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17 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
bardoxolone methyl (RTA 402) / Kyowa Kirin, Biogen
2016-004365-16: An open-label study to learn if Bardoxolone Methyl is safe in the long-term in patients with pulmonary hypertension. Estudio abierto para comprobar si bardoxolona metilo es seguro a largo plazo en pacientes con hipertensión pulmonar

Ongoing
3
414
Europe
Bardoxolone Methyl, RTA 402, Capsule, hard
Reata Pharmaceuticals, Inc., Reata Pharmaceuticals, Inc.
Pulmonary Hypertension Hipertensión pulmonar, Raised blood pressure in the arteries that supply the lungs Aumento de la presión arterial en las arterias que suministran los pulmones, Diseases [C] - Cardiovascular Diseases [C14]
 
 
AYAME, NCT03550443: A Phase 3 Study of Bardoxolone Methyl in Patients With Diabetic Kidney Disease; Study

Terminated
3
1323
Japan
Bardoxolone methyl, RTA 402, Placebo
Kyowa Kirin Co., Ltd.
Diabetic Kidney Disease
11/22
07/23
EAGLE, NCT03749447 / 2018-003253-24: An Extended Access Program for Bardoxolone Methyl in Patients With CKD

Terminated
3
270
Europe, Japan, US, RoW
Bardoxolone methyl, RTA 402
Biogen, Reata Pharmaceuticals, Inc.
Chronic Kidney Diseases, Alport Syndrome, Autosomal Dominant Polycystic Kidney
08/23
08/23
FALCON, NCT03918447 / 2018-004651-20: A Trial of Bardoxolone Methyl in Patients With ADPKD -

Terminated
3
667
Europe, Japan, US, RoW
Bardoxolone methyl oral capsule, RTA 402, Placebo oral capsule
Biogen, Reata Pharmaceuticals, Inc., REATA PHARMACEUTICALS, INC
Autosomal Dominant Polycystic Kidney, ADPKD
08/23
08/23
Skyclarys (omaveloxolone) / Biogen
NCT06953583: A Study to Learn More About the Effects and Long-Term Safety of BIIB141 (Omaveloxolone) in Participants With Friedreich's Ataxia Aged 2 to 15 Years Old

Recruiting
3
255
Europe, Canada, US, RoW
Omaveloxolone, BIIB141, SKYCLARYS, RTA-408, Placebo
Biogen
Friedreich Ataxia
11/27
11/29
NCT02255435 / 2015-002762-23: RTA 408 Capsules in Patients With Friedreich's Ataxia - MOXIe

Active, not recruiting
2
172
Europe, US, RoW
Omaveloxolone Capsules, 2.5 mg, RTA 408 Capsules 2.5 mg, Omaveloxolone Capsules, 5 mg, RTA 408 capsules, 5 mg, Omaveloxolone Capsules, 10 mg, RTA 408 capsules, 10 mg, Placebo, Omaveloxolone Capsules, 20 mg, RTA 408 capsules, 20 mg, Omaveloxolone Capsules, 40 mg, RTA 408 capsules, 40 mg, Omaveloxolone Capsules, 80 mg, RTA 408 capsules, 80 mg, Omaveloxolone Capsules, 160 mg, RTA 408 capsules, 160 mg, Omaveloxolone Capsules, 300 mg, RTA 408 capsules, 300 mg, Omaveloxolone Capsules, 150 mg, RTA 408 capsules, 150 mg
Biogen, AbbVie, Friedreich's Ataxia Research Alliance
Friedreich Ataxia
10/19
06/25
NCT05909644: An Open-label DDI Study of Omaveloxolone in Healthy Subjects

Completed
1
20
US
Omaveloxolone, RTA 408, Efavirenz
Biogen, Celerion, Q2 Solutions, Altasciences Company Inc.
Healthy Adult Subjects
08/23
08/23
NCT05927649: A TQTc Study for Omaveloxolone

Completed
1
30
US
Omaveloxolone, RTA 408, Moxifloxacin
Biogen, Celerion, Q2 Solutions
Health Adult Subjects
09/23
09/23
NCT06054893: A Study to Find Out How BIIB141 (Omaveloxolone) is Processed in the Body and to Learn More About Its Safety in Participants With Friedreich's Ataxia Aged 2 to 15 Years Old

Recruiting
1
35
US
Omaveloxolone, RTA 408, SKYCLARYS, BIIB141
Biogen
Friedreich Ataxia
02/30
02/30
NCT06612879: A Study to Find Out How BIIB141 (Omaveloxolone) Moves From the Blood Into the Breastmilk of Healthy Women Who Are Breastfeeding or Pumping Milk

Completed
1
12
US
Omaveloxolone, BIIB141, SKYCLARYS
Biogen
Healthy Volunteer
03/25
04/25
NCT07019064: A Study to Learn How BIIB141 (Omaveloxolone) is Processed in the Body When Taken as Capsules Compared to Sprinkled on Yogurt in Healthy Adults Aged 18 to 55

