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29 Trials

   

Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Penthrox (methoxyflurane) / Medical Developments International
ACTRN12606000073505: Methoxyflurane for cancer patients with incident pain receiving radiotherapy

Not yet recruiting
4
50
 
Peter MacCallum Cancer Centre, Peter MacCallum Cancer Centre
Incident or movement related pain during transportation to and delivery of radiation therapy
 
 
ACTRN12620000216910: Methoxyflurane pain relief for awake hysteroscopy.

Not yet recruiting
4
120
 
Waikato DHB, Douglas Pharmaceuticals
abnormal uterine bleeding, pain relief
 
 
ACTRN12620000216910p: Methoxyflurane pain relief for awake hysteroscopy.

Not yet recruiting
4
120
 
Waikato DHB, Douglas Pharmaceuticals
abnormal uterine bleeding; pain relief
 
 
ACTRN12621000941864: Methoxyflurane versus Nitrous Oxide: Which provides better pain relief in patients undergoing Trans-Vaginal Oocyte Retrieval (TVOR) with conscious sedation?

Recruiting
4
86
 
Dr Aine McNally Bogue, The Fertility Centre Liverpool
Trans vaginal oocyte retrieval
 
 
ACTRN12623000936628: Self-administered inhaled methoxyflurane (Penthrox®) as pre-injection analgesia in Podiatry Outpatients: A blinded, randomised study.

Recruiting
4
40
 
Claire Huxtable, Flinders Foundation, The Hospital Research Foundation Group
pain
 
 
2017-004469-28: Study assessing the efficacy and safety of Penthrox® combined with a standard analgesia in comparison to a placebo combined with a standard analgesia in adult patients admitted to the Emergency Department with moderate to severe pain associated with trauma Etude évaluant l'efficacité et la tolérance de Penthrox® associé à une analgésie standard en comparaison au placebo associé à une analgésie standard chez des patients adultes admis en service d'urgence avec des douleurs modérées à sévères associées à un traumatisme

Not yet recruiting
4
360
Europe
Inhalation vapour, liquid, PENTHROX 3 ml liquide avec inhalateur (METHOXYFLURANE)
MUNDIPHARMA, MUNDIPHARMA
Emergency relief of moderate to severe pain associated with trauma in conscious adult patients Soulagement d’urgence des douleurs modérées à sévères associées à un traumatisme chez des patients adultes conscients., Emergency relief of moderate to severe pain associated with trauma Soulagement d’urgence des douleurs modérées à sévères associées à un traumatisme, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
2018-003939-30: Determination of equal analgesic doses between inhaled metoxyflurane and intravenous fentanyl using ice-water test in volunteers.

Not yet recruiting
4
12
Europe
Inhalation vapour, liquid, Concentrate and solvent for solution for injection, Penthrox 3 ml®, Fentanyl
Oslo University Hospital, Oslo University Hospital
Experimental pain model (cold pressor test – CPT) will be used to determinate equipotent doses of inhaled metoxyflurane vs. intravenous fentanyl., The aim of this study is to determinate equipotent doses of inhaled metoxyflurane vs. intravenous fentanyl., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
2020-005865-14: Pain relief of methoxyflurane in patients with burns

Not yet recruiting
4
30
Europe
Penthrox
Rigshospitalet, Rigshospitalet
Pain after burns, Burns, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
NCT04287803: Prehospital Analgesia in Adults Using Inhaled Methoxyflurane : A Feasibility Study

Completed
4
97
Canada
Methoxyflurane, Penthrox, Penthrane
Ottawa Hospital Research Institute, University of Ottawa
Pain, Acute, Trauma
11/21
11/21
2019-004144-29: Comparing two analgesics, methoxyflurane and fentanyl, in an experimental model of hypovolemia in healthy volunteers

