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- || Paxlovid (PF-07321332) / Pfizer
Why Paxlovid is a Just-in-Time Breakthrough, by @EricTopol https://t.co/JgGVnz5gTb (Twitter) - Dec 16, 2021
- || Paxlovid (PF-07321332) / Pfizer
Why Paxlovid is a Just-in-Time Breakthrough, by @EricTopol https://t.co/a8ykkpLyMl Excellent must-read article on #Paxlovid @HBS_Eric @DrEricDing @AlbertBourla @DrLeanaWen @ASlavitt @drdanchoi @WmHaseltine @CDCDirector (Twitter) - Dec 16, 2021
- || Paxlovid (PF-07321332) / Pfizer
Why Paxlovid is a Just-in-Time Breakthrough, by @EricTopol https://t.co/3FY5j67v2w (Twitter) - Dec 16, 2021
- || Paxlovid (PF-07321332) / Pfizer
Dear Drs. @EricTopol and @PeterHotez - have you reviewed the data yourself? If not, please wait until we've seen the actual data before making the 'Paxlovid is a breakthrough'-declarations. It will build more trust in medical authorities, like yourselves. (Twitter) - Dec 16, 2021
- || Paxlovid (PF-07321332) / Pfizer
Why Paxlovid is a Just-in-Time Breakthrough, by @EricTopol https://t.co/5nkSftku0U (Twitter) - Dec 16, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Muy buen análisis (y dosis de buenas noticias) del nuevo tratamiento anti COVID por @EricTopol 👉Why Paxlovid is a Just-in-Time Breakthrough - by Eric Topol https://t.co/XkN6bVdIoh (Twitter) - Dec 16, 2021
- || Paxlovid (PF-07321332) / Pfizer
"#Paxlovid is a breakthrough, and I don’t use that term lightly. It not only provides a new layer of defense, but a unique one that is not dependent on our immune system and not affected by #Omicron or other variants." by @EricTopol https://t.co/J1gIBs6hcp #nirmatrelvir (Twitter) - Dec 16, 2021
- || Paxlovid (PF-07321332) / Pfizer
I love Paxlovid. Thank you @EricTopol for the amazing work you do keep the world informed. Absolutely wonderful, orienting, and life saving. 🙏 https://t.co/fQtMjuvwTv (Twitter) - Dec 16, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical, Review: Another superb @SubstackInc review by @EricTopol; this on Paxlovid, Pfizer's new oral antiviral. Given its preserved efficacy vs. Omicron & fact that it's likely to ⬇infectivity as well as severe illness, it's crucial to expedite approval & distribution. https://t.co/GDzVzLiiMF (Twitter) - Dec 16, 2021
- | Paxlovid (PF-07321332) / Pfizer
Journal: Characterization of the non-covalent interaction between the PF-07321332 inhibitor and the SARS-CoV-2 main protease. (Pubmed Central) - Dec 16, 2021
When the catalytic dyad is in the neutral state, the non-covalent binding is likely to be stronger. Molecular dynamics simulations seems to lend support for an inhibitory mechanism in two steps: a first non-covalent addition with the dyad in neutral form and then the formation of the thiolate-imidazolium ion pair and the ligand relocation for finalising the electrophilic attack.
- | Trial completion date, Trial primary completion date: RECOVERY: Randomised Evaluation of COVID-19 Therapy (clinicaltrials.gov) - Dec 16, 2021
P2/3, N=45000, Recruiting, Sponsor: University of Oxford
Molecular dynamics simulations seems to lend support for an inhibitory mechanism in two steps: a first non-covalent addition with the dyad in neutral form and then the formation of the thiolate-imidazolium ion pair and the ligand relocation for finalising the electrophilic attack. Trial completion date: Dec 2031 --> Nov 2032 | Trial primary completion date: Dec 2021 --> Nov 2022
- ||||| ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Clinical: #Pfizer Says #COVID-19 #Pill Near 90% Effective in Final Analysis #Coronavirus #Pandemic #Antiviral #Paxlovid #Ritonavir #Vaccine #Hospitalizations #Omicron #Variant #Delta @pfizer @PaulSaxMD @harvardmed https://t.co/MOPFZxbT74 (Twitter) - Dec 15, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical, Interview: Interviewed @KCBSRadio re Paxlovid pill, vaccine efficacy w/ #Omicron, & the holidays https://t.co/bAyR2XnXBI (Twitter) - Dec 15, 2021
- || Paxlovid (PF-07321332) / Pfizer
FWIW .. @jpogue1 and I reverted to Paxlovid after about 2 tries 😂 (Twitter) - Dec 15, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: 5)Paxlovid asap 6)Acknowledge natural immunity more like Europe 7)CDC reporting: Better data on severe breakthroughs so can advise boosters, masks, etc. 8) Stop travel bans, harm reduction approach, global equity, acknowledge endemic, prevent illness https://t.co/LhIOW9yh4b (Twitter) - Dec 15, 2021
- || Paxlovid (PF-07321332) / Pfizer
Paxlovid is some good organic chemistry reading. (Twitter) - Dec 15, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: #Unitedairline says 8 million to fly Xmas #Omicron will be a Xmas superspreader @DrEricDing @CDCDirector @DrNancyM_CDC @CDCgov @US_FDA @DrWoodcockFDA @SteveFDA @ASlavitt #Paxlovid is approvable now We can’t booster or vaccinate enough in time Booster, yes + #Paxlovid (Twitter) - Dec 15, 2021
