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- |||| azithromycin / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: And please for the love of everyone (for those that do this) stop giving Azithromycin for COVID! Even more so now if you’re going to try to Rx the still scarce supply of Paxlovid for your patients. (Twitter) - Jan 31, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@circus_nurse are all high blood pressure medications negatively impacted by Paxlovid?? (Twitter) - Jan 31, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Any patient I’ve wanted to give Paxlovid to has either had too many meds that are contraindicated and they can’t stop taking, has too many comorbidities, or we got to them too late (5+ days later). (Twitter) - Jan 31, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
My old place just recently got Paxlovid available, only prescribed it once so far after a pretty in depth discussion w our ID doc (young pt who gets regular infusions of an immunomodulator, doesn't take any other Rx at baseline, and tested + just a few days after recent infusion) (Twitter) - Jan 31, 2022
- || Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
What are the problems with this idea? Some might wonder, how do we protect the immunocompromised? Good news is that Evusheld (protective monoclonal) is becoming more available As is Paxlovid, a great oral antiviral And IC folks can protect themselves with good masking 7/9 (Twitter) - Jan 31, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: NYC also refers people to NY State prioritization of paxlovid therapy, which suggests prioritizing to the unvaccinated or 'incompletely vaccinated' or those with immune compromise or over age 65 Details of priority group not though required on prescription, with no way to check (Twitter) - Jan 31, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Same day home delivery of paxlovid in NYC. Prescriptions require date of symptom onset and patient race/ethnicity on prescription. Will be interesting to see how complete that info is and to see how equitable prescribing and dispensing are. https://t.co/KFN2HadNE7 (Twitter) - Jan 31, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Better way to say: 1) we have mRNA/DNA vaccines & therapeutics (but need more production of Paxlovid, monoclonal Abs); 2) more vaccines pending (nasal, pan-virus); 3) know 1-way masking works; 4) ventilation too; 5) other problems in society; can move on from emergency phase (Twitter) - Jan 31, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Anything on the right inducers will make the COVID pill not work as well Anything on the left could cause high drug concentrations and toxicity Talk to your doctor about medications you are taking that can interact with Paxlovid Source for chart https://t.co/2MDVfEBa1K (Twitter) - Jan 31, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid Co-administration with potent CYP3A inducers where significantly reduced nirmatrelvir or ritonavir plasma concentrations may be associated with the potential for loss of virologic response and possible resistance (Twitter) - Jan 31, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
I’d like to see a RCT looking at Pfizer’s Paxlovid Vs Merck’s molnupiravir (COVID-19 pills) vs monoclonal antibodies (Twitter) - Jan 31, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Drug interactions are very likely with Paxlovid, so if you take other medications make sure to talk to ur Dr Co-administration with drugs highly dependent on CYP3A for clearance and for which elevated concentrations are associated with serious and/or life-threatening reactions (Twitter) - Jan 31, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Important to know about Paxlovid***** HIV-1 Drug Resistance: PAXLOVID use may lead to a risk of HIV-1 developing resistance to HIV protease inhibitors in individuals with uncontrolled or undiagnosed HIV-1 infection (Twitter) - Jan 31, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Clinical: What are people prescribing or taking more of for COVID in not hospitalized patients? Pfizer’s COVID-19 pill Paxlovid (generic name nirmatrelvir/ ritonavir) Or Merck’s COVID-19 pill molnupiravir (UK brand name Lagevrio) (Twitter) - Jan 31, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
New York City is offering free home delivery of #Covid19 antiviral pills, though supply is limited, by @wongalum https://t.co/3Fz7CBEjXr via @nytimes @EricTopol #Paxlovid (Twitter) - Jan 31, 2022
- ||| Paxlovid (nirmatrelvir/ritonavir) / Pfizer
