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- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: I think we really need pediatric hospitalists and pediatricians to lead in improving mask quality for kids in the US. And vaccine/treatments? Why must it be so hard for them to get a mask with a good seal? When will they get a 3rd dose of Pfizer? Kid Paxlovid? (Twitter) - Jan 26, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Review, Journal: Structure genomics of SARS-CoV-2 and its Omicron variant: drug design templates for COVID-19. (Pubmed Central) - Jan 26, 2022
These examples highlight the importance of structure in drug discovery to combat COVID-19. We also discussed the recent variants of Omicron and its implication in immunity escape from existing vaccines and antibody therapies.
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical: In my experience working w/my mom's PCP's in VA, doctors are not willing to call the pharmacists to chat abt their patients medications and the modifications needed. No sotrovimab but paxlovid available. Could find no one to prescribe it or even investigate the possibility (Twitter) - Jan 26, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Real-world evidence: Appreciate this real world paxlovid experience w #COVID19 treatment in a patient on tacrolimus - big FK trough spike after just 3 days of use , we need to educate our transplant teams and our patients that this drug’s impact is more than just a Z pack ! @AST_IDCOP @MattDavis138 (Twitter) - Jan 26, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical: @AADmember I just presented @MauiDerm @NPF #COVID19 TF recs. 1. #psoriasis patients on #immune #modulators w #SARSCoV2 can follow @CDC #isolation recs for general population 2. Best #treatments for early #COVID19 in high risk patients: #Paxlovid & #Sotrovimab #MauiDerm2022 (Twitter) - Jan 26, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid® : 1er antiviral anti-SARS-CoV-2 disponible en ville https://t.co/x2K5uCJIbm via @medscape (Twitter) - Jan 26, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical: But UW is using NIH “strict eligibility criteria” & prioritizing UNvaccinated folks for post-infection Covid treatment (not Evushield). In WA, unless you’re severely immunocompromised, e.g., organ transplant, if you’re vaxxed, realistically, you can’t get Paxlovid or Sotrovimab. (Twitter) - Jan 26, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Something that is used frequently in Covid, listed in the FLCC protocol is methlyprednisolone, starting the 6th day. What do you think about using this along with Paxlovid ? (Twitter) - Jan 26, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
How about not test, stay home until you’re asymptomatic and then go back to work. How about DEMAND access to Paxlovid & monoclonal AB’s. Where the eff are the therapeutics?! Stop talking about effing testing & best the drum of therapeutics being withheld from the gov’t PURPOSELY! (Twitter) - Jan 26, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid is contraindicated for so many, who take commonly prescribed drugs. We still need the monoclonal antibody by Glaxo. When will that be more available? Need an array of therapeutics to be available. (Twitter) - Jan 26, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
You should probably wait until Paxlovid is easily available before you go expose yourself to Covid. Sadly it’s still too early in the pandemic to say whether any of us has good long term immunity to the strains circulating now or the ones that will be in six months or more. (Twitter) - Jan 26, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
And whats going on with mass production of Sotrovimab, Paxlovid? (Twitter) - Jan 25, 2022
- || Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
2000+ Americans still dying every day. Raising awareness on how higher risk folks can access early treatment (Paxlovid) or pre-exposure prophylaxis (Evusheld) is critical, especially for the next few weeks. Search by zip code here: https://t.co/xkwJWqll9y (Twitter) - Jan 25, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Lovely graphic! NB: I've almost prescribed Paxlovid 3x in the last week. It's a great med. But- outside of access issues - 2/3 had drug-drug interactions that made it contraindicated. 😢 (Twitter) - Jan 25, 2022
- ||| remdesivir / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
For Omicron the @GSK monoclonal Sotrovimab still work as do the entibiarla Remdesivir, Paxlovid and Molnupuravir. @RMKGandhi @PreetiNMalani and I recently published this in @JAMA_current https://t.co/qyL9y2PS0J (Twitter) - Jan 25, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Many Americans are on meds that interact with Paxlovid. We need to be mindful of that. https://t.co/NYHeOsYap8 (Twitter) - Jan 25, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: I'd rather see paxlovid in inpatients than molnupravir. (Twitter) - Jan 24, 2022