Not yet recruiting
4
15
Europe
Penthrox 99,9%, 3 ml væske til inhalasjonsdamp, Inhalation vapour, liquid, Solution for injection, Penthrox 99,9%, 3 ml væske til inhalasjonsdamp, Fentanyl Hameln 50 mikrog/ml injeksjonsvæske, oppløsning
Oslo University Hospital, Oslo University Hospital
The study will investigate and compare the responses to experimental hypovolemia of methoxyflurane, fentanyl and placebo (NaCl) using the "lower body negative pressure" (LBNP)-model ., The aim of the study is to compare the effects of two different analgesics (methoxyflurane and fentanyl) and placebo to experimental hypovolemia., Body processes [G] - Physiological processes [G07]
 
 
NCT05766397: Prehospital Inhaled Methoxyflurane Non-Clinical Occupational Exposure Study

Enrolling by invitation
4
30
Canada
Methoxyflurane
Ottawa Hospital Research Institute, Mayday Fund
Occupational Exposure
07/24
09/24
2022-002944-40: Prospective monocentric randomized study: use of Methoxyflurane via a mouth-nose mask versus inhaler in the management of pain following limb trauma

Not yet recruiting
4
60
Europe
Inhalation vapour, liquid, PENTHROX 99,9%
CHU Brugmann, CHU Brugmann
Acute limb trauma, Acute limb trauma, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
METHANE, NCT04442919: Influence of METHoxyflurane on ANtiplatelet Effect of Ticagrelor in Patients With Unstable Angina Pectoris

Completed
4
72
Europe
Ticagrelor followed with Methoxyflurane, Brilique + Penthrox, Ticagrelor followed with Morphine, Brilique + Morphine, Ticagrelor alone, Brilique
Collegium Medicum w Bydgoszczy
Unstable Angina
01/24
02/24
NCT06392087: Prehospital Analgesia in Adults Using Inhaled Methoxyflurane Study

Not yet recruiting
4
1800
NA
Methoxyflurane, Penthrox, Standard Care
Ottawa Hospital Research Institute
Pain, Acute
03/25
12/25
NCT05821517: METHOXYFLURANE or Virtual Reality Headset vs Standard Analgesic Management for the Reduction of Anterior Shoulder Dislocation (HYPNOLUX)

Recruiting
4
150
Europe
Helmet virtual reality., Administration of METHOXYFLURANE, Standard of care
Centre Hospitalier Universitaire de Nice
Anterior Shoulder Dislocation
11/24
02/25
ACTRN12624001117505: Penthrox vs nitrous oxide for painful emergency medicine procedures

Not yet recruiting
3
198
 
Eastern Health, Eastern Health Foundation
Painful emergency medicine procedures
 
 
ACTRN12613000709741: Patient-controlled analgesia with methoxyflurane (Penthrox inhaler) versus conventional endoscopist-provided sedation for colonoscopy: a randomized multi-centre trial

Recruiting
3
300
 
Dr. Nam Q Nguyen, Department of Gastroenterology & Hepatology, Royal Adelaide Hospital, Medical Developments International Ltd
Alternative Pain relief in patients undergoing colonoscopy
 
 
ACTRN12623001127695: PROMPT: PROcedural sedation vs Methoxyflurane a Prospective cohorT Study.

Recruiting
3
150
 
South Western Sydney Local Health District Human Research Ethics Committee, Ross Copping, Paul Balamon, Jules Catt, Liverpool Hospital (Interventional Radiology Deparment).
Interventional Radiology procedural analgesia
 
 
ACTRN12623001167651: MONITOR - MethOxyfluraNe in InTerventiOnal Radiology

Recruiting
3
400
 
South Western Sydney Local Health District Human Research Ethics Committee, Ross Copping, Paul Balamon, Interventional Radiology Deparment, Liverpool Hospital, Medical Developments International (MDI)
Deep tissue core biopsy, Insertion or removal of portacaths.
 
