tirofiban combined with aspirin in the treatment of moderate and severe perforator atherosclerotic cerebral infarction

Recruiting
4
140
 
Tirofiban + Antiplatelet therapy ;Antiplatelet therapy
The Second People's Hospital of Chengdu; The Second People's Hospital of Chengdu, self-funded
Acute Ischemia Stroke
 
 
H2-THROMBUS, NCT06769256: Intracoronary rhTNK-tPA Versus Tirofiban in Patients With STEMI and High Thrombus Burden

Recruiting
4
300
RoW
rhTNK-tPA, 4-8 mg, Tirofiban
Henan Institute of Cardiovascular Epidemiology
ST-segment Elevation Myocardial Infarction (STEMI)
12/25
12/26
ATTIS, NCT05604638: Early Administration of Tirofiban in Patients Treated With Tenecteplase for Acute Ischemic Stroke

Not yet recruiting
4
600
NA
Tenecteplase plus Tirofiban, Tenecteplase plus Placebo
Second Affiliated Hospital of Guangxi Medical University, CSPC Pharmaceutical Group Limited
Acute Ischemic Stroke
03/25
12/25
ChiCTR2200062760: Efficacy of tirofiban sequential DAPT in the treatment of perforator atherosclerosis

Not yet recruiting
4
94
 
Tirofiban sequential dual antiplatelet ;Dual antiplatelet
The First Hospital of Putian; the First Hospital of Putian, Science and Technology Project of Putian University
perforator atherosclerotic disease
 
 
ChiCTR2400086525: Registration study of early administration of tirofiban in patients treated with intravenous thrombolysis for acute ischemic stroke

Not yet recruiting
4
1000
 
None; None
The Second Affiliated Hospital of Guangxi Medical University; The Second Affiliated Hospital of Guangxi Medical University, Guangxi medical key specialty funds
acute ischemic stroke
 
 
ChiCTR2400087813: A randomized clinical trial of early administration of tirofiban in patients treated with intravenous thrombolysis for acute ischemic stroke

Recruiting
4
406
 
Intravenous thrombolysis + tirofiban + standard medication; Intravenous thrombolysis + standard medication
The Second Affiliated Hospital of Guangxi Medical University; The Second Affiliated Hospital of Guangxi Medical University, Guangxi Medical Key Specialty Funds
acute ischemic stroke
 
 
ChiCTR2300075991: Efficacy of tirofiban for acute cerebral infarction presenting beyond the time window for intravenous thrombolytic therapy

Not yet recruiting
4
128
 
Treatment with tirofiban after imaging examination; Intensive lipid-lowering therapy
Tianjin TEDA hospital; Tianjin TEDA hospital, Self-financing
acute cerebral infarction
 
 
REVIVE-FLOW, ChiCTR2400080004: no Reflow after EndoVascular therapy for acute large artery occlusIVe strokE FolLOWed by early use of tirofiban: An efficacy and safety study

Not yet recruiting
4
370
 
tirofiban hydrochloride sodium chloride injection (tirofiban hydrochloride 5mg and sodium chloride 0.9g), intravenous loading dose of 0.4ug/kg/min for 30min (total dose does not exceed 1mg), followed by 0.1ug/kg/min continuous pump for 23.5h, and then combined with other anti-thrombotic therapy.; aspirin 100mg Qd orally/nasogastric tube, and then combined with other anti-thrombotic therapy.
Traditional Chinese and Western Medicine Hospital of Wuhan (Wuhan NO. 1 Hospital); Traditional Chinese and Western Medicine Hospital of Wuhan (Wuhan NO. 1 Hospital), The second Medical Leading Talents Project of Hubei Province
Ischemic stroke
 
 
RESCUE BT3, ChiCTR2400080653: A study on the effectiveness and safety of early combined treatment with tirofiban following intravenous thrombolysis in acute ischemic stroke

