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- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: Couldn't agree with my rockstar colleague and former mentee @AbraarKaran more - Upgrade your mask - now is the time. We are hopefully only weeks away from @pfizer getting an EUA for PAXLOVID™ And @MassGovernor - time for a mask mandate! Don't push hospitals to the brink. (Twitter) - Dec 18, 2021
- || Paxlovid (PF-07321332) / Pfizer
Please tell us how paxlovid will fix it and pad your retirement! (Twitter) - Dec 18, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: Drastic times call for drastic measures #Boostervaccinatie en #Paxlovid zijn de twee sleutels om ons uit de miserie te krijgen 👉 het goede nieuws is dat beide al ontwikkeld zijn 👉 #BoosterVaccinatieNU 👉 Fasttrack evaluatie paxlovid en grootschalige productie (Twitter) - Dec 18, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: Paxlovid will likely get EUA before year end (already has in Europe) but there are only 200,000 💊 packs ready. That’s not going to cut it. With the >10-fold decrease in viral load, it would be expected to have a big effect for reducing spread. On top of ⬇️ hospitalizations (Twitter) - Dec 18, 2021
- | Paxlovid (PF-07321332) / Pfizer
Typo Paxlovid. (Twitter) - Dec 18, 2021
- || Paxlovid (PF-07321332) / Pfizer
#COVID19 @EMA_News-ek #Paxlovid baimendu du, larrialdiko erabilerarako. Ez dago gomendatuta haurdunetan, edoskitzean edo haurdun geratu nahi dutenentzat: https://t.co/w0vsarm7Qb ➕ Paxlovid antibiralaz, @ElhuyarZientzia-ren bidez: https://t.co/igetkTmDtN (Twitter) - Dec 18, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer
PK/PD data: He likely meant Paxlovid, which is Pfizer's protease inhibitor. There's a detailed breakdown of the similar pharmacodynamics here. There were other errors and some overstated claims, but much of what else he said is valid and worth consideration. https://t.co/FPcuKU3HPW (Twitter) - Dec 18, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Preclinical: Bad news on MAbs vs Omicron. PAXLOVID showing good efficacy against it in vitro. Per latest update by @DanielGriffinMD (Twitter) - Dec 18, 2021
- || Paxlovid (PF-07321332) / Pfizer
I was also placing my hope on the slower kinetics as this would have positive implications for Paxlovid and mABS. But then it was reported that omicron is 70x faster. Can you explain the difference? Is it faster in the nose/ throat, but slower in the lungs? (Twitter) - Dec 18, 2021
- || Paxlovid (PF-07321332) / Pfizer
“There's definitely going to be a shortage,” says @boulware_dr. "People have this expectation of ‘Oh yeah, I'm just going to go get this Paxlovid.’ That's not going to happen [at least in the next few months].” https://t.co/fTIEcqW0cj (Twitter) - Dec 18, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Adverse events: why don't you share the side effects for Paxlovid! I think Interferon Lambda would be a better choice!!! Even for pregnant women! @drdeannasanter @JJFeld $eigr https://t.co/AyYbA9S9Ti https://t.co/K1T7t9Iz6W (Twitter) - Dec 18, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: Jesus H. Christ! #omicron Severity + Speedy = Overflowing/closing Hospitals The Tsunami is coming faster #Paxlovid lets people treat themselves at home Approve it so @pfizer can ramp up production! @CDCDirector @DrWoodcockFDA @DrNancyM_CDC @CDCgov @US_FDA @DrEricDing (Twitter) - Dec 17, 2021
- |||| Clinical: Need more supply of Sotrovimab in anticipation of #Omicron surge. Also rapid turnaround on Molnupiravir and Paxlovid FDA EUAs would be useful. In the meantime, I’m with @PaulSaxMD - may need to liberalize use of #fluvoxamine in outpatients with #COVID19. (Twitter) - Dec 17, 2021
- || Paxlovid (PF-07321332) / Pfizer
Aww man, I was a bit hopeful to have something that was efficacious and possibly better than Paxlovid .. (Twitter) - Dec 17, 2021
- || Paxlovid (PF-07321332) / Pfizer
Are you optimistic about Paxlovid as well? (Twitter) - Dec 17, 2021
- || Paxlovid (PF-07321332) / Pfizer
I still believe Paxlovid will be a better and safer option. We will just have to agree to disagree….. (Twitter) - Dec 17, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: To the Unvaccinated Vaccinate asap Mask indoors #omicron is not a forgiving virus @Franklin_Graham @foxnation @GovRonDeSantis @DrEricDing @DrLeanaWen @pfizer @AlbertBourla @JoeBiden @CDCDirector @US_FDA We need #Paxlovid now (Twitter) - Dec 17, 2021
- ||| ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer, ibrutinib / Generic mfg.
