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- ||| remdesivir / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Unless we mitigate the system issues, the same barriers/issues are likely to similarly impact use of additional effective therapeutics like Paxlovid & Remdesivir, regardless of supply. Leading to more preventable hospitalizations and deaths. (Twitter) - Feb 6, 2022
- |||| Covaxin (BBV152 COVID Vaccine) / Bharat Biotech, Indian Council of Medical Research, Ocugen, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Would add 1) give US vax options (e.g. whole inactivated virion Covaxin, protein+ adjuvant Novavax); 2) treatments, esp oral, Paxlovid; 3) global vax equity; 4) wastewater surveillance; 5) ventilation; 6) when mask optional, right kind N95, KN95, FFP2, KF94, double, cloth+filter (Twitter) - Feb 6, 2022
- |||| Covaxin (BBV152 COVID Vaccine) / Bharat Biotech, Indian Council of Medical Research, Ocugen, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: No giving up, @DrTomFrieden, add 1) making more vax options available (e.g. whole inactivated virion, protein+ adjuvant) in US (Covaxin, Novavax) vax-hesitant; 2) treatments important, especially oral e.g. Paxlovid; 3) global vax equity; 4) wastewater surveillance; 5) ventilation (Twitter) - Feb 6, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Adverse events: Makes surely sense. What then will happen for someone who came up with no antibodies after 3-4 doses? Pills? Monoclonal antibodies? I’ve read about Paxlovid side effects and surely more scared to use it than having infected. (Twitter) - Feb 6, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Pfizer's Paxlovid contract with the government has some surprises : Shots - Health News @NPR https://t.co/0k3JWZ2Yk6 (Twitter) - Feb 5, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
100% exercise=worse. walk ystdy. woke up w pain base spine (virus persists csf), guts (yellow discharge still/virus persists), kidneys, liver, base skull. lots symptoms/answers but drs disinterested. plz microclot therapy, paxlovid to clear virus. dying #nobodycares @VinGuptaMD (Twitter) - Feb 5, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Test on 10/6/21, 4 weeks after the booster. Got COVID on 1/17/22,so I’m assuming Omicron. Shook it pretty quick,but I was also on a course of Paxlovid too. (Twitter) - Feb 5, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: The supply of nirmatrelvir should improve soon based on recent excellent reporting by @lupkin for @NPRHealth. Need to brush up on your drug interactions? U of Liverpool again to the rescue https://t.co/pFBsTuxMaY 23/x (Twitter) - Feb 5, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: February 1 2022 updated NIH guidelines for outpatient treatment shown here, with RTV-boosted nirmatrelvir (Paxlovid) right at the top. Agree with this order! And I'm even getting better at pronouncing "nirmatrelvir" https://t.co/sUGfbxsa4g 21/x (Twitter) - Feb 5, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Dr., not sure if anything can be done to get anti-vaxxers to vax. Don't think many of them will take Novavax. And not sure they'll take Paxlovid. (Twitter) - Feb 5, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
At this point we have no choice but to keep boosting with mRNAs that we already have. I'm seriously looking into my 4th 100mcg Moderna shot after 4 months of last moderna shot. Just to buy time until paxlovid is widely available with an Ag test and Novavax is out for boosting. (Twitter) - Feb 5, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Covid Marche, confezioni di Paxlovid (prodotte ad Ascoli Piceno) in tutto il territorio regionale https://t.co/RZJIJ5q2Mr #coronavirus #Covid19 @RegioneMarcheIT @pfizeritalia (Twitter) - Feb 4, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Nirmatrelvir-ritonavir (marketed as Paxlovid) is an antiviral medication for #COVID19 that could reduce hospitalizations when prescribed within 5 days of symptom onset to high-risk outpatients. Here are 5 things to know: https://t.co/qYCdNtswCH @DrEmilyMcD @DrToddLee #CdnHealth (Twitter) - Feb 4, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
