| Sustol (granisetron ER) / Heron Therapeutics |
NCT05434663: Safety Study of Repeat Doses of SUSTOL in Adults |
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| Active, not recruiting | 4 | 300 | US | SUSTOL, Granisetron extended-release injection for subcutaneous use | Heron Therapeutics | Chemotherapy-Induced Nausea and Vomiting (CINV) | 10/25 | 10/25 | | |
| Cinvanti (aprepitant IV) / Heron Therapeutics |
ChiCTR2200062608: Randomized, open-label, two-formulation, single-dose, three-period, crossover bioequivalence study of Aprepitant Injectable Emulsion in healthy subjects |
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| Not yet recruiting | N/A | 108 | | 2min intravenous injection of aprepitant injection (test formulation) ;30min intravenous infusion of aprepitant injection (test formulation) ;30min intravenous infusion of aprepitant injection (reference formulation) | Shulan (Hangzhou) Hosipital; CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., LTD, CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., LTD | Nausea and vomiting associated with chemotherapy | | | | |
| Zynrelef (bupivacaine/meloxicam ER) / Heron Therapeutics |
NCT06109428: A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE |
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| Completed | 4 | 30 | US | HTX-011, Bupivacaine Hydrochloride, Ibuprofen, Acetaminophen, Luer lock applicator | Heron Therapeutics | Analgesia | 03/22 | 04/22 | | |
NCT06109415: A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE. |
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| Completed | 4 | 30 | US | HTX-011, Bupivacaine Hydrochloride, Ibuprofen, Acetaminophen, Luer lock applicator | Heron Therapeutics | Postoperative Pain, Total Shoulder Arthroplasty, Multimodal Analgesia | 07/22 | 07/22 | | |
NCT05188053: Periarticular Bupivacaine + Meloxicam ER Solution Versus Standard Practice During Total Knee Arthroplasty |
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| Completed | 4 | 209 | US | HTX-011, Zynrelef, ropivacaine , epinephrine , ketorolac diluted in sodium chloride, Mayo Clinic standard arthroplasty block | Mayo Clinic | Total Knee Arthroplasty | 04/24 | 04/24 | | |
NCT05109312: A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE. Master Protocol HTX-011-401. |
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| Active, not recruiting | 4 | 90 | US | Bupivacaine Hydrochloride, HTX-011, Luer lock applicator, Ibuprofen, Acetaminophen | Heron Therapeutics | Analgesia | 06/24 | 06/24 | | |
| Recruiting | 4 | 120 | US | ZYNRELEF 200Mg-6Mg Extended-Release Solution | Dr. Yannis Raftopoulos, Heron Therapeutics | Post Operative Pain, Acute, Bariatric Surgery Candidate, Postoperative Pain | 10/24 | 10/24 | | |
NCT05644496: ZYNRELEF for Pain Management in Total Knee Arthroplasty |
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| Recruiting | 4 | 242 | US | Bupivacaine-Meloxicam 400 Mg-12 Mg/14 mL Injectable Solution, Extended Release, Zynrelef | Baptist Health South Florida | Post Operative Pain, Osteoarthritis, Knee | 04/25 | 04/26 | | |
| Enrolling by invitation | 3 | 60 | US | Zynrelef (Bupivacaine 60 MG / Meloxicam 1.8 MG) Per 2.3 ML Extended Release Solution, Bupivacaine HCl 0.5% Injectable Solution, primary total knee replacement | Rothman Institute Orthopaedics | Pain, Postoperative | 02/24 | 02/24 | | |
| Completed | 2 | 32 | US | Bupivacaine HCI without epinephrine, HTX-011, Luer Lock Applicator | Heron Therapeutics | Post-Operative Pain, Lumbar Laminectomy | 07/22 | 08/22 | | |
NCT03922048: Pediatric Postoperative Analgesia Herniorrhaphy Study |
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| Withdrawn | 2 | 336 | NA | HTX-011, Bupivacaine HCl, Luer Lock Applicator | Heron Therapeutics | Analgesia | 11/25 | 12/25 | | |
NCT06349772: Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy |
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| Not yet recruiting | 1 | 130 | NA | Zynrelef, Exparel | Texas Tech University Health Sciences Center | Post Operative Pain | 04/25 | 04/25 | | |
