Alzheimer's Disease Cooperative Study 
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19 Trials

   

Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Humulin R (recombinant human insulin) / Alzheimer's Disease Cooperative Study, Eli Lilly
NCT05768191: Comparative Efficacy of a Two Daily Mixed Insulin Injection Versus a Basal-bolus Scheme With Human Insulin

Completed
4
22
RoW
premix insulin human isophane suspension and insulin human, Humulin N plus Humulin R
Université NAZI BONI, Juvenile Diabetes Research Foundation, International Society for Pediatric and Adolescent Diabetes, Société de Médecine Interne du Burkina Faso, Association pour la Formation, la Recherche et l'Education sur le Diabète, Burkina Faso
Type 1 Diabetes
04/24
05/24
NCT02102243: Neural Mechanism of Aldosterone-induced Insulin Resistance

Withdrawn
4
2
US
DEFINITY® infusion, (IND# 104397), Human Recombinant Regular Insulin infusion, Humulin R, National Drug Code # 0002-8501-01, Dextrose infusion, Dextrose 20%, Flow mediated vasodilation, FMD, Endothelial Dependent Vasodilation, Endothelial cell collection, Microvascular perfusion assessment using Definity, Microneurography, Assessment of sympathetic nerve activity (SNA)
Wanpen Vongpatanasin
Hypertension
12/25
12/25
LEV PS, NCT05159453: Dose Response Study of Transdermal Human Insulin in Patients

Not yet recruiting
2/3
30
US
Human Insulin, Humulin(R), Novolin(R), Finger-actuated, Metered Pump Sprayer
Transdermal Delivery Solutions Corp, Langford Research Institute, Inc.
Glucose, High Blood
10/25
12/25
2015-005727-80: Effect of insulin on renal maximum glucose transport capacity: interaction with empagliflozin. Effetto dell'insulina sulla massima capacità di riassorbimento del glucosio del tubulo renale: interazione con il farmaco empagliflozin.

Not yet recruiting
2
30
Europe
[JARDIANCE 25 mg 28 compresse], [Humulin R], [Somatostatina 3mg/2ml], [GLUCAGEN], JARDIANCE - 25 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PVC/ALU) - 28 COMPRESSE, HUMULIN - R 1 FLAC. 10 ML 100 U/ML, SOMATOSTATINA HIKMA - 3 MG/2 ML POLVERE E SOLVENTE PER SOLUZIONE PER INFUSIONE ENDOVENOSA 3 FLACONCINI POLVERE + 3 FIALE SOLVENTE 2 ML, GLUCAGEN - 1 FLAC. LIOF 1 MG + FIALA 1 ML
FONDAZIONE TOSCANA GABRIELE MONASTERIO, Fondazione Toscana Gabriele Monasterio, Boehringer Ingelheim Italia Spa
Patients with diabetes mellitus type 2 Pazienti con diabete mellito di tipo 2, Patients with diabetes mellitus type 2 Pazienti con diabete mellito di tipo 2, Diseases [C] - Hormonal diseases [C19]
 
 
NCT03857321: Study of Nasal Insulin to Fight Forgetfulness - Device Study

Active, not recruiting
2
30
US
Insulin, Humulin® R U-100, Placebo, placebo to Humulin® R U-100, Sterile saline, intranasal nebulizer-like device
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment
08/25
08/25
NCT04199767: SNIFF Multi-Device Study 2

Suspended
2
30
US
20 IU Humulin® R U-100 (NDC: 0002-8215, Eli Lilly & Company), Humulin® R U-100, 40 IU Humulin® R U-100 (NDC: 0002-8215, Eli Lilly & Company)
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment
10/26
10/27
IAA, NCT05742243: Insulin and Abatacept in Recently-diagnosed Type 1 Diabetes

Active, not recruiting
2
62
RoW
Abatacept (CTLA4-Ig) and nasal insulin (Humulin R®), Abatacept and nasal insulin, Abatacept (CTLA4-Ig) and nasal placebo (0.9% sodium chloride), Abatacept and nasal placebo
Melbourne Health, National Health and Medical Research Council, Australia, Juvenile Diabetes Research Foundation
Type 1 Diabetes, Diabetes Mellitus, Type 1
02/26
02/27
NCT05081219: SNIFF - Combo INI+EMPA Trial

Completed
2
30
US
Insulin (Humulin® R U-100), Empagliflozin 10 MG, Aptar Pharma CPS Intranasal Delivery Device, Placebo (Insulin Diluent), Placebo (Capsules)
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment, Alzheimer Disease
09/24
09/24
NCT05006599: SNIFF - 3-Week Aptar CPS Device

