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3150 Trials

   

Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Elahere (mirvetuximab soravtansine-gynx) / AbbVie
NCT05622890: A Single-arm Clinical Trial of IMGN853 in Chinese Adult Patients With Platinum-resistant, Epithelial Ovarian Cancer

Recruiting
3
35
RoW
Mirvetuximab Soravtansine, IMGN853, MIRV
Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Epithelial Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
04/23
12/23
MIRASOL, NCT04209855 / 2019-003509-80: A Study of Mirvetuximab Soravtansine vs. Investigator's Choice (IC) of Chemotherapy in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha (FRα) Expression

Hourglass Oct 2024 - Dec 2024 : Approval for 2L+ FRα +ve PROC
Jan 2023 - Dec 2023: Market entry in ex-US for platinum-resistant ovarian cancer
Hourglass Jan 2023 - Mar 2023 : Top-line data from MIRASOL trial for high-grade epithelial ovarian cancer
Hourglass Jul 2022 - Sep 2022 : Approval for high-grade epithelial ovarian cancer (based on MIRASOL trial)
Completed
3
453
Europe, Canada, US, RoW
Mirvetuximab Soravtansine, MIRV, IMGN853, Paclitaxel, Topotecan, Pegylated liposomal doxorubicin
AbbVie, Gynecologic Oncology Group, European Network of Gynaecological Oncological Trial Groups (ENGOT)
Epithelial Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
03/23
08/24
NCT06682988: A Study to Assess Adverse Events and Change in Disease Activity in Participants With Platinum-Resistant Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression Treated With Intravenously (IV) Infused Mirvetuximab Soravtansine

Not yet recruiting
3
110
NA
Mirvetuximab Soravtansine, MIRV, IMGN853
AbbVie
Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, Fallopian Tube Cancers, High Folate Receptor-Alpha Expression, Platinum Resistant
03/28
03/28
GLORIOSA, NCT05445778: Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Ovarian, Fallopian Tube, or Peritoneal Cancer

Recruiting
3
418
Europe, Canada, Japan, US, RoW
Mirvetuximab soravtansine plus Bevacizumab, MIRV, Bevacizumab
AbbVie, GOG Foundation
Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
03/27
04/29
2018-004207-39: Mirvetuximab Soravtansine in patients with high expression of folate receptor alpha in their tumor and recurrent ovarian cancer

Not yet recruiting
2
136
Europe
Mirvetuximab Soravtansine, Powder and solvent for concentrate for solution for infusion, Solution for infusion, Capsule, hard, Film-coated tablet, , Caelyx, Carboplatin Kabi, Paclitaxel-GRY®, Gemedac®, Zejula, Lynparza, Rubraca
AGO Research GmbH, ImmunoGen, Inc.
This trial evaluates the efficacy and safety of Mirvetuximab soravtansine (IMGN853) plus Carboplatin chemotherapy in FRα high patients with recurrent ovarian cancer who are eligible for platinum-based chemotherapy., Safety and efficacy for carboplatin with Mirvetuximab soravtansine (IMGN853) compared to carboplatin combination chemotherapy, Diseases [C] - Cancer [C04]
 
 
2021-003592-34: c Un estudio para probar mirvetuximab soravtansina en mujeres con cánceres epiteliales de ovario, peritoneales primarios o de trompa de Falopio sensibles al platino.

Not yet recruiting
2
75
Europe
mirvetuximab soravtansine, IMGN853, Concentrate for solution for injection/infusion, Pred Forte
ImmunoGen, Inc., IMMUNOGEN, INC., ImmunoGen, Inc.
Recurrent Platinum-Sensitive, High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers with High Folate Receptor-Alpha Expression Cánceres epiteliales de ovario, peritoneales primarios o de trompa de Falopio recurrentes, sensibles al platino y con alta expresión del receptor de folatos alfa, Cancer of ovary and related organs Cáncer de ovario y órganos afines, Diseases [C] - Cancer [C04]
 
 
NCT03835819: A Phase 2 Study of Mirvetuximab Soravtansine (IMGN853) and Pembrolizumab in Endometrial Cancer (EC)

Active, not recruiting
2
18
US
Pembrolizumab, Keytruda, IMGN853, Mirvetuximab soravtansine, Elahere
Dana-Farber Cancer Institute, ImmunoGen, Inc., Merck Sharp & Dohme LLC
Endometrial Cancer
06/24
05/27
NCT03832361: Evaluation of Mirvetuximab Soravtansine (IMGN853) in Women With Folate Receptor-α Positive Endometrial Cancer

Recruiting
2
50
US
IMGN853, mirvetuximab soravtansine
Alessandro Santin, ImmunoGen, Inc.
Endometrial Cancer
10/25
10/28
MIROVA, NCT04274426 / 2018-004207-39: Mirvetuximab Soravtansine (IMGN853), in Folate Receptor Alpha (FRα) High Recurrent Ovarian Cancer

Active, not recruiting
2
136
Europe
Carboplatin, Pegylated liposomal doxorubicin (PLD), Gemcitabine, Paclitaxel, Mirvetuximab Soravtansine
AGO Research GmbH, ImmunoGen, Inc.
Recurrent Epithelial Ovarian, Fallopian or Peritoneal Carcinoma
12/25
12/26
PICCOLO, NCT05041257: Mirvetuximab Soravtansine Monotherapy in Platinum-Sensitive Epithelial, Peritoneal, and Fallopian Tube Cancers

Hourglass Oct 2024 - Dec 2024 : Approval for 2L+ FRα +ve PROC
Hourglass Jan 2024 - Jun 2024 : sBLA approval for ovarian cancer
Hourglass Jan 2024 - Jun 2024 : FDA action date for approval for ovarian cancer with high FRAC
Hourglass Jan 2023 - Dec 2023 : ORR data from PICCOLO trial for platinum sensitive ovarian cancer
Completed
2
79
Europe, Canada, US, RoW
Mirvetuximab soravtansine, MIRV, IMGN853
AbbVie
Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
01/24
12/24
NCT05456685: Mirvetuximab Soravtansine (MIRV) With Carboplatin in Second-line Treatment of Folate Receptor Alpha (FRα) Expressing, Platinum-sensitive Epithelial Ovarian Cancer

Checkmark Data from trial in combination with carboplatin for platinum-sensitive epithelial ovarian cancer at IGCS 2022
Sep 2022 - Oct 2022: Data from trial in combination with carboplatin for platinum-sensitive epithelial ovarian cancer at IGCS 2022
Active, not recruiting
2
125
Europe, Canada, US, RoW
Mirvetuximab soravtansine, MIRV, IGN853, Carboplatin
AbbVie
High Grade Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer
05/26
05/26
NCT06365853: A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression

Recruiting
2
100
Europe, Canada, US, RoW
Mirvetuximab Soravtansine, IMGN853, MIRV, Lubricating Eye Drops, Prednisolone acetate ophthalmic suspension 1% eye drops, Brimonidine tartrate ophthalmic solution eye drops
AbbVie
Recurrent Ovarian Cancer, Folate Receptor-Alpha Positive
06/26
06/27
NCT06890338: A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.

Not yet recruiting
2
140
NA
Carboplatin, Mirvetuximab Soravtansine, MIRV, IMGN853, ELAHERE™
AbbVie
Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer, Neoadjuvant
10/29
10/29
NCT05887609: An Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib

Recruiting
2
53
US
Mirvetuximab Soravtansine, IMGN853, MIRV, Olaparib
University of Colorado, Denver, ImmunoGen, Inc.
Ovary Cancer, Peritoneal Cancer, Fallopian Tube Cancer
04/26
12/27
NCT04606914: Study of Carboplatin and Mirvetuximab Soravtansine in First-Line Treatment of Patients Receiving Neoadjuvant Chemotherapy with Advanced-Stage Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Recruiting
2
70
US
mirvetuximab soravtansine (MIRV; IMGN853)
University of Alabama at Birmingham
Ovarian Cancer, Fallopian Tube, Primary Peritoneal Cancer
05/26
05/28
TAK-853-1501, NCT06390995: A Study of TAK-853 in Adult Participants With Folate Receptor Alpha-Positive Advanced Ovarian Cancer And Other Solid Tumors

Recruiting
1/2
25
Japan
TAK-853, Mirvetuximab Soravtansine
Takeda
Ovarian Cancer, Solid Tumors
09/25
09/26
NCI-2018-00438, NCT03552471: Mirvetuximab Soravtansine and Rucaparib Camsylate in Treating Participants with Recurrent Endometrial, Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Completed
1
25
US
Laboratory Biomarker Analysis, Mirvetuximab Soravtansine, IMGN853, M9346A-sulfo-SPDB-DM4, Pharmacokinetic Study, PHARMACOKINETIC, PK Study, Rucaparib Camsylate, 8-Fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonic Acid Salt, C0-338, Rubraca, Rucaparib Phosphate
Ohio State University Comprehensive Cancer Center, ImmunoGen, Inc., Clovis Oncology, Inc.
BRCA1 Gene Mutation, BRCA2 Gene Mutation, Folate Receptor Alpha Positive, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma, Recurrent Uterine Corpus Carcinoma, Recurrent Uterine Serous Carcinoma, Recurrent Uterine Carcinosarcoma, Platinum Resistant Ovarian Cancer
06/22
12/22
NCI-2016-01913, NCT02996825: Mirvetuximab Soravtansine and Gemcitabine Hydrochloride in Treating Patients With FRalpha-Positive Recurrent Ovarian, Primary Peritoneal, Fallopian Tube, Endometrial, or Triple Negative Breast Cancer

Completed
1
44
US
Gemcitabine, dFdC, dFdCyd, Difluorodeoxycytidine, Gemcitabine Hydrochloride, Difluorodeoxycytidine Hydrochloride, FF 10832, FF-10832, FF10832, Gemcitabine HCI, Gemzar, LY-188011, LY188011, Laboratory Biomarker Analysis, Mirvetuximab Soravtansine, IMGN853, M9346A-sulfo-SPDB-DM4, Pharmacological Study
City of Hope Medical Center, National Cancer Institute (NCI)
Recurrent Breast Carcinoma, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma, Recurrent Uterine Corpus Carcinoma, Triple-Negative Breast Carcinoma
02/24
02/24
SL03-OHD-105, NCT05483933: Phase 1b Study of SL-172154 Administered with Combination Agent(s) in Subjects with Ovarian Cancers

Completed
1
86
Europe, Canada, US
Pegylated Liposomal Doxorubicin + SL-172154, Doxil, PLD, Caelyx, Mirvetuximab + SL-172154, IMGN853, MIRV
Shattuck Labs, Inc.
Platinum-resistant Ovarian Cancer, Fallopian Tube Cancer, Epithelial Ovarian Cancer, Ovarian Cancer, Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma, Primary Peritoneal Carcinoma
02/25
02/25
ChiCTR2400088269: A real-world study evaluating the safety and efficacy of Mirvetuximab Soravtansine (MIRV) in platinum-resistant ovarian, primary peritoneal, or fallopian tube cancer with high folate receptor alpha expression

Recruiting
N/A
50
 
None
Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital Hainan Hospital; Hangzhou ZhongMei Huadong Pharmaceutical Co., Ltd., Hangzhou ZhongMei Huadong Pharmaceutical Co., Ltd.
High expression of folate receptor alpha in platinum-resistant advanced high-grade ovarian, primary peritoneal, or fallopian tube cancer
 
 
cendakimab (CC-93538) / AbbVie, BMS
NCT05214768: A Study to Evaluate the Efficacy and Safety of CC-93538 in Adult and Adolescent Japanese Participants With Eosinophilic Gastroenteritis

Active, not recruiting
3
48
Japan
CC-93538, Cendakimab, BMS-986355, Placebo
Celgene
Eosinophilic Gastroenteritis
07/24
09/25
NCT04753697 / 2020-004336-16: A Study to Evaluate the Efficacy and Safety of CC-93538 in Adult and Adolescent Participants With Eosinophilic Esophagitis

Hourglass Jul 2024 - Dec 2024 : Data readout from CC-93538-EE-001 trial for EoE
Completed
3
430
Europe, Canada, Japan, US, RoW
CC-93538, RPC4046, Placebo
Celgene
Eosinophilic Esophagitis
01/24
08/24
NCT04991935 / 2020-004335-24: Safety Study of CC-93538 in Adult and Adolescent Participants With Eosinophilic Esophagitis

Active, not recruiting
3
259
Europe, Canada, Japan, US, RoW
CC-93538, BMS-986355, cendakimab
Celgene
Eosinophilic Esophagitis
06/26
09/26
2020-005212-22: The purpose of this study is to see if CC-93538 is safe and effective as a possible treatment for moderate to severe Atopic Dermatitis. Multicentrické globální, randomizované, dvojitě zaslepené, placebem kontrolované klinické hodnocení fáze 2 s paralelními skupinami hodnotící bezpečnost a snášenlivost cendakimabu (CC-93538) u dospělých pacientů se středně těžkou až těžkou atopickou dermatitidou

Not yet recruiting
2
200
RoW
Cendakimab, CC-93538, Solution for injection/infusion in pre-filled syringe
Celgene International II Sàrl, Celgene Corporation
ATOPIC DERMATITIS, Atopic dermatitis (AD) is a common and chronic inflammatory skin disorder that affects a broad demographic, with an increasing prevalence worldwide., Diseases [C] - Skin and Connective Tissue Diseases [C17]
 
 
RN Immuno-1: RPC4046 in healthy and asthma patients

Completed
1
0
RestOfWorld
RPC4046
Receptos
Other Inflammatory Diseases / Healthy Sub.; Asthma
 
 
NCT05337345: A Study to Evaluate the Drug Levels of Cendakimab Delivered Subcutaneously in Healthy Participants

Completed
1
104
US
Cendakimab, CC-93538, BMS-986355, RPC4046
Bristol-Myers Squibb
Healthy Volunteers
12/22
12/22
NCT05638282: A Study to Evaluate the Safety and Tolerability of Cendakimab in Chinese Healthy Participants

Completed
1
25
RoW
Cendakimab, CC-93538, BMS-986355, RPC4046, Placebo
Bristol-Myers Squibb
Healthy Participants
06/23
06/23
NCT05175352: A Study Evaluating Potential Disease-Mediated Drug-Drug Interaction in Adult Participants With Active Eosinophilic Esophagitis Receiving Cendakimab

Completed
1
16
US
Cendakimab, CC-93538, BMS-986355, CYP substrates
Celgene
Eosinophilic Esophagitis
10/24
10/24
Exviera (dasabuvir) / AbbVie
2016-003607-59: An Open-Label Study to Evaluate Long-Term Results With Ombitasvir-Paritaprevir-Ritonavir and Dasabuvir With or Without Ribavirin (RBV) on ovarian function in fertile women With Genotype 1 and 4 Chronic Hepatitis C Virus (HCV) Infection. Studio in aperto per valutare i risultati a lungo termine con Ombitasvir-paritaprevir-Ritonavir e Dasabuvir, con o senza ribavirina (RBV) sulla funzione ovarica delle donne in et¿ fertile con epatite cronica HCV-positiva, genotipo 1 e 4 .