Recruiting
4
1314
 
Tirofiban+Standard medical treatment; Placebo+Standard medical treatment
The Second Affiliated Hospital of the Army Medical University; The Second Affiliated Hospital of the Army Medical University, The funding for this project was provided by three sources:(1) Project "Basic and clinical translation research on new strategies for reperfusion therapy in acute ischemic stroke", project number:2022XKRC002. (2) Project "Clinical research on new strategies for recanalization therapy in acute ischemic stroke", project number:2023GGXM007. (3) Project "Basic research on the mechanism of neuronal injury and repair strategies in ischemic stroke", project number:82090040.
Acute ischemic stroke
 
 
ChiCTR2500095812: Efficacy and safety of Tirofiban after PCI in patients with non-emergency coronary complex high-risk characteristics

Not yet recruiting
4
468
 
Patients in the experimental group received intravenous tirofiban immediately after PCI; Patients in the control group received intravenous 0.9% sodium chloride solution (normal saline) immediately after PCI
Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology; Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology, Self-selected project (self-funded)
Coronary atherosclerotic heart disease
 
 
ChiCTR2100052029: Safety and efficacy of thrombolysis combined with tirofiban in acute ischemic stroke

Not yet recruiting
3
584
 
rtPA(recombinant tissue plasminogenactivator) and tirofiban ;rtPA
The First Affiliated Hospital of Bengbu Medical College; The First Affiliated Hospital of Bengbu Medical College, Special Fund of Bengbu Medical College
Acute ischemic stroke
 
 
ASSET-IT, NCT06134622: Advancing Stroke Safety and Efficacy Through Early Tirofiban Administration After Intravenous Thrombolysis

Completed
3
832
RoW
Intravenous thrombolysis plus tirofiban, Intravenous thrombolysis plus placebo
The First Affiliated Hospital of University of Science and Technology of China
Acute Ischemic Stroke
09/24
12/24
NCT06319846: Tirofiban for Patients With intraCranial Artery Stenosis and High-risk Acute Non-disabling Cerebrovascular Events(CHANCE-4)

Recruiting
3
4674
RoW
Tirofiban, Placebo
Beijing Tiantan Hospital
Ischemic Stroke, Acute, TIA, Symptomatic Intracranial Artery Stenosis
10/25
12/26
BRANT, NCT06037889: Efficacy and Safety of Tirofiban for Patients With BAD

Recruiting
3
516
RoW
Tirofiban, Tirofiban Hydrochloride and Sodium Chloride Injection, Aspirin tablet, Clopidogrel tablet
Peking Union Medical College Hospital, Pharmaron (Chengdu) Clinical Services Co., Ltd.
Branch Atheromatous Disease
07/25
10/25
PICASSO, NCT05611242: Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial

Recruiting
3
404
US
MT+CAS with IV-AP, Thrombectomy, MT+CAS with PO-AP, MT+CAT with PO-AP
Mercy Health Ohio
Acute Ischemic Stroke
03/26
05/27
TREND, NCT04491695: Tirofiban for the Prevention of Neurological Deterioration in Acute Ischemic Stroke

Recruiting
2/3
420
RoW
Tirofiban Hydrochloride, Oral antiplatelet
Capital Medical University
Acute Stroke
12/22
03/23
TEAR, NCT06238115: Tirofiban for Reduction of Thromboembolic Events in Endovascular Unruptured Aneurysm Repair

Recruiting
2/3
190
RoW
Tirofiban, aspirin, clopidogrel
Beijing Tiantan Hospital
Unruptured Intracranial Aneurysm, Flow Diverter, Stent-assisted Coiling, Thromboembolic Events
12/24
06/25
ATTRACTION, NCT06265051: Tirofiban After Successful MT Recanalization in AIS

Recruiting
2/3
1360
RoW
Tirofiban, trade name: Xinweining; Wuhan Grand Pharmaceutical Group Co., LTD. (China), Saline placebo
Xiang Luo, Wuhan Central Hospital, Zhongnan Hospital of Wuhan University, Renmin Hospital of Wuhan University, Second Affiliated Hospital of Soochow University, The First Affiliated Hospital of Zhengzhou University, Wuhan Hospital of Traditional Chinese Medicine, The Central Hospital of Enshi Tujia And Miao Autonomous Prefecture, Huangshi Central Hospital, China, The First Affiliated Hospital of Yangtze University, The Fifth Hospital of Wuhan, Wuhan Puren Hospital, Xiangyang No.1 People's Hospital, Xianning Central Hospital, Wuhan Hanyang Hospital, Wuhan Third Hospital, Yichang Central People's Hospital, Affiliated Hospital of Chengde Medical University, Beijing Tiantan Hospital, Nanyang Central Hospital, Jingzhou Central Hospital, Taihe Hospital, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Acute Ischemic Stroke, Vessel Occlusion
03/27
09/27
ADJUVANT-2, NCT06373042: Tirofiban for Successful Endovascular Stroke Thrombectomy