How about Paxlovid (Pfizer)? (Twitter) - Feb 4, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Review: What is "the fastest any drug company has ever moved from a synthesizing a new chemical to proving that it safely treats a disease"? Paxlovid Few people realize that it was like the hyper=accelerated success of the vaccines https://t.co/1WJ8jFDPBY @antonioregalado @techreview (Twitter) - Feb 4, 2022
- || Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Let's get sotrivimab, paxlovid and Evusheld into the hands of all of the immunocompromised with blunted/no vax response before taking away restrictions. We deserve to have normal lives too. And maybe stock up a bit for the next variant? (Twitter) - Feb 4, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Grand rounds: Looking forward to @UCSFDOM grand rounds today, 12-1 for @UCSF'ers; @YouTube tonite. George Rutherford on state of surge (inc. BA.2); then chat w/ George, @PCH_SF & Sarah Doernberg on, well, everything: "endemic," "normal," vax in kiddos, masks in schools, 2nd boost, Paxlovid... (Twitter) - Feb 4, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
PK/PD data: and....long thread from @ChristosArgyrop making a persuasive case for using Paxlovid in severe CKD and in dialysis at reduced dose/frequency based on PK data https://t.co/2X3gTQ6TxK (Twitter) - Feb 3, 2022
- ||| remdesivir / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, HEOR: It would make a good comparative effectiveness study to randomize dialysis patients to monoclonal versus remdesivir vs. nirmatrelvir ritonavir vs. other (Twitter) - Feb 3, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Le Paxlovid est efficace, mais il reste des défis à surmonter: donner le médicament à temps, ajuster la dose et éviter les interactions médicamenteuses. Un travail d’équipe nécessaire entre gestionnaires, médecins et pharmaciens #Covid_19 @DrEmilyMcD (Twitter) - Feb 3, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Si no lo está, la administración de #Paxlovid debería de estar ya perfectamente protocolarizada. (Twitter) - Feb 3, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
💊5 claves sobre #paxlovid Nirmatrelvir-ritonavir Thanks so much @DrToddLee and @DrEmilyMcD Me permito traducirlo https://t.co/BvL3SHgCSz 👇 (Twitter) - Feb 3, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Five things to know about nirmatrelvir-ritonavir https://t.co/Yw8PLXRQ2n Appendix of common drugs and interactions https://t.co/SBd1CHxriG @DrEmilyMcD @CMAJ (Twitter) - Feb 3, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Great resource for managing DDIs with Paxlovid. Yes the DDIs are many… but many can be appropriately managed. Consult your pharmacist (& the Liverpool COVID DDI website!) for help as needed to ensure patients who may benefit from Pax get timely access😬 (Twitter) - Feb 3, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Since immune system is so redundant (we work with immunity in HIV), having deficit in 1 arm (e.g. B cells) doesn't mean T cells don't work so remember complexity when advising patients. Would give 1) 4th vax dose to immunosuppressed; 2) Paxlovid ready https://t.co/LnKQ5opFVP (Twitter) - Feb 3, 2022
- || Actemra IV (tocilizumab) / Roche, JW Pharma
Clinical, Review, Journal: An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment. (Pubmed Central) - Feb 3, 2022
Hydroxychloroquine, lopinavir/ritonavir, and ribavirin are all examples of therapeutic agents, whose efficacy against COVID-19 was later disproved...We focus on currently recommended therapeutic agents, including steroids, various monoclonal antibodies, remdesivir, baricitinib, anticoagulants and PAXLOVID™ summarizing the latest original studies and meta-analyses...The results of recent studies report that hydroxychloroquine and convalescent plasma demonstrate no efficacy against SARS-CoV-2 infection. Lastly, we summarize the studies on various drugs with incoherent or insufficient data concerning their effectiveness, such as amantadine, ivermectin, or niclosamide.