Withdrawn
2
40
NA
Insulin (Humulin® R U-100), Placebo, Insulin Diluent, Aptar Pharma CPS Intranasal Delivery Device
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment, Alzheimer Disease, Early Onset
05/29
05/31
NCT03915613: Brain Insulin Resistance in Mood Disorders

Recruiting
1/2
150
Canada
Humulin R, Diluent
University Health Network, Toronto
Major Depressive Disorder, Bipolar Disorder, Anhedonia, Intranasal Insulin
10/24
10/24
NCT02729064: Intraoperative Nasal Insulin Effect on Plasma and CSF Insulin Concentration and Blood Glucose

Recruiting
1
141
Canada
Humulin R, Normal Saline
Hiroaki Sato, MD., PhD.
Ischemic Heart Disease, Aortic Aneurysm
09/21
09/21
RHINE-4, NCT05413863: Comparison of the Pharmacokinetic and Pharmacodynamic Properties of Biocon's Insulin R U-500 With Humulin® R U-500 (US Reference Product) in Healthy Subjects

Completed
1
78
Europe
Biocon's Human Insulin R U-500, Humulin® R U-500 (US Reference Product)
Biocon Limited, Profil Institut für Stoffwechselforschung GmbH
Healthy Volunteers
12/22
12/22
NCT05754424: AT278, NovoRapid® and Humulin® R (U500) in Glucose Clamp Study

Completed
1
41
Europe
AT278, NovoRapid, Humulin R 500 UNT/ML Injectable Solution
Arecor Limited
Diabetes Mellitus, Type 2
01/24
02/24
NCT06144255: Dose-Dependent Effect of Intranasal Insulin in Humans Using Functional Magnetic Resonance Imaging (fMRI)

Completed
1
6
US
Intranasal insulin, HUMULIN R U-500
Florian Schmitzberger
Healthy
02/24
02/24
NCT04118920: Safety of Topical Insulin Drops for Open-angle Glaucoma

Active, not recruiting
1
18
Canada
Topical insulin (4 units), Humulin R (100 units/mL), Topical insulin (20 units), Entuzity (500 units/mL), Artificial tears, Refresh Plus Artificial Tears
Centre hospitalier de l'Université de Montréal (CHUM)
Glaucoma
08/24
12/24
NCT06126354: Dexamethasone/Pancreatic Clamp P&F

Withdrawn
1
16
US
Insulin human, Novolin-R, Humulin-R, Octreotide Acetate, Octreotide Acetate IV, Glucagon, Glucagon IV, Human Growth Hormone, Omnitrope, Dexamethasone Oral, Dexamethasone, [6,6-2H2] D-glucose, D2-glucose, D2G, 20% D-glucose (aq), D20W, BOOST Plus, Harvard Apparatus PHD ULTRA CP syringe pump, Yellow Springs Instruments (YSI) 2500 Biochemistry Glucose/Lactate Analyzer, Normal saline, NaCl IV, Human albumin, Human albumin IV
Columbia University, Albert Einstein College of Medicine, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Insulin Resistance, Prediabetic State, Non-Alcoholic Fatty Liver Disease, Overweight and Obesity
11/25
03/26
NCT06558422: Human Models of Selective Insulin Resistance: Pancreatic Clamp

Not yet recruiting
1
36
US
Insulin human, Novolin-R, Humulin-R, Octreotide Acetate, Glucagon, Growth Hormone, Human, Omnitrope, Zomacton, 20% D-glucose (aq), D20W, [6,6-2H2] D-glucose, D2-glucose, D2G, [1-13C1] sodium acetate, 13C-acetate, C13A, Nestle BOOST Plus, KIND Bar, Harvard Apparatus PHD ULTRA CP syringe pump, Yellow Springs Instruments (YSI) 2500 Biochemistry Glucose/Lactate Analyzer
Columbia University, University of California, Berkeley, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Insulin Resistance, Hyperinsulinemia, Metabolic Dysfunction Associated Steatotic Liver Disease, Non-Alcoholic Fatty Liver Disease, Prediabetic State, Obesity
12/27
02/28
NCT03324867: The Effect of Intranasal Insulin Administration on Cognitive Function After Cardiac Surgery.