Not yet recruiting
2/3
712
NA
Intraarterial and intravenous tirofiban, Tirofiban, Intraarterial and intravenous placebo, Placebo
Zhongming Qiu, Mianyang Central Hospital, The Second Affiliated Hospital of Chongqing Medical University, The Second Hospital of Jiaozuo, Chongzhou People's Hospital, Xihua People's Hospital, Xingguo People's Hospital
Stroke, Acute Ischemic
07/26
10/26
TREND-2, NCT06587347: Tirofiban for the Prevention of Early Neurological Deterioration After Intravenous Thrombolysis in Acute Ischemic Stroke

Not yet recruiting
2/3
302
RoW
Tirofiban Hydrochloride, Standard medical treatment (SMT)
Capital Medical University
Acute Stroke, Ischemic Stroke, Acute, Cerebral Infarction
06/26
06/26
ADJUVANT, NCT05728333: Intravenous Tirofiban Versus Alteplase Before Mechanical Thrombectomy in Stroke

Recruiting
2/3
800
RoW
Tirofiban, Tirofiban & EVT, Alteplase, Alteplase & EVT
Xinqiao Hospital of Chongqing, Zhejiang University
Stroke, Acute Ischemic
03/27
06/27
ChiCTR-OIN-17013510: Safety and Efficacy of Intravenous Tirofiban in Acute Ischemic Stroke Patient without Large Arterial Occlusion

Recruiting
2
100
 
intravenous tirofiban ;Simple expansion, antiplatelet or anticoagulant therapy
Daping Hospital,Third Military Medical University; Daping Hospital, Third Military Medical University, Chongqing Science & Technology Grant (CSTC2015shmszx120089)
Acute Ischemic Stroke
 
 
ChiCTR1800014666: the study of Clinical efficacy of low-dose rt-PA combined with tirofiban in the treatment of non-cardiac acute cerebral infarction

Recruiting
2
100
 
Low-dose alteplase and tirofiban ;standard single-dose rt-PA treatment
Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University; Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Self-financing,Yantai Science and Technology Development Project,Hospital project
Cerebrovascular disease
 
 
OPTIMISTIC, NCT04851457: One Pass Tirofiban In Management of Ischemic Stroke Thrombectomy In China

Completed
2
200
RoW
Intravenous tirofiban combination therapy, Tirofiban
Shanghai East Hospital, Shanghai 6th People's Hospital, Ningbo No. 1 Hospital, Zhangzhou Municipal Hospital of Fujian Province, Shanghai 7th People's Hospital, Jinan Central Hospital, Xuchang Central Hospital
Ischemic Stroke
07/23
10/23
RESET, NCT05188417: A Study Evaluating the Safety and Efficacy of Tirofiban in Combination With Alteplase in Acute Ischemic Stroke

Active, not recruiting
2
266
RoW
Tirofiban 0.05 MG/ML, Alteplase, 0.9% sodium chloride solution
GrandPharma (China) Co., Ltd.
Acute Ischemic Stroke
03/23
06/23
ChiCTR-TRC-08000168: A Clinical Research of the Timing of Tirofiban for High-Risk non-ST-segment Elevation Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention

Completed
1
160
 
Received tirofiban with the guidewire crossing the coronary lesion. Tirofiban was administrated as a bolus dose of 10ug/kg per 3 min, following by an infusion of 0.15ug/kg/min up to 24-36h after PCI. ;Received tirofiban within 4-6h before coronary angiography. Tirofiban was administrated as a bolus dose of 10ug/kg per 3 min, following by an infusion of 0.15ug/kg/min up to 24-36h after PCI.
Beijing Anzhen Hospital, Capital University of Medical Science; Foundation for Beijing Health-Care Project, Specific Foundation for Beijing Health-Care Project
high-risk non-ST-segment elevation acute coronary syndromes (NSTE-ACS)
 
