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- |||| Paxlovid (PF-07321332) / Pfizer
@pfizer agrees to let other companies make its #paxlovid #COVID19 therapy -- with a license granted to Medicines Patent Pool. Meaning -- Pfizer will not receive royalties on sales in low-income countries. https://t.co/Kji9eXqQdy (Twitter) - Nov 16, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer
Congrats to @MedsPatentPool for a second #COVID19 oral med license for #LMICs, this time for @pfizer’s Paxlovid. Proud to be part of MPP’s scientific advisory panel. Model is applicable for cancer medications as well! @uicc @ASCO @JCOGO_ASCO @jrgralow https://t.co/XpSrTtyDOI (Twitter) - Nov 16, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: Paxlovid hospitalization rate was 0.8%, so it seems like it would be the one that will end up being in demand. (Twitter) - Nov 16, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical: If #Molnupiravir & #paxlovid coming (in 1-2 mo) why are other early therapies needed for #COVID19? ▪️What to do now? Not in 2mo. ▪️Above meds are available worldwide today ▪️ Above meds <$10, not $700. ▪️Molnupiravir still had 7% hospitalization rate, how can we improve this? (Twitter) - Nov 15, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
America-5th wave of Covid is coming. @CDCDirector needs plan NOW to combat: 📍💉& boosters. 📍Counter disinfo. 📍Accelerate/expand vax mandates 📍Free medical 😷, rapid home test kits. 📍Soon: Molnupiravar and Paxlovid to help prevent 🏥 & ☠️ . https://t.co/d6lxw2iC8z (Twitter) - Nov 15, 2021
- | Paxlovid (PF-07321332) / Pfizer
Where is the full trial data for Molnupirivir and Paxlovid? #auspol @TGAgovau ??? (Twitter) - Nov 14, 2021
- || Paxlovid (PF-07321332) / Pfizer
And @sailorrooscout, the results when taken within 5 days of symptoms also impressive for PAXLOVID. (Twitter) - Nov 14, 2021
- || Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
it’s hard to unsee the pattern once you’ve seen it. Molnupiravir and Paxlovid won’t take this long. Of course that’s a good thing, but it’s very telling at the same time (Twitter) - Nov 13, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Great @ScienceVisuals showing the difference in mechanism between these 2 pills in the course of #SARSCoV2 replication https://t.co/vaeCRqY8bk Paxlovid inhibits the main protease (Mpro) that creates other essential proteins Molnupiravar induces lethal mutagenesis https://t.co/okuacBvsFF (Twitter) - Nov 11, 2021
- ||| ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Unless I heard it completely wrong, and please tell me if I did and I'll apologize, Campbell is also talking about Pfizer mixing Paxlovid™ (PF-07321332 + Ritonavir) and Ivermectin to get "Pfizermectin" They would never, and have no plans (Twitter) - Nov 11, 2021
- || Paxlovid (PF-07321332) / Pfizer
Clinical, Journal: Covid-19: Pfizer's paxlovid is 89% effective in patients at risk of serious illness, company reports. (Pubmed Central) - Nov 11, 2021
No abstract available
- | Comirnaty (tozinameran) / Pfizer, Fosun Pharma, BioNTech, Paxlovid (PF-07321332) / Pfizer
Wann gibts das Pfizermectin …ähm alias PF-07321332? Nehmen sie dann Comirnaty für immer vom Markt? (Twitter) - Nov 9, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Yes, @benryanwriter, and please remember that the new protease inhibitor from Pfizer (Paxlovid) is in trials for post-exposure prophylaxis as well (easy to give, oral) (Twitter) - Nov 8, 2021
- ||| ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
PAXLOVID. I heard 332 is being combined with generic ritonavir. Do not know dose, 50, 100, 200? We must ask Pfizer (Twitter) - Nov 8, 2021
- || Paxlovid (PF-07321332) / Pfizer
Paxlovid is one of the fastest targeted drugs ever made (Twitter) - Nov 8, 2021
- || Paxlovid (PF-07321332) / Pfizer
BOOSTERS on Curbsiders: We talk all things boosters and treatment on this Curbsiders edition but you see we didn't mention Paxlovid as other antiviral on horizon as this was taped before we had that press release. https://t.co/wZHNPwJT4G (Twitter) - Nov 8, 2021
- | Paxlovid (PF-07321332) / Pfizer
Ahora... ¿Cuánto costará el Paxlovid? @PfizerMx (Twitter) - Nov 8, 2021
- |||| ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Clinical: Outstanding thread on two oral options for COVID-19 treatment. In immunocompromised patients, caution and high level pharmacy expertise ought to be implemented because of potential drug-drug interactions with concomitant use of ritonavir when using PF-07321332 (Twitter) - Nov 7, 2021
- || Paxlovid (PF-07321332) / Pfizer
Nowy lek (Paxlovid) ma kilka zalet: działa, znana technologia, złożony z dwóch składników, co utrudnia wirusowi szybki rozwój oporności, nie ma skutków ubocznych w zakresie mutagenezy, szybko dostępny po rejestracji. W pierwszej kolejności będzie wskazany dla osób z obciążeniami (Twitter) - Nov 7, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
