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- || Paxlovid (PF-07321332) / Pfizer
Yet @US_FDA continues to sit on Paxlovid. (Twitter) - Dec 1, 2021
- || Paxlovid (PF-07321332) / Pfizer
Why the @US_FDA delay in Paxlovid??? (Twitter) - Dec 1, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: Paxlovid meeting is important, but consider that the true critical path to its delivery is production ramp-up not approval. Also, process for patient test to pill needs to be accelerated. Current process takes too long. Need rapid test and immediate pill in hand. (Twitter) - Dec 1, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: Yes @drklausner. Pre-travel screening in a global pandemic of a highly transmissible respiratory virus not as effective as 2021 tools: vaccines and upcoming oral antivirals (when is Paxlovid meeting?) for those unvaccinated (Twitter) - Dec 1, 2021
- |||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical, Review: To dig in a bit: Paxlovid made by @pfizer showed 89% effectiveness against hospitalization or death and will soon go under review for emergency use by @FDA; Molnupiravir made by @merck narrowly won EUA yesterday. Analysis shows 30% effectiveness, but... (Twitter) - Dec 1, 2021
- || Paxlovid (PF-07321332) / Pfizer
Review: When will the FDA’s AMDAC convene to review and discuss Paxlovid? (Twitter) - Nov 30, 2021
- | Paxlovid (PF-07321332) / Pfizer
Paxlovid looks better, but we need complete data (Twitter) - Nov 30, 2021
- | Paxlovid (PF-07321332) / Pfizer
In that case Paxlovid should pass with flying colours. (Twitter) - Nov 30, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer
New data to show that Paxlovid (the Pfizer anti-Covid pill) overrides concerns about variants https://t.co/AG5Z5XmUM8 (Twitter) - Nov 30, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: #Omicron THREE TO FOUR DAYS TO DOUBLE @CDCDirector @DrNancyM_CDC @DrWoodcockFDA @US_FDA @ASlavitt @JoeBiden @VP @DrEricDing @WmHaseltine PLEASE GET #Paxlovid ready. We’ll need tons of it. 50 million adults unvaccinated + children Half-dosed Didn’t get booster (Twitter) - Nov 30, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: @DrEricDing @DrLeanaWen @ScottGottliebMD @WmHaseltine @CDCDirector @DrNancyM_CDC @DrWoodcockFDA @US_FDA If the @pfizer vaccine needs tweaking we better have tons of #Paxlovid ...while it’s cooked up. @pfizer says it #Paxlovid works bc it aims at the body not the spikes (Twitter) - Nov 30, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer
Clinical: Pfizer, Merck Pills Renew Concerns on Covid Treatment Equity - I don't think joining Medicines Patent Pool for Paxlovid lets Pfizer off the hook for the failure to help the world with the vaccines https://t.co/yql3b9szHc (Twitter) - Nov 29, 2021
- ||| fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Fluvoxamine is not standard of care anywhere. Crazy. There is no delay for paxlovid i am aware of. Merck's pill is in trouble, though. No evidence it works against delta. (Twitter) - Nov 29, 2021
- || fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer
I didn't know they still didn't fully release the results. In general what is with the hang-ups with all early treatments. Is fluvoxamine part of guidelines yet? Even Paxlovid seems to be getting hung up on release? (Twitter) - Nov 29, 2021
- | Paxlovid (PF-07321332) / Pfizer
Journal: Virtual Double-System Single-Box for Absolute Dissociation Free Energy Calculations in GROMACS. (Pubmed Central) - Nov 29, 2021
The proposed protocol, by exploiting its inherent parallelism and the power of the GROMACS code on graphical processing units, has the potential to afford accurate and precise estimates of the dissociation constants in drug-receptor systems described at the atomistic level. The procedure has been applied to the calculation of the absolute dissociation free energy of PF-07321332, an oral antiviral proposed by Pfizer, with the main protease (3CL) of SARS-CoV-2.
- || Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Molnupiravir still will be authorized & Paxlovid's meeting should be in December? Oral antivirals will work against variants (they work on viral replication upstream) https://t.co/kYl4iXmGjg (Twitter) - Nov 28, 2021
- ||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical, FDA event: Update on molnupiravir in advance of FDA meeting 11/30. Data on n=1433; hospitalizations now reduced by 30% (not 48% as before) in molnupiravir group compared to placebo; 9 deaths in placebo, 1 in molnupiravir. Paxlovid still 89% reduction hospitalizations https://t.co/a4mc5btqy5 (Twitter) - Nov 28, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: To @AlbertBourla IMO #Paxlovid will be as important as any vaccine @WmHaseltine says @merck antiviral pill “may supercharge variants” What if it supercharges #Omicron ? @DrEricDing @DrNancyM_CDC @DrWoodcockFDA @CDCDirector @US_FDA (Twitter) - Nov 28, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: The EUA being sought for Paxlovid would limit use to the unvaccinated. (Twitter) - Nov 28, 2021
- |||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical: If Omicron turns out to have substantial immune evasiveness, the pills will add a significant layer of defense. We should get these small molecules into mass production, especially Paxlovid, with its takedown of upstream Mpro, and much higher efficacy than Molnupiravir (to date) https://t.co/uxFKD27brV (Twitter) - Nov 28, 2021
- || Paxlovid (PF-07321332) / Pfizer
hmm... paxlovid over monoclonal antibodies ? guess becos they are resilient to variants ? (Twitter) - Nov 27, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: But if evolution isn't maintaining a record of selection against those epitopes, then maybe immunity through prior infection isn't significantly more robust than the vaccines. We need some additional protection; I hope Paxlovid is approved STAT @califf001 (when you get in!) (Twitter) - Nov 27, 2021
- |||| remdesivir / Generic mfg., Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical: Ironically the best evidence for the efficacy of remdesivir comes from the halted PINETREE study in outpatients -- better than molnupiravir, comparable to Paxlovid. An oral option would be highly desirable! https://t.co/o9e0IBPH0F https://t.co/FSWbbONiWB (Twitter) - Nov 27, 2021
- ||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Verschwörungstheorie! Vertrauen Sie gefälligst auf die prodrug Molnupiravir (NHC) und das HIV-Mittel Retonavir + Augenwischerunbekanntchemikalie = Paxlovid! Hören Sie auf, eventuell zu erklären, wieso eine rein antivirale Behandlung, ohne Entzündungshemmung GAR NICHTS bringen (Twitter) - Nov 27, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer
Pfizer’s Paxlovid protease inhibitor pill will largely mitigate the entire covid pandemic. (Twitter) - Nov 26, 2021
- || Paxlovid (PF-07321332) / Pfizer
Ik vraag me af hoe ze het zullen brengen de verminderde effectiviteit v Pfizer tegen Nu. Waarschijnlijk een reeks artikelen die geleidelijk afzwakken en bagatelliseren totdat ze verklaren dat de wetenschap veranderd is. @PfizerNL zsm update vaccin en opvoeren productie Paxlovid! (Twitter) - Nov 26, 2021
- | Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
All hail Paxlovid $PFE (NB $MRK molnupiravir is already approved in the UK). (Twitter) - Nov 26, 2021
- || Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
And finally, someone asked me if antiviral therapies still work against variants- yes, they are not directed against spike proteins- they are directed against enzymes in the viral lifecycle that enable the virus to replicate. Molnupiravir and Paxlovid https://t.co/kYl4iXmGjg (Twitter) - Nov 25, 2021
- ||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical: Vaccines work & I am grateful for them as safer way to gain control than natural immunity (India/Bangladesh tragically gained) & I am grateful for the upcoming antivirals (Paxlovid, molnupiravir) here before Jan 2022 to prevent severe disease; targeted oral therapy (Twitter) - Nov 25, 2021
- |||||| Paxlovid (PF-07321332) / Pfizer
Clinical: ICYMI: 11/20 @IDSAInfo/@CDCgov Clinician Call Updates in #COVIDTreatment & #Antibody-Based Prevention @RMKGandhi @MassGeneralNews discussing #Pfizer oral medication PF-07321332 (‘332) #RealTimeCOVID19 @SHEA_Epi @SocietyHospMed @SIDPharm @SCCM (Twitter) - Nov 24, 2021
- ||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical: And for those who decline vaccination, Paxlovid (here soon) literally prevents severe disease at the same rate as vaccines & molnupiravir being reviewed next Tuesday: https://t.co/kYl4iXmGjg (Twitter) - Nov 23, 2021
- || Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
#7 - TREATMENTS AND PROPHYLAXIS referring to the two new exciting game-changing antivirals coming out (molnupiravir & Paxlovid) mainly since monoclonal antibodies great but harder to administer (IV, subcutaneous, need monitoring): https://t.co/kYl4iXmGjg (Twitter) - Nov 23, 2021
- | Paxlovid (PF-07321332) / Pfizer
La @EMA_News examinará los datos de un estudio en el que se compara el efecto de #Paxlovid de @pfizer_spain con el de un tratamiento ficticio https://t.co/2EJzqbMnOV (Twitter) - Nov 22, 2021
- || Paxlovid (nirmatrelvir/ritonavir) / Pfizer
New P1 trial: Food Effect Study to Evaluate the Effect of High-Fat Meal on the Relative Bioavailability of PF-07321332 Boosted With Ritonavir in Healthy Adult Participants (clinicaltrials.gov) - Nov 21, 2021
P1, N=12, Not yet recruiting, Sponsor: Pfizer
- |||| ivermectin oral / Generic mfg., Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Hard not to laugh at the latest conspiracy theory that molnupiravir and paxlovid (Merck and Pfizer PO antiCOVID drugs) are actually repackaged ivermectin... (Twitter) - Nov 21, 2021
- |||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical, FDA event: TREATMENTS: We need designated antiviral outpatient treatments for COVID to prevent severe disease and we discussed Paxlovid's EUA was filed but excited that molnupiravir being discussed next Tuesday Nov 30 at FDA meeting: https://t.co/tX0Nxbf22E (Twitter) - Nov 21, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Lol at Pfizer.... they would have the audacity to create a synthetic "vitamin process" pill called paxlovid and claim it as a "miracle"... (Twitter) - Nov 21, 2021
- |||| Paxlovid (PF-07321332) / Pfizer, paracetamol / Generic mfg.