 
ChiCTR-IOR-14005295: The safety and efficiency of selectively early combination with tirofiban based on the monitoring of thromboelastography after thrombolysis in acute ischemic stroke patients

Recruiting
N/A
150
 
rt-PA combination with tirofiban ;only rt-PA
Department of Neurology, Research Institute of Surgery and Daping Hospital, Third Military Medical University; Department of Neurology, Research Institute of Sur, self-raised fund
acute ischemic stroke
 
 
ChiCTR-ICR-15006964: A randomized, controlled, open, single center clinical trial of application of thrombus aspiration and injection of urokinase, tirofiban and nitroglycerin in emergency PCI for patients with ST segment elevation myocardial infarction

Recruiting
N/A
40
 
PCI Operation + thrombus aspiration combined with coronary artery thrombus local injection of fixed dose urokinase,tirofiban and nitroglycerin ;PCI Operation + tirofiban and nitroglycerin + implant stent
Nanjing drum tower hospital; Nan jing Drum Tower Hospital, Nan jing university
acute myocardial infarction
 
 
ATTACK, ChiCTR-ONN-17013512: Safety and Efficacy of Intravenous Tirofiban in Patients with Recurrent Transient Ischemic Attack

Recruiting
N/A
80
 
intravenous tirofiban ;expansion only, oral antiplatelet or anticoagulant therapy
Da Ping Hospital of Third Military Medical University; Daping hospital, Third Military Medical University, Chongqing Science & Technology Grant (CSTC2015shmszx120089)
Transient Ischemic Attack
 
 
ChiCTR1900025936: Clinical efficacy and safety of clofibroxaol in the treatment of non-thrombolytic cerebral infarction and transient ischemic attack: a real-world retrospective study based on case database

Not yet recruiting
N/A
440
 
Tirofiban ;Aspirin and/or Clopidogrel
The Affiliated Weihai Central Hospital of Qingdao University; The Affiliated Weihai Central Hospital of Qingdao University, Self-financing
acute ischemic stroke
 
 
TITOCNI, ChiCTR1800014908: Comparison the efficacy and safety of ticagrelor and TEG-optimized clopidogrel on emergency PCI for patients with acute non-ST segment-elevation myocardial infarction

Not yet recruiting
N/A
2000
 
180mg loading dose of ticagrelor, followed by 90mg q12h.; 600mg loading dose of clopidogrel, with TEG-guided upstream tirofiban, followed by clopidogrel 75mg/day ;Rosuvastatin of 20mg are given twice in the first 24 hours, followed by 20mg/day ;Rosuvastatin are given 5mg/day
Tianjin Cardiogy Institue; Level of the institution:, Health and Family Planning Commision of Tianjin
acute non-ST-elevation myocardial infarction
 
 
ChiCTR-ONN-17013511: Safety and Efficacy of Intervention of Tirofiban during Perioperative period of Endovascular Therapy in Patients with Acute Ischemic Stroke

Recruiting
N/A
160
 
intravenous or intra-arterial tirofiban ;Mechanical thrombectomy and drug treatment programs include expansion, control of blood pressure, blood sugar, moderate sedation, etc.
Daping Hospital of Third Military Medical University; DaPing Hospital of Third Military Medical University, Livelihood project of Chongqing science and technology commission (CSTC2015-shmszx120089)
acute ischemic stroke
 
 
ChiCTR2000029556: Clinical safety and efficacy of low dose RT-PA combined with Tirofiban in the treatment of acute non-cardiac cerebral infarction with unknown onset time of DWI-Flair mismatch

Not yet recruiting
N/A
80
 
试验组 ;对照组
Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University; Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Self-Financing, Yantai Science and Technology Development Project, Hospital Project
Cerebrovascular disease
 
 
ChiCTR1800018167: Application of ERAS in cardiovascular surgery

Recruiting
N/A
750
 
early ambulation ;Respiratory exercise ;acupuncture ;Video visitation ;Leosimendan ;tirofiban ;esmolol ;Improved extracorporeal circulation perfusion
Shandong Provincial Hospital; Shandong Provincial Hospital, self-financing
cardiovascular diseases
 
