| Niagen (nicotinamide riboside) / ChromaDex |
ACTRN12622000340730: Testing the ability of oral nicotinamide riboside to replenish heart tissue levels of oxidized nicotinamide adenine dinucleotide using heart biopsies taken at the time of surgery. |
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| Not yet recruiting | 4 | 40 | | | Sydney Local Health District, NSW Government , The Heart Foundation | Heart failure with preserved ejection fraction (HFpEF) | | | | |
ACTRN12622000372785: Replenishing a vital molecule in stiff heart failure patients and examining effect on heart stiffness, blood pressure, and exercise tolerance |
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| Not yet recruiting | 4 | 400 | | | Sydney Local Health District, NSW Government , Heart Foundation | Heart failure with preserved ejection fraction (HFpEF) | | | | |
NCT04809974: Clinical Trial of Niagen to Examine Recovery in People With Persistent Cognitive and Physical Symptoms After COVID-19 Illness (Long-COVID) |
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| Completed | 4 | 70 | US | Niagen, Nicotinamide Riboside, TruNiagen, Vitamin B3 | Massachusetts General Hospital | Covid19, Sequelae of; Infection, Cognitive Symptom | 10/23 | 02/24 | | |
NCT05483465: The Effect of NAD Supplementation on Brain Vascular Health in Aging |
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| Recruiting | 4 | 214 | US | Nicotinamide riboside, NR, Placebo, Sugar pill | University of Oklahoma, University of Pennsylvania, Oklahoma Medical Research Foundation, Elysium Health | Aging | 06/27 | 12/27 | | |
NICE, NCT03743636: Nicotinamide Riboside With and Without Resveratrol to Improve Functioning in Peripheral Artery Disease |
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| Completed | 3 | 90 | US | Nicotinamide riboside, NR, Niagen, Resveratrol, Placebo | Northwestern University, American Heart Association | Peripheral Artery Disease | 05/23 | 05/23 | | |
| Completed | 3 | 166 | RoW | Cytoflavin ((Inosine + Nicotinamide + Riboflavin + Succinic Acid), Placebo | POLYSAN Scientific & Technological Pharmaceutical Company | Head Trauma,Closed | 05/24 | 09/24 | | |
NCT05935787: Cytoflavin in the Complex Rehabilitation of Stroke Patients |
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| Recruiting | 3 | 196 | RoW | Cytoflavin (Inosine + Nicotinamide + Riboflavin + Succinic Acid), Placebo | POLYSAN Scientific & Technological Pharmaceutical Company | Stroke | 09/24 | 12/24 | | |
NCT03568968: A Randomized Controlled Trial of Nicotinamide Riboside Supplementation in Early Parkinson's Disease |
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| Recruiting | 3 | 400 | Europe | Nicotinamide Riboside, NR, NAD, TruNiagen, Placebo | Haukeland University Hospital | Parkinson Disease | 12/24 | 04/25 | | |
ACTRN12621001699853: The ENHANCE study. Can a daily supplement improve egg quality?
The effects of NR (Nicotinamide riboside) supplementation on the egg quality of women of advanced age undergoing IVF: a randomised placebo-controlled double-blind proof of concept clinical trial
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| Not yet recruiting | 2/3 | 60 | | | University of New South Wales - UNSW, University of New South Wales - UNSW | Infertility, Poor ovarian reserve | | | | |
SUNRISE, NCT04614714: Milk Volume Outcomes Following Oral Nicotinamide Riboside Supplementation in Mothers of Extremely Preterm Infants |
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| Not yet recruiting | 2/3 | 32 | NA | Nicotinamide riboside chloride, Niagen, Placebo | University of California, Davis | Preterm Birth, Inadequate Milk Production | 12/26 | 12/27 | | |
| Terminated | 2 | 5 | US | Nicotinamide Riboside, NIAGEN®) | Donna Hammond, PhD, National Cancer Institute (NCI), ChromaDex, Inc. | Chemotherapy-induced Peripheral Neuropathy, Breast Cancer Metastatic, Platinum-resistant Recurrent Ovarian Cancer, Head and Neck Cancer Stage IV, Endometrial Cancer Stage IV | 08/21 | 02/22 | | |
| Completed | 2 | 28 | US | Placebo, Microcrystalline cellulose, Nicotinamide riboside, Niagen | The University of Texas Health Science Center at San Antonio, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | SARS-CoV-2 Infection, Acute Kidney Injury | 12/21 | 01/22 | | |