I've joked that in the future Tylenol will have "Severe Cold, Flu and COVID" over the counter medicine. Pfizer's PAXLOVID™ sure sounds hopeful. I'm curious what models predict the R0 will be like in say 2025 once the "novel" part of "novel coronavirus" has completely worn off. (Twitter) - Nov 21, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer
From @NIH: Early Data Suggests #Pfizer Pill May Prevent Severe #COVID19 https://t.co/OKKZ7Ccu0n #RealTimeCOVID19 #PAXLOVID @IDSAInfo @SHEA_Epi @SIDPharm @SCCMPresident @SocietyHospMed @JGPharmD @Dr_Mike_Stevens @Payal_Patel @Sonali_Advani @ACEPNow (Twitter) - Nov 19, 2021
- ||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
I am personally eligible for monoclonal antibody treatments, but not everyone is. Any proven protease inhibitor (approved or repurposed), antiviral that has studies behind them is better than nothing. Eventually molnupiravir and paxlovid will be available. (Twitter) - Nov 19, 2021
- || Paxlovid (PF-07321332) / Pfizer
Pfizer's paxlovid (a combination treatment, actually) is basically a grand slam. (Twitter) - Nov 18, 2021
- || Paxlovid (nirmatrelvir/ritonavir) / Pfizer
Trial completion: Renal Impairment Study of PF-07321332 Boosted With Ritonavir in Adult Participants With Renal Impairment and in Healthy Participants With Normal Renal Function. (clinicaltrials.gov) - Nov 18, 2021
P1, N=35, Completed, Sponsor: Pfizer
The procedure has been applied to the calculation of the absolute dissociation free energy of PF-07321332, an oral antiviral proposed by Pfizer, with the main protease (3CL) of SARS-CoV-2. Recruiting --> Completed
- |||| Paxlovid (PF-07321332) / Pfizer
Clearly the Pfizer paxlovid data look great. If one gets COVID today, get into a time machine to transport yourself 6 weeks into the future (so long as you are in the USA and qualify for high-risk EUA criteria). (Twitter) - Nov 17, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Pfizer requests emergency authorization for five-day COVID-19 drug regimen #Paxlovid https://t.co/ccmMhKMH1O (Twitter) - Nov 17, 2021
- || Paxlovid (PF-07321332) / Pfizer
My old eyes keep seeing Pavlovid instead of Paxlovid—and I get images of drooling dogs! (Twitter) - Nov 16, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical, FDA event: Paxlovid is pending to FDA approval. In patients treated within three days of developing COVID-19 symptoms, 0.8% of who received PAXLOVID™ were hospitalized compared to 7% of the placebo group. https://t.co/QCl6rEpbjH (Twitter) - Nov 16, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical: Pfizer’s requests EUA for Paxlovid, oral COVID drug. Reduced risk of hospitalizations and deaths by almost 90% in trial. Merck has already submitted request for its oral drug, molnupiravir last month. Can't wait for these drugs to become available! https://t.co/OaoOsAiRwz (Twitter) - Nov 16, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Pfizer submitting #Paxlovid data to @US_FDA for EUA application. Story in @statnews (Twitter) - Nov 16, 2021
- |||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
FDA event: ANTIVIRALS (oral, 5 day courses, twice a day): Biden administration has bought 10 million doses of Paxlovid ahead of time & 3 million doses of molnupiravir This is how the antivirals work- FDA meeting for molnupiravir Nov 30; Pfizer put in EUA for Paxlovid today (Twitter) - Nov 16, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Will this affect how much paxlovid Pfizer sells at ~$700? Probably not. If they estimate they can produce 50 Million courses that are going to high- or middle- income countries, they will sell all that they can make. (Twitter) - Nov 16, 2021