- || Paxlovid (PF-07321332) / Pfizer
#Paxlovid #Paxlovid #Paxlovid @dianaberrent @Survivor_Corps @drdanchoi @DrLeanaWen @WmHaseltine @CDCgov @CDCDirector @DrNancyM_CDC @US_FDA @DrWoodcockFDA @SteveFDA (Twitter) - Dec 15, 2021
- || Paxlovid (PF-07321332) / Pfizer
We follow the U.K. I pray #paxlovid will be approved and available Every single day we approach a cliff. @CDCDirector @US_FDA @DrNancyM_CDC @CDCgov @DrWoodcockFDA @SteveFDA (Twitter) - Dec 15, 2021
- || Paxlovid (PF-07321332) / Pfizer
Das halte ich für an den Haaren herbei gezogen. So enthielte man Paxlovid allen anderen vor, weil man die Studie ja nicht beendet... (Twitter) - Dec 15, 2021
- || Paxlovid (PF-07321332) / Pfizer
Die Paxlovid Studie wurde meines Wissens abgebrochen, weil es ethisch nicht vertretbar war, der Kontrollgruppe Paxlovid vorzuenthalten. Trotzdem wird es wahrscheinlich noch Monate dauern, bis die FDA Paxlovid zulässt. (Twitter) - Dec 15, 2021
- || Paxlovid (PF-07321332) / Pfizer
Please authorize Paxlovid asap @US_FDA. 88 percent protection against severe disease maintained (Twitter) - Dec 15, 2021
- || Paxlovid (PF-07321332) / Pfizer
So far Omicron looks about the same for inherent severity, just more likely to reinfect/breakthrough. If so, it won’t be necessary to know which variant someone has to decide how much they’d likely benefit from Paxlovid. But if needed we can detect SGTF with Taqpath PCR. (Twitter) - Dec 15, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: My recollection is there were some people polled who would take Regeneron but not vaccines, but there are some who would refuse both. There is also this, but I don’t know if the need for this fact check means Paxlovid will be more or less popular: https://t.co/C4gI56ZE0w (Twitter) - Dec 15, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: Note that Pfizer’s eua request for paxlovid was submitted for use in unvaccinated only. (Twitter) - Dec 15, 2021
- |||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical: I assume Paxlovid not going to be approved for (on-label) pediatric use, so that’s one set of infections out. Curious about whether it will be considered in pregnancy? The mechanism seemed less concerning than molnupiravir (Twitter) - Dec 15, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: Curious how much Paxlovid refusal clinicians expect, in unvaccinated populations in particular. (Particularly since it’d need to be given fairly early, right? So would one also need to get people to test often?) OTOH it might help in long term care & other monitored settings (Twitter) - Dec 15, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
"Current variants of concern can be resistant to treatments that are focused on spike protein expressed on surface of the SARS-CoV-2 virus, due to mutations in this region. PAXLOVID works intracellularly on the protease of the SARS-CoV-2 virus by inhibiting viral replication." (Twitter) - Dec 15, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: We feel dangerously close to a permanent world where people must sacrifice their freedoms and cover their children’s faces from this point forward no matter what vaccine or therapeutic is available. Ballot boxes will change it, hopefully. #Omicron #paxlovid (Twitter) - Dec 15, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
@AlbertBourla Can @pfizer speed up making #Paxlovid ? The situation is getting dire as I tweet. @ScottGottliebMD @DrEricDing @EricTopol @DrLeanaWen @JoeBiden PLEASE HELP. (Twitter) - Dec 15, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: In the final analysis of its Phase 2/3 clinical trial, the antiviral, called Paxlovid, was found to be 89% effective at preventing high-risk people from being hospitalized or dying from Covid, the company said. https://t.co/wrbFjfrGOo via @nbcnews (Twitter) - Dec 14, 2021
- || Paxlovid (PF-07321332) / Pfizer
180,000 courses of Paxlovid is just 2 weeks of mAbs deliveries https://t.co/s5QcpjafWz (Twitter) - Dec 14, 2021
- || Paxlovid (PF-07321332) / Pfizer
Analysts don't think that generics manufacturers will be able to produce large quantities of generic Paxlovid for the developing world before Q3-2022. https://t.co/d3XYLlpYW2 (Twitter) - Dec 14, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: Paxlovid protects from hospitalization and death in outpatients up to 5 days from start of symptoms. If you want to know efficacy of COVID antiviral therapies in non-immunocompromised patients, look at those treated early and before severe disease. https://t.co/puanx3NqyP (Twitter) - Dec 14, 2021
