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- ||| Paxlovid (nirmatrelvir) / Pfizer
Helpful thread by @AlisonGulbis about potential drug interactions with #Paxlovid and other drugs including calcineurin inhibitors used after HCT. (Twitter) - Dec 22, 2021
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
I think Paxlovid plus fluvoxamine will be an extremely effective duo, but also a drug drug interaction here. Would probably do 50mg BID not 100 BID or TID. (Twitter) - Dec 22, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
La FDA autoriza por primera vez una pastilla para tratar #COVID19 Paxlovid se puede usar en pacientes con riesgo de #COVID19 severo. #SinCienciaNohayFuturo (Twitter) - Dec 22, 2021
- ||||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: The @US_FDA authorized the first oral antiviral treatment for COVID-19 Paxlovid can be used for patients who are at high risk for progression to severe COVID-19, including hospitalization or death. #VaccinesWork (Twitter) - Dec 22, 2021
- || Paxlovid (nirmatrelvir) / Pfizer
#paxlovid needs extremely urgent #mhra approval. #rightnow We would all wish to have it (Twitter) - Dec 22, 2021
- ||| remdesivir / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
Clinical: Wow. I did not see this one coming on Paxlovid day. Outpatient remdesivir in high risk patients, started within 7 days of symptom onset. (Twitter) - Dec 22, 2021
- |||| colchicine / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
Clinical: Very happy about Paxlovid. Watch out for statins and colchicine, both commonly given to covid patients at various stages of disase for anti inflammatory purposes, and the former, a lot of patients will already be on one. I'd say don't give colchicine, and reduce statin dose. (Twitter) - Dec 22, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: But as I wrote back in September 2021, control is not a bad place to be - we have vaccines to age 5, Paxlovid now. Control manageable https://t.co/8O14LU5td9 (Twitter) - Dec 22, 2021
- |||| Paxlovid (nirmatrelvir) / Pfizer
.@US_FDA grants authorization to Pfizer's Paxlovid antiviral pill💊for COVID. https://t.co/VfZVT9Lj9t BUT, IMPACT will be LIMITED if we don't have: - free, widely available/accessible testing - a way to provide treatment for free within 3-5 days of exposure/symptom onset (Twitter) - Dec 22, 2021
- |||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: What does #Paxlovid mean for #COVID19? ▪️ 88% reduction in hospitalization is great. ▪️ ~3-4 months from now, this is huge once it is widely available. ▪️ 750 course per 1 million population by end of Jan is not that many. ▪️Now? You had better be vaccinated & boosted. (Twitter) - Dec 22, 2021
- |||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: What does #Paxlovid mean for #COVID19? ▪️ 88% reduction in hospitalization is great. ▪️ ~3-4 months from now, this is huge once it is widely available. ▪️ 750 doses per 1 million population by end of Jan is not that may. ▪️ Now? You had better be vaccinated & boosted. (Twitter) - Dec 22, 2021
- || Paxlovid (nirmatrelvir) / Pfizer
Kansas as a state is likely to get ~2200 doses of paxlovid by the end of Jan. (based on ~750 doses per 1 million population of paxlovid procurred nationwide) (Twitter) - Dec 22, 2021
- |||| ritonavir / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
Clinical: What do we know about Paxlovid? 🔹nirmatrelvir & ritonavir tabs co-formulated 🔹3 tabs q12h x5 days 🔹 approved for mild-to-moderate COVID in adults/peds (>=12 years & >40 kg) at high risk for progression to severe COVID-19 🔹EPIC-HR: 88% ⬇️ in hospitalization/death vs placebo (Twitter) - Dec 22, 2021
- || Paxlovid (nirmatrelvir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Absolutely. Looking at our supply numbers and the recent delivery of sotrovimab...helped a little, but it's not gonna last too long unless we get more in early Jan. Paxlovid - sounds like it will be in community pharmacies to start. (Twitter) - Dec 22, 2021
- || Paxlovid (nirmatrelvir) / Pfizer
BIG NEWS for high risk, and just in time. Paxlovid should be effective vs. Omicron, 2 of 3 monoclonal Ab are not. And Paxlovid is oral! Problems? LOTS of drug interactions. initial supply likely small. EUA for ≥12 years, so older kids benefit, too. https://t.co/R8ns303IKw (Twitter) - Dec 22, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
And also as GSK/Vir MAb (for Omicron) and Paxlovid are in limited supply, people do not need both. (Twitter) - Dec 22, 2021
- || Paxlovid (nirmatrelvir) / Pfizer
Where is production per week at with Paxlovid? (Twitter) - Dec 22, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