Not yet recruiting
4
50
Europe
VIEKIRAX, EXVIERA, 043841, Film-coated tablet, VIEKIRAX - 12,5MG/75MG/50MG COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PVC/PE/PCTFE/ALU) - 56 COMPRESSE (CONFEZIONE MULTIPLA), EXVIERA - 250 MG COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PVC/PE/PCTFE/ALU) - 56 COMPRESSE (CONFEZIONE MULTIPLA)
DIPARTIMENTO AD ATTIVITà INTEGRATA CHIRURGICO, MEDICO, ODONTOIATRICO E DI SCIENZE MORFOLOGICHE, ABBVIE SRL
Genotype 1 and 4 Chronic Hepatitis C Virus (HCV) Infection Epatite cronica HCV-positiva, genotipo 1 e 4, Hepatitis C EPATITE C, Diseases [C] - Virus Diseases [C02]
 
 
NCT02460133: Understanding HCV Reinfection Rates in an Incarcerated Population After Cure With Interferon Free HCV Treatment

Active, not recruiting
4
44
NA
Paritaprevir, Ritonavir, Dasabuvir, Ombitasvir, Ribavirin
Nova Scotia Health Authority, Provincial Correction Centre (PEI)
Hepatitis C Virus
10/25
10/25
2014-002962-57: Hepatitis C meggyógyítása, cryoglobunaemia és szövödményeinek (vaculitis, neuritis) megszüntetése

Ongoing
3
1
Europe
ABT-450/r/ABT-267; ABT333
Egyesített Szent István és Szent László Kórház - Rendelőintézet
 
 
2014-004111-37: Individual Patient Access to AbbVie ABT-450/rítonavir/ABT-267 and ABT333 Coadministered witb Ribavirín (RBV) in Patient with Genotype 1 Hepatitis C VírusInfection witb Cirrhosis

Ongoing
3
1
Europe
ABT-450/r/ABT-267+ABT-333
BUDAI HEPATOLÓGIAI CENTRUM
 
 
2014-004268-38: Individual Patient Access to AbbVie ABT-450/ritopnavir/ABT-267 and ABT-333 Coadministeres with ribavirin (RBV) in Adult Liver Transplant Recipient with Genotype 1 Hepatitis C Virus Infection

Ongoing
3
1
Europe
ABT-450/ritonavir/ABT-267, ABT-333,
Semmelweis Egyetem Transzplantációs és Sebészeti Klinika
 
 
2015-005004-28: Stratified Treatment OPtimisation for HCV-1 (STOPHCV-1)

Ongoing
2
408
Europe
Viekirax, Exviera (Dasabuvir), Harvoni, Ribavirin (film-coated 200mg), Ribavirin (hard capsule, 200mg), Ribavirin (film-coated, 400mg), Maviret, Film-coated tablet, , Viekirax, Exviera (Dasabuvir), Harvoni, Maviret
Imperial College London, NIHR Efficacy and Mechanism Evaluation Programme
Hepatitis C Infection (HCV) (genotype 1a/1b/4), Hepatitis C infection, Diseases [C] - Virus Diseases [C02]
 
 
C-DIAMOND, NCT04952207: Effectiveness and Safety of Direct-Acting Antiviral Agents for the Treatment of Chronic Hepatitis C

Recruiting
N/A
300
RoW
Direct-acting antiviral agents, daclatasvir, asunaprevir, ombitasvir, paritaprevir, dasabuvir, sofosbuvir, velpatasvir, ledipasvir, elbasvir, grazoprevir, danoprevir, glecaprevir, pibrentasvir, voxilaprevir
Qing XIe, Gilead Sciences, Tigermed Consulting Co., Ltd
Hepatitis C, Chronic
07/21
08/21
Imbruvica (ibrutinib) / AbbVie, J&J
ChiCTR2100053513: Prospective, controlled, multicenter real-world clinical study of zanubrutinib versus ibrutinib in maintenance monotherapy for chronic lymphocytic leukemia/small cell lymphoma and mantle cell lymphoma

Recruiting
4
210
 
Zanubrutinib ;Ibrutinib ;Initial maintenance therapy with ibrutinib and then switched to zanubrutinib due to intolerance or voluntary
The Second Affiliated Hospital of Nanchang University; The Second Affiliated Hospital of Nanchang University, self-funded
Chronic lymphocytic leukemia/small cell lymphoma and mantle cell lymphoma
 
 
NCT03190330: A Study to Assess Safety of ImbruvicaTM in Indian Participants With Chronic Lymphocytic Leukemia or Mantle Cell Lymphoma Who Have Received at Least One Prior Therapy or Chronic Lymphocytic Leukemia With 17p Deletion

Completed
4
75
RoW
Ibrutinib 420 mg, Imbruvica, Ibrutinib 560 mg
Johnson & Johnson Private Limited
Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Mantle-Cell
05/23
05/23
ChiCTR2000041420: A randomized, open label, multicenter study of ibotinib monotherapy versus ibotinib combined with nitrogen mustard in the first-line treatment of chronic lymphocytic leukemia / small lymphocytic lymphoma

Recruiting
4
300
 
Ibrutinib monotherapy ;Ibrutinib plus chlorambucil
Ruijin Hospital Shanghai Jiaotong University School of Medicine; Ruijin Hospital Shanghai Jiaotong University School of Medicine, Investigator-sponsored
Chronic lymphocytic leukemia/small lymphocytic lymphoma
 
 
NCT04042376: A Study of Ibrutinib (PCI-32765) in Chinese Participants With Relapse or Refractory Waldenstrom's Macroglobulinemia (WM)

Completed
4
17
RoW
Ibrutinib, JNJ-54179060, PCI-32765
Janssen Research & Development, LLC
Waldenstrom Macroglobulinemia
03/24
03/24
ChiCTR2000038447: Clinical study of ibrutinib combined with pirfenidone in the treatment of bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation

Not yet recruiting
4
15
 
Ibutenib and pirfenidone
Sichuan Provincial People's Hospital, Affliated Hospital of University of Electronic Science and Technology of China; Sichuan Provincial People's Hospital, Affliated Hospital of University of Electronic Science and Technology of China, self-raised
bronchiolitis obliterans syndrome
 
 
NCT03229200 / 2016-004356-30: Extended Treatment Protocol for Subjects Continuing to Benefit From Ibrutinib.

Enrolling by invitation
4
600
Europe, Canada, US, RoW
Ibrutinib
Pharmacyclics Switzerland GmbH, Janssen Biotech, Inc., including Johnson & Johnson
Lymphoma, B-Cell, Lymphoma, Non-Hodgkin, Leukemia, B-cell, Graft Vs Host Disease, Solid Tumor
05/27
05/27
2014-001363-12: Autologous Transplantation after a Rituximab/Ibrutinib/Ara-c containing iNduction in Generalized mantle cell Lymphoma – a randomized European MCL Network trial

Ongoing
3
870
Europe, RoW
Ibrutinib, PCI-32765, Capsule, hard, Imbruvica
Klinikum der Universität München, Medizinische Klinik und Poliklinik III, HOVON Foundation, KroHem, Janssen Pharmaceutica NV, Skåne University Hospital, Department of Oncology, Dutch Cancer Society
Generalized mantle cell Lymphoma, Generalized mantle cell Lymphoma, Diseases [C] - Blood and lymphatic diseases [C15]
 
 
ALLIANCE A041202, NCT01886872: Rituximab and Bendamustine Hydrochloride, Rituximab and Ibrutinib, or Ibrutinib Alone in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia

Checkmark Ibrutinib + Rituxan for 1L CLL
Dec 2018 - Dec 2018: Ibrutinib + Rituxan for 1L CLL
Active, not recruiting
3
547
Canada, US
Bendamustine Hydrochloride, Belrapzo, Bendamustin Hydrochloride, Bendeka, CEP 18083, CEP-18083, CEP18083, Cytostasan Hydrochloride, Levact, Ribomustin, SyB L-0501, Treakisym, Treanda, VIVIMUSTA, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy, Biopsy of Bone Marrow, Biopsy, Bone Marrow, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Ibrutinib, BTK Inhibitor PCI-32765, CRA 032765, CRA-032765, CRA032765, Imbruvica, PCI 32765, PCI-32765, PCI32765, Laboratory Biomarker Analysis, Quality-of-Life Assessment, Quality of Life Assessment, Rituximab, ABP 798, ABP-798, ABP798, BI 695500, BI-695500, BI695500, Blitzima, C2B8 Monoclonal Antibody, Chimeric Anti-CD20 Antibody, CT P10, CT-P10, CTP10, GP 2013, GP-2013, GP2013, IDEC 102, IDEC-102, IDEC-C2B8, IDEC-C2B8 Monoclonal Antibody, IDEC102, Ikgdar, Mabtas, MabThera, Monoclonal Antibody IDEC-C2B8, PF 05280586, PF-05280586, PF05280586, Riabni, Ritemvia, Rituxan, Rituximab ABBS, Rituximab ARRX, Rituximab Biosimilar ABP 798, Rituximab Biosimilar BI 695500, Rituximab Biosimilar CT-P10, Rituximab Biosimilar GB241, Rituximab Biosimilar GP2013, Rituximab Biosimilar IBI301, Rituximab Biosimilar JHL1101, Rituximab Biosimilar PF-05280586, Rituximab Biosimilar RTXM83, Rituximab Biosimilar SAIT101, Rituximab Biosimilar SIBP-02, rituximab biosimilar TQB2303, Rituximab PVVR, Rituximab-abbs, Rituximab-arrx, Rituximab-blit, Rituximab-pvvr, Rituximab-rite, Rituximab-rixa, Rituximab-rixi, Rixathon, Riximyo, RTXM 83, RTXM-83, RTXM83, Ruxience, Truxima
National Cancer Institute (NCI)
Stage I Chronic Lymphocytic Leukemia, Stage II Chronic Lymphocytic Leukemia, Stage III Chronic Lymphocytic Leukemia, Stage IV Chronic Lymphocytic Leukemia
08/18
04/26
ECOG-ACRIN E1912, NCT02048813: Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Checkmark Approved in combination with rituximab for CLL
Jan 2021 - Jan 2021: Approved in combination with rituximab for CLL
Checkmark CHMP Positive opinion in combination with rituximab or obinutuzumab for previously untreated CLL
Oct 2020 - Oct 2020: CHMP Positive opinion in combination with rituximab or obinutuzumab for previously untreated CLL
Checkmark Positive CHMP opinion in combination with rituximab for the treatment of 1L CLL
More
Active, not recruiting
3
529
US
Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B 518, B-518, B518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR 138719, WR- 138719, WR-138719, WR138719, Fludarabine Phosphate, 2-F-ara-AMP, 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-, Beneflur, Fludara, SH T 586, Ibrutinib, BTK Inhibitor PCI-32765, CRA 032765, CRA-032765, CRA032765, Imbruvica, PCI 32765, PCI-32765, PCI32765, Laboratory Biomarker Analysis, Pharmacogenomic Study, PHARMACOGENOMIC, Quality-of-Life Assessment, Quality of Life Assessment, Rituximab, ABP 798, ABP-798, ABP798, BI 695500, BI-695500, BI695500, Blitzima, C2B8 Monoclonal Antibody, Chimeric Anti-CD20 Antibody, CT P10, CT-P10, CTP10, GP 2013, GP-2013, GP2013, IDEC 102, IDEC-102, IDEC-C2B8, IDEC-C2B8 Monoclonal Antibody, IDEC102, Ikgdar, Mabtas, MabThera, Monoclonal Antibody IDEC-C2B8, PF 05280586, PF-05280586, PF05280586, Riabni, Ritemvia, Rituxan, Rituximab ABBS, Rituximab ARRX, Rituximab Biosimilar ABP 798, Rituximab Biosimilar BI 695500, Rituximab Biosimilar CT-P10, Rituximab Biosimilar GB241, Rituximab Biosimilar GP2013, Rituximab Biosimilar IBI301, Rituximab Biosimilar JHL1101, Rituximab Biosimilar PF-05280586, Rituximab Biosimilar RTXM83, Rituximab Biosimilar SAIT101, Rituximab Biosimilar SIBP-02, rituximab biosimilar TQB2303, Rituximab PVVR, Rituximab-abbs, Rituximab-arrx, Rituximab-blit, Rituximab-pvvr, Rituximab-rite, Rituximab-rixa, Rituximab-rixi, Rixathon, Riximyo, RTXM 83, RTXM-83, RTXM83, Ruxience, Truxima
National Cancer Institute (NCI)
Anemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
10/18
01/26
NCT02414022: Economic Analysis of Alliance A041202 CLL Study

Checkmark Presentation of data from Alliance A041202 CLL study for CLL at ASH 2018
Dec 2018 - Dec 2018: Presentation of data from Alliance A041202 CLL study for CLL at ASH 2018
Active, not recruiting
3
55
Canada
Canadian Cancer Trials Group
Chronic Lymphocytic Leukemia
04/19
01/26
REACH3, NCT03112603 / 2016-004432-38: A Study of Ruxolitinib vs Best Available Therapy (BAT) in Patients With Steroid-refractory Chronic Graft vs. Host Disease (GvHD) After Bone Marrow Transplantation

Checkmark Approved in Korea for acute or chronic GvHD patients aged 12 years and older
May 2022 - May 2022: Approved in Korea for acute or chronic GvHD patients aged 12 years and older
Checkmark CHMP issued a positive opinion for acute or chronic GvHD patients aged 12 years and older
Mar 2022 - Mar 2022: CHMP issued a positive opinion for acute or chronic GvHD patients aged 12 years and older
Checkmark Approved in US for SR-cGVHD
More
Completed
3
330
Europe, Canada, Japan, US, RoW
Ruxolitinib, Jakafi, INCB018424, Extracorporeal photopheresis (ECP), Low-dose methotrexate (MTX), Mycophenolate mofetil (MMF), mechanistic Target of Rapamycin (mTOR) inhibitors (everolimus or sirolimus), Infliximab, Rituximab, Pentostatin, Imatinib, Ibrutinib
Incyte Corporation
Graft-versus-host Disease (GVHD)
05/20
12/22
ELEVATE-RR, NCT02477696 / 2014-005530-64: Study of Acalabrutinib (ACP-196) Versus Ibrutinib in Previously Treated Participants With High Risk Chronic Lymphocytic Leukemia (CLL)

Checkmark Presentation of data from ELEVATE-RR trial in r/r CLL at ASH 2022
Nov 2022 - Nov 2022: Presentation of data from ELEVATE-RR trial in r/r CLL at ASH 2022
Checkmark From ELEVATE-RR trial in r/r CLL at ASH 2021
Dec 2021 - Dec 2021: From ELEVATE-RR trial in r/r CLL at ASH 2021
Checkmark From ELEVATE-RR trial in combination with Ibrutinib for previously Treated Patients With CLL
More
Active, not recruiting
3
533
Europe, US, RoW
Acalabrutinib, ACP-196, Ibrutinib
Acerta Pharma BV
Chronic Lymphocytic Leukemia
09/20
01/28
GLOW, NCT03462719 / 2017-004699-77: A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Checkmark Data from GLOW trial in combination with Venclexta for CLL at ASH 2022
Dec 2022 - Dec 2022: Data from GLOW trial in combination with Venclexta for CLL at ASH 2022
Checkmark New data from the P3 GLOW study in combination with ibrutinib in 1L CLL/SLL at ASH 2022
Dec 2022 - Dec 2022: New data from the P3 GLOW study in combination with ibrutinib in 1L CLL/SLL at ASH 2022
Checkmark CHMP positive opinion in a fixed-duration combination regimen venetoclax for adult patients with 1L CLL
More
Active, not recruiting
3
211
Europe, Canada, US, RoW
Ibrutinib, Venetoclax, Chlorambucil, Obinutuzumab, Ibrutinib (as Subsequent Therapy)
Janssen Research & Development, LLC, Pharmacyclics LLC.
Leukemia, Lymphocytic, Chronic, B-Cell
02/21
04/29
TRIANGLE, NCT02858258: ASCT After a Rituximab/Ibrutinib/Ara-c Containing iNduction in Generalized Mantle Cell Lymphoma

Hourglass May 2019 - Dec 2023 : Regulatory submission in EU for front line maintenance MCL
Recruiting
3
870
Europe
R-CHOP/R-DHAP, rituximab, CHOP, DHAP, Ibrutinib (Induction), Imbruvica, ASCT conditioning, THAM or BEAM, Ibrutinib (Maintenance)
Prof. Dr. M. Dreyling (co-chairman), LMU Klinikum
Mantle Cell Lymphoma
05/21
05/26
SHINE , NCT01776840 / 2012-004056-11: A Study of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib Given in Combination With Bendamustine and Rituximab in Patients With Newly Diagnosed Mantle Cell Lymphoma

Checkmark J&J withdrawn marketing authorization application for Imbruvica in combination with bendamustine and rituximab for 1L MCL based on SHINE study
Dec 2022 - Dec 2022: J&J withdrawn marketing authorization application for Imbruvica in combination with bendamustine and rituximab for 1L MCL based on SHINE study
Checkmark Data from SHINE trial in 1L MCL at ASCO 2022
Jun 2022 - Jun 2022: Data from SHINE trial in 1L MCL at ASCO 2022
Checkmark Regulatory submission in EU for 1L MCL (based on SHINE trial)
More
Completed
3
523
Europe, Canada, Japan, US, RoW
Bendamustine, Rituximab, Ibrutinib, Placebo
Janssen Research & Development, LLC, Pharmacyclics LLC.
Mantle Cell Lymphoma
06/21
06/24
2020-004553-72: A clinical study to assess the effectiveness and safety of LOXO-305 compared to standard of care treatment chosen by the Investigator in patients with previously treated Mantle Cell Lymphoma

