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- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
return to last summer by mid-march, return to better than last summer but still masking in supermarkets by summer, maybe another variant during the winter but not anything paxlovid can't handle, keep doing the easy public health interventions forever but more or less 2019 in 2023 (Twitter) - Jan 20, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Do you have a reference for that data on Paxlovid from Israel? (Twitter) - Jan 20, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: So far there is no clinical trials data showing that Paxlovid actually benefits vaccinated people. (Twitter) - Jan 20, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
DHHS Website where doctors can find the available new antiviral drugs like #Paxlovid. Just prescribed, pharmacy had it, system works! https://t.co/6jSZcFNWTC @CarlosdelRio7 @MonicaGandhi9 #testandtreat (Twitter) - Jan 19, 2022
- |||| Clinical: @AADmember join me @LCalabreseDO & @AmeshAA 4 a #COVID19 #webinar Jan 21 1PM EST. Do patients on #biologics need to isolate x 20 days w #SARSCoV2? Should U upgrade to #N95? Do we need a 2nd #booster? Who should get #Paxlovid #Sotrovimab #remdesivir or #molnupiravir? #Dermtwitter (Twitter) - Jan 19, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
This administration needs to do a much better job getting treatments to the public. Paxlovid is VERY hard to find and its unavailability adds tremendous stress and risk of more serious illness when searching for it. Time is of the essence when diagnosed! (Twitter) - Jan 19, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
They are taken separately (not in same pill) but packaged together. If Pfizer could speed up production of nirmatrelvir, and let others in US supply ritonavir, pharmacists can supply in indiv bottles (not daily packages which are time consuming). (Twitter) - Jan 19, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@megtirrell @HelenBranswell @EricTopol @VinGuptaMD @ashishkjha @RebeccaDRobbins 1. One component of Paxlovid, ritonavir (Norvir) is protease inhibitor booster supplied by 5 manuf in US, see drugs@fda. Other component is patented nirmatrelvir, new Pfizer protease inhibitor. (Twitter) - Jan 19, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
“🦠COVID-19💊Drug-Drug💊Interactions🦠: Fluvoxamine, Paxlovid….” with @AngelaReiersen, Dr. Eric Osgood MD, Dr. Jalali, @BramanteCarolyn, @calirunnerdoc, and 2nd Time Around. Sunday, Jan 23 at 11:00 AM MST in @clubhouse! https://t.co/j1nOBCYGMK (Twitter) - Jan 19, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Preclinical: Structural basis for Nirmatrelvir in vitro efficacy against the Omicron variant of SARS-CoV-2 | bioRxiv https://t.co/VlDbGSL64w (Twitter) - Jan 19, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Omicron posed no match to Paxlovid https://t.co/IkGC1UIMXj A new lab study report of the anti-Covid pill, woefully in less than scarce availability (Twitter) - Jan 19, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Fluvoxamine, originally used as a psychiatric drug, has shown benefit in RCTs as a COVID19 treatment. Paxlovid is a recently developed antiviral with EUA for COVID19. Both have interactions with other drugs. Let’s talk about it on Clubhouse this Saturday! https://t.co/G9IOv0ND0c (Twitter) - Jan 19, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
We also need to rapidly produce billions of Pfizer’s Paxlovid and provide a a full dose to every adult globally along with testing kits … if you have symptoms, test and get on paxlovid. (Twitter) - Jan 19, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid is not easy to produce. (Twitter) - Jan 19, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid is not easy to produce is one thing I have read. (Twitter) - Jan 19, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Providers, Paxlovid and molnupiravir are currently in stock #NYC! Learn more about prioritization and ordering oral-antivirals here: https://t.co/VR4k19ZlRy @florian_krammer @CamaraJones @uche_blackstock @AmmahStarr @Craig_A_Spencer @toyinajayidoc @DrKamLeigh @KellyMDoran (Twitter) - Jan 19, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