Trial withdrawal: Study to Investigate the Mass Balance, Metabolism, and Excretion of [14C]PF-07321332 in Healthy Male Participants. (clinicaltrials.gov) - Jan 31, 2022
P1, N=0, Withdrawn, Sponsor: Pfizer
Not yet recruiting --> Withdrawn
- ||||| Paxlovid (nirmatrelvir/ritonavir) / Pfizer
Enrollment closed, Phase classification: Evaluation of Protease Inhibition for COVID-19 in Standard-Risk Patients (EPIC-SR). (clinicaltrials.gov) - Jan 31, 2022
P2/3, N=1150, Active, not recruiting, Sponsor: Pfizer
Not yet recruiting --> Withdrawn Recruiting --> Active, not recruiting | Phase classification: P3 --> P2/3
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Vaikka lääkkeiden saatavuus on vielä huono,tärkeä tutkimus @NEJM . Monoklonaaliset liian spesifisiä omikronille toisin kuin Paxlovid& molnupiravir. Molemmat hyviä lisiä kliinikoiden työkalupakkiin, vaatii tosin nopeaa SARS-CoV-2 diagnostiikkaa. https://t.co/EoU95yFNaN (Twitter) - Jan 30, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Free, same day delivery of anti-Covid pills with a prescription in New York City https://t.co/OB7IpHx7KC When there's an ample supply of Paxlovid, this kind of program could be very helpful for reducing hospitalizations and deaths in high-risk individuals (Twitter) - Jan 30, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
A friend told me about one local guy she knows who was given Paxlovid. He immediately started having shooting nerve pain down his arms to fingertips. He could only manage 4 days before he couldn’t get thru any more doses 🤷🏽♂️ (Twitter) - Jan 30, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
News just said Paxlovid will be in very short supply till end of pandemic, er I mean for next 3 months. Goddammit Joe. Yeah, let's blame the Joe Rogan guy vs the Joe Biden guy. (Twitter) - Jan 30, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Where is Paxlovid? (Twitter) - Jan 30, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I noticed that ritonavir in paxlovid reduces levels of ethinyl estradiol. Anyone know how that works? (Twitter) - Jan 30, 2022
- |||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Clinical: On call and have had to 📞 in molnupiravir for 4 patients today - have used this very helpful @HHSGov site to figure out availability of #COVID treatments #paxlovid #molnupiravir #Evusheld https://t.co/JsGB9GAgsw (Twitter) - Jan 29, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Finally, Dr. Fauci asked about treatments there -the antivirals (molnupiravir/Paxlovid) work against all variants (work upstream) but we need more courses (up production). Also asked about vax for <=4 but I have idea for that & we could get out right away! https://t.co/V8jQyqDTWZ (Twitter) - Jan 29, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Paxlovid is in sufficiently short supply that my understanding is (per last week’s @DanielGriffinMD update on This Week in Virology) that it’s being reserved for only the highest-risk patients. Hospital pharmacies are your best bet if this person falls into that category. (Twitter) - Jan 29, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical: If you are really that concerned about health care workers why no outrage at the very limited supply of sotrovimab and Paxlovid. Paxlovid 90% reduction hosp and death. It is unconscionable these treatments were not a priority, 20 million treatment courses will be ready in April (Twitter) - Jan 29, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: losing their daddy. I will never understand their choice to not get vaccinated.😢I am praying that he will be able to beat the virus, but TX is completely out of the monoclonal antibodies & Paxlovid. (Twitter) - Jan 29, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Last weekend’s Sunday clubhouse room is available for replay. We focused on drug interactions of Paxlovid and fluvoxamine with other medications. https://t.co/ELYZ0LPgDH (Twitter) - Jan 28, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Two lines or one? @Roche Day 4 #paxlovid (Twitter) - Jan 28, 2022
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Quasi dimenticavo l'editoriale di oggi per @UnivadisItalia sull'autorizzazione di #paxlovid da parte di @EMA_News, in attesa della pubblicazione dei dati https://t.co/6JlrL4h3D2 (Twitter) - Jan 28, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Adverse events: Will you prescribe Paxlovid? After reading the side effects provided by Pfizer? (Twitter) - Jan 28, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical data, Adverse events: Anti virals??? Untested with possible serious side effects ?? 5 WARNINGS AND PRECAUTIONS There are limited clinical data available for PAXLOVID. Serious and unexpected adverse events may occur that have not been previously reported with PAXLOVID use. https://t.co/WqmffYr3mO (Twitter) - Jan 28, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Important #COVID19 therapeutics news today ➡️@EU_Commission has authorised the use of Paxlovid in 🇪🇺 A key step in bringing the most promising therapeutics 💊💊to citizens and a strong, second line of defence against the pandemic after vaccination. (Twitter) - Jan 28, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