Not yet recruiting
3
500
Europe, RoW
pirtobrutinib, Ibrutinib, [na], [LOXO-305], Film-coated tablet, Tablet, IMBRUVICA
Loxo Oncology, Inc., a wholly owned subsidiary of Eli Lilly and Company, LOXO ONCOLOGY INCORPORATED, Loxo Oncology, Inc., a wholly owned subsidiary of Eli Lilly and Company, Loxo Oncology Inc
Mantle cell lymphoma, a cancer of white blood cells (developing in a certain part of the lymph node), which help the body fight infections, Diseases [C] - Cancer [C04]
 
 
SELENE , NCT01974440 / 2013-003093-27: A Study of PCI-32765 (Ibrutinib) in Combination With Either Bendamustine and Rituximab or Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Participants With Previously Treated Indolent Non-Hodgkin Lymphoma

Hourglass Jul 2022 - Dec 2022 : Data from SELENE trial for follicular lymphoma/MZL
Completed
3
403
Europe, Japan, US, RoW
Bendamustine, Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisone, PCI-32765 (Ibrutinib), Placebo
Janssen Research & Development, LLC, Pharmacyclics LLC.
Lymphoma
05/22
06/23
2021-003206-41: A Phase 3 Study Comparing Pirtobrutinib to Ibrutinib in CLL/SLL

Ongoing
3
650
Europe
Pirtobrutinib, Ibrutinib, LOXO-305, Tablet, Capsule, hard, IMBRUVICA
Loxo Oncology, Inc., Loxo Oncology, Inc.
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma krónikus limfocitás leukémia / kis limfocitás limfóma, Chronic lymphocytic leukaemia/Small Lymphocytic Lymphoma is a type of cancer that affects the white blood cells and tends to progress slowly over many years, Diseases [C] - Cancer [C04]
 
 
ALPINE, NCT03734016 / 2018-001366-42: A Study of Zanubrutinib (BGB-3111) Versus Ibrutinib in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia

Checkmark Approved for the treatment of patients with CLL or SLL based on data from ALPINE and SEQUOIA trials
Jan 2023 - Jan 2023: Approved for the treatment of patients with CLL or SLL based on data from ALPINE and SEQUOIA trials
Checkmark Data from ALPINE trial for CLL at ASH 2022
Dec 2022 - Dec 2022: Data from ALPINE trial for CLL at ASH 2022
Checkmark FDA approval
More
Completed
3
652
Europe, US, RoW
Zanubrutinib, BGB-3111, Brukinsa, Ibrutinib, Imbruvica
BeiGene
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
08/22
02/24
2022-001547-25: A Phase 3 study of Zilovertamab in addition to Ibrutinib in Subjects with Relapsed or Refractory Mantle Cell Lymphoma Estudio en fase III de zilovertamab en combinación con ibrutinib en pacientes con linfoma de células del manto recidivante o resistente

Ongoing
3
365
Europe
Zilovertamab, Ibrutinib, Zilovertamab, PCI-32765, Solution for infusion, Capsule, hard
Oncternal Therapeutics, Inc, Oncternal Therapeutics, Inc
Relapsed or Refractory Mantle Cell Lymphoma Linfoma de células del manto recidivante o resistente, Mantle Cell Lymphoma Linfoma de células del manto, Diseases [C] - Cancer [C04]
 
 
NCT01724346 / 2012-003968-44: Open-label Extension Study in Patients 65 Years or Older With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Completed
3
269
Europe, Canada, US, RoW
Ibrutinib, PCI-32765, Next-line ibrutinib
Pharmacyclics LLC., Janssen Research & Development, LLC
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
08/23
08/23
BELLWAVE-011, NCT06136559: A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/)

Recruiting
3
1200
Europe, Canada, Japan, US, RoW
Nemtabrutinib, MK-1026, ARQ 531, Ibrutinib, Acalabrutinib
Merck Sharp & Dohme LLC
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
09/32
09/32
GAIA, NCT02950051 / 2015-004936-36: Standard Chemoimmunotherapy (FCR/BR) Versus Rituximab + Venetoclax (RVe) Versus Obinutuzumab (GA101) + Venetoclax (GVe) Versus Obinutuzumab + Ibrutinib + Venetoclax (GIVe) in Fit Patients with Previously Untreated Chronic Lymphocytic Leukemia (CLL) Without Del(17p) or TP53 Mutation

Hourglass Jan 2021 - Dec 2021 : From CLL13 trial in combination with Venclexta for 1L CLL
Completed
3
926
Europe, RoW
Fludarabine, Fludura, Cyclophosphamide, Endoxan, Rituximab, MabThera, Rituxan, Bendamustine, Ribomustin, Levact, Venetoclax, Venclexta, Venclyxto, Obinutuzumab, Gazyva, Gazyvaro, Ibrutinib, Imbruvica
German CLL Study Group, Janssen-Cilag Ltd., Hoffmann-La Roche, AbbVie, Stichting Hemato-Oncologie voor Volwassenen Nederland, Nordic CLL Study Group (NCLLSG), Swiss Group for Clinical Cancer Research, Cancer Trials Ireland, Israeli CLL Study Group
Chronic Lymphocytic Leukemia
02/24
02/24
NCT02443077: Ibrutinib Before and After Stem Cell Transplant in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma

Active, not recruiting
3
92
US, RoW
Autologous Bone Marrow Transplantation, ABMT, Autologous Blood and Marrow Transplantation, Autologous Bone Marrow Transplant, Autologous Marrow Transplantation, Autologous Hematopoietic Stem Cell Transplantation, AHSCT, Autologous, Autologous Hematopoietic Cell Transplantation, Autologous Stem Cell Transplant, Autologous Stem Cell Transplantation, Stem Cell Transplantation, Autologous, Carmustine, BCNU, Becenum, Becenun, BiCNU, Bis(chloroethyl) Nitrosourea, Bis-Chloronitrosourea, Carmubris, Carmustin, Carmustinum, FDA 0345, N,N'-Bis(2-chloroethyl)-N-nitrosourea, Nitrourean, Nitrumon, NSC 409962, NSC409962, SK 27702, SRI 1720, WR 139021, WR-139021, WR139021, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B 518, B-518, B518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR 138719, WR- 138719, WR-138719, WR138719, Cytarabine, .beta.-Cytosine arabinoside, 1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone, 1-.beta.-D-Arabinofuranosylcytosine, 1-Beta-D-arabinofuranosyl-4-amino-2(1H)pyrimidinone, 1-Beta-D-arabinofuranosylcytosine, 1.beta.-D-Arabinofuranosylcytosine, 2(1H)-Pyrimidinone, 4-Amino-1-beta-D-arabinofuranosyl-, 2(1H)-Pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl-, Alexan, Ara-C, ARA-cell, Arabine, Arabinofuranosylcytosine, Arabinosylcytosine, Aracytidine, Aracytin, Aracytine, Beta-Cytosine Arabinoside, CHX-3311, Cytarabinum, Cytarbel, Cytosar, Cytosine Arabinoside, Cytosine-.beta.-arabinoside, Cytosine-beta-arabinoside, Erpalfa, Starasid, Tarabine PFS, U 19920, U-19920, Udicil, WR-28453, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP 16213, VP-16, VP-16-213, VP-16213, VP16, VP16213, Ibrutinib, BTK Inhibitor PCI-32765, CRA 032765, CRA-032765, CRA032765, Imbruvica, PCI 32765, PCI-32765, PCI32765, Laboratory Biomarker Analysis, Melphalan, Alanine Nitrogen Mustard, CB-3025, L-PAM, L-Phenylalanine Mustard, L-Sarcolysin, L-Sarcolysin Phenylalanine mustard, L-Sarcolysine, Melphalan for Injection-Hepatic Delivery System, Melphalanum, Phenylalanine Mustard, Phenylalanine Nitrogen Mustard, Sarcoclorin, Sarkolysin, WR-19813, Pharmacogenomic Study, PHARMACOGENOMIC, Placebo Administration
National Cancer Institute (NCI)
Recurrent Diffuse Large B-Cell Lymphoma Activated B-Cell Type, Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell Type
06/24
12/25
NCT04212013: A Study of Ibrutinib With Rituximab in People With Untreated Marginal Zone Lymphoma

Active, not recruiting
3
23
US
Ibrutinib, Rituximab, Placebo
Memorial Sloan Kettering Cancer Center, Pharmacyclics LLC.
Marginal Zone Lymphoma
03/27
03/27
SYMPATICO, NCT03112174 / 2017-000129-12: Study of Ibrutinib Combined With Venetoclax in Subjects With Mantle Cell Lymphoma

Jan 2023 - Dec 2023: Data from SYMPATICO trial in combination with Venclexta for r/r MCL
Completed
3
352
Europe, Canada, US, RoW
Ibrutinib, Venetoclax, Placebo Oral tablet to match Venetoclax
Pharmacyclics LLC., Janssen Research & Development, LLC
Mantle-Cell Lymphoma
06/24
06/24
BRUIN-MCL-321, NCT04662255 / 2020-004553-72: Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)

Active, not recruiting
3
500
Europe, Canada, Japan, US, RoW
Pirtobrutinib, LOXO-305, LY3527727, Ibrutinib, Imbruvica, Acalabrutinib, Calquence, Zanubrutinib, Brukinsa
Loxo Oncology, Inc., Eli Lilly and Company
Lymphoma, Mantle-Cell
01/27
04/28
NCT06821542: A Study to Evaluate Axatilimab Versus Best Available Therapy in Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy

Recruiting
3
300
Europe, RoW
INCA034176, Axatilimab, Best Available Therapy (BAT), BAT could include:, • Calcineurin inhibitor (cyclosporine or tacrolimus), • Extracorporeal photopheresis (ECP), • Mycophenolate mofetil (MMF), • A mammalian target of rapamycin (mTOR) inhibitor (everolimus or sirolimus), • Rituximab, • Pentostatin, • Proteasome inhibitors, • Imatinib, • Ibrutinib
Incyte Corporation
Chronic Graft-versus-host-disease
05/28
11/32
PERSPECTIVE, NCT02947347 / 2016-003202-14: Study of Ibrutinib and Rituximab in Treatment Naïve Follicular Lymphoma

Active, not recruiting
3
445
Europe, Canada, US, RoW
ibrutinib, Imbruvica, placebo to match ibrutinib, rituximab
Pharmacyclics LLC.
Follicular Lymphoma
02/24
06/26
NCT05431179 / 2022-001547-25: A Study of Zilovertamab and Ibrutinib in Patients With Relapsed or Refractory Mantle Cell Lymphoma

Withdrawn
3
365
NA
Zilovertamab, Cirmtuzumab, UC961, Ibrutinib, Imbruvica, Placebo
Oncternal Therapeutics, Inc, Pharmacyclics LLC.
Lymphoma, Mantle-Cell, Lymphoma, Lymphoproliferative Disorders, Lymphatic Diseases, Immunoproliferative Disorders, Immune System Diseases, Lymphoma, Non-Hodgkin, Lymphoma, B-Cell
11/26
12/26
NCT01804686 / 2012-004225-24: A Long-term Extension Study of PCI-32765 (Ibrutinib)

Recruiting
3
700
Europe, Canada, Japan, US, RoW
Ibrutinib, PCI-32765
Janssen Research & Development, LLC, Pharmacyclics LLC.
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, Follicular Lymphoma, Diffuse Large B-cell Lymphoma, Waldenstrom Macroglobulinemia, Chronic Graft Versus Host Disease
12/26
01/27
CLL17, NCT04608318 / 2019-003854-99: Ibrutinib Monotherapy Versus Fixed-duration Venetoclax Plus Obinutuzumab Versus Fixed-duration Ibrutinib Plus Venetoclax in Patients with Previously Untreated Chronic Lymphocytic Leukaemia (CLL)

Active, not recruiting
3
897
Europe, RoW
Ibrutinib, Imbruvica, Venetoclax, ABT-199, Venclyxto, Obinutuzumab, GA101, Gazyvaro
German CLL Study Group, Stichting Hemato-Oncologie voor Volwassenen Nederland (HOVON), Nordic CLL Study Group (NCLLSG), Swiss Group for Clinical Cancer Research (SAKK), Cancer Trials Ireland, Gruppo Italiano Malattie EMatologiche dell'Adulto (GIMEMA), Grupo Español de Leucemia Linfocítica Crónica (GELLC), The Israeli CLL Study Group (ICLLSG), Janssen Pharmaceutica N.V., Belgium, AbbVie, Hoffmann-La Roche
Chronic Lymphoid Leukemia
09/27
09/27
A041702, NCT03737981: Testing the Addition of a New Anti-cancer Drug, Venetoclax, to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated, Older Patients With Chronic Lymphocytic Leukemia

Active, not recruiting
3
465
US
Ibrutinib, BTK Inhibitor PCI-32765, CRA 032765, CRA-032765, CRA032765, Imbruvica, PCI 32765, PCI-32765, PCI32765, Obinutuzumab, Anti-CD20 Monoclonal Antibody R7159, GA 101, GA-101, GA101, Gazyva, huMAB(CD20), R 7159, R-7159, R7159, RO 5072759, RO-5072759, RO5072759, Observation Activity, Observation, Venetoclax, ABT 199, ABT-0199, ABT-199, ABT199, GDC 0199, GDC-0199, GDC0199, RG7601, Venclexta, Venclyxto
National Cancer Institute (NCI)
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
01/25
05/26
BRUIN-CLL-314, NCT05254743 / 2021-003206-41: A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Active, not recruiting
3
650
Europe, Canada, Japan, US, RoW
Pirtobrutinib, LOXO-305, LY3527727, Ibrutinib
Loxo Oncology, Inc., Eli Lilly and Company
Chronic Lymphocytic Leukemia, Leukemia, Lymphocytic, Leukemia, B-cell, Small Lymphocytic Lymphoma
06/25
01/28
NCT03701282: Assessing the Ability of Combination Treatment With Venetoclax to Permit Time Limited Therapy in Chronic Lymphocytic Leukemia

Active, not recruiting
3
720
US, RoW
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Biopsy, Biopsy of Bone Marrow, Biopsy, Bone Marrow, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Ibrutinib, BTK Inhibitor PCI-32765, CRA 032765, CRA-032765, CRA032765, Imbruvica, PCI 32765, PCI-32765, PCI32765, Obinutuzumab, Anti-CD20 Monoclonal Antibody R7159, GA 101, GA-101, GA101, Gazyva, huMAB(CD20), R 7159, R-7159, R7159, RO 5072759, RO-5072759, RO5072759, Quality-of-Life Assessment, Quality of Life Assessment, Venetoclax, ABT 199, ABT-0199, ABT-199, ABT199, GDC 0199, GDC-0199, GDC0199, RG7601, Venclexta, Venclyxto
National Cancer Institute (NCI)
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
05/28
05/28
2015-000832-13: Ibrutinib for untreated mantle cell lymphoma

Ongoing
2/3
400
Europe
Ibrutinib, Rituximab, Bendamustine hydrochloride, Cyclophosphamide, Doxorubicin hydrochloride, Vincristine sulphate, Prednisolone, Capsule, hard, Concentrate for solution for injection/infusion, Lyophilisate for solution for infusion, Powder for solution for infusion, Solution for infusion, Solution for injection, Tablet, Ibrutinib, doxorubicin
Plymouth Hospitals NHS Trust, Cancer Research UK, Janssen Pharmaceutica NV
Untreated symptomatic Mantle Cell Lymphoma, Untreated symptomatic Mantle Cell Lymphoma, Diseases [C] - Cancer [C04]
 
 
2019-001261-33: Study of Rituximab and Ibrutinib (RI) versus Dexamethasone, Rituximab and Cyclophosphamide (DRC) as initial therapy for Waldenström's macroglobulinaemia

Not yet recruiting
2/3
148
Europe
Ibrutinib, Rituximab, Dexamethasone, Cyclophosphamide, Capsule, hard, Concentrate for solution for infusion, , Ibrutinib, Rituximab, Dexamethasone, Cyclophosphamide
University College London
Waldenström's macroglobulinaemia, a blood cancer, Diseases [C] - Cancer [C04]
 
 
NCT03642236: Combination of BTK Inhibitor Overcomes Drug-resistance in Refractory/Relapsed FLT3 Mutant AML

Enrolling by invitation
2/3
122
RoW
Ibrutinib
Nanfang Hospital of Southern Medical University
FLT3-ITD Mutation, Acute Myeloid Leukemia, Brutons Tyrosine Kinase
08/22
09/23
2022-000364-21: A Study of Ibrutinib in Combination With Rituximab Versus Lenalidomide Plus Rituximab or Bortezomib Plus Rituximab, in Relapsed/Refractory Mantle Cell Lymphoma Estudio de ibrutinib en combinación con rituximab frente a lenalidomida más rituximab o bortezomib más rituximab para el tratamiento de linfoma de células del manto recidivante/refractario.

