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- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid in 20 hours - test to pill. @DanielGriffinMD (Twitter) - Jan 17, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Excellent! This fits what others have been saying as well. @ErinMcCreary @PaulSaxMD @BWDionne Starting paxlovid? •D/C offending concomitant med today •Restart concomitant medication 2-3 days after paxlovid is done (Twitter) - Jan 17, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: @CBCNews @aartipole will @pfizer’s #PAXLOVID be prioritized for #Disabled folks who are immunocompromised or medically not eligible for #Vaccinations? #DisabilityJustice #Equity #CovidEugenics @ccdonline (Twitter) - Jan 17, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
At the cancer center we’ve been through this and paxlovid essentially impossible as of sometime last week. molnupiravir not as effective, but more available and without the drug drug interactions. (Twitter) - Jan 17, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Can you also ask him to please just stop the repeated lies about Paxlovid being available to the public “soon”... Every time he says that I want to scream. He knows that’s a lie, right? Or is he so privileged that he doesn’t even know what the public can access? (Twitter) - Jan 17, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Having just reviewed patients for #paxlovid will say it is hard - cancer patients are often on multiple agents that need to be held or dose adjusted if considered. It is a heavy lift to organize with pharmacy and provider input - & added challenge of the 5 day window (Twitter) - Jan 17, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: @EricTopol warns that we might get an "#Omicron successor" that has higher clinical severity, but we cannot predict that. How can we get ahead of the next variant? 1. Make PAXLOVID accessible to all 2. Make a pan-sarbecovirus vaccine the highest priority https://t.co/lsLk0iU3dK (Twitter) - Jan 17, 2022
- || dexamethasone / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Dexamethasone. Various monoclonal antibodies. Nirmatrelvir/ritonavir. Molnupiravir. Just to name a few. I could name many more that we use. (Twitter) - Jan 17, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Tried to order Paxlovid on Friday night for a patient. The challenge? Figuring out where they can get it. Per @HHSGov there are 9 locations across my state. https://t.co/tfgWQStYeo (Twitter) - Jan 16, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Anyone want to be a moderator or panelist on a clubhouse room next weekend? We’ll talk about drug interactions relevant to Paxlovid and/or fluvoxamine. (Twitter) - Jan 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Pt with “mild” cold-like symptoms two weeks ago. +COVID Got prescribed Paxlovid but not able to fill. Today woke up with acute shortness of breath. CT chest shows Saddle Pulmonary Embolus. #Omicron #MedTwitter (Twitter) - Jan 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@umang_vohra @Cipla_Global @drreddys @adarpoonawalla @torrentsmd @samirmehta @SunPharma_Live @HeteroHCL @satya_yadav @mla_sudhakar @eloder @singhak_endo @Merck @Ind_Pharma @moderna_tx @pfizer @narendramodi Action for PATENT free PAXLOVID PILL (PFIZER) to manufacture in INDIA (Twitter) - Jan 16, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Clinical: EBM is EBM. There will be many Paxlovid and particularly Molnupiravir cases who will be admitted. Unfair to claim fluvoxamine is quackery. Nobody has claimed it will work in every case @AngelaReiersen (Twitter) - Jan 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: I can perhaps see a scenario where patients who are enrolling after day 5 into an FLV arm could be instead enrolled in FLV + Cyproheptadine arm, given what we know so far about poorer efficacy if FLV started after day 5. This would one up what’s doable with Paxlovid. (Twitter) - Jan 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Meaning no one is protected from #LongCovid Scary. Mask up. N95. Period. #paxlovid when available (hopefully soon) @DrEricDing @WmHaseltine @EricTopol @DrLeanaWen @CDCDirector (Twitter) - Jan 16, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
3/ and I have not used this drug. I favor RDV x 3 days if #paxlovid cannot be administered safely. https://t.co/hKVD8Qf6Mj @PergamIC #TxID @MichaelGIsonMD (Twitter) - Jan 16, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD), Nulojix (belatacept) / BMS
