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- || fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer
I would like to hear more talk about fluvoxamine, given the relative absence of mABs right now and no paxlovid yet. Has good evidence supporting its use. (Twitter) - Dec 21, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
I often hope there is a 7am press release that brings good news about Covid. Today would be a good day to hear that FDA has authorized Paxlovid (the highly effective oral antiviral) and the govt’t secured agreements with Pfizer to quadruple manufacturing capacity. (Twitter) - Dec 21, 2021
- || fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Do you think fluvoxamine is worth considering as a treatment option before Paxlovid becomes available? (Twitter) - Dec 21, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: @DrEricDing @DrLeanaWen @drdanchoi @ScottGottliebMD Croup Very common in 0-2 year olds Common in rest of children IMO since #Omicron first attacks the breathing tube it puts many children into the hospital @CDCDirector @US_FDA #paxlovid must be sized for them-emergency use (Twitter) - Dec 21, 2021
- ||| colchicine / Generic mfg., fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Clinical: We are still waiting for your take on #fluvoxamine, colchicine and inhaled steroids. Hope you write something about these poor countries therapies soon. Before of course some another variant arises. Vaccine equity is illusion. Paxlovid equity will again be illusion. (Twitter) - Dec 21, 2021
- ||| colchicine / Generic mfg., fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Clinical: We are still waiting for your take on #fluvoxamine, colchicine and inhaled steroids. Hope you write something about these poor countries therapies soon. Before of course some another variant arises. Vaccine equity is illusion. Paxlovid equity will again be illusion. (Twitter) - Dec 21, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
FDA event: How about the FDA works on approving Paxlovid? (Twitter) - Dec 21, 2021
- || Paxlovid (PF-07321332) / Pfizer
Need the RDV po prodrug in trials… and paxlovid approved (Twitter) - Dec 20, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: Intriguing data though iv meds are very difficult to arrange for outpatients timely. An oral med such as paxlovid would be much more practical (Twitter) - Dec 20, 2021
- || Paxlovid (PF-07321332) / Pfizer
i have a better idea. get Paxlovid approved and available (Twitter) - Dec 20, 2021
- |||| Covaxin (BBV152 COVID Vaccine) / Bharat Biotech, Indian Council of Medical Research, Ocugen, Paxlovid (PF-07321332) / Pfizer
Clinical: Frankly, @MikeRizo3, we needed Paxlovid yesterday so that @POTUS can tell nation tomorrow - hey, we have your back with an oral therapeutic that is 5 days & prevents hospitalizations/deaths almost as effectively as a vax if you are unvax'd (we also need Covaxin/Novavax asap too) (Twitter) - Dec 20, 2021
- || Paxlovid (PF-07321332) / Pfizer, Spikevax (elasomeran) / Moderna, Takeda, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
#رشتو https://t.co/2K47eI7UOD این درحالی که شرکت #فايزر و #مرک دو دارو #paxlovid و #molnupiravir آنتی بادی مونوکلونال روانه بازار کردن که وارد بازار رقابتی شده، و این یعنی آینده آنتی بادی به سمت آنتی بادی مونوکلونال، و کد ژنتیکی mRNA-1273 و mRNA3، خواهد رفت که شرکت @LillyPad (Twitter) - Dec 20, 2021
- | Paxlovid (PF-07321332) / Pfizer
Mit Paxlovid gab es eine Studie mit 2246 Teilnehmern: https://t.co/AOpgI0uJXu (Twitter) - Dec 20, 2021
- || Paxlovid (PF-07321332) / Pfizer
Is there any word on using paxlovid for post exposure ppx? (Twitter) - Dec 20, 2021
- || Paxlovid (PF-07321332) / Pfizer
I was thinking the time for paxlovid (Twitter) - Dec 20, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: Paxlovid can’t come fast enough (would also like to see efficacy data) (Twitter) - Dec 20, 2021
- || Paxlovid (PF-07321332) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Thank you. I thought that was whzt it said. Appreciate the response. Yes, not ideal. I hope they are able to push out many doses of Sotrovimab, get Paxlovid approved, and reconstitute a vax that is Omicron specific early in 2022. (Twitter) - Dec 20, 2021
- || fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer
We’re going to need a lot of Paxlovid, Fluvoxamine and accessible and affordable tests—quickly! (Twitter) - Dec 20, 2021
- || Paxlovid (PF-07321332) / Pfizer
Paxlovid is not available. (Twitter) - Dec 20, 2021
- || Paxlovid (PF-07321332) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Yes definitely and need Paxlovid out ASAP since not affected by variants and more sotrovimab for omicron. Thanks @davetp for update. Same in SF (Twitter) - Dec 20, 2021
- ||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (PF-07321332) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Review: Early data on #Evusheld from two different groups - I am still digesting details but clear that #sotrovimab will be key for us. We also need #paxlovid review by FDA. https://t.co/vddZ7L7frI https://t.co/LpkFuY7AZw (Twitter) - Dec 20, 2021
- || Paxlovid (PF-07321332) / Pfizer
Yeah. Waiting on Paxlovid at this point in time. (Twitter) - Dec 20, 2021
- || Until we have wider access to sotrovimab for therapy, evusheld for longer term prophylaxis and hopefully soon ritonavir (Paxlovid) for oral therapy we are in a challenging window period given the omicron prevalence (Twitter) - Dec 20, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer
FDA event: What is update on Pfizer Paxlovid and FDA approval? Seems like a good time for an EUA if the drug is safe and effective. @FDACommissioner @US_FDA @statnews Pfizer will submit full data on Covid treatment pill to the FDA in a few days, CEO says https://t.co/wCvXyeqfps (Twitter) - Dec 20, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: So are you suggesting Paxlovid should only be given to unvaccinated? That doesn't seem like "providing the best care" either. (Twitter) - Dec 20, 2021
- || Paxlovid (PF-07321332) / Pfizer
#Paxlovid kills ALL VARIANTS! @DrEricDing @ScottGottliebMD @WmHaseltine @EricTopol @drdanchoi @DrLeanaWen @dianaberrent FOCUS ON #Paxlovid (Twitter) - Dec 20, 2021
- || Paxlovid (PF-07321332) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
That would defeat the purpose. By then Sotrovimab and PAXLOVID will be widely available (Twitter) - Dec 19, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: Inaccurate; not ok for doctors to not treat the unvaccinated; MDs taught to treat patients with compassion, provide best care possible (if you see the Atlantic article I wrote on antivirals, unvax'd is one of the biggest reasons to get Paxlovid out now) https://t.co/PNPkY8oEj2 (Twitter) - Dec 19, 2021
- ||| fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Yes, and moreover #paxlovid is looking far better than molnupiravir. Focus seems to have shifted towards antivirals; worth pointing out that this isn't the relevant Rx space. Fluvoxamine's evident utility is in preventing the worsening of symptoms to frank COVID. (Twitter) - Dec 19, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
@ASlavitt USA Forget COVID tests in two weeks Test + Not enough #Paxlovid for most Use #oximeter reading to guide use of limited supply of #Paxlovid @CDCDirector @US_FDA @DrEricDing @EricTopol @DrLeanaWen @ScottGottliebMD @WmHaseltine (Twitter) - Dec 19, 2021
- || Paxlovid (PF-07321332) / Pfizer
Is there a point in testing? Is the supply of #paxlovid for #omicron ready? @DrEricDing @WmHaseltine @EricTopol @DrLeanaWen Loss of smell or taste means it’s probably Delta REGN MAB still is for #delta #Paxlovid supply for #omicron is tiny Oximeter reading is more useful (Twitter) - Dec 19, 2021
- || Paxlovid (PF-07321332) / Pfizer
If I feel sick, do I get REGN MAB for Delta, or the other MAB for #omicron? Or just stay home. And pray. @DrEricDing @DrLeanaWen @PeterHotez @ScottGottliebMD @EricTopol @WmHaseltine @dianaberrent I feel lost. #Paxlovid works on all variants. But it’s only approved in Europe. (Twitter) - Dec 19, 2021
- || Paxlovid (PF-07321332) / Pfizer
Paxlovid - FDA analogy: P: I want to get a life vest when boating just in case FDA: No, it's illegal because you haven't yet proved they save lives P: Ok can I keep giving it to people in trials to show it works? (Twitter) - Dec 19, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
