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- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
¿Paxlovid (Pfizer)? (Twitter) - Jan 14, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid? (Twitter) - Jan 14, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Do treatments exist for #covidpositive ppl w 2+ weeks of #GI #stomach symptoms to try to avoid #longcovid? Can #Highriskcovid ppl take #MonoclonalAntibodies more than 10 days (#sotrovimab), 7 days (#fluvoxamine) or 5 days (#paxlovid) after symptom onset/positive #rat/#pcr? #mab (Twitter) - Jan 14, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Clinical: Wonderful to have nirmatrelvir/ritonavir and molnupiravir for COVID, esp in vulnerable patients. 🔑 to remember ritonavir can ⬆️ CsA and Tac levels 5-50x. Should avoid mTORis and may not need to re-dose CsA or Tac until ritonavir completed. (Twitter) - Jan 14, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Special Considerations for Paxlovid Treatment Among Transplant Recipients With SARS-CoV-2 Infection https://t.co/kfhaoAvvsO "we suggest reduction or withholding of CNI after Paxlovid initiation-... subsequent CNI dosing on trough drug levels during Paxlovid treatment" @AJKDonline (Twitter) - Jan 14, 2022
- || Actemra IV (tocilizumab) / Roche, JW Pharma
Review, Journal: The need for a multi-level drug targeting strategy to curb the COVID-19 pandemic. (Pubmed Central) - Jan 14, 2022
Several drugs have been identified that can fit this potential role by targeting different stages of COVID-19 including baricitinib, molnupiravir and PF-07321332/ritonavir and also the combination of deferiprone with N-acetylcysteine for inhibiting the vicious circle of oxidative stress toxicity and endothelial cell damage. Most of these drugs are expected to be effective against all the SARS-CoV-2 variants including Omicron (B.1.1.529) and also the associated COVID-19 complications.
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Yeah, it is a great question. I think once the oral antiviral is easily available that the risk will be much lower and things will open up. A total guess: spring this year when paxlovid is easily available. That is when the unvaccinated won't fill up the hospitals anymore. (Twitter) - Jan 14, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@umang_vohra @Cipla_Global @drreddys @adarpoonawalla @torrentsmd @samirmehta @SunPharma_Live @HeteroHCL @satya_yadav @mla_sudhakar @MoHFW_INDIA @eloder @singhak_endo @Merck @POTUS @Ind_Pharma @moderna_tx @pfizer @narendramodi Honourable P.M, Pl confirm DATE of PAXLOVID in INDIA (Twitter) - Jan 14, 2022
- |||| Clinical: Please find out about how Atrial Fibrillation patients on Xarelto, Flecainide, Diltiazem be able to take Paxlovid. May be by adjusting doses of these medications or prescribing alternate medicines for the duration of Paxlovid course. (Twitter) - Jan 14, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Six to eight months to manufacture Paxlovid. Yowza! 😧 (Twitter) - Jan 14, 2022
- ||| Clinical: Can Afib patients post ablation and normal rhythm on Xarelto, Flecainide, Diltiazem and Atorvastatin take Paxlovid by altering or reducing these drug dosages? Can Xarelto be changed to Pradaxa or Eliquis while on Paxlovid if Flacainide and Atorvastatin can be stopped for few day? (Twitter) - Jan 13, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
If molnupiravir is the same formula as Paxlovid, how can they take different times to produce? (Twitter) - Jan 13, 2022
- || remdesivir / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
These days, the only option in most places is remdesivir. Paxlovid is a unicorn and sotrovimib isn’t much better. I’m guessing March will look very different (Twitter) - Jan 13, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD), Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical: My thoughts. I've been quite a bit of COID in CLL and these patients really struggle. Agree that #sotrovimab would be best option. I'd use paxlovid as second choice (check for DDIs), RDV as third. I'm not at all impressed with molnupiravir data. I'd suspect #Omicron. (Twitter) - Jan 13, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
You could give Regeneron if you know that the rate of Delta remains fairly high in your area, but its a shot in the dark. Otherwise try to get access to molnupiravir/Paxlovid. All of this easier said than done. We are in a tough place for COVID therapy at the moment (Twitter) - Jan 13, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