FDA event: And the FDA approved dog medication today. But don’t worry, they’ll get to Paxlovid some point this week (Twitter) - Dec 22, 2021
- || Paxlovid (nirmatrelvir) / Pfizer
Why having Molnupiravar when you can have Paxlovid? (Twitter) - Dec 22, 2021
- |||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: 1️⃣This anti-covid pill intervention is the most important advance since vaccines for the pandemic. 2️⃣To be familiar with why this is important and the issues surrounding these new anti-Covid pills, here are 2 recent essays. #Paxlovid @EricTopol https://t.co/IgR5XOYhlL (Twitter) - Dec 22, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
If we allow the infections to occur which is going to happen REGARDLESS of vax status etc. I like the idea of the Paxlovid treatment or similar (Twitter) - Dec 22, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: Yeah, not only is efficacy weak, especially when compared w/ Paxlovid, but it seems likely to encourage emergence of possible new escapees... (Twitter) - Dec 22, 2021
- || Paxlovid (nirmatrelvir) / Pfizer
Paxlovid is synthetically difficult target with several novel intermediates to be produced. If chemical reaction takes certain time you can't speed it up by throwing $$ into the reactor. Plan for 80 mln courses, ~500 K lbs in 2022 is an amazing ramp-up. Molnu will be available. (Twitter) - Dec 22, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
There are several mITT populations described, but in those who received paxlovid and did not receive MAb, here are the results: (Twitter) - Dec 22, 2021
- ||||| ritonavir / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
Clinical: EUA granted for a pill reduce death/hospitalizations in outpatients with COVID Paxlovid (300mg nirmatrelvir + 100mg ritonavir) BID x5 days is indicated in outpts >12yo who tested positive w/in 5 days Note the CYP3A4 interactions & full prescribing info👇 https://t.co/c06AdjpHtV (Twitter) - Dec 22, 2021
- || ritonavir / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
3/ Some caveats to the elation over Paxlovid - supply likely to be limited initially - needs to taken within 5 days of symptom onset, so access to testing with a reasonable turn around time is important - drug interactions with ritonavir may limit use in some (Twitter) - Dec 22, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: 2/ Why is Paxlovid huge? - Oral pill, means easier access for patients, less burden on healthcare system - Unlike monoclonals, this should retain efficacy against variants (Twitter) - Dec 22, 2021
- |||| ritonavir / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
Clinical: An important addition to our COVID mitigation toolkit. 5 day oral course of Paxlovid - (combination nirmatrelvir- ritonavir) given within 5 days of symptom onset, cuts risk of hospitalization by 89% FDA authorized for high risk pts, 12 and older https://t.co/XNzGudr3CR (Twitter) - Dec 22, 2021
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
#Paxlovid = antiviral. #Fluvoxamine = anti-inflammatory. So, they have complimentary mechanisms. Would be nice to see an RCT using them together, but in the meantime, I think the dosing strategy suggested by @boulware_dr makes sense. (Twitter) - Dec 22, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
Excellent thread by @tmhohl71 on #Paxlovid @sloan_kettering 👇🏽 (Twitter) - Dec 22, 2021
- |||| Paxlovid (nirmatrelvir) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
Clinical: Pills to fight #COVID? 💊 #Omicron upping need for Molnupiravir & Paxlovid In light of this week’s @NEJM paper on Molnupiravir, I was starting 🧵 on the other pill - PAXLOVID - to reduce hospitalizations. But @nickmmark already has 💎👇 Both still awaiting EUA by @US_FDA. (Twitter) - Dec 22, 2021
- |||| Paxlovid (nirmatrelvir) / Pfizer
If you have any questions about @US_FDA EUA for #Paxlovid for #COVID19 check out this excellent 🧵 from @sloan_kettering @tmhohl71 👇 #Omicron (Twitter) - Dec 22, 2021
- ||| ritonavir / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
Happy we will soon be able to prescribe paxlovid (nirmatrelvir + ritonavir); but man, that package insert: 6 pages of drug-drug interactions. HIV docs used to working with ritonavir will be quick learners; the rest of us...not so much (Twitter) - Dec 22, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Paxlovid fact sheet additionally highlights these contraindications: (Twitter) - Dec 22, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Here is the FDA fact sheet on how to use #Paxlovid Here are some important situations where it should not be used (contraindications) See the fact sheet at this link for full prescribing information. https://t.co/jqzizQspJZ (Twitter) - Dec 22, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: Breaking: FDA authorizes Paxlovid, a pill, for preventing severe disease in COVID patients 12 & older who are at high risk due to comorbidities or advanced age. I welcome this. In trials, this drug reduced risk of deaths or hospitalization by almost 90% https://t.co/y9fmLJYo0M (Twitter) - Dec 22, 2021