Completed
2/3
490
Europe, RoW
ibrutinib, JNJ-54179060, Capsule, hard, Concentrate for solution for infusion, Powder for solution for injection, IMBRUVICA, Ruxience, Lenalidomide Accord, VELCADE
Janssen-Cilag International NV, Janssen Research & Development, LLC
Relapsed or Refractory Mantle Cell Lymphoma Linfoma de células del manto recidivante o refractario, Blood Cancer Cáncer de sangre, Diseases [C] - Cancer [C04]
 
 
RAINBOW, NCT04061512: Rituximab and Ibrutinib (RI) Versus Dexamethasone, Rituximab and Cyclophosphamide (DRC) as Initial Therapy for Waldenström's Macroglobulinaemia

Recruiting
2/3
148
Europe
Dexamethasone, cyclophosphamide, rituximab, Rituximab, ibrutinib
University College, London, Janssen-Cilag Ltd.
Waldenstrom Macroglobulinemia
03/30
03/30
PS-CLL-002, NCT04754035: Clinical Study With Ibrutinib and Venetoclax for Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia

Active, not recruiting
2a
31
Europe
Venetoclax, Imbruvica Oral Product
Paolo Ghia
Chronic Lymphocytic Leukemia
07/18
09/25
12-H-0035, NCT01500733: PCI-32765 for Special Cases of Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Checkmark AACR 2016
Mar 2016 - Mar 2016: AACR 2016
Checkmark ASH 2013
Nov 2013 - Nov 2013: ASH 2013
Checkmark For CLL/SLL
More
Active, not recruiting
2
86
US
PCI 32765
National Heart, Lung, and Blood Institute (NHLBI)
Leukemia, Leukemia, Lymphocytyc, CLL (Chronic Lymphocytic Leukemia), SLL (Small Lymphocytic Lymphoma)
06/14
09/34
2015-005273-20: Multicenter phase II single arm open-label study on the feasibility, safety and efficacy of combination of CHOP-21 supplemented with Obinutuzumab and Ibrutinib in untreated young high risk Diffuse Large B-cell Lymphoma (DLBCL) patients. Studio multicentrico di fase II a braccio singolo sulla fattibilit¿, sicurezza ed efficacia della combinazione CHOP-21 con Obinutuzumab e Ibrutinib come terapia di prima linea in pazienti giovani ad alto rischio affetti da linfoma a grandi cellule B.

Not yet recruiting
2
90
Europe
Imbruvica, Ibrutinib, Concentrate for solution for infusion, Capsule, hard, GAZYVARO - 1000 MG - CONCENTRATO PER SOLUZIONE PER INFUSIONE - USO ENDOVENOSO - FLACONCINO - 1000MG/40ML - 1 FLACONCINO, IMBRUVICA - 140 MG -CAPSULE RIGIDE -USO ORALE - FLACONE (HDPE) - 1 FLACONE (90 CAPSULE RIGIDE)
FONDAZIONE ITALIANA LINFOMI ONLUS, Roche, Janssen - Cilag
Diffuse Large B-Cell lymphoma (DLBCL) Linfoma a grandi cellule B (DLBCL), Diffuse Large B-Cell lymphoma Linfoma a grandi cellule B, Diseases [C] - Blood and lymphatic diseases [C15]
 
 
2015-002855-85: A randomized study to assess the tolerability and efficacy of the addition of ibrutinib to 10-day decitabine treatment in patients with AML and high risk myelodysplasia (MDS), UNFIT for intensive chemotherapy, aged >= 66 years.

Ongoing
2
170
Europe
Decitabine, ibrutinib, Powder for concentrate for solution for infusion, Capsule, soft, Dacogen, Imbruvica
HOVON Foundation, Dutch Cancer Society, Janssen-Cilag International NV
Acute Meyloid Leukemia and High Risk Myelodysplastic syndromes, Acute Meyloid Leukemia and High Risk Myelodysplastic syndromes, Diseases [C] - Cancer [C04]
 
 
2012-003608-11: Assessing how the drug ibrutinib works in Chronic Lymphocytic Leukaeamia.

Ongoing
2
40
Europe
Ibrutinib, PCI-32765,
University of Birmingham, LLR, Pharmacyclics
Chronic Lymphocytic leukaemia
 
 
2015-005525-39: The iMYC study to assess the effectiveness and safety of ibrutinib in patients with advanced oesophagogastric cancer with c-MYC and HER2 gene amplification

Ongoing
2
17
Europe
Ibrutinib, JNJ-54179060, Capsule, Ibrutinib
The Royal Marsden NHS Foundation Trust
Her2 or cMYC positive advanced oesophagogastric carcinomas, Cancers arising from either the oesophagus or stomach that display abnormalities of 2 specific genes which are implicated in cancer development: either the Her2 gene, the cMYC gene or both., Diseases [C] - Cancer [C04]
 
 
NCT01849263: Ibrutinib in Treating Patients With Relapsed or Refractory Follicular Lymphoma

Active, not recruiting
2
41
Canada, US, RoW
Ibrutinib, BTK Inhibitor PCI-32765, CRA 032765, CRA-032765, CRA032765, Imbruvica, PCI 32765, PCI-32765, PCI32765, Laboratory Biomarker Analysis
National Cancer Institute (NCI)
Grade 3a Follicular Lymphoma, Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma, Recurrent Grade 3 Follicular Lymphoma, Refractory Follicular Lymphoma
06/16
03/26
NCT01589302: PCI-32765 (Ibrutinib) in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or B-cell Prolymphocytic Leukemia

Checkmark P1/2 data-EHA
May 2012 - May 2012: P1/2 data-EHA
Active, not recruiting
2
154
US
ibrutinib, Bruton's tyrosine kinase inhibitor PCI-32765, BTK inhibitor PCI-32765, PCI-32765, Correlative laboratory samples, laboratory biomarker anyalysis, quality of life assessment
Kami Maddocks, MD
Prolymphocytic Leukemia, Recurrent Small Lymphocytic Lymphoma, Refractory/Relapsed Chronic Lymphocytic Leukemia
07/16
06/25
2015-005454-35: An early phase study using a response based combination therapy of rituxumab and ibrutinib in patients with post-transplant lymphoproliferative disorder (PTLD)

Ongoing
2
60
Europe
Imbruvica, Rituximab, Cyclophosphamide, Doxorubicin, Prednisolone, Vincristine, Capsule, hard, Infusion, Oral solution, Imbruvica, MabThera, Myocet, Prednisolone
University of Birmingham, Bloodwise, Janssen
Post-transplant lymphoproliferative disorder, Post-transplant lymphoproliferative disorder, Diseases [C] - Cancer [C04]
 
 
NCT02989532: Ibrutinib in Treating Patients With Relapsed or Refractory Follicular Lymphoma

Active, not recruiting
2
41
US, Canada, RoW
Ibrutinib, BTK Inhibitor PCI-32765, CRA-032765, Imbruvica, PCI-32765, Laboratory Biomarker Analysis
Mayo Clinic, National Cancer Institute (NCI)
Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma, Recurrent Grade 3 Follicular Lymphoma, Refractory Follicular Lymphoma
10/16
 
NCT01981512: Study of Ibrutinib for Treatment of Relapsed Hairy Cell Leukemia

Recruiting
2
18
US
Ibrutinib
National Cancer Institute (NCI)
Hairy Cell Leukemia
05/17
05/17
2016-004707-32: Clinical trial with Ibrutinib and Venetoclax for patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Studio Clinico con Ibrutinib e Venetoclax per pazienti con Leucemia Linfatica Cronica Recidivante o Refrattaria

Ongoing
2
31
Europe
VENETOCLAX, [ABT-199], Film-coated tablet
OSPEDALE SAN RAFFAELE, Abbvie
Relapsed or Refractory Chronic Lymphocytic Leukemia Leucemia Linfatica Cronica Recidivante o Refrattaria, Chronic Lymphocytic Leukemia relapsed or refractory to previous treatments Leucemia Linfatica Cronica ricaduta o non responsiva ai trattamenti precedenti, Diseases [C] - Blood and lymphatic diseases [C15]
 
 
2016-002599-29: A trial evaluating treatment with ibrutinib plus venetoclax in patients with creatinine clearance ≥ 30 ml/min who have relapsed or refractory chronic lymphocytic leukemia (RR-CLL)

Ongoing
2
230
Europe
venetoclax 10 mg, venetoclax 50 mg, venetoclax 100 mg, ibrutinib, Tablet, Capsule, hard, Venclyxto, Imbruvica
HOVON Foundation, AbbVie, Janssen
Chronic Lymphocytic Leukemia, Chronic Lymphocytic Leukemia, Diseases [C] - Cancer [C04]
 
 
NCI9922, NCT02581930: Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanoma

Active, not recruiting
2
18
US
Ibrutinib, BTK Inhibitor PCI-32765, CRA 032765, CRA-032765, CRA032765, Imbruvica, PCI 32765, PCI-32765, PCI32765, Laboratory Biomarker Analysis, Pharmacogenomic Study, PHARMACOGENOMIC, Pharmacological Study
National Cancer Institute (NCI)
Metastatic Melanoma, Recurrent Cutaneous Melanoma, Stage IV Cutaneous Melanoma AJCC v6 and v7
02/18
03/26
NCT03427398: Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanoma

Active, not recruiting
2
18
US
Ibrutinib, BTK Inhibitor PCI-32765, CRA-032765, Imbruvica, PCI-32765, Laboratory Biomarker Analysis, Pharmacogenomic Study, PHARMACOGENOMIC, Pharmacological Study
National Cancer Institute (NCI)
Metastatic Melanoma, Recurrent Melanoma of the Skin, Stage IV Cutaneous Melanoma AJCC v6 and v7
02/18
 
2017-003256-22: Ibrutinib and Standard Immuno-Chemotherapy (R-CHOEP-14) In Younger, High-Risk Patients with Diffuse Large B-Cell Lymphoma Ibrutinib und Standard-Immunochemotherapie (R-CHOEP-14) in jungen Hochrisiko- Patienten mit diffusem großzelligem B-Zell-Lymphom

Not yet recruiting
2
40
Europe
Capsule, hard, IMBRUVICA 140 mg hard capsules
Universitätsklinikum Münster, Janssen-Cilag GmbH
diffuse large B-cell lymphoma diffuses großzelliges B-Zell-Lymphom, malignant disease of the lymphatic system bösartige Erkrankung des lymphatischen Systems, Diseases [C] - Blood and lymphatic diseases [C15]
 
 
2017-001099-49: therapy with ibrutinib for patients with Chronic lymphocytic leukemia with subclonal TP53 aberrations terapia con Ibrutinib per pazienti affetti da leucemia linfatica cronica che presentano alterazioni subclonali di TP53

Ongoing
2
185
Europe
ibrutinib, [PCI-32765], Capsule, hard
OSPEDALE SAN RAFFAELE, Janssen-Cilag International N.V., Belgium
Chronic Lymphocytic Leukemia (CLL) leucemia linfatica cronica (LLC), Chronic Lymphocytic Leukemia never treated leucemia linfatica cronica mai trattata, Diseases [C] - Cancer [C04]
 
 
GELLC-7, NCT03280160 / 2016-004937-26: Protocol Ibrutinib Followed by Ibrutinib Consolidation in Combination With Ofatumumab

Active, not recruiting
2
84
Europe
Ibrutinib 140 MG Oral Capsule [Imbruvica], Ofatumumab
PETHEMA Foundation
Chronic Lymphocytic Leukemia
07/18
09/22
ACTRN12615000551594: A Phase II Study of Ibrutinib, Rituximab and mini-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) therapy in very elderly patients with newly diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

Completed
2
80
 
Australasian Leukaemia and Lymphoma Group, Janssen-Cilag Pty Ltd
elderly DLBCL
 
 
2017-005137-23: Ibrutinib in combination to rituximab-CHOP followed by ibrutinib maintenance in untreated patients with (ABC) DLBCLat intermediate-high and high risk Terapia R-CHOP in combinazione con ibrutinib e successivo mantenimento con ibrutinib in pazienti non trattati con linfoma diffuso a grandi cellule B con profilo ABC e rischio intermedio/alto o alto.

Not yet recruiting
2
90
Europe
Ibrutinib, IMP1, Capsule, hard, IMBRUVICA - 140 MG -CAPSULE RIGIDE -USO ORALE - FLACONE (HDPE) - 1 FLACONE (120 CAPSULE RIGIDE)
FONDAZIONE ITALIANA LINFOMI ONLUS, Janssen-Cilag S.p.A
Activated-B-Cell Lymphoma (ABC)-DLBCLat intermediate-high and high risk (IPI =2) Linfoma diffuso a grandi cellule B con profilo ABC (Activated-B-Cell) e rischio intermedio/alto o alto (IPI = 2), B-Cell Lymphoma (ABC)-DLBCLat intermediate-high and high risk Linfoma diffuso a grandi cellule B con profilo ABC e rischio intermedio/alto o alto, Diseases [C] - Blood and lymphatic diseases [C15]
 
 
NCT02514083: A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Treatment-Naive CLL

Active, not recruiting
2
29
US
Ibrutinib, Imbruvica, Fludarabine, Fludara
National Heart, Lung, and Blood Institute (NHLBI)
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
10/19
10/34
GELTAMO-IMCL-2015, NCT02682641 / 2015-004158-17: Ibrutinib in Combination With Rituximab in Patients With Indolent Clinical Forms of MCL

Active, not recruiting
2
50
Europe
IBRUTINIB, Imbruvica, Rituximab
Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea, Janssen-Cilag, S.A.
Mantle Cell Lymphoma
12/19
12/24
2018-002364-44: Clinical study of ibrutinib and rituximab in untreated marginal zone lymphomas

Ongoing
2
175
Europe
MabThera Uso sottocutaneo, MabThera, Imbruvica, [NA], Solution for injection, Concentrate for solution for infusion, Capsule, hard, MabThera, Imbruvica
IELSG - INTERNATIONAL EXTRANODAL LYMPHOMA STUDY GROUP, Janssen-Cilag AG, F. Hoffmann La Roche Ltd, Janssen Pharmaceutica NV
Previously untreated and symptomatic patients with histologically proven CD20-positive marginal zone B-cell lymphoma (MZL) in need of systemic treatment, Previously untreated marginal zone lymphoma, Diseases [C] - Cancer [C04]
 
 
2015-003128-30: Ibrutinib in relapsed lymphocyte-predominant Hodgkin lymphoma Ibrutinib zur Behandlung des rezidivierten nodulär Lymphozyten-prädominanten Hodgkin Lymphom

Not yet recruiting
2
36
Europe
Capsule, hard, Imbruvica
University of Cologne, JANSSEN-CILAG GmbH
relapsed lymphocyte-predominant Hodgkin lymphoma rezidiviertes nodulär Lymphozyten-prädominantes Hodgkin Lymphom, relapsed Hodgkin lymphoma (cancer of lymphatic system) Rückfall eines Hodgkin Lymphoms (Krebserkrankung des lymphatischen Systems), Diseases [C] - Cancer [C04]
 
 
2019-003632-23: Lenalidomide and Ibrutinib in association with R-MPV first-line treatment of Primary Central Nervous System Lymphoma for patients aged 18 to 60 Lénalidomide et Ibrutinib en association avec le R-MPV en traitement d’induction de première ligne pour les patients âgés de 18 à 60 ans présentant un lymphome primitif du système nerveux central (LCP).