 
NCT06260969: Endovascular Treatment of Acute Ischemic Stroke With Underlying Intracranial Artery Stenosis

Recruiting
N/A
470
RoW
balloon dilatation, endovascular stenting, aspiration catheter, stent retriever, Tirofiban, intracranial stenting, normal saline
Tianjin Huanhu Hospital
Large Vessel Occlusion, Intracranial Artery Occlusion With Cerebral Infarction, Endovascular Treatments, Acute Ischemic Stroke
09/25
09/25
ChiCTR2200058513: Clinical application of multimodal evaluation and individualized treatment in patients with acute cerebral infarction after ineffective intravenous thrombolysis or arterial thrombectomy

Not yet recruiting
N/A
200
 
Tirofiban was used after intravenous thrombolysis ;Routine treatment after intravenous thrombolysis
Kunshan First People's Hospital; Kunshan First People's Hospital, Grant, Suzhou Science and Technology Bureau Financial Grant
stroke
 
 
ChiCTR2100045661: One Pass Tirofiban In Management of Ischemic Stroke Thrombectomy In China

Recruiting
N/A
200
 
intravenous tirofiban plus MT therapy ;MT therapy with no antiplatelet drugs (intravenous or intra-arterial) are administered
East Hospital, Tongji University School of Medicine; East Hospital, Tongji University School of Medicine, Stroke and Dementia Special Committee of Shanghai Science & Technology Development Foundation
Acute Ischemic Stroke
 
 
ChiCTR2100046570: The study of clinical efficacy of platelet GPII b / III a receptor antagonist in the treatment of acute non-cardiac stroke which screened by imaging

Recruiting
N/A
80
 
intravenous infusion of tirofiban ;Standard antiplatelet therapy
Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University; Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Self-Financed, Yantai Science and Technology Development Project, Hospital Project
Cerebrovascular disease
 
 
ChiCTR2200055661: An ambispective study of the efficacy and safety of tirofiban and heparin in 30 days after coronary artery bypass grafting combined with coronary endarterectomy

Recruiting
N/A
390
 
;
Capital Medical University Affiliated Beijing Anzhen Hospital; Capital Medical University Affiliated Beijing Anzhen Hospital, The capital health research and development of special
coronary heart disease
 
 
ChiCTR1900024123: Effect of thrombolytic therapy on prognosis in acute stage of large artery occlusive cerebral infarction

Not yet recruiting
N/A
574
 
rtPA + tirofiban ;rtPA
The First Affiliated Hospital of Bengbu Medical College; Daping Hospital, Army Medical University, Bengbu Medical College Special Fund
Cardia-cerebrovascular Disease
 
 
TITACIPPI, NCT05733507: Tirofiban Plus Intravenous Thrombolysis in Acute Anterior Choroidal Infarction or Paramedian Pontine Infarction

Completed
N/A
48
Europe
IVT with tenecteplase or alteplase, Intervention Name : Tirofiban and IVT with tenecteplase or alteplase
Centre Hospitalier Sud Francilien
Acute Anterior Choroidal Infarction (ACI), Paramedian Pontine Infarction (IPP)
09/23
09/23
AIS ICAS-MT, NCT06702657: A Randomized Clinical Trial on Urgent Angioplasty for IntraCranial Atherosclerotic Stenosis-related Large-Vessel Occlusion After Mechanical Thrombectomy

Not yet recruiting
N/A
612
NA
balloon dilatation and/or stenting, medication
Changhai Hospital, The First People's Hospital of Changzhou
AIS, ICAS - Intracranial Atherosclerosis, Stroke
11/26
08/27
NCT06836531: POCT Detection for Blood Concentration of Tirofiban in Acute Myocardial Infarction Based on Azo-POP Probe.