No Pfizer's Paxlovid / PF-07321332 is completely different from Ivermectin. This thread explains why it is effective and ivermectin is not as a 3CLpro inhibitor. But the Pfizermectin meme is pretty funny nonetheless😂 https://t.co/WKIMZUndFU (Twitter) - Nov 6, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
No Pfizer's Paxlovid / PF-07321332 is completely different from Ivermectin. This thread explains why it is effective and ivermectin is not as a 3CLpro inhibitor. But the Pfizermectin meme is pretty funny nonetheless😂 https://t.co/WKIMZUndFU (Twitter) - Nov 6, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: True, but patients on Paxlovid used in very early disease shouldn't often also be on systemic dex used in patients who have progressed to requiring oxygen. Now, they could be also on inhaled steroids if that pans out, but unlikely to be significant impact in short-course tx. (Twitter) - Nov 6, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical: Dos prometedores antivirales orales contra COVID. 💊🦠 - Molnupiravir: redujo riesgo de hospitalización en 50% y redujo mortalidad de 14 a 7%. - Paxlovid: redujo riesgo de hospitalización en 89% y redujo mortalidad de 8.2 a 0.7%. Aquí una tabla de @EricTopol que resume los datos (Twitter) - Nov 6, 2021
- |||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
A few updates Price for Paxlovid is to be same as Molnupiravir, which is disappointing https://t.co/E6FidKFq2n by @RebeccaDRobbins Origin of Molnupiravir https://t.co/qfUkyREdRD Worth highlighting that these pills would not be expected to be affected by #SARSCoV2 variants👍 https://t.co/IJOy7g03d4 (Twitter) - Nov 6, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: 3 of 389 patients (0.8%) on Paxlovid within 3 days of symptom onset were hospitalized and none died. Comparatively, in 385 patients on placebo within 3 days, 27 were hospitalized and 7 died (7%) Paxlovid reduces COVID hospitalization & death by 89% https://t.co/23FWeEfVgn (Twitter) - Nov 6, 2021
- |||| ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Clinical, Adverse events: Breaking news from EPIC HR study. #Paxlovid (ritonavir) reduced COVID hospitalizations from 6.7% (including 10 deaths) to 1.0% (O death), p<0.0001 at day 28. Side effects 19%placebo, 21%Paxlovid. 💪Early trial stop due to overwhelming efficacy. https://t.co/GDiN7Uz6xv… (Twitter) - Nov 6, 2021
- |||| ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Clinical, Adverse events: Breaking news from EPIC HR study. #Paxlovid (ritonavir) reduced COVID hospitalizations from 6.7% (including 10 deaths) to 6.7% (O death), p<0.001 at day 28. Side effects 19%placebo, 21%Paxlovid. 💪Early trial stop due to overwhelming efficacy. https://t.co/rDhORXCdTr (Twitter) - Nov 6, 2021
- |||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical: Thus reduction in hospitalization ▪️ #Paxlovid 85% reduction ▪️ #Molnupiravir 47% reduction (+1 placebo person lost to follow up, counted as failure in Press Release) Both trials had zero deaths with therapy. Differential hospitalization rate due to differences in location of RCT (Twitter) - Nov 6, 2021
- |||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical: How does @Pfizer #paxlovid compare to #Molnupiravir? Both double-blind RCTs enrolled <=5 days of symptoms ▪️ 6.7% vs. 1.0% Hosp/Death w PAX (n=1219) ▪️ 13.8% vs 7.3% Hosp/death w MPV (n=775) Location 45% of PAX enrolled in USA, MPV >50% in Latin America. https://t.co/Du6O9tucFe (Twitter) - Nov 6, 2021
- |||| rifampicin / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Clinical: My understanding (from the great @BWDionne @jeffpears0n and @davidwkubiak) is that these RTV effects are short-lived -- different than rifampin. Have also faced this in HIV/covid pts, and been reassured the same. Since PAXLOVID given early, dex late, probably won't matter! (Twitter) - Nov 6, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
“ The company aims to produce 180 thousand packages of Paxlovid by the end of 2021 and 50 million packages by the end of 2022” (BBC news) Do you think the production of 50 million packages of drug will be enough? @DrEricDing @EricTopol @pfizer @mugecevik (Twitter) - Nov 6, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
5 day treatment course. How to use paxlovid in immunocompromised will be an open question. Based on past experience of difficult to clear sars-cov-2, doubling the duration may be a good starting point for future cohort studies. (Twitter) - Nov 6, 2021
- || Paxlovid (PF-07321332) / Pfizer
COVID-19, il farmaco orale #Paxlovid sviluppato da @pfizeritalia riduce il rischio di ospedalizzazione e morte dell'89% https://t.co/sqVGGS9rrP (Twitter) - Nov 5, 2021
