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- |||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: Agree can't pretend this is Q3 2020. We have vaccines available for everyone > 5. Boosters soon to be available for those over 12. Oral therapeutics like Paxlovid and just as important 65% of all Chicagoans are vaccinated. That doesn't include those that have already gotten covid (Twitter) - Dec 31, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
Good news on New Year's eve - Paxlovid: UK medicines regulator approves second Covid antiviral pill. #ClinicSpeak 2022 is going to be a good one! https://t.co/CJboZ1pqUw (Twitter) - Dec 31, 2021
- ||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical: Finally, hope on way: new outpatient tx for high risk kids ≥12y to decrease hosp risk include paxlovid (oral), convalescent plasma, sotrovimab + evusheld for pre-exposure prophylaxis in immunocompromised. All in short supply, but when more available, will help ⬇️ hosp #. 22/ (Twitter) - Dec 31, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
This list of medication interactions with #paxlovid is very useful. And scary how many meds need to be considered before using to treat #COVID19 (Twitter) - Dec 31, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: Yes!! Have seen way too many posts from providers stating they wont be able to use paxlovid because of x,y,or z.... and in vast majority of cases easy solution. (Twitter) - Dec 31, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
I’m not sure I totally get it - there’s all this caution about using other 3A4 inhibitors with Pax. They are telling pharmacy to remove a dose of the nirmatrelvir for moderate renal impairment, why not remove the /r if someone is already taking /r or /c? (Twitter) - Dec 31, 2021
- || Paxlovid (nirmatrelvir) / Pfizer
Fabulous! Thank you…I can sleep easy now…nirmatrelvir all round… (Twitter) - Dec 31, 2021
- || Paxlovid (nirmatrelvir) / Pfizer
Although Liverpool doesn’t the Paxlovid EUA actually does address this, and surprisingly they say…just keep them on both: (Twitter) - Dec 31, 2021
- ||| darunavir/ritonavir / Generic mfg., ritonavir / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
Clinical: FWIW, my gut tells me only give one ritonavir (so can keep on the regular ritonavir for the darunavir/r patients) and just take the ritonavir out of the paxlovid pack, but cobi? No info on cobi from paxlovid… (Twitter) - Dec 31, 2021
- |||| Prezista (darunavir) / J&J, Paxlovid (nirmatrelvir) / Pfizer
Clinical: I wish NIH or Liverpool would add a fairly (to me) obvious interaction for HIV pharm to reference with management of Paxlovid in patients on boosted Darunavir (not an uncommon regimen), or even what to do about Cobi boosted regimens? Do u give two boosters? (Twitter) - Dec 31, 2021
- || Paxlovid (nirmatrelvir) / Pfizer, clopidogrel / Generic mfg.
So is this really a hard no for 5 days of paxlovid + plavix?? They sound like they should go so great together... (Twitter) - Dec 31, 2021
- |||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: What about if the patient on Paxlovid needs admission for Covid - does the Dex dose need to be altered Sanjay? (Twitter) - Dec 31, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: Thank you Dr. Mike:) Saving for our local hem/onc. UVA in Charlottesville VA is out of MAbs and Paxlovid isn't available yet, so at least we can try this! What are guidelines for use in immunocompromised pts? Positive test? Symptoms? Within how many days? TYIA. (Twitter) - Dec 31, 2021
- ||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir) / Pfizer
@US_FDA @AstraZenecaUS @SenBobCasey @SenToomey Why can't my immunologist find Evusheld for me? Or Paxlovid? Your immunodeficient constituent in 19128 needs these meds! https://t.co/r1Xosure3L (Twitter) - Dec 31, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: Patient information sheet (including the many drug interactions) for Paxlovid here: https://t.co/Z3gjfUwmAx (Twitter) - Dec 31, 2021
- || Paxlovid (nirmatrelvir) / Pfizer
If one has an rx or two from the second column that are prn, how long before/after a course of paxlovid are they advising one would need to stop taking? Or would they not prescribe the paxlovid at all based on rx history? (Twitter) - Dec 31, 2021
- ||| fluvoxamine / Generic mfg., Actemra IV (tocilizumab) / Roche, JW Pharma, Paxlovid (nirmatrelvir) / Pfizer
Clinical: Look! (It's a miracle!) He haunts Pierre Kory. He's almost A.I. He just posted this: skyylark @phish73 · 7h Replying to @suzpyoung and PierreKory Dexamathesone , paxlovid and fluvoxamine is standard care now. Tocilizumab instead of paxlovid for cases over 6 days (Twitter) - Dec 31, 2021