| Completed | 2 | 80 | Europe | Exercise, Time restricted feeding, Nicotinamide riboside | University of Copenhagen, Elysium Health | Aging | 12/22 | 12/22 | | |
NCT03912220: Evaluation of Nicotinamide Riboside in Prevention of Small Fiber Axon Degeneration and Promotion of Nerve Regeneration |
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| Completed | 2 | 45 | US | Nicotinamide riboside, Placebo Oral Tablet | Johns Hopkins University, Adelson Medical Research Foundation | Small Fiber Neuropathy | 05/23 | 05/23 | | |
NCT03821623: Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults |
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| Recruiting | 2 | 118 | US | Nicotinamide riboside, Placebo | Douglas Seals | Hypertension, Aging | 12/24 | 12/24 | | |
NCT04112641: NIAGEN and Persistent Chemotherapy-Induced Peripheral Neuropathy |
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| Active, not recruiting | 2 | 48 | US | Nicotinamide riboside, NIAGEN, Placebo capsules, Placebo | Donna Hammond, PhD | Chemotherapy-induced Peripheral Neuropathy | 02/25 | 03/25 | | |
NADage, NCT06208527: The Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging |
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| Not yet recruiting | 2 | 100 | Europe | Nicotinamide Riboside (NR), Placebo | Haukeland University Hospital | Frailty, Frail Elderly Syndrome, Frailty Syndrome, Aging | 12/27 | 12/28 | | |
NADAPT, NCT06162013: The Study: a Randomized Double-blind Trial of NAD Replenishment Therapy for Atypical Parkinsonism |
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| Recruiting | 2 | 330 | Europe | Nicotinamide Riboside, NR, Placebo | Haukeland University Hospital, Oslo universitetssykehus HF, Akershus Universitetssykehus HF, Vestre Viken Hospital Trust, Sykehuset Ostfold, Nevro Arendal AS, Helse Forde, Helse Fonna HF, Universitetssykehuset Nord Norge HF, Helse Møre og Romsdal HF, Nordlandssykehuset HF, Elysium Health | Progressive Supranuclear Palsy, Multiple System Atrophy, Corticobasal Syndrome | 12/28 | 12/28 | | |
| Recruiting | 2 | 310 | Europe | Nicotinamide Riboside (NR), Mind-body reprocessing therapy (MBRT), Care as usual, Placebo | University Hospital, Akershus | Long COVID | 10/24 | 07/25 | | |
NCT04040959: Nicotinamide Riboside Supplementation for Treating Arterial Stiffness and Elevated Systolic Blood Pressure in Patients With Moderate to Severe CKD |
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| Recruiting | 2 | 118 | US | Nicotinamide riboside | University of Colorado, Denver, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Vascular Diseases, Kidney Disease, Blood Pressure, Oxidative Stress | 05/24 | 09/24 | | |
NCT04870866: NAD Supplementation to Prevent Progressive Neurological Disease in Ataxia Telangiectasia |
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| Active, not recruiting | 2 | 13 | Europe | Nicotinamide ribonucleoside, Niagen | University Hospital, Akershus, The Bergesen Foundation, South-Eastern Norway Regional Health Authority, Sykehuset Innlandet HF, Oslo University Hospital, St. Olavs Hospital, Haukeland University Hospital, University Hospital of North Norway, University of Bergen | Ataxia Telangiectasia | 09/24 | 06/27 | | |
NCT05617508: N-DOSE AD: A Dose Optimization Trial of Nicotinamide Riboside in Alzheimer's Disease |
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| Recruiting | 2 | 80 | Europe | Placebo, Nicotinamide Riboside supplementation 1000mg daily in total, Niagen, NR, Nicotinamide Riboside dose escalation (up to 3000 mg daily in total) | Haukeland University Hospital, Haraldsplass Deaconess Hospital | Alzheimer Disease, Dementia | 12/24 | 03/25 | | |
NCT05589766: N-DOSE: A Dose Optimization Trial of Nicotinamide Riboside in Parkinson's Disease |
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| Recruiting | 2 | 80 | Europe | Nicotinamide Riboside, Niagen, NR, Placebo | Haukeland University Hospital | Parkinson Disease | 12/24 | 12/24 | | |
| Not yet recruiting | 2 | 60 | US | Zinc, Placebos for zinc and nicotinamide riboside, Nicotinamide riboside | Cedars-Sinai Medical Center | Idiopathic Pulmonary Fibrosis | 03/26 | 06/26 | | |
NARNIA, NCT05732051: Nicotinamide Riboside and Prevention of Cancer Therapy Related Cardiac Dysfunction in Breast Cancer Patients |