- ||| Paxlovid (PF-07321332) / Pfizer, molnupiravir (MK-4482) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical: 0 deaths in those who got PAXLOVID, 10 deaths in those who got the placebo (pill with nothing in it). So, this is a twice a day medication given for 5 days just like molnupiravir. Oral, give to someone after diagnosis & high chance of preventing severe disease in someone at risk (Twitter) - Nov 5, 2021
- |||| ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
This protease inhibitor also comes co-formulated with ritonavir to boost its levels. The Pfizer protease inhibitor is called PAXLOVID as its brand name but the protease inhibitor (PI) drug is PF-07321332 and it comes with ritonavir. Press release here https://t.co/nJ7XYW1jf0 (Twitter) - Nov 5, 2021
- ||| Paxlovid (PF-07321332) / Pfizer, molnupiravir (MK-4482) / Emory University, Ridgeback Biotherap, Merck (MSD)
ORAL ANTIVIRALS (e.g. molnupiravir and now "Paxlovid"): Why is everyone so excited about designated antivirals that target enzymes involved in the viral lifecycle of SARS-CoV-2? Because they will directly treat COVID & hopefully prevent severe disease https://t.co/LmZdJepEOH (Twitter) - Nov 5, 2021
- |||||| Paxlovid (PF-07321332) / Pfizer
Clinical: With the addition of Pfizer's Paxlovid to the inventory of tools we have for fighting Covid-19, I worry we'll have more people to convince to take it. Maybe pill pockets would help? (Twitter) - Nov 5, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Pfizer new antiviral paxlovid, is highly effective , cutting severe outcomes by 98% when used early! More good news!! https://t.co/sku2QyXy6b (Twitter) - Nov 5, 2021
- || Paxlovid (PF-07321332) / Pfizer
One the horizon is the companion post-exposure prophylaxis trial among household contacts (presumably of those enrolled in the current trial) testing 5 vs 10 days of boosted PF07321332 (Paxlovid). This should work really well -- but which duration? https://t.co/sfm0MiowAQ (Twitter) - Nov 5, 2021
- ||| Paxlovid (PF-07321332) / Pfizer, molnupiravir (MK-4482) / Emory University, Ridgeback Biotherap, Merck (MSD)
Did the age of REALLY effective oral anti #COVID19 just start with PAXLOVID and MOLNUPIRAVIR? I SURE HOPE SO - but can we give them simpler names like #COVIDKillerByMerk and #COVIDKillerByPfizer or something like that? (Twitter) - Nov 5, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: It would be interesting to see what Paxlovid does to people with Multiple Sclerosis with Covid, given its seeming impact on viral load. @GavinGiovannoni https://t.co/zdcxaUK3NN (Twitter) - Nov 5, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: It would be interesting to see what Paxlovid does to people with Multiple Sclerosis with Covid, given its seeming impact on viral load. @GavinGiovannoni https://t.co/zdcxaUK3NN (Twitter) - Nov 5, 2021
- |||| Arzerra (ofatumumab) / Novartis, Genmab, Paxlovid (PF-07321332) / Pfizer, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Clinical: Am I correct in thinking that the new Pfizer antiviral PAXLOVID is fantastic news for those that are immunocompromised where vaccination does not work that well? Like patients taking rituximab or ofatumumab? (Twitter) - Nov 5, 2021
- |||||| ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Clinical, DSMB: ⚠️ Press release only. DB-RCT of Paxlovid (PF-07321332; ritonavir), an oral #SARSCoV2-3CL protease inhibitor, vs placebo in high-risk outpatients w/ #COVID19: stat sig 89% ⬇️ risk of hosp/death. Enrollment halted per IDMC at pre-planned interim analysis. #MedTwitter NCT04960202 (Twitter) - Nov 5, 2021
P3
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: BTW, Paxlovid is the fastest progression from a new chemical entity to proof of benefit in a clinical trial in history. Less than 2 years! (Twitter) - Nov 5, 2021
- | Paxlovid (PF-07321332) / Pfizer
Okay got it!! @US_FDA was manipulated or instructed by the masters, into stalling $HGEN as $PFE had a drug incoming. Paxlovid!! Could this be a conspiracy theory??? (Twitter) - Nov 5, 2021
- || ritonavir / Generic mfg., PF-07321332 / Pfizer
PF-07321332; ritonavir (Twitter) - Nov 5, 2021
- |||||| ritonavir / Generic mfg., PF-07321332 / Pfizer
Clinical: ⭐️🚨Pfizer’s Novel COVID-19 Oral Antiviral Treatment Candidate PAXLOVID™ (PF-07321332) co-administered with ritonavir 👉🏼Reduced Risk of Hospitalization or Death by 89% in Interim Analysis of Phase 2/3 EPIC-HR Study. https://t.co/REChU9y6rZ (Twitter) - Nov 5, 2021
- || PF-07321332 / Pfizer
PF-07321332 (better known by its nom de plume as ’332) has entered the building. Via @matthewherper https://t.co/lJwGr41t7M (Twitter) - Nov 5, 2021
- |||||| PF-07321332 / Pfizer
Clinical: Pfizer’s oral protease inhibitor PF-07321332 for #COVID19 Reduced Risk of Hospitalization or Death from 6.7% (41/612) to 1.0% (6/607) when starting within 5 days of symptom onset. 10 vs 0 deaths. #idtwitter https://t.co/ZAIm6Y5mAt (Twitter) - Nov 5, 2021