4. If within 5 days of symptom onset and have fever and shortness of breath - contact your GP about access to one of the COVID antiviral meds (#Paxlovid or #Lagevrio. They may be in very limited supply at this point. Do not panic! (Twitter) - Jan 13, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: So let me understand this. Patient refuses vaccine manufactured by Pfizer to prevent serious illness/death, but will accept Paxlovid, made by same? (Twitter) - Jan 13, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Special Considerations for Paxlovid Treatment Among Transplant Recipients With SARS-CoV-2 Infection https://t.co/toO3hXTDs8 (FREE) @sfishbane @jam_hirsch @vinaynairdo @HofstraKidney #COVID19 #kidneytransplant (Twitter) - Jan 13, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Special Considerations for Paxlovid Treatment Among Transplant Recipients With SARS-CoV-2 Infection https://t.co/r36PAu50ev @AJKDonline @sfishbane @vinaynairdo @jam_hirsch (Twitter) - Jan 13, 2022
- || Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Maybe that is the view inside the WH but try to get any of the new drugs anywhere. A call to a few physicians on the ground will tell you Paxlovid, Sitrovimab, Evusheld and Malnupuravir not available in their States or available in very limited quantities. (Twitter) - Jan 13, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
The Ontario FLVX guideline is awesome. Thanks for sharing. The DDI-Flvx-(by itself)-road to successful covid tx is easy to navigate. But Paxlovid added to it, will need a super GPS. You'll get there but may have to go through lots of detours. Check w/ pharm when in doubt. (Twitter) - Jan 13, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: The only effective weapons NOW are vaccines+boosters, paxlovid, N95. We need to mandate vaccine proof to work (like Italy by Feb 15) and acknowledge this endemic phase and need to shift strategy and policies accordingly. We are running out of people to run hospitals schools, etc (Twitter) - Jan 13, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Actually, I sort of thought that 'everyone would get it' when it first took off, when I realized it was like measles. But the emotion was more like "Acceptance" I suppose, for myself, yet worry and fear for my immunocompromised friends. Now I hope they crank out more Paxlovid. (Twitter) - Jan 13, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
👇🏻 is The only smart thing to do (N95 and Paxlovid if infected) We are in a post pandemic to endemic shift that we need to navigate! (Twitter) - Jan 13, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical: Pushing for Evushield as pre-EP on all fresh Tx (inc. Covid+ donor). Sotrovimab for outpatient🦠. Paxlovid on high risk pts esp. in the setting of no Sotrovimab, subject to availability-even though our pharmacists are hesitant due to feared interactions. @ryankdare @Jcrico78 (Twitter) - Jan 13, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: The most important treatment is the now approved 4th dose of mRNA vaccine for all our patients! Paxlovid unfortunately has lower efficacy for Omicron (Twitter) - Jan 13, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
How did you get Paxlovid and what symptoms did it help you with? I'm also curious about antiviral combo. (Twitter) - Jan 13, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
How did you get accès to paxlovid? (Twitter) - Jan 13, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: I’m pretty sure you can dose adjust the Paxlovid for eGFR 30-60. Can’t use with eGFR<30. So still usable for many CKD patients (just not the highest risk ones). (Twitter) - Jan 12, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Licensing / partnership: Q. Does Paxlovid work? Ans. Yes Let us provide access to these therapies to all those who need it @PowerUSAID @WHO and prevent hospitalization from @COVID == need to develop partnerships with global pharma companies worldwide @pfizer @drreddys @SunPharma_Live @ZydusUniverse (Twitter) - Jan 12, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical: Sorry, I meant to say that Paxlovid is for treatment of COVID post exposure and has significant interactions with CNIs and Evushield is the preexposure drug with lowere efficacy against Omicron! Sotrovimab may be better for omicron tx? (Twitter) - Jan 12, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
And finally, this is how we propose specifics: 1. Booster nuance with young men (Dr. Paul Offit Atlantic article yesterday); 2. Mask mandates end but specific mask recommendations for those who want no exposure; 3. Need more production of Paxlovid + tests https://t.co/dCJvEm4I04 (Twitter) - Jan 12, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