- |||||| Paxlovid (PF-07321332) / Pfizer
Clinical: BREAKING NEWS! @pfizer announces #PAXLOVID ⬇️ risk of hospitalization or death by 89% (within 3 days symptom onset) & 88% (within 5 days symptom onset) vs. placebo https://t.co/IpiSAkoURd #RealTimeCOVID19 @IDSAInfo @SHEA_Epi @SCCMPresident @SocietyHospMed @SIDPharm @JGPharmD (Twitter) - Dec 14, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: @JGPharmD do you have a handy cheat sheet on interactions to watch for ? Also if patient has lots of GI symptoms at time, might be exacerbated a bit with paxlovid ( BUT PREVENTS HOSPITAL/DEATH) I’d rather be home with diarrhea than hospitalized 🤓 (Twitter) - Dec 14, 2021
- || Paxlovid (PF-07321332) / Pfizer
Eff that. I’m saying paxlovid. (Twitter) - Dec 14, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical, Interview: “I just took a few until I felt better, and the white ones upset my stomach so I didn’t take any of those.” -interview with Patient Zero of the Paxlovid-resistant Pi variant outbreak (They have to skip Pi, right? Can’t ruin pie for everyone!) (Twitter) - Dec 14, 2021
- || ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer, apixaban / Generic mfg.
Great news. Handling the ritonavir interactions will be key with high risk meds. For example, apixaban’s dose is to be halved with ritonavir per the Eliquis label. Will be interesting to see Paxlovid EUA if authorized. https://t.co/HpQCraDWCl (Twitter) - Dec 14, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer
Clinical: 1. Paxlovid from Pfizer won’t be available in quantity for several weeks to Rx patients with breakthrough infections or the unvaccinated (Twitter) - Dec 14, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Good context on paxlovid. One key stat: "The company is expected to deliver only enough of its pills to cover 300,000 Americans before the end of February" There are >100,000 infections each day right now. At peak Jan 21 almost 250,000. Few getting this https://t.co/Fi3iqKfMQQ (Twitter) - Dec 14, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: When a virus is recognized to have properties that will make it endemic but have strategies to protect against severe disease (vaccines & therapeutics-Paxlovid- for those who decline), we track cases in health departments, policy formed on hospitalizations https://t.co/LhIOW9yh4b (Twitter) - Dec 14, 2021
- || Paxlovid (PF-07321332) / Pfizer
Nice summary of the #paxlovid data written up in more than 288 characters at a time by @matthewherper in @statnews (Twitter) - Dec 14, 2021
- || Paxlovid (PF-07321332) / Pfizer
Was just talking to someone about this. Huge issue if we end up with delta and omicron around at same time, and Paxlovid is an option, but supply is limited and certain mABs will only work with delta not omicron. How to choose wisely? Testing again is achilles heel. (Twitter) - Dec 14, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer
Clinical: .@pfizer Announces Additional Phase 2/3 Study Results Confirming Robust Efficacy of Novel COVID-19 Oral Antiviral Treatment Candidate in Reducing Risk of Hospitalization or Death | Pfizer https://t.co/cDCt90YfmQ The data for PAXLOVID is very encouraging. (Twitter) - Dec 14, 2021
- ||| ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Clinical: Final data… PAXLOVID™ (nirmatrelvir [PF-07321332] tablets and ritonavir tablets) reduced risk of hospitalization or death by 89% (within three days of symptom onset) and 88% (within five days of symptom onset) compared to placebo https://t.co/s7pgupUGe1 (Twitter) - Dec 14, 2021
- |||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
I think of molnupiravir a bit like AZT (not specific for SARS-CoV-2 but important) and Paxlovid a bit like HIV specific protease inhibitors which were revolutionary https://t.co/9RNcafrlaK (Twitter) - Dec 14, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical, FDA event: PAXLOVID: Good news. Final outcomes of Paxlovid EPIC-HR trial did not change: 88% reduction in hospitalization & death among unvaccinated at high risk. Must provide compassionate care with this med (eventually could be used for vax breakthroughs, prophylaxis). FDA meeting day? (Twitter) - Dec 14, 2021
- || Paxlovid (PF-07321332) / Pfizer
Smart PR to release the commercial Paxlovid name that one is able to pronounce first, then Nirmatrelvir later. (Twitter) - Dec 14, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer
Clinical: #Science of the "COVID era" hits another home run! Paxlovid- a protease inhibitor results in: 88% reduction (6.3%->0.8%) in hospitalization/death in high risk adults w/in 5 days of symptom onset. 94% (16.3%->1.1%) reduction among 65+ years (& no deaths) https://t.co/D2o0CoybWT (Twitter) - Dec 14, 2021