| dorocubicel (UM171 cell therapy) / ExCellThera |
| Active, not recruiting | 2 | 30 | Europe, US | ECT-001-CB (UM171-Expanded Cord Blood Transplant) | ExCellThera inc., Fred Hutchinson Cancer Center | High Risk Hematological Malignancy, Cord Blood Transplant | 02/26 | 02/26 | | |
NCT03913026: UM171 Expanded Cord Blood In Patients With High-Risk Acute Leukemia/Myelodysplasia |
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| Active, not recruiting | 2 | 30 | Canada | Transplant with an expanded ECT-001 cord blood | Ciusss de L'Est de l'Île de Montréal, Stem Cell Network, ExCellThera inc. | High Risk Hematologic Malignancy, Cord Blood Transplant | 10/24 | 10/27 | | |
2024-000261-24: A Phase I/II Open-Label Study of ECT-001-Expanded Cord Blood Transplantation in pediatric and young adult (<21year) Patients with High-Risk and Very High-Risk Myeloid Malignancies (ECT-001-CB.007) |
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| Not yet recruiting | 2 | 15 | US | ECT-001-CB, Dispersion for infusion | Cordex Biolohics Inc, Cordex Biologics Inc | High-Risk and Very High-Risk Paediatric Myeloid Malignancies, Acute Myeloid Leukaemia, Diseases [C] - Blood and lymphatic diseases [C15] | | | | |
NCT03441958: ECT-001 (UM171) Expanded Cord Blood Transplant to Treat High-risk Multiple Myeloma |
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| Active, not recruiting | 1/2 | 20 | Canada | ECT-001 (UM171) expanded cord blood | Ciusss de L'Est de l'Île de Montréal, ExCellThera inc., Centre C3i | Multiple Myeloma | 10/23 | 10/25 | | |
NCT04990323: US Study of ECT-001-CB in Pediatric and Young Adult Patients With High-Risk Myeloid Malignancies |
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| Recruiting | 1/2 | 12 | US | ECT-001-CB (UM171-Expanded Cord Blood Transplant), Conditioning Regimen (Preferred): clofarabine:30 mg/m2/day IV x 4 days, fludarabine:10 mg/m2/day IV x 4 days, busulfan: daily for 4 days with cumm Bu target = 90mg h/L, Conditioning Regimen (Alternative): MIDI: fludarabine: 30 mg/m2/day IV x 5 days, cyclophosphamide: 50 mg/kg IV , thiotepa: 5 mg/kg/day IV x 2 days , TBI: 400 cGy, GVHD Prophylaxis: Tacrolimus/MMF | ExCellThera inc., Memorial Sloan Kettering Cancer Center | High Risk Myeloid Malignancies, Cord Blood Transplant | 06/26 | 06/26 | | |
