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- || Paxlovid (PF-07321332) / Pfizer
Paxlovid just cleared by FDA! Will be available in days Just not enough of it to go around and that needs to be fixed ASAP (Twitter) - Dec 22, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: 9/9 The safety and effectiveness of Paxlovid for the treatment of COVID-19 continue to be evaluated. (Twitter) - Dec 22, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
FDA authorizes Paxlovid for emergency use. Decision on Merck pill pending! (Twitter) - Dec 22, 2021
- || Paxlovid (PF-07321332) / Pfizer
And why Paxlovid such a big deal https://t.co/9RNcafIWzk (Twitter) - Dec 22, 2021
- || Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Here is a thread on how Paxlovid (and molnupiravir work) https://t.co/kYl4iX55rI (Twitter) - Dec 22, 2021
- || Paxlovid (PF-07321332) / Pfizer
@US_FDA @FDA_Drug_Info Paxlovid… (Twitter) - Dec 22, 2021
- || fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Thanks. So, since the antiviral Paxlovid would only be continued for 5 days, then anti-inflammatory fluvoxamine could be started at same time as Paxlovid at a low dose, then fluvoxamine could be increased to full dose on day 6, after the Paxlovid is stopped. Makes sense. (Twitter) - Dec 22, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: @Gorskon might be interested. This (once sane) channel is hugely-viewed & spreading lots of stuff on: > Vitamin D > Ivermectin > Aspiration > Ivermectin "is" Paxlovid > Omicron is good news > & vaccine "questions" at every turn (Twitter) - Dec 22, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
PF-07321332 protease inhibitor (“Paxlovid”) Whoo Hooo (Twitter) - Dec 22, 2021
- || Paxlovid (PF-07321332) / Pfizer
Scale paxlovid (Twitter) - Dec 22, 2021
- || fluvoxamine / Generic mfg., ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
The ritonavir will increase the serum concentrations of fluvoxamine, thus I would start with 50mg 2x/day while on paxlovid and increase to 100mg 2x/day on day 6 to run for a 10-15 day course, stopping when symptoms are better. (Twitter) - Dec 22, 2021
- |||| fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical, Real-world evidence: The Pfizer paxlovid supply numbers that I have heard: 180k by end of Dec; 250k end of Jan; 300k by end of Feb. Still not a lot. There is a lot of Merck's molnupiravir, which has the same effect as fluvoxamine. Combo could be better, should be studied in real world data. (Twitter) - Dec 22, 2021
- || fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Even with paxlovid and molnupiravir to be authorized, they will be in very short supply or contraindicated. Great info on data behind fluvoxamine in preprint and thread below. Also see NIH guidelines for data and their reasoning against routine use now. https://t.co/GpZBOhkKYI (Twitter) - Dec 22, 2021
- || Paxlovid (PF-07321332) / Pfizer
Enact the DPA, and make N95’s, rapid tests, Paxlovid, etc for rapid distribution via USPS. (Twitter) - Dec 22, 2021
- || Paxlovid (PF-07321332) / Pfizer
Paxlovid over 10x more expensive to produce, poor blokes will be getting the mulnapaulrevere (Twitter) - Dec 22, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
This anti-Covid pill changes everything. So why won’t it be available for all? | @EricTopol #Paxlovid https://t.co/NJOUF3akYt (Twitter) - Dec 22, 2021
- || Paxlovid (PF-07321332) / Pfizer
Now we need paxlovid in the cupboard. Paxlovid + antigen test = end of pandemic. (Twitter) - Dec 22, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: Agree but it takes time and corona might be faster … give 6 months .. and we have Omega … while we will be deploying an omicron vaccine.. kinda thing.. we need both. Most of all we need paxlovid at home in the cupboard with the antigenic test. As soon we are positive we take it (Twitter) - Dec 22, 2021
- || Paxlovid (PF-07321332) / Pfizer
Great read - perhaps a glimmer of hope? From @EricTopol Why Paxlovid is a Just-in-Time Breakthrough - by Eric Topol https://t.co/zdb5d9WsNS (Twitter) - Dec 22, 2021