Not yet recruiting
1
52
NA
Omaveloxolone, BIIB141
Biogen
Healthy Volunteer
09/25
09/25
NCT03593499: Expanded Access to Omaveloxolone for Melanoma for Patients Previously Enrolled in 408-C-1401

No Longer Available
N/A
NA
omaveloxolone, RTA 408
Biogen
Melanoma
 
 
NCT06623890: A Study to Learn More About the Long-Term Safety of BIIB141 (Omaveloxolone) in Participants With Friedreich's Ataxia Who Are Prescribed it by Their Own Doctors

Recruiting
N/A
300
Europe, US, RoW
Omaveloxolone, SKYCLARYS, BIIB141
Biogen
Friedreich Ataxia
10/29
10/29
NCT07013292: Efficacy of Omaveloxolone Treatment for Dysphagia in French Patients With Friedreich's Ataxia

Not yet recruiting
N/A
40
Europe
SKYCLARYS (omaveloxolone)
Centre Hospitalier Universitaire de Nice
Friedreich Ataxia
09/25
10/25
NCT06628687: A Study to Learn How BIIB141 (Omaveloxolone) Affects the Health of Participants With Friedrich's Ataxia Who Took it During Pregnancy and/or During Breastfeeding and About the Health of Their Babies

Recruiting
N/A
20
US
Omaveloxolone, SKYCLARYS, BIIB141, RTA 408
Biogen
Friedreich Ataxia
04/35
04/35
cemdomespib (RTA 901) / Biogen
CYPRESS, NCT06893094: A Phase 2 Study of RTA 901 (BIIB143) in Participants With Diabetic Peripheral Neuropathic Pain

Terminated
2
209
US
RTA 901, BIIB143, Cemdomespib, RTA 901-Matching Placebo
Reata, a wholly owned subsidiary of Biogen
Diabetic Peripheral Neuropathic Pain
11/24
11/24
CYPRESS, NCT05895552: A Phase 2 Study of RTA 901 (BIIB143) in Participants With Diabetic Peripheral Neuropathic Pain

Terminated
2
209
US
RTA 901, BIIB143, Cemdomespib, RTA 901-Matching Placebo
Biogen
Diabetic Peripheral Neuropathic Pain
11/24
11/24
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
bardoxolone methyl (RTA 402) / Kyowa Kirin, Biogen
2016-004365-16: An open-label study to learn if Bardoxolone Methyl is safe in the long-term in patients with pulmonary hypertension. Estudio abierto para comprobar si bardoxolona metilo es seguro a largo plazo en pacientes con hipertensión pulmonar

Ongoing
3
414
Europe
Bardoxolone Methyl, RTA 402, Capsule, hard
Reata Pharmaceuticals, Inc., Reata Pharmaceuticals, Inc.
Pulmonary Hypertension Hipertensión pulmonar, Raised blood pressure in the arteries that supply the lungs Aumento de la presión arterial en las arterias que suministran los pulmones, Diseases [C] - Cardiovascular Diseases [C14]
 
 
AYAME, NCT03550443: A Phase 3 Study of Bardoxolone Methyl in Patients With Diabetic Kidney Disease; Study

Terminated
3
1323
Japan
Bardoxolone methyl, RTA 402, Placebo
Kyowa Kirin Co., Ltd.
Diabetic Kidney Disease
11/22
07/23
EAGLE, NCT03749447 / 2018-003253-24: An Extended Access Program for Bardoxolone Methyl in Patients With CKD

Terminated
3
270
Europe, Japan, US, RoW
Bardoxolone methyl, RTA 402
Biogen, Reata Pharmaceuticals, Inc.
Chronic Kidney Diseases, Alport Syndrome, Autosomal Dominant Polycystic Kidney
08/23
08/23
FALCON, NCT03918447 / 2018-004651-20: A Trial of Bardoxolone Methyl in Patients With ADPKD -

Terminated
3
667
Europe, Japan, US, RoW
Bardoxolone methyl oral capsule, RTA 402, Placebo oral capsule
Biogen, Reata Pharmaceuticals, Inc., REATA PHARMACEUTICALS, INC
Autosomal Dominant Polycystic Kidney, ADPKD
08/23
08/23
Skyclarys (omaveloxolone) / Biogen
NCT06953583: A Study to Learn More About the Effects and Long-Term Safety of BIIB141 (Omaveloxolone) in Participants With Friedreich's Ataxia Aged 2 to 15 Years Old

Recruiting
3
255
Europe, Canada, US, RoW
Omaveloxolone, BIIB141, SKYCLARYS, RTA-408, Placebo
Biogen
Friedreich Ataxia
11/27
11/29
NCT02255435 / 2015-002762-23: RTA 408 Capsules in Patients With Friedreich's Ataxia - MOXIe