 
2017-004601-40: Methoxyflurane efficacy and safety in hostile environment Efficacia e sicurezza del metossiflurano vaporizzato somministrato a pazienti soccorsi mediante elisoccorso in ambienti non raggiungibili da altri mezzi di soccorso

Not yet recruiting
3
200
Europe
metossiflurano vaporizzato, [metossiflurano vaporizzato], Nebuliser solution, Penthrox®
MUNDIPHARMA RESEARCH LIMITED, Mundipharma Pharmaceutical s.r.l.
moderate to severe pain secondary to minor trauma dolore da moderato a severo secondario a trauma minore, traumatic pain dolore in seguito a trauma, Diseases [C] - Musculoskeletal Diseases [C05]
 
 
MAGPIE, NCT03215056 / 2016-004290-41: Methoxyflurane Analgesia for Paediatric Injuries

Completed
3
192
Europe
Methoxyflurane, Penthrox®, Normal saline
Medical Developments International Limited, Pediatric Emergency Research in the UK and Ireland (PERUKI), Quintiles, Inc.
Pain, Acute
06/22
06/22
PreMeFen, NCT05137184 / 2021-000549-42: A Comparison of Three Regimens of Acute Pain Management: Methoxyflurane; Intranasal Fentanyl; Intravenous Morphine

Completed
3
338
Europe
Methoxyflurane, Fentanyl, Morphine hydrochloride
Oslo University Hospital, Sykehuset Innlandet HF, Norwegian Air Ambulance Foundation, University of Oslo
Acute Pain, Ambulances
04/23
04/23
ANEMON, NCT04476173: ANalgesic Efficacy and Safety of MOrphiNe Versus Methoxyflurane in Patients With Acute Myocardial Infarction

Recruiting
3
200
Europe
Methoxyflurane - Penthrox, Morphine
Collegium Medicum w Bydgoszczy
ST Elevation Myocardial Infarction, Non ST Segment Elevation Acute Coronary Syndrome
06/24
12/24
METODO, NCT06495372: Study of the Use of Methoxyflurane Vs Placebo in the Management of Pain in Oral and Dental Emergencies in Adults: (METhoxyflurane in ODOntology)

Recruiting
3
192
Europe
Experimenta group (standard of care + Methoxyflurane)., control group (standard of care + placebo).
University Hospital, Brest
Dental Pain and Sensation Disorder
10/26
10/26
NCT07017452: Trial to Assess the Efficacy and Safety During Convective Radiofrequency Water Vapor Thermal Therapy (REZUM) for Benign Prostate Hyperplasia

Not yet recruiting
3
48
Canada
Methoxyflurane - Penthrox, Control, Percocet Pill, Lorazepam (drug)
University of Manitoba
Benign Prostate Hypertrophy(BPH)
12/25
06/26
NCT06750302: Effectiveness of Penthrox vs Placebo in Sinus Procedures, a Clinical Trial

Recruiting
1/2
100
Canada
Methoxyflurane - Penthrox, Placebo
St. Paul's Hospital, Canada
Chronic Rhinosinusitis (CRS)
04/26
06/26
PenthroxOTL, NCT07003880: Penthrox in Otolaryngology

Not yet recruiting
N/A
50
NA
Methoxyflurane anesthesia
Sir Mortimer B. Davis - Jewish General Hospital
All Adult Patients Undergoing an Otolaryngology Procedure With Inhaled Methoxyflurane as an Adjunct to Topical or Local Anesthesia
05/27
06/27
NCT06899724: Methoxyflurane for Analgesia During Hysteroscopy

Not yet recruiting
N/A
54
Canada
Anesthetics, Inhalation, Methoxyflurane, Intravenous Sedatives with or Without Analgesia
Dr. John A. Thiel Medical Professional Corporation
Analgesia
12/25
01/26
NCT07046572: Methoxyflurane for IUD Insertion and Endometrial Biopsy

Recruiting
N/A
174
Canada
Methoxyflurane - Penthrox, Placebo Penthrox inhaler
Mount Sinai Hospital, Canada, Matthew Morton Research Award
Endometrial Biopsy, Intrauterine Devices
12/25
03/26
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Penthrox (methoxyflurane) / Medical Developments International
ACTRN12606000073505: Methoxyflurane for cancer patients with incident pain receiving radiotherapy

Not yet recruiting
4
50
 
Peter MacCallum Cancer Centre, Peter MacCallum Cancer Centre
Incident or movement related pain during transportation to and delivery of radiation therapy
 
 
ACTRN12620000216910: Methoxyflurane pain relief for awake hysteroscopy.