Not yet recruiting
2
128
Europe
Ibrutinib 140 mg, Rituximab, Methotrexate, Procarbazine, Vincristine, Prednisone, Capsule, hard, Solution for infusion, Capsule, Tablet, Revlimid 5 mg, Revlimid 10 mg, Imbruvica 140 mg
Institut Curie, PHRC-K 2018 Public Health Grant, CELGENE SAS, JANSSEN-CILAG, KEOCYT SAS
Primary Central Nervous System Lymphoma (PCNSL) in patients aged 18 to 60, in first-line treatment Lymphome primitif du système nerveux central chez des patients âgés de 18 à 60 ans, en traitement de première ligne, Primary Central Nervous System Lymphoma in patients aged 18 to 60, first treatment Lymphome primitif du système nerveux central chez des patients âgés de 18 à 60 ans, 1er traitement, Diseases [C] - Cancer [C04]
 
 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Elahere (mirvetuximab soravtansine-gynx) / AbbVie
NCT05622890: A Single-arm Clinical Trial of IMGN853 in Chinese Adult Patients With Platinum-resistant, Epithelial Ovarian Cancer

Recruiting
3
35
RoW
Mirvetuximab Soravtansine, IMGN853, MIRV
Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Epithelial Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
04/23
12/23
MIRASOL, NCT04209855 / 2019-003509-80: A Study of Mirvetuximab Soravtansine vs. Investigator's Choice (IC) of Chemotherapy in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha (FRα) Expression

Hourglass Oct 2024 - Dec 2024 : Approval for 2L+ FRα +ve PROC
Jan 2023 - Dec 2023: Market entry in ex-US for platinum-resistant ovarian cancer
Hourglass Jan 2023 - Mar 2023 : Top-line data from MIRASOL trial for high-grade epithelial ovarian cancer
Hourglass Jul 2022 - Sep 2022 : Approval for high-grade epithelial ovarian cancer (based on MIRASOL trial)
Completed
3
453
Europe, Canada, US, RoW
Mirvetuximab Soravtansine, MIRV, IMGN853, Paclitaxel, Topotecan, Pegylated liposomal doxorubicin
AbbVie, Gynecologic Oncology Group, European Network of Gynaecological Oncological Trial Groups (ENGOT)
Epithelial Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
03/23
08/24
NCT06682988: A Study to Assess Adverse Events and Change in Disease Activity in Participants With Platinum-Resistant Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression Treated With Intravenously (IV) Infused Mirvetuximab Soravtansine

Not yet recruiting
3
110
NA
Mirvetuximab Soravtansine, MIRV, IMGN853
AbbVie
Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, Fallopian Tube Cancers, High Folate Receptor-Alpha Expression, Platinum Resistant
03/28
03/28
GLORIOSA, NCT05445778: Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Ovarian, Fallopian Tube, or Peritoneal Cancer

Recruiting
3
418
Europe, Canada, Japan, US, RoW
Mirvetuximab soravtansine plus Bevacizumab, MIRV, Bevacizumab
AbbVie, GOG Foundation
Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
03/27
04/29
2018-004207-39: Mirvetuximab Soravtansine in patients with high expression of folate receptor alpha in their tumor and recurrent ovarian cancer

Not yet recruiting
2
136
Europe
Mirvetuximab Soravtansine, Powder and solvent for concentrate for solution for infusion, Solution for infusion, Capsule, hard, Film-coated tablet, , Caelyx, Carboplatin Kabi, Paclitaxel-GRY®, Gemedac®, Zejula, Lynparza, Rubraca
AGO Research GmbH, ImmunoGen, Inc.
This trial evaluates the efficacy and safety of Mirvetuximab soravtansine (IMGN853) plus Carboplatin chemotherapy in FRα high patients with recurrent ovarian cancer who are eligible for platinum-based chemotherapy., Safety and efficacy for carboplatin with Mirvetuximab soravtansine (IMGN853) compared to carboplatin combination chemotherapy, Diseases [C] - Cancer [C04]
 
 
2021-003592-34: c Un estudio para probar mirvetuximab soravtansina en mujeres con cánceres epiteliales de ovario, peritoneales primarios o de trompa de Falopio sensibles al platino.

Not yet recruiting
2
75
Europe
mirvetuximab soravtansine, IMGN853, Concentrate for solution for injection/infusion, Pred Forte
ImmunoGen, Inc., IMMUNOGEN, INC., ImmunoGen, Inc.
Recurrent Platinum-Sensitive, High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers with High Folate Receptor-Alpha Expression Cánceres epiteliales de ovario, peritoneales primarios o de trompa de Falopio recurrentes, sensibles al platino y con alta expresión del receptor de folatos alfa, Cancer of ovary and related organs Cáncer de ovario y órganos afines, Diseases [C] - Cancer [C04]
 
 
NCT03835819: A Phase 2 Study of Mirvetuximab Soravtansine (IMGN853) and Pembrolizumab in Endometrial Cancer (EC)

Active, not recruiting
2
18
US
Pembrolizumab, Keytruda, IMGN853, Mirvetuximab soravtansine, Elahere
Dana-Farber Cancer Institute, ImmunoGen, Inc., Merck Sharp & Dohme LLC
Endometrial Cancer
06/24
05/27
NCT03832361: Evaluation of Mirvetuximab Soravtansine (IMGN853) in Women With Folate Receptor-α Positive Endometrial Cancer

Recruiting
2
50
US
IMGN853, mirvetuximab soravtansine
Alessandro Santin, ImmunoGen, Inc.
Endometrial Cancer
10/25
10/28
MIROVA, NCT04274426 / 2018-004207-39: Mirvetuximab Soravtansine (IMGN853), in Folate Receptor Alpha (FRα) High Recurrent Ovarian Cancer

Active, not recruiting
2
136
Europe
Carboplatin, Pegylated liposomal doxorubicin (PLD), Gemcitabine, Paclitaxel, Mirvetuximab Soravtansine
AGO Research GmbH, ImmunoGen, Inc.
Recurrent Epithelial Ovarian, Fallopian or Peritoneal Carcinoma
12/25
12/26
PICCOLO, NCT05041257: Mirvetuximab Soravtansine Monotherapy in Platinum-Sensitive Epithelial, Peritoneal, and Fallopian Tube Cancers

Hourglass Oct 2024 - Dec 2024 : Approval for 2L+ FRα +ve PROC
Hourglass Jan 2024 - Jun 2024 : sBLA approval for ovarian cancer
Hourglass Jan 2024 - Jun 2024 : FDA action date for approval for ovarian cancer with high FRAC
Hourglass Jan 2023 - Dec 2023 : ORR data from PICCOLO trial for platinum sensitive ovarian cancer
Completed
2
79
Europe, Canada, US, RoW
Mirvetuximab soravtansine, MIRV, IMGN853
AbbVie
Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
01/24
12/24
NCT05456685: Mirvetuximab Soravtansine (MIRV) With Carboplatin in Second-line Treatment of Folate Receptor Alpha (FRα) Expressing, Platinum-sensitive Epithelial Ovarian Cancer

Checkmark Data from trial in combination with carboplatin for platinum-sensitive epithelial ovarian cancer at IGCS 2022
Sep 2022 - Oct 2022: Data from trial in combination with carboplatin for platinum-sensitive epithelial ovarian cancer at IGCS 2022
Active, not recruiting
2
125
Europe, Canada, US, RoW
Mirvetuximab soravtansine, MIRV, IGN853, Carboplatin
AbbVie
High Grade Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer
05/26
05/26
NCT06365853: A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression

Recruiting
2
100
Europe, Canada, US, RoW
Mirvetuximab Soravtansine, IMGN853, MIRV, Lubricating Eye Drops, Prednisolone acetate ophthalmic suspension 1% eye drops, Brimonidine tartrate ophthalmic solution eye drops
AbbVie
Recurrent Ovarian Cancer, Folate Receptor-Alpha Positive
06/26
06/27
NCT06890338: A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.

Not yet recruiting
2
140
NA
Carboplatin, Mirvetuximab Soravtansine, MIRV, IMGN853, ELAHERE™
AbbVie
Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer, Neoadjuvant
10/29
10/29
NCT05887609: An Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib

Recruiting
2
53
US
Mirvetuximab Soravtansine, IMGN853, MIRV, Olaparib
University of Colorado, Denver, ImmunoGen, Inc.
Ovary Cancer, Peritoneal Cancer, Fallopian Tube Cancer
04/26
12/27
NCT04606914: Study of Carboplatin and Mirvetuximab Soravtansine in First-Line Treatment of Patients Receiving Neoadjuvant Chemotherapy with Advanced-Stage Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Recruiting
2
70
US
mirvetuximab soravtansine (MIRV; IMGN853)
University of Alabama at Birmingham
Ovarian Cancer, Fallopian Tube, Primary Peritoneal Cancer
05/26
05/28
TAK-853-1501, NCT06390995: A Study of TAK-853 in Adult Participants With Folate Receptor Alpha-Positive Advanced Ovarian Cancer And Other Solid Tumors

Recruiting
1/2
25
Japan
TAK-853, Mirvetuximab Soravtansine
Takeda
Ovarian Cancer, Solid Tumors
09/25
09/26
NCI-2018-00438, NCT03552471: Mirvetuximab Soravtansine and Rucaparib Camsylate in Treating Participants with Recurrent Endometrial, Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Completed
1
25
US
Laboratory Biomarker Analysis, Mirvetuximab Soravtansine, IMGN853, M9346A-sulfo-SPDB-DM4, Pharmacokinetic Study, PHARMACOKINETIC, PK Study, Rucaparib Camsylate, 8-Fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonic Acid Salt, C0-338, Rubraca, Rucaparib Phosphate
Ohio State University Comprehensive Cancer Center, ImmunoGen, Inc., Clovis Oncology, Inc.
BRCA1 Gene Mutation, BRCA2 Gene Mutation, Folate Receptor Alpha Positive, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma, Recurrent Uterine Corpus Carcinoma, Recurrent Uterine Serous Carcinoma, Recurrent Uterine Carcinosarcoma, Platinum Resistant Ovarian Cancer
06/22
12/22
NCI-2016-01913, NCT02996825: Mirvetuximab Soravtansine and Gemcitabine Hydrochloride in Treating Patients With FRalpha-Positive Recurrent Ovarian, Primary Peritoneal, Fallopian Tube, Endometrial, or Triple Negative Breast Cancer

Completed
1
44
US
Gemcitabine, dFdC, dFdCyd, Difluorodeoxycytidine, Gemcitabine Hydrochloride, Difluorodeoxycytidine Hydrochloride, FF 10832, FF-10832, FF10832, Gemcitabine HCI, Gemzar, LY-188011, LY188011, Laboratory Biomarker Analysis, Mirvetuximab Soravtansine, IMGN853, M9346A-sulfo-SPDB-DM4, Pharmacological Study
City of Hope Medical Center, National Cancer Institute (NCI)
Recurrent Breast Carcinoma, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma, Recurrent Uterine Corpus Carcinoma, Triple-Negative Breast Carcinoma
02/24
02/24
SL03-OHD-105, NCT05483933: Phase 1b Study of SL-172154 Administered with Combination Agent(s) in Subjects with Ovarian Cancers

Completed
1
86
Europe, Canada, US
Pegylated Liposomal Doxorubicin + SL-172154, Doxil, PLD, Caelyx, Mirvetuximab + SL-172154, IMGN853, MIRV
Shattuck Labs, Inc.
Platinum-resistant Ovarian Cancer, Fallopian Tube Cancer, Epithelial Ovarian Cancer, Ovarian Cancer, Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma, Primary Peritoneal Carcinoma
02/25
02/25
ChiCTR2400088269: A real-world study evaluating the safety and efficacy of Mirvetuximab Soravtansine (MIRV) in platinum-resistant ovarian, primary peritoneal, or fallopian tube cancer with high folate receptor alpha expression

Recruiting
N/A
50
 
None
Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital Hainan Hospital; Hangzhou ZhongMei Huadong Pharmaceutical Co., Ltd., Hangzhou ZhongMei Huadong Pharmaceutical Co., Ltd.
High expression of folate receptor alpha in platinum-resistant advanced high-grade ovarian, primary peritoneal, or fallopian tube cancer
 
 
cendakimab (CC-93538) / AbbVie, BMS
NCT05214768: A Study to Evaluate the Efficacy and Safety of CC-93538 in Adult and Adolescent Japanese Participants With Eosinophilic Gastroenteritis

Active, not recruiting
3
48
Japan
CC-93538, Cendakimab, BMS-986355, Placebo
Celgene
Eosinophilic Gastroenteritis
07/24
09/25
NCT04753697 / 2020-004336-16: A Study to Evaluate the Efficacy and Safety of CC-93538 in Adult and Adolescent Participants With Eosinophilic Esophagitis

Hourglass Jul 2024 - Dec 2024 : Data readout from CC-93538-EE-001 trial for EoE
Completed
3
430
Europe, Canada, Japan, US, RoW
CC-93538, RPC4046, Placebo
Celgene
Eosinophilic Esophagitis
01/24
08/24
NCT04991935 / 2020-004335-24: Safety Study of CC-93538 in Adult and Adolescent Participants With Eosinophilic Esophagitis

Active, not recruiting
3
259
Europe, Canada, Japan, US, RoW
CC-93538, BMS-986355, cendakimab
Celgene
Eosinophilic Esophagitis
06/26
09/26
2020-005212-22: The purpose of this study is to see if CC-93538 is safe and effective as a possible treatment for moderate to severe Atopic Dermatitis. Multicentrické globální, randomizované, dvojitě zaslepené, placebem kontrolované klinické hodnocení fáze 2 s paralelními skupinami hodnotící bezpečnost a snášenlivost cendakimabu (CC-93538) u dospělých pacientů se středně těžkou až těžkou atopickou dermatitidou

Not yet recruiting
2
200
RoW
Cendakimab, CC-93538, Solution for injection/infusion in pre-filled syringe
Celgene International II Sàrl, Celgene Corporation
ATOPIC DERMATITIS, Atopic dermatitis (AD) is a common and chronic inflammatory skin disorder that affects a broad demographic, with an increasing prevalence worldwide., Diseases [C] - Skin and Connective Tissue Diseases [C17]
 
 
RN Immuno-1: RPC4046 in healthy and asthma patients

Completed
1
0
RestOfWorld
RPC4046
Receptos
Other Inflammatory Diseases / Healthy Sub.; Asthma
 
 
NCT05337345: A Study to Evaluate the Drug Levels of Cendakimab Delivered Subcutaneously in Healthy Participants

Completed
1
104
US
Cendakimab, CC-93538, BMS-986355, RPC4046
Bristol-Myers Squibb
Healthy Volunteers
12/22
12/22
NCT05638282: A Study to Evaluate the Safety and Tolerability of Cendakimab in Chinese Healthy Participants

Completed
1
25
RoW
Cendakimab, CC-93538, BMS-986355, RPC4046, Placebo
Bristol-Myers Squibb
Healthy Participants
06/23
06/23
NCT05175352: A Study Evaluating Potential Disease-Mediated Drug-Drug Interaction in Adult Participants With Active Eosinophilic Esophagitis Receiving Cendakimab

Completed
1
16
US
Cendakimab, CC-93538, BMS-986355, CYP substrates
Celgene
Eosinophilic Esophagitis
10/24
10/24
Exviera (dasabuvir) / AbbVie
2016-003607-59: An Open-Label Study to Evaluate Long-Term Results With Ombitasvir-Paritaprevir-Ritonavir and Dasabuvir With or Without Ribavirin (RBV) on ovarian function in fertile women With Genotype 1 and 4 Chronic Hepatitis C Virus (HCV) Infection. Studio in aperto per valutare i risultati a lungo termine con Ombitasvir-paritaprevir-Ritonavir e Dasabuvir, con o senza ribavirina (RBV) sulla funzione ovarica delle donne in et¿ fertile con epatite cronica HCV-positiva, genotipo 1 e 4 .