Active, not recruiting
2
172
Europe, US, RoW
Omaveloxolone Capsules, 2.5 mg, RTA 408 Capsules 2.5 mg, Omaveloxolone Capsules, 5 mg, RTA 408 capsules, 5 mg, Omaveloxolone Capsules, 10 mg, RTA 408 capsules, 10 mg, Placebo, Omaveloxolone Capsules, 20 mg, RTA 408 capsules, 20 mg, Omaveloxolone Capsules, 40 mg, RTA 408 capsules, 40 mg, Omaveloxolone Capsules, 80 mg, RTA 408 capsules, 80 mg, Omaveloxolone Capsules, 160 mg, RTA 408 capsules, 160 mg, Omaveloxolone Capsules, 300 mg, RTA 408 capsules, 300 mg, Omaveloxolone Capsules, 150 mg, RTA 408 capsules, 150 mg
Biogen, AbbVie, Friedreich's Ataxia Research Alliance
Friedreich Ataxia
10/19
06/25
NCT05909644: An Open-label DDI Study of Omaveloxolone in Healthy Subjects

Completed
1
20
US
Omaveloxolone, RTA 408, Efavirenz
Biogen, Celerion, Q2 Solutions, Altasciences Company Inc.
Healthy Adult Subjects
08/23
08/23
NCT05927649: A TQTc Study for Omaveloxolone

Completed
1
30
US
Omaveloxolone, RTA 408, Moxifloxacin
Biogen, Celerion, Q2 Solutions
Health Adult Subjects
09/23
09/23
NCT06054893: A Study to Find Out How BIIB141 (Omaveloxolone) is Processed in the Body and to Learn More About Its Safety in Participants With Friedreich's Ataxia Aged 2 to 15 Years Old

Recruiting
1
35
US
Omaveloxolone, RTA 408, SKYCLARYS, BIIB141
Biogen
Friedreich Ataxia
02/30
02/30
NCT06612879: A Study to Find Out How BIIB141 (Omaveloxolone) Moves From the Blood Into the Breastmilk of Healthy Women Who Are Breastfeeding or Pumping Milk

Completed
1
12
US
Omaveloxolone, BIIB141, SKYCLARYS
Biogen
Healthy Volunteer
03/25
04/25
NCT07019064: A Study to Learn How BIIB141 (Omaveloxolone) is Processed in the Body When Taken as Capsules Compared to Sprinkled on Yogurt in Healthy Adults Aged 18 to 55

Not yet recruiting
1
52
NA
Omaveloxolone, BIIB141
Biogen
Healthy Volunteer
09/25
09/25
NCT03593499: Expanded Access to Omaveloxolone for Melanoma for Patients Previously Enrolled in 408-C-1401

No Longer Available
N/A
NA
omaveloxolone, RTA 408
Biogen
Melanoma
 
 
NCT06623890: A Study to Learn More About the Long-Term Safety of BIIB141 (Omaveloxolone) in Participants With Friedreich's Ataxia Who Are Prescribed it by Their Own Doctors

Recruiting
N/A
300
Europe, US, RoW
Omaveloxolone, SKYCLARYS, BIIB141
Biogen
Friedreich Ataxia
10/29
10/29
NCT07013292: Efficacy of Omaveloxolone Treatment for Dysphagia in French Patients With Friedreich's Ataxia

Not yet recruiting
N/A
40
Europe
SKYCLARYS (omaveloxolone)
Centre Hospitalier Universitaire de Nice
Friedreich Ataxia
09/25
10/25
NCT06628687: A Study to Learn How BIIB141 (Omaveloxolone) Affects the Health of Participants With Friedrich's Ataxia Who Took it During Pregnancy and/or During Breastfeeding and About the Health of Their Babies

Recruiting
N/A
20
US
Omaveloxolone, SKYCLARYS, BIIB141, RTA 408
Biogen
Friedreich Ataxia
04/35
04/35
cemdomespib (RTA 901) / Biogen
CYPRESS, NCT06893094: A Phase 2 Study of RTA 901 (BIIB143) in Participants With Diabetic Peripheral Neuropathic Pain

Terminated
2
209
US
RTA 901, BIIB143, Cemdomespib, RTA 901-Matching Placebo
Reata, a wholly owned subsidiary of Biogen
Diabetic Peripheral Neuropathic Pain
11/24
11/24
CYPRESS, NCT05895552: A Phase 2 Study of RTA 901 (BIIB143) in Participants With Diabetic Peripheral Neuropathic Pain

Terminated
2
209
US
RTA 901, BIIB143, Cemdomespib, RTA 901-Matching Placebo
Biogen
Diabetic Peripheral Neuropathic Pain
11/24
11/24

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