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| Recruiting | 2 | 60 | Europe | Nicotinamide Riboside, Niagen (serial number 85932490, registration number 4606519), Placebo | University Hospital, Akershus, ChromaDex, Inc., Norwegian Cancer Society, Norwegian Breast Cancer Association, Helse Sor-Ost | Breast Cancer, Metastatic Breast Cancer, Cancer Therapy-Related Cardiac Dysfunction, Cardiotoxicity, Heart Failure | 08/25 | 09/35 | | |
NCT05590468: A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy |
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| Recruiting | 2 | 34 | US | Nicotinamide Riboside, Placebo | Eduardo N. Chini | Mitochondrial Myopathy | 11/25 | 11/25 | | |
| Recruiting | 2 | 120 | Europe | Dasatinib 100 Mg Oral Tablet, Sprycel, Quercetin 1.250 mg (oral), Quercetin Phytosome, Nicotinamide Riboside 1g (oral), NR | Odense University Hospital, Odense Patient Data Explorative Network, Novo Nordisk A/S | Osteopenia, Osteoporosis | 12/25 | 12/25 | | |
| Recruiting | 2 | 53 | US | Potassium Nitrate, KNO3, Potassium Nitrate + Propionyl-L-Carnitine + Nicotinamide Riboside, KNO3 + PLC + NR, Potassium Chloride, PCl | University of Pennsylvania | Heart Failure With Preserved Ejection Fraction | 01/26 | 01/26 | | |
IAMFIT, NCT05194397: Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors |
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| Recruiting | 2 | 80 | US | Nicotinamide Riboside, Placebo, Exercise Intervention | Children's Hospital of Philadelphia, National Institutes of Health (NIH), City of Hope Medical Center, St. Jude Children's Research Hospital, National Cancer Institute (NCI), University of Pennsylvania | Lymphoblastic Leukemia, Cancer Survivors, Aplastic Anemia, Myelodysplastic Syndromes, Myeloid Leukemia | 06/26 | 06/26 | | |
| Recruiting | 2 | 300 | Europe | Nicotinamid riboside, Placebo | Haukeland University Hospital | Multiple Sclerosis, Progressive Multiple Sclerosis | 08/27 | 12/27 | | |
| Completed | 1/2 | 57 | Europe | Nicotinamide riboside, Placebo | Oslo University Hospital, ChromaDex, Inc. | Inflammation, Acute Illness | 12/22 | 12/23 | | |
| Active, not recruiting | 1/2 | 8 | US | Nicotinamide riboside, NR | University of Oklahoma | Peripheral Artery Disease | 07/24 | 12/24 | | |
NCT03482167: NAD Therapy for Improving Memory and Brain Blood Flow in Older Adults With Mild Cognitive Impairment |
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| Completed | 1/2 | 64 | US | Niagen®, nicotinamide riboside chloride, Placebo | University of Delaware, National Institute on Aging (NIA) | Mild Cognitive Impairment | 01/24 | 01/24 | | |
NCT06032923: Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus |
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| Recruiting | 1/2 | 78 | US | Nicotinamide Riboside | National Heart, Lung, and Blood Institute (NHLBI) | Systemic Lupus Erythematosus (Sle) | 08/28 | 08/28 | | |
NEET, NCT04112043: Nicotinamide Riboside as an Enhancer of Exercise Therapy in Hypertensive Older Adults (The Trial) |
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| Completed | 1 | 147 | US | Walking Exercise, Nicotinamide Riboside (NR) | University of Florida, National Institute on Aging (NIA) | Hypertension | 05/23 | 05/23 | | |
NCT06214468: Protective Effect of Nicotinamide Riboside Against Acetaminophen Toxicity |
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| Recruiting | 1 | 40 | US | Acetaminophen and Nicotinamide Riboside, Tylenol and Vitamin B3, Acetaminophen, Tylenol | University of South Alabama, National Aeronautics and Space Administration (NASA), University of Nevada, Las Vegas, University of Alabama at Birmingham, Rutgers University | Drug Toxicity | 06/24 | 04/25 | | |
NCT06280482: Nicotinamide Riboside (NR) to Treat Moyamoya-like Cerebrovascular Disease in Smooth Muscle Dysfunction Syndrome (SMDS) |
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| Recruiting | 1 | 5 | US | Nicotinamide riboside (NR) | The University of Texas Health Science Center, Houston | Smooth Muscle Dysfunction Syndrome (SMDS) | 07/25 | 07/25 | | |
NCT04332341: Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplantation |
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| Recruiting | 1 | 20 | US | Nicotinamide riboside (NR) | Case Comprehensive Cancer Center | Allogeneic Hematopoietic Cell Transplantation | 04/25 | 04/26 | | |