- || Paxlovid (nirmatrelvir) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Molnupiravir has *NOT* been authorized in France. Paxlovid probably will however. (Twitter) - Dec 22, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: I agree with the second part of your tweet. However, Paxlovid is used < 3 days of symp. onset. Mod & Sev disease are not always diagnosed < 3 days. Strategy suggested in your tweet would be less effective. Better to risk stratify pts or use for everyone at the time of diagnosis. (Twitter) - Dec 22, 2021
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
Mechanistically they should be complimentary: Paxlovid is antiviral, fluvoxamine is anti-inflammatory. So,I think they could work well together. I don’t know enough about Paxlovid to say whether there could be any interactions related to drug metabolism. (Twitter) - Dec 22, 2021
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
Clinical: @AngelaReiersen @farid__jalali @EdoajoEric @boulware_dr @YoDoctorYo do you think there will be potential interaction issues with pts taking both paxlovid and fluvoxamine? Do you expect it to be one or the other or both as potential tx (Twitter) - Dec 22, 2021
- ||| Paxlovid (PF-07321332) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
@nytimes reporting on possible shortages of promising drug treatment against #Omicron in the US: What will be available in the EU? Have doses of @GSK's #sotrovimab or @pfizer's #paxlovid already been ordered? @SKyriakidesEU @Karl_Lauterbach https://t.co/6HC4CbT8Lq (Twitter) - Dec 22, 2021
- ||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Yes to Paxlovid, but big friggin no to molnupiravir. A drug that intentionally causes mutations? Every infection is already a workbench for the virus to try new mutations, why intentionally encourage it?! (Twitter) - Dec 22, 2021
- || Paxlovid (PF-07321332) / Pfizer
https://t.co/HTifsiFXZ9 I guess this study has me concerned, but not sure of the dose effect of the inhibition of 100 BID vs 300 BID. Hopefully we canget better guidance on a washout period. Maybe contributing to paxlovid approval delay? (Twitter) - Dec 21, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
I was thinking of 10 points to consider in our next phase of US strategy for the pandemic & looks like test-to-stay endorsed; Paxlovid hopefully on its way; isolation shortening on the table (Twitter) - Dec 21, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: Convalescent plasma early prevented hospitalization w #COVID19. Pre-omicron, but still news, since 2 mAbs not effective against omicron, effective one in short supply. CP from triple vaxxed/COVID-19 + vax effective v. omicron? Option while awaiting more sotro & paxlovid EUA? (Twitter) - Dec 21, 2021
- || Paxlovid (PF-07321332) / Pfizer
And finally a bonus explainer: why ivermectin isn’t remotely the same thing as paxlovid. Yes ivermectin very weakly inhibits the viral main protease but at a dose that would certainly kill you (please don’t try taking a 1000x the safe dose of ivermectin at 🏠) 3/ (Twitter) - Dec 21, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
See my prior 🧵 for deep dive 🤿 on the mechanism of paxlovid & why main protease (Mpro/3CLpro) inhibitors as such a tempting target for COVID. 2/ (Twitter) - Dec 21, 2021
- ||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
The FDA is expected to authorize two new oral COVID therapies (paxlovid & molnupiravir) this week. This is a big deal if true. More so for the former than the latter. 1/ https://t.co/0aU50IBltP (Twitter) - Dec 21, 2021
- ||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
The backup plan for Paxlovid is Merck’s Molnupiravir. For old man like me, it is OK if it slightly affects my DNA. Chances for a 5 day treatment to cause problem is very low. I’ll take it. Life is more previous (Twitter) - Dec 21, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Looks like Paxlovid (and Molnupiravar) are getting FDA authorized tomorrow. It's an exciting step forward. If you're not familiar with why this is important and the issues surrounding these new anti-Covid pills, here are 2 recent essays https://t.co/qClag5KjUy (Twitter) - Dec 21, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
7% of children 8% of adults Have asthma IMO (a foreboding) #omicron is a killer it attacks the breathing (bronchial) tube @CDCDirector @US_FDA @NIH @ASlavitt @dianaberrent @DrEricDing @WmHaseltine @DrLeanaWen #paxlovid to size of children emergency use Don’t let them die (Twitter) - Dec 21, 2021
- || fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer
For your category I would say boost, get a flu shot, mask for now, hang in there for therapeutics with actual data, like monoclonal antibodies (being rationed now) or Paxlovid, and maybe even fluvoxamine. (Twitter) - Dec 21, 2021
- || Paxlovid (PF-07321332) / Pfizer
What is taking so long with Paxlovid? (Twitter) - Dec 21, 2021
- || Paxlovid (PF-07321332) / Pfizer
So paxlovid is better and safer ? (Twitter) - Dec 21, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: Kicking the can down the road saved thousands of lives by being able to vaccinate before Delta arrived in the community here. If Paxlovid and other medications work, then we’ll have further reduced morbidity/mortality. Last out is just fine by us. (Twitter) - Dec 21, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: PCR+Paxlovid... per rapidly & accurately detecting & then distributing hospitalization preventing pills... needed to be today's DPA priority. Antigen take home kits? Useless to task. https://t.co/uLKqIrAeOr (Twitter) - Dec 21, 2021
- || Paxlovid (PF-07321332) / Pfizer
Too bad that they're useless for XMas & Paxlovid distribution... ya know? ... "A negative rapid antigen test just before a meeting offers no guarantee to protect others, in particular when the person tested has recently been exposed to the virus,"... https://t.co/NLkoBst9wb (Twitter) - Dec 21, 2021
- || Paxlovid (PF-07321332) / Pfizer
For that reason I think we should consider offering second boosters to HCWs to keep them in the workforce. Also another problem: at least one of the mabs maybe two not effective vs omicron due to SGTF and we don’t yet have Paxlovid available (Twitter) - Dec 21, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Review: Yup and when is the @US_FDA meeting to review Paxlovid? (Twitter) - Dec 21, 2021
- || Paxlovid (PF-07321332) / Pfizer
School closing in US. Agree with Biden on more tests but 1) Paxlovid now for unvax'd (compassionate care); 2) Blanket masks not helpful; recommend right masks indoors for those who want/need no risk; 3) Prioritize schools, risk-stratification in recs https://t.co/jjHsywIzsZ (Twitter) - Dec 21, 2021
- || Paxlovid (PF-07321332) / Pfizer
Schools closing in US. Agree with Biden plan to increase testing & watch areas of low vax carefully but commit to 1) Paxlovid for unvax'd now; 2) Focused mask protection (right kind of masks) for vulnerable, not blanket masks of wrong type; 3) schools open https://t.co/jjHsywIzsZ (Twitter) - Dec 21, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Neither Paxlovid nor molnupravir will have impact to treat COVID without a foundation of cheap/free, reliable, & accessible testing. (Twitter) - Dec 21, 2021
- || Paxlovid (PF-07321332) / Pfizer
Remember how limited Paxlovid is going to be https://t.co/6KNBDwEhdW (Twitter) - Dec 21, 2021
- ||| Paxlovid (PF-07321332) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical: 5. Finally, who gets molnupiravir vs. Paxlovid. One apparently much more effective and likely increased safety (latter). Who gets what? Who decides? Who monitors? Will there be a lottery? Will people know how to choose? How gov't distributes therapy is key to equity. (Twitter) - Dec 21, 2021
- || Paxlovid (PF-07321332) / Pfizer
2. Lack of Rx options. At least one of our mabs not effective vs omicron due to SGTF mutations and as @EricTopol points out in his new opinion piece we don’t have paxlovid in quantity https://t.co/VAEgIRqHRn (Twitter) - Dec 21, 2021
- | Phase classification, Enrollment change, Trial completion date, Trial primary completion date: REMAP-CAP: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (clinicaltrials.gov) - Dec 21, 2021
P3, N=10000, Recruiting, Sponsor: UMC Utrecht
Phase classification: P4 --> P3 | N=7100 --> 10000 | Trial completion date: Dec 2023 --> Dec 2025 | Trial primary completion date: Dec 2021 --> Dec 2023
- || remdesivir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
On April 29,2020 three things happened with remdesivir: Wuhan RCT published, NIH press released results from ACTT-1, and Gilead press released 5 d = 10. Two days later there was an EUA. The data for Paxlovid appear more compelling & there is a greater need. Where is the urgency? (Twitter) - Dec 21, 2021