Not yet recruiting
4
120
 
Waikato DHB, Douglas Pharmaceuticals
abnormal uterine bleeding, pain relief
 
 
ACTRN12620000216910p: Methoxyflurane pain relief for awake hysteroscopy.

Not yet recruiting
4
120
 
Waikato DHB, Douglas Pharmaceuticals
abnormal uterine bleeding; pain relief
 
 
ACTRN12621000941864: Methoxyflurane versus Nitrous Oxide: Which provides better pain relief in patients undergoing Trans-Vaginal Oocyte Retrieval (TVOR) with conscious sedation?

Recruiting
4
86
 
Dr Aine McNally Bogue, The Fertility Centre Liverpool
Trans vaginal oocyte retrieval
 
 
ACTRN12623000936628: Self-administered inhaled methoxyflurane (Penthrox®) as pre-injection analgesia in Podiatry Outpatients: A blinded, randomised study.

Recruiting
4
40
 
Claire Huxtable, Flinders Foundation, The Hospital Research Foundation Group
pain
 
 
2017-004469-28: Study assessing the efficacy and safety of Penthrox® combined with a standard analgesia in comparison to a placebo combined with a standard analgesia in adult patients admitted to the Emergency Department with moderate to severe pain associated with trauma Etude évaluant l'efficacité et la tolérance de Penthrox® associé à une analgésie standard en comparaison au placebo associé à une analgésie standard chez des patients adultes admis en service d'urgence avec des douleurs modérées à sévères associées à un traumatisme

Not yet recruiting
4
360
Europe
Inhalation vapour, liquid, PENTHROX 3 ml liquide avec inhalateur (METHOXYFLURANE)
MUNDIPHARMA, MUNDIPHARMA
Emergency relief of moderate to severe pain associated with trauma in conscious adult patients Soulagement d’urgence des douleurs modérées à sévères associées à un traumatisme chez des patients adultes conscients., Emergency relief of moderate to severe pain associated with trauma Soulagement d’urgence des douleurs modérées à sévères associées à un traumatisme, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
2018-003939-30: Determination of equal analgesic doses between inhaled metoxyflurane and intravenous fentanyl using ice-water test in volunteers.

Not yet recruiting
4
12
Europe
Inhalation vapour, liquid, Concentrate and solvent for solution for injection, Penthrox 3 ml®, Fentanyl
Oslo University Hospital, Oslo University Hospital
Experimental pain model (cold pressor test – CPT) will be used to determinate equipotent doses of inhaled metoxyflurane vs. intravenous fentanyl., The aim of this study is to determinate equipotent doses of inhaled metoxyflurane vs. intravenous fentanyl., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
2020-005865-14: Pain relief of methoxyflurane in patients with burns

Not yet recruiting
4
30
Europe
Penthrox
Rigshospitalet, Rigshospitalet
Pain after burns, Burns, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
NCT04287803: Prehospital Analgesia in Adults Using Inhaled Methoxyflurane : A Feasibility Study

Completed
4
97
Canada
Methoxyflurane, Penthrox, Penthrane
Ottawa Hospital Research Institute, University of Ottawa
Pain, Acute, Trauma
11/21
11/21
2019-004144-29: Comparing two analgesics, methoxyflurane and fentanyl, in an experimental model of hypovolemia in healthy volunteers