finally got in touch with the urgent care, who said they dont have any where to even refer for mabs or paxlovid, and told me to call another urgent care that isnt answering the phone🥲 can we Bully @POTUS @PressSec @jrpsaki @CDCgov @CDCDirector about this next? (Twitter) - Jan 19, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
What it took for @RebeccaDRobbins to get her 73 year old mother Paxlovid is inexcusable https://t.co/q6Sbb6HLV4 (Twitter) - Jan 19, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Pricing: Lots of options now for outpatient COVID therapy. Here’s our article that compares and contrasts efficacy vs cost per hospitalization prevented. Paxlovid NNT 24 but cost/hosp/prevented is $$$. 3 dollar signs being a lot 😁 (Twitter) - Jan 19, 2022
- || Paxlovid (nirmatrelvir/ritonavir) / Pfizer
Trial completion: PF-07321332/Ritonavir and Ritonavir on Dabigatran Study in Healthy Participants (clinicaltrials.gov) - Jan 19, 2022
P1, N=24, Completed, Sponsor: Pfizer
Recruiting --> Completed
- || Paxlovid (nirmatrelvir/ritonavir) / Pfizer
Trial completion: Drug-Drug Interaction Study to Estimate the Effect of PF-07321332/Ritonavir and Ritonavir on Midazolam in Healthy Participants (clinicaltrials.gov) - Jan 19, 2022
P1, N=12, Completed, Sponsor: Pfizer
Recruiting --> Completed Recruiting --> Completed
- || Paxlovid (nirmatrelvir/ritonavir) / Pfizer
Trial completion: Study to Estimate the Effects of Hepatic Impairment on the Pharmacokinetics (PK) of PF-07321332 (clinicaltrials.gov) - Jan 19, 2022
P1, N=17, Completed, Sponsor: Pfizer
Recruiting --> Completed Recruiting --> Completed
- || chloroquine phosphate / Generic mfg., camostat mesilate / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
reflecting on therapeutics, camostat &family) would be put at rest during omicron crisis, but what about those cheap drugs that partly worked by disturbing the endosomal pathway? ( chloroquine, ivermectin etc.). is the conversation coming back again, or it's still only paxlovid? (Twitter) - Jan 19, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Unfortunately is very difficult to get early meds for #covid sotrivimab or paxlovid). My PCP didn’t even know what Paxlovid was. (Twitter) - Jan 19, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: I just don’t listen to Media, I read scientific literature. There is not enough Data out on Paxlovid. But the point is Merck didn’t use this to make money. They gave it for free to many poor countries. We need them to mass produce Peter’s vaccine. That was my point. (Twitter) - Jan 19, 2022
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid (nirmatrelvir) gets props (Twitter) - Jan 18, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
A lot of the work on Paxlovid was done 18 yrs ago (for SARS). The alterations to update the drug for COVID were impressive, but not iconic, IMO. (Twitter) - Jan 18, 2022
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid? (Twitter) - Jan 18, 2022
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer
When Paxlovid pill? (Twitter) - Jan 18, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
No. Just looks like they are still studying it. From their pdf “Other therapeutics in progress for this WHO living guideline include new antiviral treatments (molnupiravir and nirmatrelvir) and fluvoxamine. (Twitter) - Jan 18, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Review: Thinking of prescribing Paxlovid as an early treatment for your COVID-19 patients also on cardiac meds? Best to review these meds with pt's cardiologist before doing so. https://t.co/fYxL6vpJhp (Twitter) - Jan 18, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
What about Paxlovid? (Twitter) - Jan 18, 2022
- |||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Two rooms about interactions of Paxlovid and fluvoxamine with other medications this weekend. 1) Sat 10 AM CST—Word Mental Health Club 2) Sun Noon CST—2nd Time Around Club **Join us in one or both rooms!** (Twitter) - Jan 18, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, apixaban / Generic mfg.
