Kafrelsheikh University Trials

Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

isotretinoin / Kafrelsheikh University

NCT04623385: Clinical Role of Testosterone and Dihydrotestosterone and Which of Them Should be Inhibited in COVID-19 Patients - A Double-edged Sword?

Not yet recruiting

1000

Aerosolized 13 cis retinoic acid plus Inhalation Inhaled testosterone, The standard therapy

Kafrelsheikh University

Covid19

12/20

12/21

NCT05002530: Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.

Not yet recruiting

10000

RoW

Aerosolized 13 cis retinoic acid plus Vitamin D, Aerosolized All trans retinoic acid plus Vitamin D, Standard therapy

Kafrelsheikh University, Ministry of Health, Saudi Arabia, Foshan University Laboratory of Emerging Infectious Disease Institute of Translational Medicine , Jilin University China, Montefiore Health System and Albert Einstein College of Medicine, Newyork, United States of America (USA), Faculty of Science, Kafrelsheikh University, Egypt.

Post COVID-19 Anosmia (Loss of Smell)

12/21

01/22

NCT04353180: Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized)

Not yet recruiting

100000

RoW

Drug Isotretinoin (13 cis retinoic acid ) capsules+standard treatment, 13 cis retinoic acid, Isotretinoin(Aerosolized 13 cis retinoic acid) +standard treatment, Aerosolized 13 cis retinoic acid, Isotretinoin (13 cis retinoic acid ) capsules, Standard treatment

Kafrelsheikh University, 1-Foshan University Laboratory of Emerging Infectious Disease Institute of Translational Medicine The First Hospital of Jilin University China, 2-Montefiore Health System and Albert Einstein College of Medicine, Newyork, United States of America (U.S.A)., 2-Faculty of Science, Kafrelsheikh University, Egypt.

COVID19

10/21

11/21

NCT04396067: Aerosol Combination Therapy of All-trans Retinoic Acid and Isotretinoin as A Novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients Better Than Vaccine : An Innovative Treatment

Not yet recruiting

360

Aerosolized 13 cis retinoic acid, Aerosolized All trans retinoic acid, Placebo

Kafrelsheikh University, Damietta University

COVID-19

10/20

12/20

Isotretinoin, NCT04577378: Efficacy and Safety of Drug Combination Therapy of and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19

Not yet recruiting

RoW

Drug: Isotretinoin(Aerosolized 13 cis retinoic acid) plus Aerosolized Itraconazole, Drug: Isotretinoin(Aerosolized 13 cis retinoic acid)

Kafrelsheikh University

Covid19

11/20

NCT04578236: Efficacy of Aerosol Combination Therapy of 13 Cis Retinoic Acid and Captopril for Treating Covid-19 Patients Via Indirect Inhibition of Transmembrane Protease, Serine 2 (TMPRSS2)

Not yet recruiting

360

Aerosolized 13 cis retinoic acid plus Inhalation administration by nebulization captopril 25mg, Drug: Standard treatment Standard treatment

Kafrelsheikh University

Covid19

12/20

01/21

NCT04389580: Combination Therapy With Isotretinoin and Tamoxifen Expected to Provide Complete Protection Against Severe Acute Respiratory Syndrome Coronavirus

Not yet recruiting

160

Drug: Isotretinoin plus Tamoxifen, Aerosolized Isotretinoin plus Tamoxifen

Kafrelsheikh University

COVID-19

10/21

12/21

NCT05077813: Utilizing the Crosstalk Among Chicoric Acid, 13-Cis Retinoic Acid(Aerosolized), Minocycline and Vitamin D as a Potent Quadrate Therapy for Treating Patients With Multidrug-resistant TB and Patient With Both Multidrug-resistant TB and COVID-19

Not yet recruiting

250

RoW

13 cis retinoic acid, Minocycline, Chicroic Acid and Vitamin D for (MDR-TB), 9 cis retinoic acid, Minocycline, Chicroic Acid and Vitamin D for (MDR-TB), All trans retinoic acid , Minocycline,Chicroic Acid and Vitamin D for (MDR-TB), All trans retinoic acid, Minocycline, Chicroic Acid and Vitamin D For (COVID-19 and MDR-TB), 13 cis retinoic acid, Minocycline, Chicroic Acid and Vitamin D For (COVID-19 and MDR-TB), The standard therapy

Kafrelsheikh University, Ministry of Health, Saudi Arabia

Tuberculosis

02/22

Isotretinoin, NCT04730895: Investigating the Role of 13cis Retinoic Acid in the Treatment of COVID-19 and Enhancement of Its Spike Protein Based Vaccine Efficacy and Safety.