Not yet recruiting
4
50
Europe
VIEKIRAX, EXVIERA, 043841, Film-coated tablet, VIEKIRAX - 12,5MG/75MG/50MG COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PVC/PE/PCTFE/ALU) - 56 COMPRESSE (CONFEZIONE MULTIPLA), EXVIERA - 250 MG COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PVC/PE/PCTFE/ALU) - 56 COMPRESSE (CONFEZIONE MULTIPLA)
DIPARTIMENTO AD ATTIVITà INTEGRATA CHIRURGICO, MEDICO, ODONTOIATRICO E DI SCIENZE MORFOLOGICHE, ABBVIE SRL
Genotype 1 and 4 Chronic Hepatitis C Virus (HCV) Infection Epatite cronica HCV-positiva, genotipo 1 e 4, Hepatitis C EPATITE C, Diseases [C] - Virus Diseases [C02]
 
 
NCT02460133: Understanding HCV Reinfection Rates in an Incarcerated Population After Cure With Interferon Free HCV Treatment

Active, not recruiting
4
44
NA
Paritaprevir, Ritonavir, Dasabuvir, Ombitasvir, Ribavirin
Nova Scotia Health Authority, Provincial Correction Centre (PEI)
Hepatitis C Virus
10/25
10/25
2014-002962-57: Hepatitis C meggyógyítása, cryoglobunaemia és szövödményeinek (vaculitis, neuritis) megszüntetése

Ongoing
3
1
Europe
ABT-450/r/ABT-267; ABT333
Egyesített Szent István és Szent László Kórház - Rendelőintézet
 
 
2014-004111-37: Individual Patient Access to AbbVie ABT-450/rítonavir/ABT-267 and ABT333 Coadministered witb Ribavirín (RBV) in Patient with Genotype 1 Hepatitis C VírusInfection witb Cirrhosis

Ongoing
3
1
Europe
ABT-450/r/ABT-267+ABT-333
BUDAI HEPATOLÓGIAI CENTRUM
 
 
2014-004268-38: Individual Patient Access to AbbVie ABT-450/ritopnavir/ABT-267 and ABT-333 Coadministeres with ribavirin (RBV) in Adult Liver Transplant Recipient with Genotype 1 Hepatitis C Virus Infection

Ongoing
3
1
Europe
ABT-450/ritonavir/ABT-267, ABT-333,
Semmelweis Egyetem Transzplantációs és Sebészeti Klinika
 
 
2015-005004-28: Stratified Treatment OPtimisation for HCV-1 (STOPHCV-1)

Ongoing
2
408
Europe
Viekirax, Exviera (Dasabuvir), Harvoni, Ribavirin (film-coated 200mg), Ribavirin (hard capsule, 200mg), Ribavirin (film-coated, 400mg), Maviret, Film-coated tablet, , Viekirax, Exviera (Dasabuvir), Harvoni, Maviret
Imperial College London, NIHR Efficacy and Mechanism Evaluation Programme
Hepatitis C Infection (HCV) (genotype 1a/1b/4), Hepatitis C infection, Diseases [C] - Virus Diseases [C02]
 
 
C-DIAMOND, NCT04952207: Effectiveness and Safety of Direct-Acting Antiviral Agents for the Treatment of Chronic Hepatitis C

Recruiting
N/A
300
RoW
Direct-acting antiviral agents, daclatasvir, asunaprevir, ombitasvir, paritaprevir, dasabuvir, sofosbuvir, velpatasvir, ledipasvir, elbasvir, grazoprevir, danoprevir, glecaprevir, pibrentasvir, voxilaprevir
Qing XIe, Gilead Sciences, Tigermed Consulting Co., Ltd
Hepatitis C, Chronic
07/21
08/21
Imbruvica (ibrutinib) / AbbVie, J&J
ChiCTR2100053513: Prospective, controlled, multicenter real-world clinical study of zanubrutinib versus ibrutinib in maintenance monotherapy for chronic lymphocytic leukemia/small cell lymphoma and mantle cell lymphoma

Recruiting
4
210
 
Zanubrutinib ;Ibrutinib ;Initial maintenance therapy with ibrutinib and then switched to zanubrutinib due to intolerance or voluntary
The Second Affiliated Hospital of Nanchang University; The Second Affiliated Hospital of Nanchang University, self-funded
Chronic lymphocytic leukemia/small cell lymphoma and mantle cell lymphoma
 
 
NCT03190330: A Study to Assess Safety of ImbruvicaTM in Indian Participants With Chronic Lymphocytic Leukemia or Mantle Cell Lymphoma Who Have Received at Least One Prior Therapy or Chronic Lymphocytic Leukemia With 17p Deletion

Completed
4
75
RoW
Ibrutinib 420 mg, Imbruvica, Ibrutinib 560 mg
Johnson & Johnson Private Limited
Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Mantle-Cell
05/23
05/23
ChiCTR2000041420: A randomized, open label, multicenter study of ibotinib monotherapy versus ibotinib combined with nitrogen mustard in the first-line treatment of chronic lymphocytic leukemia / small lymphocytic lymphoma

Recruiting
4
300
 
Ibrutinib monotherapy ;Ibrutinib plus chlorambucil
Ruijin Hospital Shanghai Jiaotong University School of Medicine; Ruijin Hospital Shanghai Jiaotong University School of Medicine, Investigator-sponsored
Chronic lymphocytic leukemia/small lymphocytic lymphoma
 
 
NCT04042376: A Study of Ibrutinib (PCI-32765) in Chinese Participants With Relapse or Refractory Waldenstrom's Macroglobulinemia (WM)

Completed
4
17
RoW
Ibrutinib, JNJ-54179060, PCI-32765
Janssen Research & Development, LLC
Waldenstrom Macroglobulinemia
03/24
03/24
ChiCTR2000038447: Clinical study of ibrutinib combined with pirfenidone in the treatment of bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation

Not yet recruiting
4
15
 
Ibutenib and pirfenidone
Sichuan Provincial People's Hospital, Affliated Hospital of University of Electronic Science and Technology of China; Sichuan Provincial People's Hospital, Affliated Hospital of University of Electronic Science and Technology of China, self-raised
bronchiolitis obliterans syndrome
 
 
NCT03229200 / 2016-004356-30: Extended Treatment Protocol for Subjects Continuing to Benefit From Ibrutinib.

Enrolling by invitation
4
600
Europe, Canada, US, RoW
Ibrutinib
Pharmacyclics Switzerland GmbH, Janssen Biotech, Inc., including Johnson & Johnson
Lymphoma, B-Cell, Lymphoma, Non-Hodgkin, Leukemia, B-cell, Graft Vs Host Disease, Solid Tumor
05/27
05/27
2014-001363-12: Autologous Transplantation after a Rituximab/Ibrutinib/Ara-c containing iNduction in Generalized mantle cell Lymphoma – a randomized European MCL Network trial

Ongoing
3
870
Europe, RoW
Ibrutinib, PCI-32765, Capsule, hard, Imbruvica
Klinikum der Universität München, Medizinische Klinik und Poliklinik III, HOVON Foundation, KroHem, Janssen Pharmaceutica NV, Skåne University Hospital, Department of Oncology, Dutch Cancer Society
Generalized mantle cell Lymphoma, Generalized mantle cell Lymphoma, Diseases [C] - Blood and lymphatic diseases [C15]
 
 
ALLIANCE A041202, NCT01886872: Rituximab and Bendamustine Hydrochloride, Rituximab and Ibrutinib, or Ibrutinib Alone in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia

Checkmark Ibrutinib + Rituxan for 1L CLL
Dec 2018 - Dec 2018: Ibrutinib + Rituxan for 1L CLL
Active, not recruiting
3
547
Canada, US
Bendamustine Hydrochloride, Belrapzo, Bendamustin Hydrochloride, Bendeka, CEP 18083, CEP-18083, CEP18083, Cytostasan Hydrochloride, Levact, Ribomustin, SyB L-0501, Treakisym, Treanda, VIVIMUSTA, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy, Biopsy of Bone Marrow, Biopsy, Bone Marrow, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Ibrutinib, BTK Inhibitor PCI-32765, CRA 032765, CRA-032765, CRA032765, Imbruvica, PCI 32765, PCI-32765, PCI32765, Laboratory Biomarker Analysis, Quality-of-Life Assessment, Quality of Life Assessment, Rituximab, ABP 798, ABP-798, ABP798, BI 695500, BI-695500, BI695500, Blitzima, C2B8 Monoclonal Antibody, Chimeric Anti-CD20 Antibody, CT P10, CT-P10, CTP10, GP 2013, GP-2013, GP2013, IDEC 102, IDEC-102, IDEC-C2B8, IDEC-C2B8 Monoclonal Antibody, IDEC102, Ikgdar, Mabtas, MabThera, Monoclonal Antibody IDEC-C2B8, PF 05280586, PF-05280586, PF05280586, Riabni, Ritemvia, Rituxan, Rituximab ABBS, Rituximab ARRX, Rituximab Biosimilar ABP 798, Rituximab Biosimilar BI 695500, Rituximab Biosimilar CT-P10, Rituximab Biosimilar GB241, Rituximab Biosimilar GP2013, Rituximab Biosimilar IBI301, Rituximab Biosimilar JHL1101, Rituximab Biosimilar PF-05280586, Rituximab Biosimilar RTXM83, Rituximab Biosimilar SAIT101, Rituximab Biosimilar SIBP-02, rituximab biosimilar TQB2303, Rituximab PVVR, Rituximab-abbs, Rituximab-arrx, Rituximab-blit, Rituximab-pvvr, Rituximab-rite, Rituximab-rixa, Rituximab-rixi, Rixathon, Riximyo, RTXM 83, RTXM-83, RTXM83, Ruxience, Truxima
National Cancer Institute (NCI)
Stage I Chronic Lymphocytic Leukemia, Stage II Chronic Lymphocytic Leukemia, Stage III Chronic Lymphocytic Leukemia, Stage IV Chronic Lymphocytic Leukemia
08/18
04/26
ECOG-ACRIN E1912, NCT02048813: Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Checkmark Approved in combination with rituximab for CLL
Jan 2021 - Jan 2021: Approved in combination with rituximab for CLL
Checkmark CHMP Positive opinion in combination with rituximab or obinutuzumab for previously untreated CLL
Oct 2020 - Oct 2020: CHMP Positive opinion in combination with rituximab or obinutuzumab for previously untreated CLL
Checkmark Positive CHMP opinion in combination with rituximab for the treatment of 1L CLL
More
Active, not recruiting
3
529
US
Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B 518, B-518, B518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR 138719, WR- 138719, WR-138719, WR138719, Fludarabine Phosphate, 2-F-ara-AMP, 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-, Beneflur, Fludara, SH T 586, Ibrutinib, BTK Inhibitor PCI-32765, CRA 032765, CRA-032765, CRA032765, Imbruvica, PCI 32765, PCI-32765, PCI32765, Laboratory Biomarker Analysis, Pharmacogenomic Study, PHARMACOGENOMIC, Quality-of-Life Assessment, Quality of Life Assessment, Rituximab, ABP 798, ABP-798, ABP798, BI 695500, BI-695500, BI695500, Blitzima, C2B8 Monoclonal Antibody, Chimeric Anti-CD20 Antibody, CT P10, CT-P10, CTP10, GP 2013, GP-2013, GP2013, IDEC 102, IDEC-102, IDEC-C2B8, IDEC-C2B8 Monoclonal Antibody, IDEC102, Ikgdar, Mabtas, MabThera, Monoclonal Antibody IDEC-C2B8, PF 05280586, PF-05280586, PF05280586, Riabni, Ritemvia, Rituxan, Rituximab ABBS, Rituximab ARRX, Rituximab Biosimilar ABP 798, Rituximab Biosimilar BI 695500, Rituximab Biosimilar CT-P10, Rituximab Biosimilar GB241, Rituximab Biosimilar GP2013, Rituximab Biosimilar IBI301, Rituximab Biosimilar JHL1101, Rituximab Biosimilar PF-05280586, Rituximab Biosimilar RTXM83, Rituximab Biosimilar SAIT101, Rituximab Biosimilar SIBP-02, rituximab biosimilar TQB2303, Rituximab PVVR, Rituximab-abbs, Rituximab-arrx, Rituximab-blit, Rituximab-pvvr, Rituximab-rite, Rituximab-rixa, Rituximab-rixi, Rixathon, Riximyo, RTXM 83, RTXM-83, RTXM83, Ruxience, Truxima
National Cancer Institute (NCI)
Anemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
10/18
01/26
NCT02414022: Economic Analysis of Alliance A041202 CLL Study

Checkmark Presentation of data from Alliance A041202 CLL study for CLL at ASH 2018
Dec 2018 - Dec 2018: Presentation of data from Alliance A041202 CLL study for CLL at ASH 2018
Active, not recruiting
3
55
Canada
Canadian Cancer Trials Group
Chronic Lymphocytic Leukemia
04/19
01/26
REACH3, NCT03112603 / 2016-004432-38: A Study of Ruxolitinib vs Best Available Therapy (BAT) in Patients With Steroid-refractory Chronic Graft vs. Host Disease (GvHD) After Bone Marrow Transplantation

Checkmark Approved in Korea for acute or chronic GvHD patients aged 12 years and older
May 2022 - May 2022: Approved in Korea for acute or chronic GvHD patients aged 12 years and older
Checkmark CHMP issued a positive opinion for acute or chronic GvHD patients aged 12 years and older
Mar 2022 - Mar 2022: CHMP issued a positive opinion for acute or chronic GvHD patients aged 12 years and older
Checkmark Approved in US for SR-cGVHD
More
Completed
3
330
Europe, Canada, Japan, US, RoW
Ruxolitinib, Jakafi, INCB018424, Extracorporeal photopheresis (ECP), Low-dose methotrexate (MTX), Mycophenolate mofetil (MMF), mechanistic Target of Rapamycin (mTOR) inhibitors (everolimus or sirolimus), Infliximab, Rituximab, Pentostatin, Imatinib, Ibrutinib
Incyte Corporation
Graft-versus-host Disease (GVHD)
05/20
12/22
ELEVATE-RR, NCT02477696 / 2014-005530-64: Study of Acalabrutinib (ACP-196) Versus Ibrutinib in Previously Treated Participants With High Risk Chronic Lymphocytic Leukemia (CLL)

Checkmark Presentation of data from ELEVATE-RR trial in r/r CLL at ASH 2022
Nov 2022 - Nov 2022: Presentation of data from ELEVATE-RR trial in r/r CLL at ASH 2022
Checkmark From ELEVATE-RR trial in r/r CLL at ASH 2021
Dec 2021 - Dec 2021: From ELEVATE-RR trial in r/r CLL at ASH 2021
Checkmark From ELEVATE-RR trial in combination with Ibrutinib for previously Treated Patients With CLL
More
Active, not recruiting
3
533
Europe, US, RoW
Acalabrutinib, ACP-196, Ibrutinib
Acerta Pharma BV
Chronic Lymphocytic Leukemia
09/20
01/28
GLOW, NCT03462719 / 2017-004699-77: A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Checkmark Data from GLOW trial in combination with Venclexta for CLL at ASH 2022
Dec 2022 - Dec 2022: Data from GLOW trial in combination with Venclexta for CLL at ASH 2022
Checkmark New data from the P3 GLOW study in combination with ibrutinib in 1L CLL/SLL at ASH 2022
Dec 2022 - Dec 2022: New data from the P3 GLOW study in combination with ibrutinib in 1L CLL/SLL at ASH 2022
Checkmark CHMP positive opinion in a fixed-duration combination regimen venetoclax for adult patients with 1L CLL
More
Active, not recruiting
3
211
Europe, Canada, US, RoW
Ibrutinib, Venetoclax, Chlorambucil, Obinutuzumab, Ibrutinib (as Subsequent Therapy)
Janssen Research & Development, LLC, Pharmacyclics LLC.
Leukemia, Lymphocytic, Chronic, B-Cell
02/21
04/29
TRIANGLE, NCT02858258: ASCT After a Rituximab/Ibrutinib/Ara-c Containing iNduction in Generalized Mantle Cell Lymphoma

Hourglass May 2019 - Dec 2023 : Regulatory submission in EU for front line maintenance MCL
Recruiting
3
870
Europe
R-CHOP/R-DHAP, rituximab, CHOP, DHAP, Ibrutinib (Induction), Imbruvica, ASCT conditioning, THAM or BEAM, Ibrutinib (Maintenance)
Prof. Dr. M. Dreyling (co-chairman), LMU Klinikum
Mantle Cell Lymphoma
05/21
05/26
SHINE , NCT01776840 / 2012-004056-11: A Study of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib Given in Combination With Bendamustine and Rituximab in Patients With Newly Diagnosed Mantle Cell Lymphoma

Checkmark J&J withdrawn marketing authorization application for Imbruvica in combination with bendamustine and rituximab for 1L MCL based on SHINE study
Dec 2022 - Dec 2022: J&J withdrawn marketing authorization application for Imbruvica in combination with bendamustine and rituximab for 1L MCL based on SHINE study
Checkmark Data from SHINE trial in 1L MCL at ASCO 2022
Jun 2022 - Jun 2022: Data from SHINE trial in 1L MCL at ASCO 2022
Checkmark Regulatory submission in EU for 1L MCL (based on SHINE trial)
More
Completed
3
523
Europe, Canada, Japan, US, RoW
Bendamustine, Rituximab, Ibrutinib, Placebo
Janssen Research & Development, LLC, Pharmacyclics LLC.
Mantle Cell Lymphoma
06/21
06/24
2020-004553-72: A clinical study to assess the effectiveness and safety of LOXO-305 compared to standard of care treatment chosen by the Investigator in patients with previously treated Mantle Cell Lymphoma