Clinical: Thank you @AST_info and @AST_IDCOP for the helpful guide to #COVID19 oral antivirals. Bottom line, drug-drug interactions w #paxlovid and decreased efficacy w #molnupiravir make them poor choices for transplant pts on CNI. One exception: #paxlovid for pts on #belatacept (Twitter) - Jan 16, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Are you referring to PrEP mABS, post exposure mABS (sotrovimab and Paxlovid), or both. Thanks so much. Hoping the supply gets better for all of us SOT recipients! (Twitter) - Jan 16, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I assume here you are talking the Paxlovid component alone, rather than the Paxlovid-Ritonavir pair used in trials (ritonavir-boosted) Since it seems ritonavir carries the bulk of the drug-interaction risk Also have to weigh certainty/comfort around FLV known drug vs newcomer (Twitter) - Jan 16, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
This drug interaction checker is not showing anything concerning as far as interactions between Paxlovid & fluvoxamine. https://t.co/HlkD8kqxFz (Twitter) - Jan 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
When nirmatrelvir is given by itself, it is broken down and leaves the body too quickly. This is why Paxlovid includes both nirmatrelvir (which has antiviral action against SARS-CoV-2) and ritonavir (which boosts the level of nirmatrelvir, so it can do its job). (Twitter) - Jan 16, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid = (nirmatrelvir + ritonavir), co-packaged for oral use. The ritonavir component is the one we need to be most concerned about as far as drug-drug interactions are concerned. In combining ritonavir with nirmatrelvir, Paxlovid takes advantage of a drug-drug interaction. (Twitter) - Jan 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid = ( nirmatrelvir + ritonavir ) (Twitter) - Jan 15, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid Fact Sheet: https://t.co/WcpZqL3Bxa (Twitter) - Jan 15, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
FAQ document regarding Paxlovid: https://t.co/fSGcbGzxjg (Twitter) - Jan 15, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@umang_vohra @Cipla_Global @drreddys @adarpoonawalla @torrentsmd @samirmehta @SunPharma_Live @HeteroHCL @satya_yadav @mla_sudhakar @eloder @singhak_endo @Merck @Ind_Pharma @moderna_tx @pfizer @narendramodi Honourable P.M, Please Confirm DATE of PAXLOVID PILL (PFIZER) in INDIA (Twitter) - Jan 15, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid + FLVX own their own, easy to navigate DDI. It's the co-meds prescribed with each med that makes more complex. Especially, Paxlovid (ritonavir). Not impossible but would rec consult with your trusted pharmacist. (Twitter) - Jan 15, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@AngelaReiersen (from WashU STL) is running useful info sessions, tomorrow on fluvoxamine and paxlovid and their interactions w/ other Rx: (Twitter) - Jan 15, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
How complex Paxlovid (ritonavir) biotransformation? Let me count the ways: Rit is substrate of 3A4 (mainly), 2D6, P-gp. Rit is inhibitor of 3A4 (strong), 2D6, 2C19, P-gp. Rit is inducer of 3A4, 1A2, 2C9, 2C19, 2B6, UGT. Rit + drugs metab by 3A4 & 2D6 - inc 3x & 2x in AUC, resp. (Twitter) - Jan 15, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
We need a generic name for Paxlovid, now that it will be known in Bangladesh as Bexovid: https://t.co/qlY2jBSCdk Suggest co-nirmatonavir Others? @US_FDA @MHRAgovuk (Twitter) - Jan 15, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Granted the buck stops with Biden, but so many things that have been obvious to an informed member of the public have been disregarded by the CDC. Walensky was busy being profiled in Vogue when she should have been focused on masks, testing, boosters, and Paxlovid. (Twitter) - Jan 15, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Clinical: Aren't you the smart one... You also called (in the same piece) Merck's molnupiravir a "wonder drug" on par with Pfizer's Paxlovid. Quite a lot of people called for deployment of rapid tests without upsaling ineffectual mutagenic nucleoside analog. (Twitter) - Jan 15, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@ShaneyWright we need Paxlovid and we need monoclonal antibodies. How can we rally around this? How can we lead studies on this? #teamclots is already doing their thing. Any doctor interested in championing this or is @VirusesImmunity all we got? (Twitter) - Jan 15, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