Enrolling by invitation
N/A
100
RoW
First Affiliated Hospital of Ningbo University
Acute Myocardial Infarction (AMI)
07/25
07/25
NCT06966674: No-Reflow in Patients With STEMI After Intracoronary Tirofiban After Opening of the Track

Recruiting
N/A
60
RoW
Intracoronary tirofiban, Aggrastat, Saline 0.9%
Kafrelsheikh University
No-Reflow, STEMI, Intracoronary, Tirofiban
10/25
10/25
ANGEL-DRUG, NCT07026318: Endovascular Therapy Combined With Tirofiban for Intracranial Atherosclerotic Acute Ischemic Stroke

Not yet recruiting
N/A
716
RoW
Tirofiban, Placebo
Beijing Anzhen Hospital
Acute Ischemic Stroke
03/27
04/27
ChiCTR2200055697: Tirofiban versus heparin bridged with antiplatelet for the prevention of major cardiovascular and cerebrovascular events in patients undergoing coronary endarterectomy combined with coronary artery bypass grafting

Recruiting
N/A
726
 
heparin ;tirofiban
Capital Medical University Affiliated Beijing Anzhen Hospital; Capital Medical University Affiliated Beijing Anzhen Hospital, The capital health research and development of special
coronary heart disease
 
 
ChiCTR2400081394: The therapeutic effect of tirofiban on acute perforating artery infarct: a real-world study

Not yet recruiting
N/A
117
 
atiplatelet Agents was administrated orally; tirofiban was administrated intravenously
Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.; The First Medical Center, Chinese PLA General Hospital., No funding is required
stroke
 
 
TAIS, ChiCTR2000038771: Tirofiban for the Treatment of Acute Ischemic Stroke

Not yet recruiting
N/A
1000
 
Tirofiban
Xuanwu Hosptial, Capital Medical University; Xuanwu Hosptial, Capital Medical University, Beijing Municipal Science & Technology Commission; Ministry of Science and Technology, PRC.
Acute ischemic stroke
 
 
NCT06045156: Early Tirofiban Administration After Intravenous Thrombolysis in Acute Ischemic Stroke

Recruiting
N/A
1084
RoW
Tirofiban, Tirofiban simulant
The First Hospital of Jilin University
Acute Ischemic Stroke
01/26
12/26
TACT, ChiCTR2500099293: A randomized controlled study on the effect of thrombus aspiration combined with continuous intracoronary injection of tirofiban on IMR in STEMI patients with high thrombus burden

Not yet recruiting
N/A
60
 
Conventional thrombus aspiration, tirofiban intravenous loading dose in coronary artery and intravenous pump were used according to kg body weight for 24 hours, and 1/3 of the loading dose in coronary artery was added before stent implantation.; After conventional thrombus aspiration, stent implantation (pre expansion and post expansion if necessary) was performed. Tirofiban was given intravenous load according to kg body weight and maintained dose by intravenous pump 24 hours after operation
Zhoupu Hospital, Pudong New Area, Shanghai; Zhoupu Hospital, Pudong New Area, Shanghai, Shanghai Songjiang District Science and Technology Research Project
coronary heart disease
 
 
ChiCTR2400089572: Efficacy and safety of tirofiban after intravenous thrombolysis with tenecteplase in acute ischemic stroke: a multicenter randomized controlled trial

Not yet recruiting
N/A
310
 
Teneplase thrombolysis was followed by intravenous tirofiban antiplatelet therapy; Patients in this group received intravenous placebo
ganzhou people's hospital; ganzhou people's hospital, no funding
acute ischemic stroke
 
 
ChiCTR2400087048: Clinical study of tirofiban combined with oxiracetam in the treatment of acute progressive cerebral infarction

Not yet recruiting
N/A
114
 
conventional therapy; Conventional treatment combined with tirofiban and oxiracetam
Hebei Cangzhou Integrated Traditional Chinese and Western Medicine Hospital; Hebei Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Hebei Cangzhou Integrated Traditional Chinese and Western Medicine Hospital
Acute ischemic cerebrovascular disease
 
 
ChiCTR2400090049: Early tirofiban administration after intra-arterial thrombolysis in central retinal artery occlusion: Study protocol of a prospective, multicenter, placebo-controlled

Not yet recruiting
N/A
334
 
None; None
Xi’an No.1 Hospital; Xi’an No.1 Hospital, The Science and Technology Program of Xi’an City(2023YXYJ0005)
Center retinal artery occlusion
 