I was curious about the same - was under thr impression that paxlovid > molnupiravir but was unaware of any strain-specific data on these (Twitter) - Jan 12, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Do you have a reference demonstrating paxlovid has lower efficacy vs. omicron? The site of action (3C protease) doesn’t have relevant mutations that I am aware of. (Twitter) - Jan 12, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Not really. Paxlovid isn't coming in significant quantities until 2H. And there's nothing much short of China style lockdowns that could've slowed omicron in the US. (Twitter) - Jan 12, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
What treatments? Better sotrovimab and Paxlovid supplies? Just curious. (Twitter) - Jan 12, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
This is a great two pager for MDs and pharmacists on #Fluvoxmaine for #COVID19 with relevant drug-drug interactions, alternaitve therapies, as Ontario has put together (so no mention of paxlovid as an alternative, but it is an alternative, in theory in the USA). (Twitter) - Jan 12, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Physicians & pharmacists who would like to be on a Twitter Spaces panel about Paxlovid & fluvoxamine drug interactions this coming Sunday, January 16th, noon CST (or help prepare content), Please respond here and/or send me a DM. (Twitter) - Jan 12, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Idsa rec is to give MAb to this population (per weekly call), but for someone vaccinated x4 (or more) who has an antibody response but weak T cell response, paxlovid still may likely be the better agent. The narrow tacro therapeutic index is a challenge. (Twitter) - Jan 12, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Grateful for the pharmacists who were receptive to these calls & asked meaningful questions — patients also need good renal and hepatic function for Paxlovid. Trying to prevent severe infections for people most at risk — unvax’d & cancer is a bad combination right now. (Twitter) - Jan 12, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Also learned a ton about the new antivirals — lots of contraindicated meds for Paxlovid, fewer for molnupiravir. #COVIDCME (Twitter) - Jan 12, 2022
- |||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Clinical: Had a rough overnight call @utswcancer including 3 patients w/ cancer & new COVID infections, spent 2 hrs this AM calling 10 pharmacies in Dallas — 3 had @Merck molnupiravir & last one finally had @pfizer Paxlovid. Supplies are limited for our vulnerable patients!! 😧 @tmprowell (Twitter) - Jan 12, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: I listed this since it seems like an option for the highest risk patients since we are struggling to find paxlovid, mAb, etc. I.e. we won’t have to worry about finding treatments for these folks if we give Evushield at discharge on fresh post-ops. (Twitter) - Jan 12, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
HIV DDI guidelines rec to decrease apixa 5 to 2.5 with a PI/r containing regimen, should theoretically be the same with Paxlovid? (Twitter) - Jan 12, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Worth also looking at the 95% upper CI. Contrast to fluvoxamine and nirmatrelvir/ritonavir (Twitter) - Jan 12, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
It is clearly driven by a lack of tests. Of 500M promised by Feds only 50M have been contracted. Total Paxlovid courses on hand are 246K. Next 10M not expected until the end of June, the next 10M by September. (Twitter) - Jan 12, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Appeaes correct. Pfizer stating "10 million PAXLOVID treatment courses have been accelerated for delivery by the end of June" does appear to indicate later rather than sooner. 10M over next months serms to indicate capacity of <4M courses/month. https://t.co/LM3bwnyjcB (Twitter) - Jan 12, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Evolutionary pressure is: when virus is replicating at will in large immune/partially immune populations. Treatments that abort infections (Paxlovid) may leave individuals susceptible to a new infection, because Stimulus for immunity may be aborted too. Data needed. (Twitter) - Jan 12, 2022
- ||||| Paxlovid (nirmatrelvir/ritonavir) / Pfizer
Enrollment closed: EPIC-HR: Study of Oral PF-07321332/Ritonavir Compared With Placebo in Nonhospitalized High Risk Adults With COVID-19 (clinicaltrials.gov) - Jan 12, 2022
P3, N=2246, Active, not recruiting, Sponsor: Pfizer
Most of these drugs are expected to be effective against all the SARS-CoV-2 variants including Omicron (B.1.1.529) and also the associated COVID-19 complications. Recruiting --> Active, not recruiting
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, apixaban / Generic mfg.
Clinical: Potential Case: Patient is on apixaban 5mg BID for Afib. CHADS-VASc of 4. Presents with Rx for Paxlovid. Assume no IV options for COVID-19 management and otherwise no other interactions and normal renal function. Thoughts? (Twitter) - Jan 11, 2022