Not yet recruiting
4
15
Europe
Penthrox 99,9%, 3 ml væske til inhalasjonsdamp, Inhalation vapour, liquid, Solution for injection, Penthrox 99,9%, 3 ml væske til inhalasjonsdamp, Fentanyl Hameln 50 mikrog/ml injeksjonsvæske, oppløsning
Oslo University Hospital, Oslo University Hospital
The study will investigate and compare the responses to experimental hypovolemia of methoxyflurane, fentanyl and placebo (NaCl) using the "lower body negative pressure" (LBNP)-model ., The aim of the study is to compare the effects of two different analgesics (methoxyflurane and fentanyl) and placebo to experimental hypovolemia., Body processes [G] - Physiological processes [G07]
 
 
NCT05766397: Prehospital Inhaled Methoxyflurane Non-Clinical Occupational Exposure Study

Enrolling by invitation
4
30
Canada
Methoxyflurane
Ottawa Hospital Research Institute, Mayday Fund
Occupational Exposure
07/24
09/24
2022-002944-40: Prospective monocentric randomized study: use of Methoxyflurane via a mouth-nose mask versus inhaler in the management of pain following limb trauma

Not yet recruiting
4
60
Europe
Inhalation vapour, liquid, PENTHROX 99,9%
CHU Brugmann, CHU Brugmann
Acute limb trauma, Acute limb trauma, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
METHANE, NCT04442919: Influence of METHoxyflurane on ANtiplatelet Effect of Ticagrelor in Patients With Unstable Angina Pectoris

Completed
4
72
Europe
Ticagrelor followed with Methoxyflurane, Brilique + Penthrox, Ticagrelor followed with Morphine, Brilique + Morphine, Ticagrelor alone, Brilique
Collegium Medicum w Bydgoszczy
Unstable Angina
01/24
02/24
NCT06392087: Prehospital Analgesia in Adults Using Inhaled Methoxyflurane Study

Not yet recruiting
4
1800
NA
Methoxyflurane, Penthrox, Standard Care
Ottawa Hospital Research Institute
Pain, Acute
03/25
12/25
NCT05821517: METHOXYFLURANE or Virtual Reality Headset vs Standard Analgesic Management for the Reduction of Anterior Shoulder Dislocation (HYPNOLUX)

Recruiting
4
150
Europe
Helmet virtual reality., Administration of METHOXYFLURANE, Standard of care
Centre Hospitalier Universitaire de Nice
Anterior Shoulder Dislocation
11/24
02/25
ACTRN12624001117505: Penthrox vs nitrous oxide for painful emergency medicine procedures

Not yet recruiting
3
198
 
Eastern Health, Eastern Health Foundation
Painful emergency medicine procedures
 
 
ACTRN12613000709741: Patient-controlled analgesia with methoxyflurane (Penthrox inhaler) versus conventional endoscopist-provided sedation for colonoscopy: a randomized multi-centre trial

Recruiting
3
300
 
Dr. Nam Q Nguyen, Department of Gastroenterology & Hepatology, Royal Adelaide Hospital, Medical Developments International Ltd
Alternative Pain relief in patients undergoing colonoscopy
 
 
ACTRN12623001127695: PROMPT: PROcedural sedation vs Methoxyflurane a Prospective cohorT Study.

Recruiting
3
150
 
South Western Sydney Local Health District Human Research Ethics Committee, Ross Copping, Paul Balamon, Jules Catt, Liverpool Hospital (Interventional Radiology Deparment).
Interventional Radiology procedural analgesia
 
 
ACTRN12623001167651: MONITOR - MethOxyfluraNe in InTerventiOnal Radiology

Recruiting
3
400
 
South Western Sydney Local Health District Human Research Ethics Committee, Ross Copping, Paul Balamon, Interventional Radiology Deparment, Liverpool Hospital, Medical Developments International (MDI)
Deep tissue core biopsy, Insertion or removal of portacaths.
 