I would strongly advocate against it. My concern is that people will be very cavalier with it and use it in a kitchen sink approach in the hopes that even though monotx does very little, "maybe it will work better with Paxlovid or fluvox or all of the above!" (Twitter) - Dec 19, 2021
- || Paxlovid (PF-07321332) / Pfizer
Serious question: why do you think it took so long for Paxlovid to be developed? Lack of an "Operation Warp Speed" for treatments? (Twitter) - Dec 19, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: If US going toward focused protection strategy like Singapore (vaccines/boosters; working on unvaccinated to get vax; N95/strong masks indoors for vulnerable), getting Paxlovid protease inhibitor out asap imperative (~90% protective, works on variants) https://t.co/C12MrOWjhn (Twitter) - Dec 19, 2021
- |||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
A tale of two antiviral targets — and the COVID-19 drugs that bind them. The FDA is considering authorizations for Pfizer’s paxlovid and Merck & Co.’s molnupiravir, the first two oral COVID-19 antivirals. https://t.co/hjZ7klrEB0 (Twitter) - Dec 19, 2021
- || Paxlovid (PF-07321332) / Pfizer
All I want for Christmas is #Paxlovid … for everyone who needs it 🙏 (Twitter) - Dec 19, 2021
- || Paxlovid (PF-07321332) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Of course with Sotrovimab there is a massive shortage right now. We’ll be in a much better place when Paxlovid is widely available, but that could take quite some time (Twitter) - Dec 19, 2021
- || Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Con paxlovid y molnupiravir aún no disponibles, y los anticuerpos monoclonales más utilizados que carecen de actividad contra Omicron (más otros problemas), ¿es hora de aumentar la fluvoxamina al menos para 'considerar el estado de uso' en las pautas de tratamiento? @PaulSaxMD (Twitter) - Dec 19, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Who has said there is insuffcient evidence. Isn't there far more evidence than for Pfizer's Paxlovid? (Twitter) - Dec 19, 2021
- || fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
@dwallacewells @EricTopol Why aren’t we discussing Luvox (cheap and already widely available)...much better than Molnupiravir and almost as good as Paxlovid if taken at the recommended dosage? (Twitter) - Dec 19, 2021
- || Paxlovid (PF-07321332) / Pfizer
Fantastic discussion by all the panelists. I love and share @EricTopol's enthusiasm for paxlovid, and agree that existing manufacturing capacity (from say, generic drug manufacturers) can and should aid in scaling its production. This idea needs to be discussed more. (Twitter) - Dec 18, 2021
- || Tollovir (NLC-V-01) / Todos Medical, Paxlovid (PF-07321332) / Pfizer
#Tollovir $TOMDF. Antivirals are only solution to this problem, and they must be combined with widespread, fast TAT PCR testing that picks up asymptomatic with surveillance testing. It’s only way to address the situation. #Paxlovid way less useful w/current testing infrastructure (Twitter) - Dec 18, 2021
- |||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Gráfico actualizado sobre el tratamiento temprano de COVID19 para molnupiravir , nirmatrelvir ( Paxlovid ) y fluvoxamina. @boulware_dr (Twitter) - Dec 18, 2021
- || Paxlovid (PF-07321332) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
yes yes Sotrovimab and paxlovid will not be handed out to everyone. and the sotrovimab supply is not good either... I hope we hear some news soon for plans to speed things up. There's a lot to do! (Twitter) - Dec 18, 2021
- ||||| Tollovir (NLC-V-01) / Todos Medical, ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Clinical data: More developments... Phase 2 clinical data for 3CL protease inhibitor “Tollovir” Todos Medical $TOMDF due out soon. Appears to be safer alternative to Pfizer’s paxlovid + ritonavir combo tx. Bonus is natural product may appeal to anti vaxxers. https://t.co/mgedHSPYKx (Twitter) - Dec 18, 2021
- || Paxlovid (PF-07321332) / Pfizer
Is developing antiviral resistance a concern with Paxlovid? (Twitter) - Dec 18, 2021
- || Paxlovid (PF-07321332) / Pfizer
Paxlovid will now be produced in the amount of 80 million courses by the end of 2022,,, Today is Dec. 17, 2021. That is a lot of doses but a one year ramp tells me this holiday season is so far not in play. Mask up, vax and boost https://t.co/8tAC2lLbaY (Twitter) - Dec 18, 2021