Not yet recruiting
3
500
Europe, RoW
pirtobrutinib, Ibrutinib, [na], [LOXO-305], Film-coated tablet, Tablet, IMBRUVICA
Loxo Oncology, Inc., a wholly owned subsidiary of Eli Lilly and Company, LOXO ONCOLOGY INCORPORATED, Loxo Oncology, Inc., a wholly owned subsidiary of Eli Lilly and Company, Loxo Oncology Inc
Mantle cell lymphoma, a cancer of white blood cells (developing in a certain part of the lymph node), which help the body fight infections, Diseases [C] - Cancer [C04]
 
 
SELENE , NCT01974440 / 2013-003093-27: A Study of PCI-32765 (Ibrutinib) in Combination With Either Bendamustine and Rituximab or Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Participants With Previously Treated Indolent Non-Hodgkin Lymphoma

Hourglass Jul 2022 - Dec 2022 : Data from SELENE trial for follicular lymphoma/MZL
Completed
3
403
Europe, Japan, US, RoW
Bendamustine, Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisone, PCI-32765 (Ibrutinib), Placebo
Janssen Research & Development, LLC, Pharmacyclics LLC.
Lymphoma
05/22
06/23
2021-003206-41: A Phase 3 Study Comparing Pirtobrutinib to Ibrutinib in CLL/SLL

Ongoing
3
650
Europe
Pirtobrutinib, Ibrutinib, LOXO-305, Tablet, Capsule, hard, IMBRUVICA
Loxo Oncology, Inc., Loxo Oncology, Inc.
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma krónikus limfocitás leukémia / kis limfocitás limfóma, Chronic lymphocytic leukaemia/Small Lymphocytic Lymphoma is a type of cancer that affects the white blood cells and tends to progress slowly over many years, Diseases [C] - Cancer [C04]
 
 
ALPINE, NCT03734016 / 2018-001366-42: A Study of Zanubrutinib (BGB-3111) Versus Ibrutinib in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia

Checkmark Approved for the treatment of patients with CLL or SLL based on data from ALPINE and SEQUOIA trials
Jan 2023 - Jan 2023: Approved for the treatment of patients with CLL or SLL based on data from ALPINE and SEQUOIA trials
Checkmark Data from ALPINE trial for CLL at ASH 2022
Dec 2022 - Dec 2022: Data from ALPINE trial for CLL at ASH 2022
Checkmark FDA approval
More
Completed
3
652
Europe, US, RoW
Zanubrutinib, BGB-3111, Brukinsa, Ibrutinib, Imbruvica
BeiGene
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
08/22
02/24
2022-001547-25: A Phase 3 study of Zilovertamab in addition to Ibrutinib in Subjects with Relapsed or Refractory Mantle Cell Lymphoma Estudio en fase III de zilovertamab en combinación con ibrutinib en pacientes con linfoma de células del manto recidivante o resistente

Ongoing
3
365
Europe
Zilovertamab, Ibrutinib, Zilovertamab, PCI-32765, Solution for infusion, Capsule, hard
Oncternal Therapeutics, Inc, Oncternal Therapeutics, Inc
Relapsed or Refractory Mantle Cell Lymphoma Linfoma de células del manto recidivante o resistente, Mantle Cell Lymphoma Linfoma de células del manto, Diseases [C] - Cancer [C04]
 
 
NCT01724346 / 2012-003968-44: Open-label Extension Study in Patients 65 Years or Older With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Completed
3
269
Europe, Canada, US, RoW
Ibrutinib, PCI-32765, Next-line ibrutinib
Pharmacyclics LLC., Janssen Research & Development, LLC
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
08/23
08/23
BELLWAVE-011, NCT06136559: A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/)

Recruiting
3
1200
Europe, Canada, Japan, US, RoW
Nemtabrutinib, MK-1026, ARQ 531, Ibrutinib, Acalabrutinib
Merck Sharp & Dohme LLC
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
09/32
09/32
GAIA, NCT02950051 / 2015-004936-36: Standard Chemoimmunotherapy (FCR/BR) Versus Rituximab + Venetoclax (RVe) Versus Obinutuzumab (GA101) + Venetoclax (GVe) Versus Obinutuzumab + Ibrutinib + Venetoclax (GIVe) in Fit Patients with Previously Untreated Chronic Lymphocytic Leukemia (CLL) Without Del(17p) or TP53 Mutation

Hourglass Jan 2021 - Dec 2021 : From CLL13 trial in combination with Venclexta for 1L CLL
Completed
3
926
Europe, RoW
Fludarabine, Fludura, Cyclophosphamide, Endoxan, Rituximab, MabThera, Rituxan, Bendamustine, Ribomustin, Levact, Venetoclax, Venclexta, Venclyxto, Obinutuzumab, Gazyva, Gazyvaro, Ibrutinib, Imbruvica
German CLL Study Group, Janssen-Cilag Ltd., Hoffmann-La Roche, AbbVie, Stichting Hemato-Oncologie voor Volwassenen Nederland, Nordic CLL Study Group (NCLLSG), Swiss Group for Clinical Cancer Research, Cancer Trials Ireland, Israeli CLL Study Group
Chronic Lymphocytic Leukemia
02/24
02/24
NCT02443077: Ibrutinib Before and After Stem Cell Transplant in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma

Active, not recruiting
3
92
US, RoW
Autologous Bone Marrow Transplantation, ABMT, Autologous Blood and Marrow Transplantation, Autologous Bone Marrow Transplant, Autologous Marrow Transplantation, Autologous Hematopoietic Stem Cell Transplantation, AHSCT, Autologous, Autologous Hematopoietic Cell Transplantation, Autologous Stem Cell Transplant, Autologous Stem Cell Transplantation, Stem Cell Transplantation, Autologous, Carmustine, BCNU, Becenum, Becenun, BiCNU, Bis(chloroethyl) Nitrosourea, Bis-Chloronitrosourea, Carmubris, Carmustin, Carmustinum, FDA 0345, N,N'-Bis(2-chloroethyl)-N-nitrosourea, Nitrourean, Nitrumon, NSC 409962, NSC409962, SK 27702, SRI 1720, WR 139021, WR-139021, WR139021, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B 518, B-518, B518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR 138719, WR- 138719, WR-138719, WR138719, Cytarabine, .beta.-Cytosine arabinoside, 1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone, 1-.beta.-D-Arabinofuranosylcytosine, 1-Beta-D-arabinofuranosyl-4-amino-2(1H)pyrimidinone, 1-Beta-D-arabinofuranosylcytosine, 1.beta.-D-Arabinofuranosylcytosine, 2(1H)-Pyrimidinone, 4-Amino-1-beta-D-arabinofuranosyl-, 2(1H)-Pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl-, Alexan, Ara-C, ARA-cell, Arabine, Arabinofuranosylcytosine, Arabinosylcytosine, Aracytidine, Aracytin, Aracytine, Beta-Cytosine Arabinoside, CHX-3311, Cytarabinum, Cytarbel, Cytosar, Cytosine Arabinoside, Cytosine-.beta.-arabinoside, Cytosine-beta-arabinoside, Erpalfa, Starasid, Tarabine PFS, U 19920, U-19920, Udicil, WR-28453, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP 16213, VP-16, VP-16-213, VP-16213, VP16, VP16213, Ibrutinib, BTK Inhibitor PCI-32765, CRA 032765, CRA-032765, CRA032765, Imbruvica, PCI 32765, PCI-32765, PCI32765, Laboratory Biomarker Analysis, Melphalan, Alanine Nitrogen Mustard, CB-3025, L-PAM, L-Phenylalanine Mustard, L-Sarcolysin, L-Sarcolysin Phenylalanine mustard, L-Sarcolysine, Melphalan for Injection-Hepatic Delivery System, Melphalanum, Phenylalanine Mustard, Phenylalanine Nitrogen Mustard, Sarcoclorin, Sarkolysin, WR-19813, Pharmacogenomic Study, PHARMACOGENOMIC, Placebo Administration
National Cancer Institute (NCI)
Recurrent Diffuse Large B-Cell Lymphoma Activated B-Cell Type, Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell Type
06/24
12/25
NCT04212013: A Study of Ibrutinib With Rituximab in People With Untreated Marginal Zone Lymphoma

Active, not recruiting
3
23
US
Ibrutinib, Rituximab, Placebo
Memorial Sloan Kettering Cancer Center, Pharmacyclics LLC.
Marginal Zone Lymphoma
03/27
03/27
SYMPATICO, NCT03112174 / 2017-000129-12: Study of Ibrutinib Combined With Venetoclax in Subjects With Mantle Cell Lymphoma

Jan 2023 - Dec 2023: Data from SYMPATICO trial in combination with Venclexta for r/r MCL
Completed
3
352
Europe, Canada, US, RoW
Ibrutinib, Venetoclax, Placebo Oral tablet to match Venetoclax
Pharmacyclics LLC., Janssen Research & Development, LLC
Mantle-Cell Lymphoma
06/24
06/24
BRUIN-MCL-321, NCT04662255 / 2020-004553-72: Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)

Active, not recruiting
3
500
Europe, Canada, Japan, US, RoW
Pirtobrutinib, LOXO-305, LY3527727, Ibrutinib, Imbruvica, Acalabrutinib, Calquence, Zanubrutinib, Brukinsa
Loxo Oncology, Inc., Eli Lilly and Company
Lymphoma, Mantle-Cell
01/27
04/28
NCT06821542: A Study to Evaluate Axatilimab Versus Best Available Therapy in Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy

Recruiting
3
300
Europe, RoW
INCA034176, Axatilimab, Best Available Therapy (BAT), BAT could include:, • Calcineurin inhibitor (cyclosporine or tacrolimus), • Extracorporeal photopheresis (ECP), • Mycophenolate mofetil (MMF), • A mammalian target of rapamycin (mTOR) inhibitor (everolimus or sirolimus), • Rituximab, • Pentostatin, • Proteasome inhibitors, • Imatinib, • Ibrutinib
Incyte Corporation
Chronic Graft-versus-host-disease
05/28
11/32
PERSPECTIVE, NCT02947347 / 2016-003202-14: Study of Ibrutinib and Rituximab in Treatment Naïve Follicular Lymphoma

Active, not recruiting
3
445
Europe, Canada, US, RoW
ibrutinib, Imbruvica, placebo to match ibrutinib, rituximab
Pharmacyclics LLC.
Follicular Lymphoma
02/24
06/26
NCT05431179 / 2022-001547-25: A Study of Zilovertamab and Ibrutinib in Patients With Relapsed or Refractory Mantle Cell Lymphoma

Withdrawn
3
365
NA
Zilovertamab, Cirmtuzumab, UC961, Ibrutinib, Imbruvica, Placebo
Oncternal Therapeutics, Inc, Pharmacyclics LLC.
Lymphoma, Mantle-Cell, Lymphoma, Lymphoproliferative Disorders, Lymphatic Diseases, Immunoproliferative Disorders, Immune System Diseases, Lymphoma, Non-Hodgkin, Lymphoma, B-Cell
11/26
12/26
NCT01804686 / 2012-004225-24: A Long-term Extension Study of PCI-32765 (Ibrutinib)

Recruiting
3
700
Europe, Canada, Japan, US, RoW
Ibrutinib, PCI-32765
Janssen Research & Development, LLC, Pharmacyclics LLC.
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, Follicular Lymphoma, Diffuse Large B-cell Lymphoma, Waldenstrom Macroglobulinemia, Chronic Graft Versus Host Disease
12/26
01/27
CLL17, NCT04608318 / 2019-003854-99: Ibrutinib Monotherapy Versus Fixed-duration Venetoclax Plus Obinutuzumab Versus Fixed-duration Ibrutinib Plus Venetoclax in Patients with Previously Untreated Chronic Lymphocytic Leukaemia (CLL)

Active, not recruiting
3
897
Europe, RoW
Ibrutinib, Imbruvica, Venetoclax, ABT-199, Venclyxto, Obinutuzumab, GA101, Gazyvaro
German CLL Study Group, Stichting Hemato-Oncologie voor Volwassenen Nederland (HOVON), Nordic CLL Study Group (NCLLSG), Swiss Group for Clinical Cancer Research (SAKK), Cancer Trials Ireland, Gruppo Italiano Malattie EMatologiche dell'Adulto (GIMEMA), Grupo Español de Leucemia Linfocítica Crónica (GELLC), The Israeli CLL Study Group (ICLLSG), Janssen Pharmaceutica N.V., Belgium, AbbVie, Hoffmann-La Roche
Chronic Lymphoid Leukemia
09/27
09/27
A041702, NCT03737981: Testing the Addition of a New Anti-cancer Drug, Venetoclax, to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated, Older Patients With Chronic Lymphocytic Leukemia

Active, not recruiting
3
465
US
Ibrutinib, BTK Inhibitor PCI-32765, CRA 032765, CRA-032765, CRA032765, Imbruvica, PCI 32765, PCI-32765, PCI32765, Obinutuzumab, Anti-CD20 Monoclonal Antibody R7159, GA 101, GA-101, GA101, Gazyva, huMAB(CD20), R 7159, R-7159, R7159, RO 5072759, RO-5072759, RO5072759, Observation Activity, Observation, Venetoclax, ABT 199, ABT-0199, ABT-199, ABT199, GDC 0199, GDC-0199, GDC0199, RG7601, Venclexta, Venclyxto
National Cancer Institute (NCI)
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
01/25
05/26
BRUIN-CLL-314, NCT05254743 / 2021-003206-41: A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Active, not recruiting
3
650
Europe, Canada, Japan, US, RoW
Pirtobrutinib, LOXO-305, LY3527727, Ibrutinib
Loxo Oncology, Inc., Eli Lilly and Company
Chronic Lymphocytic Leukemia, Leukemia, Lymphocytic, Leukemia, B-cell, Small Lymphocytic Lymphoma
06/25
01/28
NCT03701282: Assessing the Ability of Combination Treatment With Venetoclax to Permit Time Limited Therapy in Chronic Lymphocytic Leukemia

Active, not recruiting
3
720
US, RoW
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Biopsy, Biopsy of Bone Marrow, Biopsy, Bone Marrow, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Ibrutinib, BTK Inhibitor PCI-32765, CRA 032765, CRA-032765, CRA032765, Imbruvica, PCI 32765, PCI-32765, PCI32765, Obinutuzumab, Anti-CD20 Monoclonal Antibody R7159, GA 101, GA-101, GA101, Gazyva, huMAB(CD20), R 7159, R-7159, R7159, RO 5072759, RO-5072759, RO5072759, Quality-of-Life Assessment, Quality of Life Assessment, Venetoclax, ABT 199, ABT-0199, ABT-199, ABT199, GDC 0199, GDC-0199, GDC0199, RG7601, Venclexta, Venclyxto
National Cancer Institute (NCI)
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
05/28
05/28
2015-000832-13: Ibrutinib for untreated mantle cell lymphoma

Ongoing
2/3
400
Europe
Ibrutinib, Rituximab, Bendamustine hydrochloride, Cyclophosphamide, Doxorubicin hydrochloride, Vincristine sulphate, Prednisolone, Capsule, hard, Concentrate for solution for injection/infusion, Lyophilisate for solution for infusion, Powder for solution for infusion, Solution for infusion, Solution for injection, Tablet, Ibrutinib, doxorubicin
Plymouth Hospitals NHS Trust, Cancer Research UK, Janssen Pharmaceutica NV
Untreated symptomatic Mantle Cell Lymphoma, Untreated symptomatic Mantle Cell Lymphoma, Diseases [C] - Cancer [C04]
 
 
2019-001261-33: Study of Rituximab and Ibrutinib (RI) versus Dexamethasone, Rituximab and Cyclophosphamide (DRC) as initial therapy for Waldenström's macroglobulinaemia

Not yet recruiting
2/3
148
Europe
Ibrutinib, Rituximab, Dexamethasone, Cyclophosphamide, Capsule, hard, Concentrate for solution for infusion, , Ibrutinib, Rituximab, Dexamethasone, Cyclophosphamide
University College London
Waldenström's macroglobulinaemia, a blood cancer, Diseases [C] - Cancer [C04]
 
 
NCT03642236: Combination of BTK Inhibitor Overcomes Drug-resistance in Refractory/Relapsed FLT3 Mutant AML

Enrolling by invitation
2/3
122
RoW
Ibrutinib
Nanfang Hospital of Southern Medical University
FLT3-ITD Mutation, Acute Myeloid Leukemia, Brutons Tyrosine Kinase
08/22
09/23
2022-000364-21: A Study of Ibrutinib in Combination With Rituximab Versus Lenalidomide Plus Rituximab or Bortezomib Plus Rituximab, in Relapsed/Refractory Mantle Cell Lymphoma Estudio de ibrutinib en combinación con rituximab frente a lenalidomida más rituximab o bortezomib más rituximab para el tratamiento de linfoma de células del manto recidivante/refractario.