- ||| ritonavir / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
عند إجازة دواء paxlovid عن طريق الفم لعلاج كوفيد سيكون الأطباء بحاجة لمراجعة قائمة الأدوية المتداخلة وذلك لكون هذا الدواء يضاف إليه دواء آخر يسمى (Ritonavir)، لرفع مستوى paxlovid في الدم وجعله أكثر فعالية هنا تبرز الحاجة للصيدلي الإكلينيكي الجيد أن فترة الاستعمال ستكون قصيرة (Twitter) - Dec 31, 2021
- || Paxlovid (nirmatrelvir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Thank you Dr. Morice! You’re an honest & genuine voice with information in a sea of swirling ridiculousness. Another quick question: will the 2 antiviral meds (#Paxlovid & #Molnupiravir) coming on to market now be effective treatments to #Omicron and future variants? (Twitter) - Dec 31, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: I’ve been worried that places like nyc using one single mail out pharmacy may not have the benefit of knowing all patient’s meds to check for drug interactions with paxlovid. We know relying on prescribers alone never works. Better for pharmacists to know patient’s other meds. (Twitter) - Dec 31, 2021
- || Paxlovid (nirmatrelvir) / Pfizer
Secured for delivery when, do you know? I looked it up but couldn't find any info beyond that deliveries would start late this year. Molnupavir also doesn't look great, at least a lot less effective than Paxlovid. https://t.co/U6BGTxTHvP (Twitter) - Dec 31, 2021
- |||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: @boulware_dr should we try to cross check FLV interaction with clop, ticag, and rivarox given that Paxlovid isn’t exactly feasible in these patients (a large portion of those at high risk for severe Covid)? (Twitter) - Dec 31, 2021
- || Paxlovid (nirmatrelvir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
And all this for an ARR of something around 5-7% at best for both Molnupiravir and Paxlovid. Unknown long term mutagenic profile and much ado over nothing? (Twitter) - Dec 31, 2021
- || ritonavir / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
"Treatment duration is 5–10 days" Referring to nirmatrelvir/ritonavir.... Where did the extra 5 days come from? (Twitter) - Dec 31, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
We have therapeutics for them. Paxlovid and multiple monoclonals. AstraZeneca has a new one that lasts 6 months. Look it up. (Twitter) - Dec 30, 2021
- |||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: This would be true of both adult and children’s hospitals, a big rise in pediatric cases, also absence of effective mabs, no Paxlovid. So even though on average omicron may produce more mild illness it will be offset by other variables (Twitter) - Dec 30, 2021
- |||| Paxlovid (nirmatrelvir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Georgia gets first shipments of Merck, Pfizer Covid pills. The initial shipments, which are expected to begin arriving Thursday, will include 1,620 doses of Pfizer's Paxlovid, and 7,500 of Merck's molnupiravir. @ajc https://t.co/8mPTMvDzXZ (Twitter) - Dec 30, 2021
- || Paxlovid (nirmatrelvir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Reimbursement: Get us Paxlovid and Lagevrio Now! Without restrictions by self serving Health Insurance Companies ! (Twitter) - Dec 30, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
Complete rubbish, its not been used as a regular treatment for infectious disease or Covid, grasping at SSRI's is no answer, they do not prevent re infection, and like paxlovid. (Twitter) - Dec 30, 2021
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Paxlovid and sotrovimab are essentially NOT available, anywhere. We must consider other options, stat! #fluvoxamine @AngelaReiersen (Twitter) - Dec 30, 2021
- ||| remdesivir / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical: Dr. Ghandi I work 60 mins from you and we don't have any access to paxlovid. We are out of sotrovimab. The ERs cannot accept anymore patients to get remdesivir infusions as they are boarding patients. (Twitter) - Dec 30, 2021
- || Paxlovid (nirmatrelvir) / Pfizer
Agree on all except Paxlovid. It is practically unavailable and won't be generally available likely until the omicron wave has passed. So it's not relevant to our current situation. (Twitter) - Dec 30, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
Paxlovid is not a treatment I would even consider.. Autonomic nerve dysfunction from anticholinergics is under DX and they cause serious medical conditions that take 1 year to work out. SSRi's good if it helps great, but we have far superior less risk treatments to hand Regards (Twitter) - Dec 30, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