- ||| الان دارو آنتی وایرال و ضد ویروسی برای بیماران covid19 با کمبود آن مواجه نیستیم؟؟ #remdesivir #Tocilizumab400 #Pirfenidone #pirfenex #bevacizumab #Lopinavir #ritonavir #Fluvoxamine #paxlovid #favipiravir #Corticosteroids #adlimumb #sarilumab #Nitazoxanide (Twitter) - Jan 24, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Hmm then why are long COVID patients anecdotally improving with monoclonals and paxlovid? Showing t-cell exhaustion like those with Hep c and hiv do? Why are tissue biopsies showing fully intact virus several months post infection? Pretty clear to me (Twitter) - Jan 24, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: The VA hospitals in California are distributing it. It's the preferred way for veterans to get Paxlovid here. (Twitter) - Jan 24, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical: #MedTwitter #sotrovimab @DanielGriffinMD @UVAHospitalists @UVAHealthCareer @NIH @CDCgov @CDCDirector My 83 YO high-risk mom is covid+, day 5 and the UVA infusion clinic in Charlottesville has ZERO Mabs (VA shortage) and her primary care has never heard of paxlovid. WHAT DO I DO? (Twitter) - Jan 24, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: 2/ 70% of world's pop use medicinal herbs. Some herbs can have bad interactions w/ Paxlovid & other drugs you take w/ it. Example, SJW may lessen efficacy of Paxlovid via inc effect on enzyme CYP3A4. Certain herbs like Paxlovid may affect blood thinners, cardiac, BP meds, etc. (Twitter) - Jan 24, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
1/ The "animal-plant warfare" started some 1200 M years ago continues. Animas eat plants - plants produce toxins (phytoalexins) to become toxic - animals produce enzymes to detoxify them - the cycle goes on. The potentially serious herb (plant)-drug (Paxlovid)-man interactions. (Twitter) - Jan 24, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Bottomline: Tell your tx provider ALL the meds (Rx'd, OTC), herbals, alcohol/beverages consumption, smoking, and substance of abuse if prescribed Paxlovid (and FLVX). Your provider should also communicate w/ the other prescribers/pharmacist for dose adjust of other meds you take. (Twitter) - Jan 24, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid needed imo (Twitter) - Jan 24, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Could be interesting to see Anti-virals (Paxlovid) effects in long COVID. (Twitter) - Jan 24, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Curious to know if Paxlovid would clear the virus. (Twitter) - Jan 24, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Here is the PA official list of dispensing facilities for paxlovid. Three in my county. I checked https://t.co/AjEUE0ounT and there are around 130 course of therapy available. (Twitter) - Jan 24, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: ICYMI from last week, from @HollyLynchez and Keith Hamilton from Penn. Essay about how Paxlovid is being distributed, and what it means that outpatient pharmacies play major role. We have heard some recent stories about equitable access, but not enough https://t.co/iDQcPqmXdz (Twitter) - Jan 24, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Wichtig ist auch, dass es Medikamente wie #paxlovid u.a. gibt, die vor schweren Verläufen schützen, die vornehmlich bei vulnerablen Gruppen auftreten. Die Mär es brauchte eine Impfpflicht ab 18 kommt vom statistischen Taschenspielertrick des RKI die 18-59 zusammen veranlagen! (Twitter) - Jan 24, 2022
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer
20 million doses of Paxlovid for a country of 330. Is the FDA ordering more? (Twitter) - Jan 23, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@drdrew please reach out to @AngelaReiersen she is doing an amazing job as a practicing psychiatric physician of spreading the word on fluvoxamine & COVID. Also, she is hosting panels with other physicians and pharmacists(international) to provide input. #fluvoxamine #paxlovid (Twitter) - Jan 23, 2022