Not just tacrolimus, but ritonavir will effect ibrutinib and many other -nibs and -nabs used to treat hematologic and solid tumor maligancies. Short five-day course x 1 makes it less of a concern than in HIV medicine, but non-ID MDs prescribing paxlovid may be in for an awakening (Twitter) - Dec 17, 2021
- || Paxlovid (PF-07321332) / Pfizer
Or Paxlovid might be a third arrow in the quiver…. (Twitter) - Dec 17, 2021
- || ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
how are people planning to handle the ritonavir part of paxlovid in their SOT recipients? Stop tacrolimus for the duration? reduce the dose? (Twitter) - Dec 17, 2021
- || Paxlovid (PF-07321332) / Pfizer
Clearing ground for paxlovid launch. (Twitter) - Dec 17, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: Jesus Christ. #omicron is a killer too. Hospitals are filling Hospital staff is getting sick Hospitals will be closing @AlbertBourla @pfizer @CDCDirector @DrNancyM_CDC @CDCgov @US_FDA @DrWoodcockFDA @SteveFDA #Paxlovid will let people treat themselves at home (Twitter) - Dec 17, 2021
- || Paxlovid (PF-07321332) / Pfizer
Europe is on the verge of using #paxlovid for at home use. @DrWoodcockFDA @US_FDA @CDCDirector @DrNancyM_CDC @CDCgov (Twitter) - Dec 17, 2021
- || Paxlovid (PF-07321332) / Pfizer
Pfizerin lääkkeen ”koodinimi” on PF-07321332. Lääke otetaan yhdessä antiviruslääke ritonaviirin kanssa. Ritonaviiri on HIV lääke? Mikä yhteys on covid-19 ja HIV:llä? (Twitter) - Dec 17, 2021
- ||||| Tollovir (NLC-V-01) / Todos Medical, Paxlovid (PF-07321332) / Pfizer
Clinical: 100%. We’re developing what we expect is better version of Paxlovid: Tollovir. 3CLpro inhibitor + anti-cytokine combo pill. Currently waiting RCT Ph 2 data in hospitalized. If works there, think also works earlier in disease and expand to moderate, pediatric & select Long COVID/1 (Twitter) - Dec 17, 2021
- || Paxlovid (PF-07321332) / Pfizer
Agreed and the caveat is start paxlovid *in time*. The window of opportunity for paxlovid is smaller than FLV. Many may struggle to get a prescription filled in time, in our current system of authorizations and “prove your +PCR first”. (Twitter) - Dec 17, 2021
- || Paxlovid (PF-07321332) / Pfizer
https://t.co/4KAHmHlpTc Unfortunately NIH doesn't agree. You agreed late and insufficiently. Preferred waiting for 2 more months before paxlovid gets available. Meantime death counts will increase. Better not talk of rest of world. (Twitter) - Dec 17, 2021
- || Paxlovid (PF-07321332) / Pfizer
Paxlovid? Yes I’ve heard it’s studies have shown good results when taken within 3-5 days (Twitter) - Dec 17, 2021
- || Paxlovid (PF-07321332) / Pfizer
Why Paxlovid is a Just-in-Time Breakthrough, by @EricTopol https://t.co/0TlzuLb2F6 (Twitter) - Dec 17, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Alla @EricTopol ketju uudesta @pfizer #Paxlovid-pilleristä, joka näyttää tehoavan myös #Omicron🚀 varianttia vastaa — ainakin laboratoriotesteissä. Hinta kuurille on $500/ hlö. Kuten järkevää nyt, sanoutuu Topol julkisesti itse irti #Pfizer-fanituksesta. Kaikki hyvin? 2/ https://t.co/xYskmCHyyq (Twitter) - Dec 17, 2021
- |||| ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Clinical: Thank you @GardeningLisa for this. What do these easy drug interactions with #Ritonavir mean for the user? As well as ’steroid levels are boosted too high? The test group was again _tiny_ for #Pfizer #Paxlovid.. Your opinion of using this kind of pill eg for children? (Twitter) - Dec 17, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: Our hospitals will soon be closed due to staff getting sick. #Paxlovid is desperately needed @CDCDirector @DrNancyM_CDC @CDCgov @DrWoodcockFDA @US_FDA The sooner it is approved #Pfizer will ramp up production @JoeBiden @ASlavitt @DrEricDing @EricTopol @CNN @MSNBC @FoxNews (Twitter) - Dec 17, 2021
- || Paxlovid (PF-07321332) / Pfizer
Paxlovid... (Twitter) - Dec 16, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: My hope, in addition to boosting vaccines and using a mask, is in the antiviral Paxlovid (Twitter) - Dec 16, 2021