- || Paxlovid (PF-07321332) / Pfizer
If find out pregnant after receipt OR determine benefit > risk and give paxlovid? Supposedly there is an observational pregnancy registry (link it if you know it) (Twitter) - Dec 22, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Scope of how #PAXLOVID is to be used: https://t.co/gOsk6je3wf (Twitter) - Dec 22, 2021
- ||| ritonavir / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Overview: paxlovid is nirmatrelvir 300mg + ritonavir 100mg (blister packed 2x 150mg nirmat and 1x 100mg riton). Take this BID x 5 days. Boxes should come with full 5 day course Ritonavir interactions ... blech. USE HIV DRUG INTERACTION DATABASES! I prefer @hivinteractions (Twitter) - Dec 22, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: BREAKING: FDA authorizes the emergency use of #PAXLOVID for the treatment of mild-tomoderate COVID-19 in certain adults and pediatric patients. https://t.co/gOsk6je3wf (Twitter) - Dec 22, 2021
- |||| fluvoxamine / Generic mfg., Paxlovid (PF-07321332) / Pfizer
Clinical, FDA event: This is good news. I hope the FDA will ALSO approve an EUA for fluvoxamine, which has a complimentary mechanism (Paxlovid = antiviral, fluvoxamine = anti-inflammatory). Fluvoxamine can already be prescribed off-label for outpatients with COVID, but an EUA would still be helpful. (Twitter) - Dec 22, 2021
- || Paxlovid (nirmatrelvir) / Pfizer, Lagevrio (molnupiravir) / Emory University, Ridgeback Biotherap, Merck (MSD)
It's time to retweet this link to a @SHEA_Epi podcast @jpogue1 and I got to record with @cjcrnich1 . We go over data and logistics of employing #Paxlovid and #Molnupiravir. It was recorded last week so some may be out of date but ... good pointers. https://t.co/wYE8Bnv8uc (Twitter) - Dec 22, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer
Clinical: More info on #Paxlovid from #FDA. It's authorized for *OUTPATIENTS* age 12+ & 88+ lbs at increased risk with a positive test for #COVID19. It's twice daily x 5 days, started within 5d of symptom onset. Note drug-drug interactions, #MedTwitter. #Omicron https://t.co/THmZbcDv9I (Twitter) - Dec 22, 2021
- || Paxlovid (PF-07321332) / Pfizer
Given #Paxlovid’s imminent authorization would be nice to know roll-out plan. Does #idtwitter @IDSAInfo @CarlosdelRio7 have any visibility? (Twitter) - Dec 22, 2021
- ||| Paxlovid (PF-07321332) / Pfizer
Clinical: As expected, the authorization for paxlovid (great news) is for people high risk, not excluding the vaccinated. Here was my prior thread in anticipation. These will be difficult decisions given extremely limited supply. Who is at highest risk? (Twitter) - Dec 22, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: I just tried to schedule #COVID19 tests for my fam. The soonest I found online to get all 5 of us tested at similar times is 7d from today. I can get us tested sooner only by pulling strings as 2 drs. That isn't fair & if we don't fix testing, expect #healthinequity w/ #Paxlovid. (Twitter) - Dec 22, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: Santa got my letter! Paxlovid now has EUA for the Rx of mild-to-moderate coronavirus disease 2019 (COVID-19) in adults and pediatric patients (12 years and older weighing at least 40 kg) with + results of SARS-CoV-2 viral testing, and who are at high risk https://t.co/lwJF3Lbz1J (Twitter) - Dec 22, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer
Clinical: BREAKING NEWS: #Paxlovid just received #EUA from #FDA as the first oral antiviral for individuals with #COVID who are at high risk for developing serious illness. A big Thank You to the scientists and drug developers @pfizer for #BreakthroughsThatChangePatientsLives! (Twitter) - Dec 22, 2021
- |||| Paxlovid (PF-07321332) / Pfizer
Clinical: 📢BREAKING: FDA has just auth #Paxlovid, the 1st antiviral pill for #COVID19. In a rand trial vs placebo in 2.2K high-risk ppl, it ⬇️risk of hosp/death by 89% if begun within 3d of symptoms. Game-changing, but ONLY with far better test access. #MedTwitter https://t.co/iAVi58mXfO (Twitter) - Dec 22, 2021
- ||||| Paxlovid (PF-07321332) / Pfizer
Clinical: Outstanding news that FDA has authorized Paxlovid (Pfizer antiviral pill). It reduces the risk of hospitalization or death by 88% in high risk individuals when taken early in the course of #covid19 illness, and can be of great help to reduce the growing strain on hospitals. (Twitter) - Dec 22, 2021