EU Approves Paxlovid For COVID-19 https://t.co/u2eJtmCJrh #PinkSheet (Twitter) - Jan 27, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@Vohra_Umang @Cipla_Global @GSK @drreddys @HeteroHCL @satya_yadav @WHO @UN_HRC @mla_sudhakar @POTUS @VP @singhak_endo @pfizer @IPAOfficialPage @malpani @ICMRDELHI @OfficeOf_MM @MoHFW_INDIA @narendramodi INDIA Confirm "TIME & DATE" to Approve PAXLOVID PILL https://t.co/uRmQIJpl9B (Twitter) - Jan 27, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@ahandvanish you realize that back then, the gov was smart enough to close/open businesses on a staggered basis... common sense existed then. A lot of long covid would go away if paxlovid and regeneron were given. But hey, more organ damage please. @VinGuptaMD @VirusesImmunity (Twitter) - Jan 27, 2022
- |||| Clinical: Because a new study came out that shows Remdesivir helps with the progression of COVID for some people that are not able to take Tocilizumab, Paxlovid & Sotrovimab. https://t.co/2UIDBWc7RN (Twitter) - Jan 27, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Number of days from first symptoms must be factored in. If you past 3-4 days it’s not going to do much good. The same thing is true with Paxlovid and especially true with molnupiravir. The most critical factor is time from very first symptoms to administration. (Twitter) - Jan 27, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Κυριακίδου: Με το Paxlovid έχουν εγκριθεί πλέον έξι θεραπείες στην ΕΕ #EU #Covid19 @SKyriakidesEU https://t.co/EZGH25cTun (Twitter) - Jan 27, 2022
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Journal: Caution required with use of ritonavir-boosted PF-07321332 in COVID-19 management. (Pubmed Central) - Jan 27, 2022
Recruiting --> Active, not recruiting | Phase classification: P3 --> P2/3 No abstract available
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Essential reading-Special Considerations for Paxlovid Treatment Among Transplant Recipients With SARS-CoV-2 Infection https://t.co/7exD4O9H7j @AJKDonline (Twitter) - Jan 27, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
EU #COVID19 Therapeutics Strategy continues to deliver for citizens! ➡️EMA recommends to approve Paxlovid, the first oral antiviral for home use approved in 🇪🇺. Data is also promising on effectiveness against #Omicron. More will come in the weeks ahead. https://t.co/Y3bVkFAbTI (Twitter) - Jan 27, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
J'ai été mal comprise. Je ne pense pas que le paxlovid soit "très toxique".... On n'a juste pas de données chez l'enfant ni la femme enceinte. @LeDevoir https://t.co/xBpFhkmlPn (Twitter) - Jan 27, 2022
- |||| remdesivir / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
4/fin @WHO needs to revisit this “strong” recommendation “against” Remdesivir for non-severe #COVID disease, because this clearly is a way to go. Other choices include monoclonal antibodies and Paxlovid. (btw, I don’t have any financial conflicts) https://t.co/fq5kPxKSiD (Twitter) - Jan 27, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I'll consider returning to normal when it's easy to get Paxlovid. (Twitter) - Jan 27, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I think we are dealing with viral persistence in the gut. Perhaps this is causing cytokines and other autoantibodies to go crazy. Do you know of any long haulers that have been able to try Paxlovid? (Twitter) - Jan 27, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Thanks. Kaiser Health News did a piece on this. I'd go for it myself, but I'm in the thick of a Paxlovid piece. And I have jury duty! (Twitter) - Jan 26, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Definitely, but it’s more available than paxlovid or MAb (Twitter) - Jan 26, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Tacrolimus spike = HELL. Ever take diflucan with tacrolimus? Whoa. Not a popular view, but as a heart tx recipient for 34 years (no high bp, no diabetes, low BMI, no anti metabolite) I’d skip paxlovid. Take the risk. By the time tacrolimus level good, pax course would be over. (Twitter) - Jan 26, 2022