- ||| remdesivir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Combination therapy: It could be wise to conduct study in combination with remdesivir or paxlovid (Twitter) - Dec 16, 2021
- || ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
While the effects where modest both trials - showed benefit although with some less than key endpoints. The downside risk is low and there is not an interaction with ritonavir if that becomes available in the paxlovid regimen. (Twitter) - Dec 16, 2021
- | Paxlovid (PF-07321332) / Pfizer
Nah. Paxlovid is the one that actually works (Twitter) - Dec 16, 2021
- || Paxlovid (PF-07321332) / Pfizer
Am I the only one who hears "McLuvin" when s/he reads "Paxlovid"? 😅 (Twitter) - Dec 16, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical: The Molnupiravir anti-Covid pill randomized trial published @NEJM today. Final results are quite different (half the efficacy) from the highly encouraging interim results https://t.co/3Pvi3iDa8P How does it compare with Paxlovid? https://t.co/qClag5KjUy (Twitter) - Dec 16, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: Our hospitals will close w/o staff @CDCDirector @DrNancyM_CDC @CDCgov @DrWoodcockFDA @US_FDA @DrEricDing @EricTopol @DrLeanaWen @WmHaseltine @AlbertBourla @ASlavitt @JoeBiden #Paxlovid is urgent To let people treat themselves at home Please (Twitter) - Dec 16, 2021
- || Paxlovid (PF-07321332) / Pfizer
I agree but I want Paxlovid out NOW (Twitter) - Dec 16, 2021
- || fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
With nirmatrelvir (Paxlovid) and molnupiravir not yet available, and the most widely used MAbs lacking activity against Omicron (+ other issues), is it time to bump up fluvoxamine at least to "consider use" status on the treatment guidelines? Two well-done RCTs show benefit. (Twitter) - Dec 16, 2021
- |||| fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Updated chart on early #COVID19 treatment for #Molnupiravir, #nirmatrelvir (#Paxlovid), and #fluvoxamine #IDTwitter (Twitter) - Dec 16, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Only 50 million Americans have booster @AlbertBourla @JoeBiden @ASlavitt @pfizer @CDCDirector @EricTopol #Paxlovid #Paxlovid #Paxlovid #Paxlovid #Paxlovid #Paxlovid #Paxlovid #Paxlovid #Paxlovid #Paxlovid (Twitter) - Dec 16, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: UK COVID hospitalisation rates rising, number of cases will break records https://t.co/toB9qZQlVu Expect Jan + Feb USA to see 200 million #omicron cases Many Hospitals close due to staff shortages @DrEricDing @ASlavitt @AlbertBourla @CDCDirector @US_FDA #paxlovid #Paxlovid (Twitter) - Dec 16, 2021
- |||| ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Ahead of FDA, European regulator EMA offers advice on #Paxlovid (PF-07321332 and ritonavir) it "can be used to treat adults with COVID-19 who do not require supplemental oxygen and who are at increased risk of progressing to severe disease. https://t.co/pWABdBEF3l (Twitter) - Dec 16, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
The anti-Covid pill (Paxlovid) is a veritable breakthrough. Just when we really need it. I wrote about it @SubstackInc. It's free. Please subscribe to follow https://t.co/qClag5KjUy (Twitter) - Dec 16, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: True, only used in the hospital setting. Paxlovid has shown a lot of promise as something for an outpatient treatment (Twitter) - Dec 16, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
“Paxlovid is a breakthrough, It not only provides a new layer of defense, but a unique one that is not dependent on our immune system and not affected by Omicron or other variants. It is the first drug specifically designed for SARS-CoV-2.” By @EricTopol https://t.co/G0IZFZMmmI (Twitter) - Dec 16, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: Dr. Wachter, Given that Paxlovid is given within five days of symptoms appearing and COVID is infectious during the pre-symptomatic period, how does it reduce infectivity? By shortening the period during which the patient is infectious? Or reducing viral count? (Twitter) - Dec 16, 2021