Arginox Pharma 
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6 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
tilarginine (L-NMMA) / Galera Therap
NCT05660083: Alpelisib/iNOS Inhibitor/Nab-paclitaxel in Patients With HER2 Negative Metaplastic Breast Cancer (MpBC)

Recruiting
2
36
US
L-NMMA, iNOS inhibitor
The Methodist Hospital Research Institute, Novartis Pharmaceuticals
HER2-negative Breast Cancer, Metastatic Breast Cancer, Metaplastic Breast Carcinoma, TNBC - Triple-Negative Breast Cancer
12/26
12/28
NCT03236935: Phase Ib of L-NMMA and Pembrolizumab

Active, not recruiting
1
12
US
L-NMMA, NG-monomethyl-L-arginine, Pembrolizumab, Keytruda
The Methodist Hospital Research Institute
Non-Small Cell Lung Cancer, Malignant Melanoma, Head and Neck Squamous Cell Carcinoma, Classical Hodgkin Lymphoma, Urothelial Carcinoma Bladder, DNA Repair-Deficiency Disorders
10/21
12/25
NCT01791816: Mechanisms of Vasovagal Syncope

Completed
1
90
US
Phenylephrine, L-Ng-monomethyl Arginine (L-NMMA)
New York Medical College
Vasovagal Syncope, Postural Tachycardia Syndrome
12/22
12/22
Gas Challenge, NCT04265053: Human Cerebral Blood Flow Regulation

Recruiting
1
111
US
Indomethacin 25 MG/50 MG, Placebo - Lactose, Ganirelix Acetate, Testosterone Transdermal Product, Estradiol Topical, Antacid
University of Wisconsin, Madison, National Heart, Lung, and Blood Institute (NHLBI)
Cerebral Arterial Diseases
07/25
07/26
NCT02966665: : Vascular Function in Health and Disease

Recruiting
1
420
US
Maximum Exercise Tests, BH4, L-NMMA, Vitamin C, Vitamin E, α-Lipoic Acid and L-Ascorbate, BQ-123, Fexofenadine, Ranitidine, Allegra, Zantac, Angiotensin-II, Valsartan, Diovan, Acetylcholine, Sodium Nitroprusside, Angiotensin-II, Norepinephrine, Phentolamine, Regitine, BQ-123, MitoQ, BH4
Russell Richardson
Chronic Obstructive Pulmonary Disease, Pulmonary Artery Hypertension, Heart Failure, Hypertension
08/25
08/25
NCT03625349: Passive Limb Movement: A Tool to Assess Vascular Health and Guide Rehabilitation

Recruiting
N/A
130
US
NG-Monomethyl-L-Arginine, LNMMA
VA Office of Research and Development
Aging, Cardiovascular Disease
10/25
10/25
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
tilarginine (L-NMMA) / Galera Therap
NCT05660083: Alpelisib/iNOS Inhibitor/Nab-paclitaxel in Patients With HER2 Negative Metaplastic Breast Cancer (MpBC)

Recruiting
2
36
US
L-NMMA, iNOS inhibitor
The Methodist Hospital Research Institute, Novartis Pharmaceuticals
HER2-negative Breast Cancer, Metastatic Breast Cancer, Metaplastic Breast Carcinoma, TNBC - Triple-Negative Breast Cancer
12/26
12/28
NCT03236935: Phase Ib of L-NMMA and Pembrolizumab

Active, not recruiting
1
12
US
L-NMMA, NG-monomethyl-L-arginine, Pembrolizumab, Keytruda
The Methodist Hospital Research Institute
Non-Small Cell Lung Cancer, Malignant Melanoma, Head and Neck Squamous Cell Carcinoma, Classical Hodgkin Lymphoma, Urothelial Carcinoma Bladder, DNA Repair-Deficiency Disorders
10/21
12/25
NCT01791816: Mechanisms of Vasovagal Syncope

Completed
1
90
US
Phenylephrine, L-Ng-monomethyl Arginine (L-NMMA)
New York Medical College
Vasovagal Syncope, Postural Tachycardia Syndrome
12/22
12/22
Gas Challenge, NCT04265053: Human Cerebral Blood Flow Regulation

Recruiting
1
111
US
Indomethacin 25 MG/50 MG, Placebo - Lactose, Ganirelix Acetate, Testosterone Transdermal Product, Estradiol Topical, Antacid
University of Wisconsin, Madison, National Heart, Lung, and Blood Institute (NHLBI)
Cerebral Arterial Diseases
07/25
07/26
NCT02966665: : Vascular Function in Health and Disease

Recruiting
1
420
US
Maximum Exercise Tests, BH4, L-NMMA, Vitamin C, Vitamin E, α-Lipoic Acid and L-Ascorbate, BQ-123, Fexofenadine, Ranitidine, Allegra, Zantac, Angiotensin-II, Valsartan, Diovan, Acetylcholine, Sodium Nitroprusside, Angiotensin-II, Norepinephrine, Phentolamine, Regitine, BQ-123, MitoQ, BH4
Russell Richardson
Chronic Obstructive Pulmonary Disease, Pulmonary Artery Hypertension, Heart Failure, Hypertension
08/25
08/25
NCT03625349: Passive Limb Movement: A Tool to Assess Vascular Health and Guide Rehabilitation

Recruiting
N/A
130
US
NG-Monomethyl-L-Arginine, LNMMA
VA Office of Research and Development
Aging, Cardiovascular Disease
10/25
10/25

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