Not yet recruiting

1/2

360

Oral 13 cis retinoic acid, Aerosolized 13 cis retinoic acid, 13 cis retinoic acid doses orally in combination with spike protein based vaccine, Aerosolized 13 cis retinoic acid in combination with spike protein based vaccine, Biological: spike protein based vaccine such as ChAdOx1 nCoV-19 vaccine

Kafrelsheikh University

Covid19 Vaccine

09/21

12/23

NCT04382950: Combination of Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP and Isotretinoin Could be Promising Treatment for COVID-19 Infection- and Its Inflammatory Complications

Not yet recruiting

Recombinant Bacterial ACE2 receptors -like enzyme of B38-CAP (rbACE2) plus Aerosolized 13 cis retinoic acid

Kafrelsheikh University

COVID

08/21

10/21

B38-CAP / Kafrelsheikh University

Bacterial ACE2, NCT04375046: Recombinant Receptors -Like Enzyme of B38-CAP Could be Promising Treatment for COVID-19 Infection- and Its Inflammatory Complications Better Than Recombinant Human ACE2

Not yet recruiting

Recombinant Bacterial ACE2 receptors -like enzyme of B38-CAP (rbACE2)

Kafrelsheikh University, Foshan University Laboratory of Emerging Infectious Disease Institute of Translational Medicine The First Hospital of Jilin University China

COVID-19

08/21

10/21

Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

isotretinoin / Kafrelsheikh University

NCT04623385: Clinical Role of Testosterone and Dihydrotestosterone and Which of Them Should be Inhibited in COVID-19 Patients - A Double-edged Sword?

Not yet recruiting

1000

Aerosolized 13 cis retinoic acid plus Inhalation Inhaled testosterone, The standard therapy

Kafrelsheikh University

Covid19

12/20

12/21

Not yet recruiting

10000

RoW

Aerosolized 13 cis retinoic acid plus Vitamin D, Aerosolized All trans retinoic acid plus Vitamin D, Standard therapy

Post COVID-19 Anosmia (Loss of Smell)

12/21

01/22

NCT04353180: Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized)

Not yet recruiting

100000

RoW

COVID19

10/21

11/21

Not yet recruiting

360

Aerosolized 13 cis retinoic acid, Aerosolized All trans retinoic acid, Placebo

Kafrelsheikh University, Damietta University

COVID-19

10/20

12/20

Isotretinoin, NCT04577378: Efficacy and Safety of Drug Combination Therapy of and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19

Not yet recruiting

RoW

Drug: Isotretinoin(Aerosolized 13 cis retinoic acid) plus Aerosolized Itraconazole, Drug: Isotretinoin(Aerosolized 13 cis retinoic acid)

Kafrelsheikh University

Covid19

11/20

NCT04578236: Efficacy of Aerosol Combination Therapy of 13 Cis Retinoic Acid and Captopril for Treating Covid-19 Patients Via Indirect Inhibition of Transmembrane Protease, Serine 2 (TMPRSS2)

Not yet recruiting

360

Aerosolized 13 cis retinoic acid plus Inhalation administration by nebulization captopril 25mg, Drug: Standard treatment Standard treatment

Kafrelsheikh University

Covid19

12/20

01/21

NCT04389580: Combination Therapy With Isotretinoin and Tamoxifen Expected to Provide Complete Protection Against Severe Acute Respiratory Syndrome Coronavirus

Not yet recruiting

160

Drug: Isotretinoin plus Tamoxifen, Aerosolized Isotretinoin plus Tamoxifen

Kafrelsheikh University

COVID-19

10/21

12/21

Not yet recruiting

250

RoW

Kafrelsheikh University, Ministry of Health, Saudi Arabia

Tuberculosis

02/22

Isotretinoin, NCT04730895: Investigating the Role of 13cis Retinoic Acid in the Treatment of COVID-19 and Enhancement of Its Spike Protein Based Vaccine Efficacy and Safety.

Not yet recruiting

1/2

360

Kafrelsheikh University

Covid19 Vaccine

09/21

12/23

NCT04382950: Combination of Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP and Isotretinoin Could be Promising Treatment for COVID-19 Infection- and Its Inflammatory Complications

Not yet recruiting

Recombinant Bacterial ACE2 receptors -like enzyme of B38-CAP (rbACE2) plus Aerosolized 13 cis retinoic acid

Kafrelsheikh University

COVID

08/21

10/21

B38-CAP / Kafrelsheikh University

Bacterial ACE2, NCT04375046: Recombinant Receptors -Like Enzyme of B38-CAP Could be Promising Treatment for COVID-19 Infection- and Its Inflammatory Complications Better Than Recombinant Human ACE2

Not yet recruiting

Recombinant Bacterial ACE2 receptors -like enzyme of B38-CAP (rbACE2)

Kafrelsheikh University, Foshan University Laboratory of Emerging Infectious Disease Institute of Translational Medicine The First Hospital of Jilin University China

COVID-19

08/21

10/21



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