| roluperidone (MIN-101) / Mitsubishi Tanabe, Minerva Neurosciences |
NCT06107803: A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Co-Administration of Roluperidone and Olanzapine in Adult Subjects With Moderate to Severe Negative Symptoms of Schizophrenia |
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| Completed | 1 | 17 | US | Roluperidone 64 mg, MIN-101, Olanzapine 10 MG | Minerva Neurosciences | Negative Symptoms in Schizophrenia | 01/24 | 01/24 | | |
| seltorexant (MIN-202) / J&J |
2020-000338-16: A study to evaluate the safety and efficacy of Seltorexant in patients with major depressive disorder (MDD) with sleep problems who have not responded well to their current depression medication. |
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| Not yet recruiting | 3 | 386 | Europe | Seltorexant 20 mg, JNJ-42847922, Film-coated tablet | Janssen-Cilag International NV, Janssen-Cilag International NV | Major Depressive Disorder (MDD), Depression, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT04533529 / 2020-000337-40: A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With Seltorexant |
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| Completed | 3 | 588 | Europe, US, RoW | Seltorexant, JNJ-42847922, Placebo | Janssen Research & Development, LLC | Depressive Disorder, Major | 04/23 | 04/24 | | |
NCT04513912 / 2020-000341-14: A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy |
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| Completed | 3 | 757 | Europe, Canada, US, RoW | Seltorexant, Matching placebo to Seltorexant, Quetiapine XR, Matching placebo to Quetiapine XR | Janssen Research & Development, LLC | Depressive Disorder, Major | 10/23 | 10/23 | | |
NCT06559306: Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms |
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| Recruiting | 3 | 752 | US, RoW | Seltorexant, JNJ 42847922, Placebo, Selective Serotonin Reuptake Inhibitor (SSRI)/Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) | Janssen Research & Development, LLC | Depressive Disorder, Major | 12/26 | 11/27 | | |
NCT05307692: A Study of Seltorexant in Participants With Probable Alzheimer's Disease |
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| Completed | 2 | 88 | US | Seltorexant, JNJ-42847922, Placebo | Janssen Research & Development, LLC | Alzheimer Disease | 11/23 | 11/23 | | |
2021-000567-77: A study to evaluate the safety and tolerability and to assess blood levels of seltorexant in adolescents with Major Depressive Disorder who have not responded well to their current antidepressant and psychotherapy |
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| Ongoing | 1 | 52 | Europe, US | Seltorexant 20mg Film Coated tablets, Seltorexant 10mg Film coated tablets, JNJ-42847922, Film-coated tablet | Janssen-Cilag International NV, Janssen-Cilag International NV | Major Depressive Disorder, Depression, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT04451187: A Study of Oral Seltorexant as an add-on Medication to an Antidepressant on On-road Driving Performance in Participants With Major Depressive Disorder |
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| Completed | 1 | 63 | Europe | Seltorexant Dose 1, JNJ-42847922, Seltorexant Dose 2, Placebo, Zopiclone | Janssen Research & Development, LLC | Depressive Disorder, Major | 03/23 | 03/23 | | |
NCT05106153: A Study to Determine the Abuse Potential of Seltorexant Compared to Suvorexant and Zolpidem |
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| Completed | 1 | 127 | US | Suvorexant, Zolpidem, Seltorexant, JNJ-42847922, Placebo | Janssen Research & Development, LLC | Healthy Non-dependent, Recreational Sedative Users, Abuse Potential | 05/23 | 05/23 | | |
NCT04951609 / 2021-000567-77: A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder Who Have an Inadequate Response to Selective Serotonin Reuptake Inhibitor (SSRI) and Psychotherapy |
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| Terminated | 1 | 31 | Europe, US | Seltorexant, JNJ-42827922, Placebo | Janssen Research & Development, LLC, Janssen-Cilag International NV | Depressive Disorder, Major | 04/24 | 04/24 | | |
| MIN-117 / Minerva Neurosciences |
| No trials found |
| MIN-301 / Minerva Neurosciences |
| No trials found |