 
ChiCTR2300073104: Multicenter Clinical study of low-dose rt-PA combined with tirofiban in the treatment of non-cardiac ischemic stroke screened by MRI within 12 h of stroke onset

Recruiting
N/A
400
 
low-dose rt-PA (0.6 mg/kg) + tirofiban ;standard dose rt-PA (0.9 mg/kg)
Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University; Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Self-financing,Yantai Science and Technology Development Project,Hospital project
Cerebrovascular disease
 
 
CHANCE-4, ChiCTR2400086742: Tirofiban for patients with intraCranial artery stenosis and High-risk Acute Non-disabling Cerebrovascular Events

Not yet recruiting
N/A
4674
 
Tirofiban; 0.9% normal saline
Beijing Tiantan Hospital, Capital Medical University; Beijing Tiantan Hospital, Capital Medical University, Beijing Hospitals Authority
Mild ischemic stroke or transient ischemic attack with symptomatic intracranial artery stenosis
 
 
ChiCTR2500103163: Effect of aspiration thrombectomy combined with tirofiban on microvascular obstruction in STEMI patients: a prospective, randomised controlled cardiac magnetic resonance trail

Not yet recruiting
N/A
80
 
Aspiration thrombectomy; None
Changzhou Second People's Hospital; Changzhou Second People's Hospital, Self-selected project (self-raised)
Acute ST-segment elevation myocardial infarction
 
 
ChiCTR2500101820: A Clinical Study on the Interventional Clinical Efficacy of Shexiang Baoxin Pills in Patients with STEMI (Qi-Stagnation and Blood-Stasis Syndrome) After PCI.

Not yet recruiting
N/A
80
 
Preoperative medication:Aspirin: 300 mg for all patients;P2Y12 inhibitors: Patients <75 years: Clopidogrel 600 mg?or?Ticagrelor 180 mg or Patients ≥75 years: Clopidogrel 300 mg. Intraoperative medication:Heparin: Intravenous injection (100 IU/kg);High thrombus burden (thrombus score ≥3):Tirofiban: Initial bolus of 10 μg/kg, followed by continuous intravenous infusion at 0.15 μg/kg/min for 24 hours.Adjusted heparin dose: 50–70 IU/kg. Long-term postoperative medication:Aspirin: 75–100 mg once daily (lifelong). P2Y12 inhibitors:Patients <75 years: Clopidogrel 75 mg once daily?or?Ticagrelor 90 mg twice daily (for at least 1 year). Other medications: Administered according to established guidelines: ACE inhibitors (ACEI)?or?angiotensin receptor blockers (ARB) or ARNI;Beta-blockers;Statins.; Standard Western medical treatment + Shexiang Baoxin Pills;Shexiang Baoxin Pills administration:Pre-PCI: 90 mg sublingually before percutaneous coronary intervention (PCI).Post-PCI: 45 mg orally three times daily, taken with warm water, for 28 days.
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Self-funded
Acute ST-Elevation Myocardial Infarction
 
 
ChiCTR2400089090: Early combination treatment with tirofiban following intravenous thrombolysis in acute ischemic stroke: a multicenter, prospective, cohort study

Not yet recruiting
N/A
454
 
NA; NA
Second Affiliated Hospital of Army Medical University, PLA; Second Affiliated Hospital of Army Medical University, PLA, 2023 General Program of the National Natural Science Foundation of China (NSFC)
Ischemic stroke
 
 
ChiCTR2500101044: The efficacy and safety of early Tirofiban adjunctive to endovascular treatment in acute basilar artery occlusive stroke (BASILAR-2)

Not yet recruiting
N/A
378
 
Treated with tirofiban. Dosage of tirofiban: Arterial administration of tirofiban, intravenous continuation until 24 hours of onset. Antithrombotic drugs were administered according to guidelines after the 24th hour of onset and continued until 90 days after randomization.; Placebo treatment with tirofiban, the usage is the same as that of tirofiban. Antithrombotic drugs were administered according to guidelines after the 24th hour of onset and continued until 90 days after randomization.
The Second Affiliated Hospital of the Army Medical University; Xinqiao Hospital, Self-funded
Acute ischemic stroke
 
 

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