ApolloBio Trials - LARVOL Sigma

Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

bizalimogene ralaplasmid (VGX-3100) / Inovio

ChiCTR2300071848: A Randomized, Double-blind, Placebo-Controlled Study in China to evaluate the efficacy and safety of VGX-3100 Delivered Intramuscularly (IM) followed by Electroporation with CELLECTRA™ 5PSP for the Treatment of HPV-16 and/or HPV-18 related High Grade Squamous Intraepithelial Lesion (HSIL) of the Cervix

Recruiting

6 mg (1 ml) VGX-3100 intramuscular injection followed by EP with the CELLECTRA 5PSP device given at Day 1, Week 4 and Week 12 ;Placebo intramuscular injection followed by EP with the CELLECTRA 5PSP device given at Day 1, Week 4 and Week 12

Chinese Academy of Medical Sciences Cancer Hospital; Beijing Apollo Saturn Biomedicine Technology Co. LTD, Beijing Apollo Saturn Biomedicine Technology Co. LTD

High Grade Squamous Intraepithelial Lesion of the Cervix

NCT03603808: VGX-3100 and Electroporation in Treating Patients With HIV-Positive High-Grade Anal Lesions

Active, not recruiting

Electroporation, electroporation therapy, EPT, HPV DNA Plasmids Therapeutic Vaccine VGX-3100, VGX-3100, Laboratory Biomarker Analysis

AIDS Malignancy Consortium, National Cancer Institute (NCI), The Emmes Company, LLC, Inovio Pharmaceuticals

Anal Intraepithelial Neoplasia, High Grade Squamous Intraepithelial Neoplasia, HIV Positivity, Human Papillomavirus-16 Positive, Human Papillomavirus-18 Positive

01/26

01/27

vocimagene amiretrorepvec/extended release flucytosine (DB107) / Denovo

NCT06264388: DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma

Recruiting

DB107-RRV, DB107-FC, Ancobon, Ancotil

Ashish Shah, Denovo Biopharma LLC, National Cancer Institute (NCI)

High Grade Glioma, Anaplastic Astrocytoma

05/34

NCT06504381: DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma

Not yet recruiting

1/2

DB107-RRV, Toca 511, Vocimagene amiretrorepvec, DB107-FC, Toca FC, Extended-release 5-fluorocytosine, 5-fluorocytosine, Radiation Therapy (RT), Radiation Treatment, Temozolomide, Temozolomide (TMZ), Magnetic Resonance Imaging (MRI), MR, MRI, Surgical resection, Surgical tumor resection, Brain surgery

Nicholas Butowski, California Institute for Regenerative Medicine (CIRM)

High Grade Glioma, MGMT-Unmethylated Glioblastoma, MGMT-Methylated Glioblastoma

01/40



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