Not yet recruiting
N/A
316
NA
Regular insulin, Humulin R, Normal Saline Flush, 0.9% Injectable Solution
McGill University Health Centre/Research Institute of the McGill University Health Centre
Cognitive Decline, Heart Diseases, Delirium
04/23
04/23
NCT03415061: Effect of Intranasal Insulin on POCD and POD

Not yet recruiting
N/A
494
Canada
Regular Insulin, Human 100 UNT/ML, Humulin R, Normal Saline Flush, 0.9% Injectable Solution, Placebo
Hiroaki Sato, MD., PhD.
Delirium, Heart Diseases
11/23
11/24
resveratrol (DB02709) / Alzheimer's Disease Cooperative Study
No trials found
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Humulin R (recombinant human insulin) / Alzheimer's Disease Cooperative Study, Eli Lilly
NCT05768191: Comparative Efficacy of a Two Daily Mixed Insulin Injection Versus a Basal-bolus Scheme With Human Insulin

Completed
4
22
RoW
premix insulin human isophane suspension and insulin human, Humulin N plus Humulin R
Université NAZI BONI, Juvenile Diabetes Research Foundation, International Society for Pediatric and Adolescent Diabetes, Société de Médecine Interne du Burkina Faso, Association pour la Formation, la Recherche et l'Education sur le Diabète, Burkina Faso
Type 1 Diabetes
04/24
05/24
NCT02102243: Neural Mechanism of Aldosterone-induced Insulin Resistance

Withdrawn
4
2
US
DEFINITY® infusion, (IND# 104397), Human Recombinant Regular Insulin infusion, Humulin R, National Drug Code # 0002-8501-01, Dextrose infusion, Dextrose 20%, Flow mediated vasodilation, FMD, Endothelial Dependent Vasodilation, Endothelial cell collection, Microvascular perfusion assessment using Definity, Microneurography, Assessment of sympathetic nerve activity (SNA)
Wanpen Vongpatanasin
Hypertension
12/25
12/25
LEV PS, NCT05159453: Dose Response Study of Transdermal Human Insulin in Patients

Not yet recruiting
2/3
30
US
Human Insulin, Humulin(R), Novolin(R), Finger-actuated, Metered Pump Sprayer
Transdermal Delivery Solutions Corp, Langford Research Institute, Inc.
Glucose, High Blood
10/25
12/25
2015-005727-80: Effect of insulin on renal maximum glucose transport capacity: interaction with empagliflozin. Effetto dell'insulina sulla massima capacità di riassorbimento del glucosio del tubulo renale: interazione con il farmaco empagliflozin.

Not yet recruiting
2
30
Europe
[JARDIANCE 25 mg 28 compresse], [Humulin R], [Somatostatina 3mg/2ml], [GLUCAGEN], JARDIANCE - 25 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PVC/ALU) - 28 COMPRESSE, HUMULIN - R 1 FLAC. 10 ML 100 U/ML, SOMATOSTATINA HIKMA - 3 MG/2 ML POLVERE E SOLVENTE PER SOLUZIONE PER INFUSIONE ENDOVENOSA 3 FLACONCINI POLVERE + 3 FIALE SOLVENTE 2 ML, GLUCAGEN - 1 FLAC. LIOF 1 MG + FIALA 1 ML
FONDAZIONE TOSCANA GABRIELE MONASTERIO, Fondazione Toscana Gabriele Monasterio, Boehringer Ingelheim Italia Spa
Patients with diabetes mellitus type 2 Pazienti con diabete mellito di tipo 2, Patients with diabetes mellitus type 2 Pazienti con diabete mellito di tipo 2, Diseases [C] - Hormonal diseases [C19]
 
 
NCT03857321: Study of Nasal Insulin to Fight Forgetfulness - Device Study

Active, not recruiting
2
30
US
Insulin, Humulin® R U-100, Placebo, placebo to Humulin® R U-100, Sterile saline, intranasal nebulizer-like device
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment
08/25
08/25
NCT04199767: SNIFF Multi-Device Study 2

Suspended
2
30
US
20 IU Humulin® R U-100 (NDC: 0002-8215, Eli Lilly & Company), Humulin® R U-100, 40 IU Humulin® R U-100 (NDC: 0002-8215, Eli Lilly & Company)
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment
10/26
10/27
IAA, NCT05742243: Insulin and Abatacept in Recently-diagnosed Type 1 Diabetes

Active, not recruiting
2
62
RoW
Abatacept (CTLA4-Ig) and nasal insulin (Humulin R®), Abatacept and nasal insulin, Abatacept (CTLA4-Ig) and nasal placebo (0.9% sodium chloride), Abatacept and nasal placebo
Melbourne Health, National Health and Medical Research Council, Australia, Juvenile Diabetes Research Foundation
Type 1 Diabetes, Diabetes Mellitus, Type 1
02/26
02/27
NCT05081219: SNIFF - Combo INI+EMPA Trial

Completed
2
30
US
Insulin (Humulin® R U-100), Empagliflozin 10 MG, Aptar Pharma CPS Intranasal Delivery Device, Placebo (Insulin Diluent), Placebo (Capsules)
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment, Alzheimer Disease
09/24
09/24
NCT05006599: SNIFF - 3-Week Aptar CPS Device

Withdrawn
2
40
NA
Insulin (Humulin® R U-100), Placebo, Insulin Diluent, Aptar Pharma CPS Intranasal Delivery Device
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment, Alzheimer Disease, Early Onset
05/29
05/31
NCT03915613: Brain Insulin Resistance in Mood Disorders