ChiCTR2200056972: Comparing nicotinamide ribose with vitamin E to improve fertility in elderly women: a single-center, randomized, parallel trial |
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| Recruiting | 1 | 60 | | Nicotinamide Riboside (NR) ;Vitamin E | The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University, The First Affiliated Hospital of Zhengzhou University | Infertility in elderly patients and ovarian dysfunction | | | | |
| Recruiting | 1 | 40 | US | Nicotinamide riboside, Placebo | University of Washington, National Heart, Lung, and Blood Institute (NHLBI) | Heart Failure, Systolic, Heart Failure NYHA Class IV, Metabolic Disturbance | 03/25 | 07/25 | | |
NCT04430517: Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia |
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| Recruiting | 1 | 50 | US | Nicotinamide riboside, Chromadex NIAGEN | Mclean Hospital, National Institute on Aging (NIA) | Mild Cognitive Impairment, Mild Alzheimer Disease | 04/25 | 04/25 | | |
| Completed | N/A | 30 | Europe | Niagen, Nicotinamide Riboside (NR), Exercise | Maastricht University Medical Center | Overweight and Obesity, Aging, Type 2 Diabetes | 12/22 | 12/22 | | |
NCT04271735: Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis |
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| Completed | N/A | 29 | US | Niagen, Nicotinamide Riboside Chloride, Nicotinamide Riboside, Placebo | National Heart, Lung, and Blood Institute (NHLBI) | Psoriasis, Atherosclerotic Cardiovascular Disease, Obesity, Dyslipidemia, Cardiometabolic Diseases | 12/22 | 12/22 | | |
NICO, NCT05517122: Effect of Oral NAD+ Precursors Administration on Blood NAD+ Concentration in Healthy Adults |
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| Active, not recruiting | N/A | 68 | Europe | Nicotinamide (NAM), Nicotinamide Riboside (NR), Nicotinamide Mono Nucleotide (NMN), Microcrystalline cellulose | Société des Produits Nestlé (SPN) | Healthy | 12/22 | 12/23 | | |
NCT05297851: Cytoflavin in Combination With Reperfusion in Stroke Patients |
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| Completed | N/A | 200 | RoW | Cytoflavin (succinic acid + inosine + nicotinamide + riboflavin), Control | POLYSAN Scientific & Technological Pharmaceutical Company | Acute Stroke | 02/23 | 03/23 | | |
| Recruiting | N/A | 6 | Europe | nicotinamide riboside, nicotinamide mononucleotide | Haukeland University Hospital | Healthy | 03/23 | 03/23 | | |
ChiCTR1900021998: Nicotinamide riboside as a neuroprotective therapy for glaucoma – A randomized controlled trial |
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| Recruiting | N/A | 125 | | Nicotinamide riboside 300mg/day ;Placebo | Research Fund Secretariat, Food and Health Bureau, The Government of HKSAR; Research Fund Secretariat, Food and Health Bureau, The Government of HKSAR, Health and Medical Research Fund 2017 | Glaucoma | | | | |
NCT06382688: IV Administration of ChromaDex's Niagen® as Compared to NAD+ |
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| Active, not recruiting | N/A | 53 | US | NAD+ (nicotinamide adenine dinucleotide) IV, NAD+, Niagen® (nicotinamide riboside) IV, Niagen® (nicotinamide riboside) oral, Niagen® (oral), Placebo | Franklin Health Research | Healthy Aging | 03/24 | 08/24 | | |
NCT03818802: Effects of Vitamin B3 Derivative Nicotinamide Riboside (NR) in Bone, Skeletal Muscle and Metabolic Functions in Aging |
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| Recruiting | N/A | 48 | US | Nicotinamide Riboside, Placebo | Mayo Clinic | Healthy Elderly Volunteers | 12/24 | 12/24 | | |
| Recruiting | N/A | 52 | US | Nicotinamide Riboside, Placebo | Roskamp Institute Inc., United States Department of Defense, Nova Southeastern University | Gulf War Illness | 02/25 | 02/25 | | |
| Recruiting | N/A | 28 | RoW | Nicotinamide Riboside (NR), Placebo | Finis Terrae University | Healthy Aging, Lifestyle-related Condition, Metabolic Diseases | 12/25 | 03/26 | | |
NCT05500170: Benefits of Nicotinamide Riboside Upon Cognition and Sleep |
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| Recruiting | N/A | 50 | US | Nicotinamide riboside, NR, vitamin B3, Placebo, Placebo pill | State University of New York at Buffalo | Cognitive Impairment, Sleep Quality | 08/27 | 08/27 | | |