Did Paxlovid and Apixaban dose adjustment work out? (Twitter) - Jan 18, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Are immunologists/ rheumatologists/ oncologists/ transplant docs able to get their hands on these [Paxlovid/appropriate monoclonals] and RESERVE them for their highly immunocompromised patients? Risk stratification I would think? (Twitter) - Jan 18, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Yeah around here, paxlovid is only possible if you "know" somebody unfortunately. And sotromivab .... forget about it.... impossible to find. But decent amount of molnupiravir, the one drug everyone is afraid to take. (Twitter) - Jan 18, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Ritonavir (a component of Paxlovid), inactivates CYP3A4, so will increase the level of medications that are broken down by this enzyme. See this link for information about drugs this will affect. https://t.co/p8z8bskdq5 (Twitter) - Jan 18, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical: The answer is there’s no good answer but at the end of the day if a patient on tac cannot get sotrovimab, I wouldn’t withhold Paxlovid just for the DDI. Get levels if you can. If not hold tac 7 days at least. It’s all just not great. (Twitter) - Jan 18, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Lab studies of Paxlovid "maintain plasma concentrations many-fold times higher than the amount required to prevent Omicron from replicating in cells" New today, along w/ @Dereklowe's piece on the chemistry & @beth_halford's @cenmag https://t.co/rB78pBcEPT https://t.co/s8IVOxYz0V (Twitter) - Jan 18, 2022
- || Disculpe Dra. Éstos medicamentos (Nirmatrelvir-ritonavir, remdesivir, and molnupiravir, sotrovimab), existen en México? Son accesibles con receta ? Cómo lo es ozeltamivir (Twitter) - Jan 18, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
If tests and Paxlovid are cheap and accessible in every pharmacy, then I will say that the pandemic has officially ended. (Twitter) - Jan 18, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical: Access early tx. Hah! Virginia currently experiencing 19,000 cases per day and getting about 1,000 courses each of Paxlovid and Sotrovimab per week. What access? (Twitter) - Jan 18, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I don’t have any chance of getting Paxlovid (Twitter) - Jan 18, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
This is maybe apples and bananas… plenty of people think human challenge trials are ethical. With Paxlovid in the picture, I don’t see a strong argument against them? (Twitter) - Jan 18, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Some trials were run *only* on unvaccinated. E.g. this Paxlovid study https://t.co/593jlTc8wx. So effect on vaccinated is unknown — which is different from known to be ineffective. Paxlovid works differently from the immune system so *probably* complementary to vaccination. (Twitter) - Jan 18, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
A great place to start! In the good ol' days of ART + booster du jour for COVID tx, even a single dose of reduced TAC w/ concomitant booster = ⬆️FK x days. https://t.co/syxRQUYrKd https://t.co/q1lu7J6wlX Longer TAC interruptions pre-#Paxlovid may be as important? (Twitter) - Jan 17, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
#IDTwitter #Medtwitter Paxlovid seems great but going to be v important to consider med interactions - many more than other #COVID19 txs As it stands, can’t drop the ritonavir even if you wish you could Ask an ID pharmacist if unsure! Cc: @mmPharmD @jeffpears0n @BWDionne (Twitter) - Jan 17, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Canadian regulatory, Clinical: Health Canada approves Pfizer's COVID-19 antiviral treatment. Paxlovid reduces rate of hospitalization and death among high-risk COVID-19 patients according to @Pfizer. @Emil_LeeMD @DrHugue https://t.co/wBfqAGQxBE (Twitter) - Jan 17, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Why are COVID tests important? - They allow us to know if we're contagious & a threat to others. - To know if we can safely return in-person to school & work. AND - To help us access early treatment (e.g. Paxlovid, monoclonal antibodies). on @CBSNews with @NorahODonnell (Twitter) - Jan 17, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
How exactly is this situation feasible if Paxlovid needs to be given within 3-5 days of symptom onset? (Twitter) - Jan 17, 2022