Recruiting
1/2
150
Canada
Humulin R, Diluent
University Health Network, Toronto
Major Depressive Disorder, Bipolar Disorder, Anhedonia, Intranasal Insulin
10/24
10/24
NCT02729064: Intraoperative Nasal Insulin Effect on Plasma and CSF Insulin Concentration and Blood Glucose

Recruiting
1
141
Canada
Humulin R, Normal Saline
Hiroaki Sato, MD., PhD.
Ischemic Heart Disease, Aortic Aneurysm
09/21
09/21
RHINE-4, NCT05413863: Comparison of the Pharmacokinetic and Pharmacodynamic Properties of Biocon's Insulin R U-500 With Humulin® R U-500 (US Reference Product) in Healthy Subjects

Completed
1
78
Europe
Biocon's Human Insulin R U-500, Humulin® R U-500 (US Reference Product)
Biocon Limited, Profil Institut für Stoffwechselforschung GmbH
Healthy Volunteers
12/22
12/22
NCT05754424: AT278, NovoRapid® and Humulin® R (U500) in Glucose Clamp Study

Completed
1
41
Europe
AT278, NovoRapid, Humulin R 500 UNT/ML Injectable Solution
Arecor Limited
Diabetes Mellitus, Type 2
01/24
02/24
NCT06144255: Dose-Dependent Effect of Intranasal Insulin in Humans Using Functional Magnetic Resonance Imaging (fMRI)

Completed
1
6
US
Intranasal insulin, HUMULIN R U-500
Florian Schmitzberger
Healthy
02/24
02/24
NCT04118920: Safety of Topical Insulin Drops for Open-angle Glaucoma

Active, not recruiting
1
18
Canada
Topical insulin (4 units), Humulin R (100 units/mL), Topical insulin (20 units), Entuzity (500 units/mL), Artificial tears, Refresh Plus Artificial Tears
Centre hospitalier de l'Université de Montréal (CHUM)
Glaucoma
08/24
12/24
NCT06126354: Dexamethasone/Pancreatic Clamp P&F

Withdrawn
1
16
US
Insulin human, Novolin-R, Humulin-R, Octreotide Acetate, Octreotide Acetate IV, Glucagon, Glucagon IV, Human Growth Hormone, Omnitrope, Dexamethasone Oral, Dexamethasone, [6,6-2H2] D-glucose, D2-glucose, D2G, 20% D-glucose (aq), D20W, BOOST Plus, Harvard Apparatus PHD ULTRA CP syringe pump, Yellow Springs Instruments (YSI) 2500 Biochemistry Glucose/Lactate Analyzer, Normal saline, NaCl IV, Human albumin, Human albumin IV
Columbia University, Albert Einstein College of Medicine, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Insulin Resistance, Prediabetic State, Non-Alcoholic Fatty Liver Disease, Overweight and Obesity
11/25
03/26
NCT06558422: Human Models of Selective Insulin Resistance: Pancreatic Clamp

Not yet recruiting
1
36
US
Insulin human, Novolin-R, Humulin-R, Octreotide Acetate, Glucagon, Growth Hormone, Human, Omnitrope, Zomacton, 20% D-glucose (aq), D20W, [6,6-2H2] D-glucose, D2-glucose, D2G, [1-13C1] sodium acetate, 13C-acetate, C13A, Nestle BOOST Plus, KIND Bar, Harvard Apparatus PHD ULTRA CP syringe pump, Yellow Springs Instruments (YSI) 2500 Biochemistry Glucose/Lactate Analyzer
Columbia University, University of California, Berkeley, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Insulin Resistance, Hyperinsulinemia, Metabolic Dysfunction Associated Steatotic Liver Disease, Non-Alcoholic Fatty Liver Disease, Prediabetic State, Obesity
12/27
02/28
NCT03324867: The Effect of Intranasal Insulin Administration on Cognitive Function After Cardiac Surgery.

Not yet recruiting
N/A
316
NA
Regular insulin, Humulin R, Normal Saline Flush, 0.9% Injectable Solution
McGill University Health Centre/Research Institute of the McGill University Health Centre
Cognitive Decline, Heart Diseases, Delirium
04/23
04/23
NCT03415061: Effect of Intranasal Insulin on POCD and POD

Not yet recruiting
N/A
494
Canada
Regular Insulin, Human 100 UNT/ML, Humulin R, Normal Saline Flush, 0.9% Injectable Solution, Placebo
Hiroaki Sato, MD., PhD.
Delirium, Heart Diseases
11/23
11/24
resveratrol (DB02709) / Alzheimer's Disease Cooperative Study
No trials found

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