Pfizer are on track to produce something like 80m courses of Paxlovid by the *end* of 2022, for the entire world. There isn't going to be anything like enough of it available in the UK in the next few months. (Twitter) - Dec 30, 2021
- |||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
Clinical: From an overall health system perspective, being able to treat 3x as many #covid19 patients with an actually available medicine with 30% reduction in ER visits/hospitalizations (#fluvoxamine) has the same impact as treating 1 patient with #paxlovid and costs 95% less. #IDtwitter (Twitter) - Dec 30, 2021
- |||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: @Dorry_Segev Prof Segev, i am a PT patient. With all the news on monoclonal antibodies and antivirals, i am very confused. I thought Paxlovid is great for me but then i read that it is not good for people with kidney disorder. What is your view on both for people like me? Thank u (Twitter) - Dec 30, 2021
- ||||| Paxlovid (nirmatrelvir) / Pfizer
Clinical: unless they cant breathe just send them home. U cant do anything for them anyway. And your genius CDC didnt pre order the Pfizer protease inhibitor Paxlovid which makes him dumber than #Trump who smartly pre ordered the vaccines that VP Harris trashed in 2020 (Twitter) - Dec 30, 2021
- || Paxlovid (nirmatrelvir) / Pfizer
Need to get that paxlovid out now! (Twitter) - Dec 30, 2021
- || Paxlovid (nirmatrelvir) / Pfizer
Should have Paxlovid in one or more of the early categories (Twitter) - Dec 29, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical: Our State supply of Sotrovimab is ~16 doses per 1 million population per day. Paxlovid supply is ~125 treatment courses per 1 million population until the mid/late Jan shipment. So we can treat maybe ~25 high risk people per 1 million population per day. (Twitter) - Dec 29, 2021
- || Paxlovid (nirmatrelvir) / Pfizer
“The important story to tell here is that severity is way down and the risk for significant severe disease [much] lower,” We have vax, Paxlovid now, and Omicron inherently less virulent besides per 5 experimental lab studies: doesn't infect lung cells well https://t.co/yCWMOjK9Z6 (Twitter) - Dec 29, 2021
- ||||| Paxlovid (nirmatrelvir) / Pfizer
We thought the anti-Covid pill Paxlovid (Nirmatrelvir) would be effective vs Omicron because there are few, if any, mutations in the main protease of the virus in variants. But good to see this confirmation of potency in an independent lab (not Pfizer) https://t.co/HyCaYtBVRA (Twitter) - Dec 29, 2021
- |||| Paxlovid (nirmatrelvir) / Pfizer
All I can say is I am so sorry. I’ll be on a cancer med soon that is an immunosuppressor AND contraindicated w/ @pfizer’s Paxlovid so I kinda understand. And am frustrated to the max. (Twitter) - Dec 29, 2021
- || Paxlovid (nirmatrelvir) / Pfizer
What will your antibody level be in 3-6 months when paxlovid is in “bigger supply”? (Twitter) - Dec 29, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical: I asked yesterday since I have a immunocompromised patient. They have new treatment guideline that includes Sotrovimab and Paxlovid but no product. No alternatives offered. (Twitter) - Dec 29, 2021
- |||| Paxlovid (nirmatrelvir) / Pfizer
And I should also clarify that protease inhibitors used alone have a history of selecting for resistance; although that has yet to be tested for paxlovid, I will feel more comfortable once we have at least a second highly effective drug against SARS-CoV-2 / COVID19 (Twitter) - Dec 29, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Clinical: Nope. I was referring to Paxlovid, not molnupiravir. The apparent higher efficacy of molnupiravir in the early analyses was a result of an unusual high percentage of hospitalization/deaths in the control arm. When the full dataset became available, that anomaly self corrected (Twitter) - Dec 29, 2021
- || ritonavir / Generic mfg., Paxlovid (nirmatrelvir) / Pfizer
Paxlovid comes with Ritonavir, and has a list of interactions and contraindications as long as your arm, many of which are classed as severe. (Twitter) - Dec 29, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
@DrEricDing @EricTopol @ScottGottliebMD @AlbertBourla @ASlavitt @DrLeanaWen @CDCDirector @DrNancyM_CDC @CDCgov @US_FDA @WmHaseltine @JoeBiden Wonderful The transmissibility of #omicron + potential more virulent COVID has a huge potential to mutate STOCK UP ON #PAXLOVID (Twitter) - Dec 29, 2021
- ||| Paxlovid (nirmatrelvir) / Pfizer
Japan finds new COVID virus strain, distinct from UK and Africa types https://t.co/XkRKoatTzd One more new variant Inevitably one will be much more virulent as well PLEASE STORE #PAXLOVID WE NEED TO BE READY @CDCDirector @CDCgov @DrNancyM_CDC @US_FDA @DrWoodcockFDA @DrLeanaWen (Twitter) - Dec 29, 2021