NICE, NCT06005350: Nicotinamide Riboside Impact on Extracellular Nicotinamide Adenine Dinucleotide (NAD+) |
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| Active, not recruiting | N/A | 54 | Europe | Niagen, Placebo | Charite University, Berlin, Germany, ChromaDex, Inc. | NAD | 12/24 | 12/24 | | |
ATNAD, NCT06324877: Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside |
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| Not yet recruiting | N/A | 10 | RoW | Nicotinamide riboside | The University of Queensland | Ataxia Telangiectasia | 10/25 | 10/25 | | |
AKI-RCT, NCT06521307: Impact of Nicotinamide Riboside (NR) on Kidney Function in Patients Undergoing Cardiac Surgery |
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| Not yet recruiting | N/A | 100 | RoW | Nicotinamide riboside, NADH Riboside, Placebo | Instituto Nacional de Cardiologia Ignacio Chavez | Acute Kidney Injury, Cardiac Valve Disease | 07/25 | 07/26 | | |
NCT05023993: The Effect of Exercise and Nicotinamide Riboside Muscle Health and Insulin Resistance in Survivors of Childhood Cancer |
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| Active, not recruiting | N/A | 20 | US | Exercise Intervention, Nicotinamide Riboside, Niagen, NR | City of Hope Medical Center, National Cancer Institute (NCI) | Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Prediabetes | 09/24 | 09/24 | | |
NOMAD, NCT06587945: Nicotinamide Riboside Oral Supplementation in Macula Off Retinal Detachment |
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| Not yet recruiting | N/A | 144 | RoW | Nicotinamide Riboside, Placebo, Vitrectomy and Gas tamponade | Center for Eye Research Australia | Retinal Detachment | 08/26 | 01/27 | | |
| Enrolling by invitation | N/A | 200 | US | Nicotinamide Riboside Malate, NRM, Placebo | Mayo Clinic | Vascular Stiffness | 02/26 | 09/26 | | |
| Recruiting | N/A | 40 | US | Nicotinamide Riboside Chloride, Placebo, Standard of Care | University of Pittsburgh, Crohn's and Colitis Foundation | Ulcerative Colitis | 12/24 | 12/25 | | |
| Recruiting | N/A | 80 | US | Nicotinamide Riboside, Placebo, Exercise Intervention | Children's Hospital of Philadelphia, National Heart, Lung, and Blood Institute (NHLBI) | Friedreich Ataxia 1 | 12/24 | 12/25 | | |
NR-VET, NCT04691986: Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans |
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| Recruiting | N/A | 144 | US | Nicotinamide Riboside, NR, Placebo | VA Office of Research and Development, University at Buffalo | Sarcopenia, Nicotinamide Adenine Dinucleotide Concentration, Muscle Quality and NAD+ Content | 03/26 | 06/26 | | |
ChiCTR2300075668: Oral nicotinamide ribose (NR) in allogeneic hematopoietic stem cell transplant donors to promote stem cell mobilization: a single center, single arm clinical research |
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| Recruiting | N/A | 39 | | Before hematopoietic stem cell collection, oral NR 500mg 2/ day for 2 months | Medical Center of Hematology, the Second Affiliated Hospital of the Army Medical University; The Second Affiliated Hospital of the Army Medical University, National Key R&D Program of China (2022YFA1103304) | Mobilization of donor allogeneic hematopoietic stem cell | | | | |
| Recruiting | N/A | 400 | Europe | Nicotinamide Riboside | Haukeland University Hospital | Safety Issues | 12/25 | 12/25 | | |
NCT06044935: Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate |
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| Recruiting | N/A | 100 | US | Standard Diet, Ketogenic Diet, Placebo, Nicotinamide Riboside | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Overweight, Obesity | 01/26 | 01/28 | | |
Emerald-NRAD, NCT05245903: Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside |
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| Not yet recruiting | N/A | 40 | NA | Emerald Device Monitoring | Mclean Hospital, National Institute on Aging (NIA) | Alzheimer Disease, Dementia Alzheimers, Dementia, Cognitive Impairment, Mild Cognitive Impairment, Neurodegenerative Diseases, Neurocognitive Disorders, Neurocognitive Dysfunction, Cognitive Dysfunction, Mental Disorder | 04/25 | 04/25 | | |