Completed
2/3
490
Europe, RoW
ibrutinib, JNJ-54179060, Capsule, hard, Concentrate for solution for infusion, Powder for solution for injection, IMBRUVICA, Ruxience, Lenalidomide Accord, VELCADE
Janssen-Cilag International NV, Janssen Research & Development, LLC
Relapsed or Refractory Mantle Cell Lymphoma Linfoma de células del manto recidivante o refractario, Blood Cancer Cáncer de sangre, Diseases [C] - Cancer [C04]
 
 
RAINBOW, NCT04061512: Rituximab and Ibrutinib (RI) Versus Dexamethasone, Rituximab and Cyclophosphamide (DRC) as Initial Therapy for Waldenström's Macroglobulinaemia

Recruiting
2/3
148
Europe
Dexamethasone, cyclophosphamide, rituximab, Rituximab, ibrutinib
University College, London, Janssen-Cilag Ltd.
Waldenstrom Macroglobulinemia
03/30
03/30
PS-CLL-002, NCT04754035: Clinical Study With Ibrutinib and Venetoclax for Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia

Active, not recruiting
2a
31
Europe
Venetoclax, Imbruvica Oral Product
Paolo Ghia
Chronic Lymphocytic Leukemia
07/18
09/25
12-H-0035, NCT01500733: PCI-32765 for Special Cases of Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Checkmark AACR 2016
Mar 2016 - Mar 2016: AACR 2016
Checkmark ASH 2013
Nov 2013 - Nov 2013: ASH 2013
Checkmark For CLL/SLL
More
Active, not recruiting
2
86
US
PCI 32765
National Heart, Lung, and Blood Institute (NHLBI)
Leukemia, Leukemia, Lymphocytyc, CLL (Chronic Lymphocytic Leukemia), SLL (Small Lymphocytic Lymphoma)
06/14
09/34
2015-005273-20: Multicenter phase II single arm open-label study on the feasibility, safety and efficacy of combination of CHOP-21 supplemented with Obinutuzumab and Ibrutinib in untreated young high risk Diffuse Large B-cell Lymphoma (DLBCL) patients. Studio multicentrico di fase II a braccio singolo sulla fattibilit¿, sicurezza ed efficacia della combinazione CHOP-21 con Obinutuzumab e Ibrutinib come terapia di prima linea in pazienti giovani ad alto rischio affetti da linfoma a grandi cellule B.

Not yet recruiting
2
90
Europe
Imbruvica, Ibrutinib, Concentrate for solution for infusion, Capsule, hard, GAZYVARO - 1000 MG - CONCENTRATO PER SOLUZIONE PER INFUSIONE - USO ENDOVENOSO - FLACONCINO - 1000MG/40ML - 1 FLACONCINO, IMBRUVICA - 140 MG -CAPSULE RIGIDE -USO ORALE - FLACONE (HDPE) - 1 FLACONE (90 CAPSULE RIGIDE)
FONDAZIONE ITALIANA LINFOMI ONLUS, Roche, Janssen - Cilag
Diffuse Large B-Cell lymphoma (DLBCL) Linfoma a grandi cellule B (DLBCL), Diffuse Large B-Cell lymphoma Linfoma a grandi cellule B, Diseases [C] - Blood and lymphatic diseases [C15]
 
 
2015-002855-85: A randomized study to assess the tolerability and efficacy of the addition of ibrutinib to 10-day decitabine treatment in patients with AML and high risk myelodysplasia (MDS), UNFIT for intensive chemotherapy, aged >= 66 years.

Ongoing
2
170
Europe
Decitabine, ibrutinib, Powder for concentrate for solution for infusion, Capsule, soft, Dacogen, Imbruvica
HOVON Foundation, Dutch Cancer Society, Janssen-Cilag International NV
Acute Meyloid Leukemia and High Risk Myelodysplastic syndromes, Acute Meyloid Leukemia and High Risk Myelodysplastic syndromes, Diseases [C] - Cancer [C04]
 
 
2012-003608-11: Assessing how the drug ibrutinib works in Chronic Lymphocytic Leukaeamia.

Ongoing
2
40
Europe
Ibrutinib, PCI-32765,
University of Birmingham, LLR, Pharmacyclics
Chronic Lymphocytic leukaemia
 
 
2015-005525-39: The iMYC study to assess the effectiveness and safety of ibrutinib in patients with advanced oesophagogastric cancer with c-MYC and HER2 gene amplification

Ongoing
2
17
Europe
Ibrutinib, JNJ-54179060, Capsule, Ibrutinib
The Royal Marsden NHS Foundation Trust
Her2 or cMYC positive advanced oesophagogastric carcinomas, Cancers arising from either the oesophagus or stomach that display abnormalities of 2 specific genes which are implicated in cancer development: either the Her2 gene, the cMYC gene or both., Diseases [C] - Cancer [C04]
 
 
NCT01849263: Ibrutinib in Treating Patients With Relapsed or Refractory Follicular Lymphoma

Active, not recruiting
2
41
Canada, US, RoW
Ibrutinib, BTK Inhibitor PCI-32765, CRA 032765, CRA-032765, CRA032765, Imbruvica, PCI 32765, PCI-32765, PCI32765, Laboratory Biomarker Analysis
National Cancer Institute (NCI)
Grade 3a Follicular Lymphoma, Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma, Recurrent Grade 3 Follicular Lymphoma, Refractory Follicular Lymphoma
06/16
03/26
NCT01589302: PCI-32765 (Ibrutinib) in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or B-cell Prolymphocytic Leukemia

Checkmark P1/2 data-EHA
May 2012 - May 2012: P1/2 data-EHA
Active, not recruiting
2
154
US
ibrutinib, Bruton's tyrosine kinase inhibitor PCI-32765, BTK inhibitor PCI-32765, PCI-32765, Correlative laboratory samples, laboratory biomarker anyalysis, quality of life assessment
Kami Maddocks, MD
Prolymphocytic Leukemia, Recurrent Small Lymphocytic Lymphoma, Refractory/Relapsed Chronic Lymphocytic Leukemia
07/16
06/25
2015-005454-35: An early phase study using a response based combination therapy of rituxumab and ibrutinib in patients with post-transplant lymphoproliferative disorder (PTLD)

Ongoing
2
60
Europe
Imbruvica, Rituximab, Cyclophosphamide, Doxorubicin, Prednisolone, Vincristine, Capsule, hard, Infusion, Oral solution, Imbruvica, MabThera, Myocet, Prednisolone
University of Birmingham, Bloodwise, Janssen
Post-transplant lymphoproliferative disorder, Post-transplant lymphoproliferative disorder, Diseases [C] - Cancer [C04]
 
 
NCT02989532: Ibrutinib in Treating Patients With Relapsed or Refractory Follicular Lymphoma

Active, not recruiting
2
41
US, Canada, RoW
Ibrutinib, BTK Inhibitor PCI-32765, CRA-032765, Imbruvica, PCI-32765, Laboratory Biomarker Analysis
Mayo Clinic, National Cancer Institute (NCI)
Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma, Recurrent Grade 3 Follicular Lymphoma, Refractory Follicular Lymphoma
10/16
 
NCT01981512: Study of Ibrutinib for Treatment of Relapsed Hairy Cell Leukemia

Recruiting
2
18
US
Ibrutinib
National Cancer Institute (NCI)
Hairy Cell Leukemia
05/17
05/17
2016-004707-32: Clinical trial with Ibrutinib and Venetoclax for patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Studio Clinico con Ibrutinib e Venetoclax per pazienti con Leucemia Linfatica Cronica Recidivante o Refrattaria

Ongoing
2
31
Europe
VENETOCLAX, [ABT-199], Film-coated tablet
OSPEDALE SAN RAFFAELE, Abbvie
Relapsed or Refractory Chronic Lymphocytic Leukemia Leucemia Linfatica Cronica Recidivante o Refrattaria, Chronic Lymphocytic Leukemia relapsed or refractory to previous treatments Leucemia Linfatica Cronica ricaduta o non responsiva ai trattamenti precedenti, Diseases [C] - Blood and lymphatic diseases [C15]
 
 
2016-002599-29: A trial evaluating treatment with ibrutinib plus venetoclax in patients with creatinine clearance ≥ 30 ml/min who have relapsed or refractory chronic lymphocytic leukemia (RR-CLL)

Ongoing
2
230
Europe
venetoclax 10 mg, venetoclax 50 mg, venetoclax 100 mg, ibrutinib, Tablet, Capsule, hard, Venclyxto, Imbruvica
HOVON Foundation, AbbVie, Janssen
Chronic Lymphocytic Leukemia, Chronic Lymphocytic Leukemia, Diseases [C] - Cancer [C04]
 
 
NCI9922, NCT02581930: Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanoma

Active, not recruiting
2
18
US
Ibrutinib, BTK Inhibitor PCI-32765, CRA 032765, CRA-032765, CRA032765, Imbruvica, PCI 32765, PCI-32765, PCI32765, Laboratory Biomarker Analysis, Pharmacogenomic Study, PHARMACOGENOMIC, Pharmacological Study
National Cancer Institute (NCI)
Metastatic Melanoma, Recurrent Cutaneous Melanoma, Stage IV Cutaneous Melanoma AJCC v6 and v7
02/18
03/26
NCT03427398: Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanoma

Active, not recruiting
2
18
US
Ibrutinib, BTK Inhibitor PCI-32765, CRA-032765, Imbruvica, PCI-32765, Laboratory Biomarker Analysis, Pharmacogenomic Study, PHARMACOGENOMIC, Pharmacological Study
National Cancer Institute (NCI)
Metastatic Melanoma, Recurrent Melanoma of the Skin, Stage IV Cutaneous Melanoma AJCC v6 and v7
02/18
 
2017-003256-22: Ibrutinib and Standard Immuno-Chemotherapy (R-CHOEP-14) In Younger, High-Risk Patients with Diffuse Large B-Cell Lymphoma Ibrutinib und Standard-Immunochemotherapie (R-CHOEP-14) in jungen Hochrisiko- Patienten mit diffusem großzelligem B-Zell-Lymphom

Not yet recruiting
2
40
Europe
Capsule, hard, IMBRUVICA 140 mg hard capsules
Universitätsklinikum Münster, Janssen-Cilag GmbH
diffuse large B-cell lymphoma diffuses großzelliges B-Zell-Lymphom, malignant disease of the lymphatic system bösartige Erkrankung des lymphatischen Systems, Diseases [C] - Blood and lymphatic diseases [C15]
 
 
2017-001099-49: therapy with ibrutinib for patients with Chronic lymphocytic leukemia with subclonal TP53 aberrations terapia con Ibrutinib per pazienti affetti da leucemia linfatica cronica che presentano alterazioni subclonali di TP53

Ongoing
2
185
Europe
ibrutinib, [PCI-32765], Capsule, hard
OSPEDALE SAN RAFFAELE, Janssen-Cilag International N.V., Belgium
Chronic Lymphocytic Leukemia (CLL) leucemia linfatica cronica (LLC), Chronic Lymphocytic Leukemia never treated leucemia linfatica cronica mai trattata, Diseases [C] - Cancer [C04]
 
 
GELLC-7, NCT03280160 / 2016-004937-26: Protocol Ibrutinib Followed by Ibrutinib Consolidation in Combination With Ofatumumab

Active, not recruiting
2
84
Europe
Ibrutinib 140 MG Oral Capsule [Imbruvica], Ofatumumab
PETHEMA Foundation
Chronic Lymphocytic Leukemia
07/18
09/22
ACTRN12615000551594: A Phase II Study of Ibrutinib, Rituximab and mini-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) therapy in very elderly patients with newly diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

Completed
2
80
 
Australasian Leukaemia and Lymphoma Group, Janssen-Cilag Pty Ltd
elderly DLBCL
 
 
2017-005137-23: Ibrutinib in combination to rituximab-CHOP followed by ibrutinib maintenance in untreated patients with (ABC) DLBCLat intermediate-high and high risk Terapia R-CHOP in combinazione con ibrutinib e successivo mantenimento con ibrutinib in pazienti non trattati con linfoma diffuso a grandi cellule B con profilo ABC e rischio intermedio/alto o alto.

Not yet recruiting
2
90
Europe
Ibrutinib, IMP1, Capsule, hard, IMBRUVICA - 140 MG -CAPSULE RIGIDE -USO ORALE - FLACONE (HDPE) - 1 FLACONE (120 CAPSULE RIGIDE)
FONDAZIONE ITALIANA LINFOMI ONLUS, Janssen-Cilag S.p.A
Activated-B-Cell Lymphoma (ABC)-DLBCLat intermediate-high and high risk (IPI =2) Linfoma diffuso a grandi cellule B con profilo ABC (Activated-B-Cell) e rischio intermedio/alto o alto (IPI = 2), B-Cell Lymphoma (ABC)-DLBCLat intermediate-high and high risk Linfoma diffuso a grandi cellule B con profilo ABC e rischio intermedio/alto o alto, Diseases [C] - Blood and lymphatic diseases [C15]
 
 
NCT02514083: A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Treatment-Naive CLL

Active, not recruiting
2
29
US
Ibrutinib, Imbruvica, Fludarabine, Fludara
National Heart, Lung, and Blood Institute (NHLBI)
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
10/19
10/34
GELTAMO-IMCL-2015, NCT02682641 / 2015-004158-17: Ibrutinib in Combination With Rituximab in Patients With Indolent Clinical Forms of MCL

Active, not recruiting
2
50
Europe
IBRUTINIB, Imbruvica, Rituximab
Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea, Janssen-Cilag, S.A.
Mantle Cell Lymphoma
12/19
12/24
2018-002364-44: Clinical study of ibrutinib and rituximab in untreated marginal zone lymphomas

Ongoing
2
175
Europe
MabThera Uso sottocutaneo, MabThera, Imbruvica, [NA], Solution for injection, Concentrate for solution for infusion, Capsule, hard, MabThera, Imbruvica
IELSG - INTERNATIONAL EXTRANODAL LYMPHOMA STUDY GROUP, Janssen-Cilag AG, F. Hoffmann La Roche Ltd, Janssen Pharmaceutica NV
Previously untreated and symptomatic patients with histologically proven CD20-positive marginal zone B-cell lymphoma (MZL) in need of systemic treatment, Previously untreated marginal zone lymphoma, Diseases [C] - Cancer [C04]
 
 
2015-003128-30: Ibrutinib in relapsed lymphocyte-predominant Hodgkin lymphoma Ibrutinib zur Behandlung des rezidivierten nodulär Lymphozyten-prädominanten Hodgkin Lymphom

Not yet recruiting
2
36
Europe
Capsule, hard, Imbruvica
University of Cologne, JANSSEN-CILAG GmbH
relapsed lymphocyte-predominant Hodgkin lymphoma rezidiviertes nodulär Lymphozyten-prädominantes Hodgkin Lymphom, relapsed Hodgkin lymphoma (cancer of lymphatic system) Rückfall eines Hodgkin Lymphoms (Krebserkrankung des lymphatischen Systems), Diseases [C] - Cancer [C04]
 
 
2019-003632-23: Lenalidomide and Ibrutinib in association with R-MPV first-line treatment of Primary Central Nervous System Lymphoma for patients aged 18 to 60 Lénalidomide et Ibrutinib en association avec le R-MPV en traitement d’induction de première ligne pour les patients âgés de 18 à 60 ans présentant un lymphome primitif du système nerveux central (LCP).

Not yet recruiting
2
128
Europe
Ibrutinib 140 mg, Rituximab, Methotrexate, Procarbazine, Vincristine, Prednisone, Capsule, hard, Solution for infusion, Capsule, Tablet, Revlimid 5 mg, Revlimid 10 mg, Imbruvica 140 mg
Institut Curie, PHRC-K 2018 Public Health Grant, CELGENE SAS, JANSSEN-CILAG, KEOCYT SAS
Primary Central Nervous System Lymphoma (PCNSL) in patients aged 18 to 60, in first-line treatment Lymphome primitif du système nerveux central chez des patients âgés de 18 à 60 ans, en traitement de première ligne, Primary Central Nervous System Lymphoma in patients aged 18 to 60, first treatment Lymphome primitif du système nerveux central chez des patients âgés de 18 à 60 ans, 1er traitement, Diseases [C] - Cancer [C04]
 
 
 

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