 
2017-004601-40: Methoxyflurane efficacy and safety in hostile environment Efficacia e sicurezza del metossiflurano vaporizzato somministrato a pazienti soccorsi mediante elisoccorso in ambienti non raggiungibili da altri mezzi di soccorso

Not yet recruiting
3
200
Europe
metossiflurano vaporizzato, [metossiflurano vaporizzato], Nebuliser solution, Penthrox®
MUNDIPHARMA RESEARCH LIMITED, Mundipharma Pharmaceutical s.r.l.
moderate to severe pain secondary to minor trauma dolore da moderato a severo secondario a trauma minore, traumatic pain dolore in seguito a trauma, Diseases [C] - Musculoskeletal Diseases [C05]
 
 
MAGPIE, NCT03215056 / 2016-004290-41: Methoxyflurane Analgesia for Paediatric Injuries

Completed
3
192
Europe
Methoxyflurane, Penthrox®, Normal saline
Medical Developments International Limited, Pediatric Emergency Research in the UK and Ireland (PERUKI), Quintiles, Inc.
Pain, Acute
06/22
06/22
PreMeFen, NCT05137184 / 2021-000549-42: A Comparison of Three Regimens of Acute Pain Management: Methoxyflurane; Intranasal Fentanyl; Intravenous Morphine

Completed
3
338
Europe
Methoxyflurane, Fentanyl, Morphine hydrochloride
Oslo University Hospital, Sykehuset Innlandet HF, Norwegian Air Ambulance Foundation, University of Oslo
Acute Pain, Ambulances
04/23
04/23
ANEMON, NCT04476173: ANalgesic Efficacy and Safety of MOrphiNe Versus Methoxyflurane in Patients With Acute Myocardial Infarction

Recruiting
3
200
Europe
Methoxyflurane - Penthrox, Morphine
Collegium Medicum w Bydgoszczy
ST Elevation Myocardial Infarction, Non ST Segment Elevation Acute Coronary Syndrome
06/24
12/24
METODO, NCT06495372: Study of the Use of Methoxyflurane Vs Placebo in the Management of Pain in Oral and Dental Emergencies in Adults: (METhoxyflurane in ODOntology)

Recruiting
3
192
Europe
Experimenta group (standard of care + Methoxyflurane)., control group (standard of care + placebo).
University Hospital, Brest
Dental Pain and Sensation Disorder
10/26
10/26
NCT07017452: Trial to Assess the Efficacy and Safety During Convective Radiofrequency Water Vapor Thermal Therapy (REZUM) for Benign Prostate Hyperplasia

Not yet recruiting
3
48
Canada
Methoxyflurane - Penthrox, Control, Percocet Pill, Lorazepam (drug)
University of Manitoba
Benign Prostate Hypertrophy(BPH)
12/25
06/26
NCT06750302: Effectiveness of Penthrox vs Placebo in Sinus Procedures, a Clinical Trial

Recruiting
1/2
100
Canada
Methoxyflurane - Penthrox, Placebo
St. Paul's Hospital, Canada
Chronic Rhinosinusitis (CRS)
04/26
06/26
PenthroxOTL, NCT07003880: Penthrox in Otolaryngology

Not yet recruiting
N/A
50
NA
Methoxyflurane anesthesia
Sir Mortimer B. Davis - Jewish General Hospital
All Adult Patients Undergoing an Otolaryngology Procedure With Inhaled Methoxyflurane as an Adjunct to Topical or Local Anesthesia
05/27
06/27
NCT06899724: Methoxyflurane for Analgesia During Hysteroscopy

Not yet recruiting
N/A
54
Canada
Anesthetics, Inhalation, Methoxyflurane, Intravenous Sedatives with or Without Analgesia
Dr. John A. Thiel Medical Professional Corporation
Analgesia
12/25
01/26
NCT07046572: Methoxyflurane for IUD Insertion and Endometrial Biopsy

Recruiting
N/A
174
Canada
Methoxyflurane - Penthrox, Placebo Penthrox inhaler
Mount Sinai Hospital, Canada, Matthew Morton Research Award
Endometrial Biopsy, Intrauterine Devices
12/25
03/26

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