- || rivaroxaban / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Article says that Xarelto is not absolutely contraindicated but not recommended. Is there a way for someone on Xarelto to take Paxlovid if Xarelto cannot be stopped for 5-7 days? (Twitter) - Jan 23, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I feel the same as you do about the pill, but unless I get REALLY unlucky & start to show some serious symptoms, I'm more than willing to forego Paxlovid & let someone at higher risk than I am have first dibs. To each his/her own, but I think that's kind of a moral imperative. (Twitter) - Jan 23, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Especially after Paxlovid becomes widely available, which I believe is projected for sometime around June (?) -- All these folks screaming about "killing Grandma" need to remember that she'll have a well-tested treatment at hand if she's unlucky enough to start showing symptoms. (Twitter) - Jan 23, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Kid: "Makes no sense. Only reason you are not going to hospital is if you have not as bad symptoms." "Paxlovid did not alleviate Covid symptoms compared to the placebo, but it cut hospitalizations by 70%" https://t.co/7DcY0OtL8r via @nbcnews (Twitter) - Jan 23, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Our question of the week involves something old and something new. Are you ready for the challenge? NAPLEX Question of the Week: Paxlovid Drug Interactions https://t.co/sukp22IUYa #accessmedicine (Twitter) - Jan 23, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
🦠COVID-19💊Drug-Drug💊Interactions🦠: Fluvoxamine, Paxlovid….. Happening now in @clubhouse! https://t.co/GfVXso46XY (Twitter) - Jan 23, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Here is the Paxlovid Fact Sheet for Healthcare Providers. It has detailed prescribing information, including information about important drug interactions. https://t.co/WcpZqL3Bxa (Twitter) - Jan 23, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: First road playoff win in history. Wow. Some LC patients KNOW microclots. Can't get help in US. Drs don't listen and don't know protocol. LC patients also KNOW in some cases virus persists. But can prove it. It's unconscionable that can't get paxlovid/mabs to try to clear it. (Twitter) - Jan 23, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@AngelaReiersen @EdoajoEric @farid__jalali #PAXLOVID (Twitter) - Jan 23, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Come listen in on & ask questions TODAY on drug-drug interactions with focusibgon #fluvoxamine and #paxlovid as hosted by the famous @AngelaReiersen on Clubhouse 😃 ! Link below at 12pm CST / 1pm EST / 10am PST. (Twitter) - Jan 23, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Now is not the time to rely on sharp descents and that somehow “it’s over". @EricTopol It’s so essential to push on pan-coronavirus vaccine, oral and nasal vaccines and get mass production of Paxlovid along with other anti-Covid pills. @ministerVWS @MarionKoopmans (Twitter) - Jan 23, 2022
- |||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Clinical: Molnupiravir is not expected to have any drug interactions, but both fluvoxamine and Paxlovid (nirmatrelvir+ritonavir) have interactions with a number of other drugs. In the case of Paxlovid, it is the ritonavir component that is responsible for most interactions. (Twitter) - Jan 23, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I'm discussing “🦠COVID-19💊Drug-Drug💊Interactions🦠: Fluvoxamine, Paxlovid….” with @EdoajoEric, @farid__jalali @BramanteCarolyn, @calirunnerdoc, & others…Today, Jan 23 at 12:00 PM CST in @clubhouse. Join us! https://t.co/auEawgYHtD (Twitter) - Jan 23, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Why Paxlovid is NOT first-line treatment in Ontario 🇨🇦. @sailorrooscout @DanielGriffinMD (Twitter) - Jan 23, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, lopinavir/ritonavir / Generic mfg.
1/ Links to different classes of drugs that may cause significant interactions with Paxlovid (nirmatrelvir + ritonavir). Will post links separately. Lopinavir-ritonavir in SARS-CoV-2 infection and Drug-Drug Interactions with Cardioactive Medications. https://t.co/ivVaXmATeA (Twitter) - Jan 23, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@colinbro don't miss this Tomorrow “🦠COVID-19💊Drug-Drug💊Interactions🦠: Fluvoxamine, Paxlovid….“ @angelareiersen, Dr. Osgood, Dr. Jalali, @bramantecarolyn, @calirunnerdoc, @hypomaniac07, Rick Sheridan. Tomorrow at 18:00 on @clubhouse! https://t.co/soNxgJqSnR (Twitter) - Jan 23, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Don't miss “🦠COVID-19💊Drug-Drug💊Interactions🦠: Fluvoxamine, Paxlovid…“ with @angelareiersen, @farid__jalali Tomorrow https://t.co/Yk04bL5vig (Twitter) - Jan 23, 2022
- |||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: I'm discussing “🦠COVID-19💊Drug-Drug💊Interactions🦠: Fluvoxamine, Paxlovid…” with @AngelaReiersen, Dr Alice Duncan, @RayTaylorUK, Eleazar San Agustin, Vipul Shah, @hypomaniac07, and World Mental Health. Today, 22 Jan at 11:00 PM GMT 7 in @clubhouse. Join us! (Twitter) - Jan 23, 2022