/3 It is by no means certain that there won't be unexpected supply chain issues with Paxlovid and Omicron specific boosters (Twitter) - Jan 15, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Real-world evidence: T cells are tired now with repeated boosting from original wuhan strain vaccines. And paxlovid is distant dream at least for now. But people have choices and they exercise them. Like living in palace in sky. For most of real world #fluvoxamine is real thing. And possible now. (Twitter) - Jan 15, 2022
- || fluvoxamine / Generic mfg., Covaxin (BBV152 COVID Vaccine) / Bharat Biotech, Indian Council of Medical Research, Ocugen, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Waiting for her response for last two months. She is right now into T cells and paxlovid and small amount if covaxin. # fluvoxamine is generic drug. Too middle class for her even to mention. (Twitter) - Jan 15, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
PK/PD data: Hmm. FluoxamineHalf life 15-20 hrs. SS reached in 4-5 days. Mutliple cyp pathways. Minimal renal elimination Inhibitor of CYP 1A2 , and to some extent 2C19 and other cyps PAXLOVID (PF-07321332/ritonavir) is more a ritonavir story. Pharmacokinetic booster inhibiting Cyp3A. (Twitter) - Jan 15, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
At risk / up front investment in Paxlovid development (Twitter) - Jan 15, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Actually, it is the opposite. Paxlovid can increase Fluvoxamine levels, although seems minimal and adjustment of dosage would likely mitigate any risk. (Twitter) - Jan 15, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Fluvoxamine Drug Interactions & Paxlovid Drug Interactions: Prescribing Considerations for COVID. (Cumbersome title) (Twitter) - Jan 15, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Evidence about accuracy of interaction between Paxlovid and Fluvoxamine not effectivity against Covid (Twitter) - Jan 15, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
To clarify, this will be a discussion regarding drug-drug interactions involving Paxlovid and/or fluvoxamine. Each of these 2 drugs has interactions with multiple other drugs (Paxlovid because of the ritonavir component). Can’t explain all that in the Twitter Space title though. (Twitter) - Jan 14, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: What about ensuring availability of meds like Paxlovid which can be given when the person has mild symptoms? What is stopping powers that be from making approved meds available? Vaccine can’t be the only solution. Multiple approaches are needed. (Twitter) - Jan 14, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Autoriza Cofepris uso de Paxlovid para tratar Covid-19 - Vía @reforma https://t.co/5ByatvgCji. (Twitter) - Jan 14, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: If the underlying mechanism is viral reservoir in tissues then I wonder if antivirals like Paxlovid will have to be lifelong maintenance meds for us. Other syndromes where the virus remains like HIV, or herpes never clear but instead are kept at bay by antivirals. (Twitter) - Jan 14, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: As the first round of COVID treatments arrive in Minnesota, IEM Member @boulware_dr, MD, MPH, advises that Paxlovid is used for people that are at high risk, with less than five days of symptoms. Read the full article on Kare 11 here: https://t.co/votLKKV1eG (Twitter) - Jan 14, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Do treatments exist for #covidpositive ppl w 2+ weeks of #GI #stomach symptoms to try to avoid #longcovid? Can #Highriskcovid ppl take #MonoclonalAntibodies more than 10 days (#sotrovimab), 7 days (#fluvoxamine) or 5 days (#paxlovid) after symptom onset/positive #rat/#pcr? #mab (Twitter) - Jan 14, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
@boulware_dr Any treatments 4 #covidpositive ppl w 2+ weeks of #GI #stomach symptoms to try to avoid #longcovid-can #Highriskcovid ppl take #MonoclonalAntibodies more than 10 days (#sotrovimab), 7 days (#fluvoxamine) or 5 days (#paxlovid) after symptom onset/positive #rat/#pcr? (Twitter) - Jan 14, 2022