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Journal: Pro108Ser mutation of SARS-CoV-2 3CL reduces the enzyme activity and ameliorates the clinical severity of COVID-19. (Pubmed Central) - Feb 3, 2022
Recently, an international randomized controlled clinical trial showed that patients with SARS-CoV-2 infection treated orally with the 3-chymotrypsin-like protease (3CL) inhibitor PF-07321332 within three days of symptom onset showed an 89% lower risk of COVID-19-related hospital admission/ death from any cause as compared with the patients who received placebo...Hydrogen/deuterium-exchange mass spectrometry (HDX-MS) revealed that the reduced activity was associated with structural perturbation surrounding the substrate-binding region of the enzyme, which is positioned behind and distant from the 108th amino acid residue. Our findings of the attenuated clinical course of COVID-19 in patients infected with SARS-CoV-2 strains with reduced 3CL enzymatic activity greatly endorses the promising result of the aforementioned clinical trial of the 3CL inhibitor.
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Help @StLouisLung and @meganranney and anyone else - a friend is posting on community groups looking for a doctor to prescribe Ivermectin - how do I convince her to try to find Paxlovid instead? Or mAbs? Sources she’ll listen to? Help! (Twitter) - Feb 3, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
For my immune compromised heart transplant son Paxlovid is life threatening drug. If he got sick with omicron on Friday night or Ner Year Eve what options does he have to get a prescription on time? (Besides ER) (Twitter) - Feb 3, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: What we think every clinician should know about the new #COVID19 antiviral nirmatrelvir-ritonavir. Spoiler: if you’re thinking of prescribing- get your friendly neighborhood #pharmacist involved. Plenty of DDIs but these can be mitigated. (Twitter) - Feb 3, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Would eMed allow me to get paxlovid with a positive Ag test? Would they also call in a prescription to my local pharmacy? (Twitter) - Feb 3, 2022
- ||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Brian, given your public health expertise I would think you'd be aware that not all the immunocompromised are a monolith, and that overall 3 vax doses provide an 88% efficacy vs severe illness Not to mention priority treatments like Evusheld and Paxlovid https://t.co/255R42NxO5 (Twitter) - Feb 3, 2022
- ||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: You know Evusheld and Paxlovid are free of charge to patients, right? (Twitter) - Feb 3, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid will be a game changer once it can be supplied easily and to all ages. (Twitter) - Feb 3, 2022
- |||| hydroxychloroquine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Name one of your "effective medications." Ivermectin works in vitro, NOT in people. Except for worms. Hydroxychloroquine went through numerous clinical trials, and FAILED. Great for lupus and malaria, though. All the AIDS drugs failed. We finally have Paxlovid, but it's scarce. (Twitter) - Feb 3, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
See the following article (esp last few paragraphs) on why melatonin may be superior to Paxlovid https://t.co/RHsvbXevMn (Twitter) - Feb 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Why do you keep repeating this 3 days crap. It's 7 days. It's not as good a trial design as an anti-viral as the Paxlovid one was, but it's all we have. Until the Japanese one end of march. https://t.co/3rFfO9fkq5 (Twitter) - Feb 2, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Are you planning to pass laws to require breastfeeding? Immunization of adults? Read to their kids? To require people to take Paxlovid if they get covid? Public health has always valued non-coercion. It’s not helpful to pretend otherwise. (Twitter) - Feb 2, 2022
- |||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Evusheld is not widely available. My transplant team is estimating many months before I maybe get it. Also, Paxlovid has a severe drug interaction with a common immune suppression drug. Things are not a simple as you imply, at least not for heart transplant patients around here. (Twitter) - Feb 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
With lower case numbers it’s already easier to give paxlovid; but looks like a few more months of needing to ration (Twitter) - Feb 2, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: you’re talking about in June-September or so when Pfizer ships out more Paxlovid and not now, right? because now, with few in supply and 500,000 inf/day = limited access to treatments also, when the health emergency ends, will these treatments still be offered for free? (Twitter) - Feb 2, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Pricing: Cost to Government for PREVENTING covid: About $18.00/vaccine dose. Cost to Government to TREAT covid: $530.00/course of Paxlovid. It’s still better to not be infected. (Twitter) - Feb 2, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Very important update from NIH💥 Special Considerations in People With HIV Vaccination Diagnosis Management of COVID-19/Paxlovid Management of HIV #IDTwitter #medtwitter #TwitteRx #MedEd #HIVTwitter @IDstewardship @PaulSaxMD @CarlosdelRio7 https://t.co/0JjRFsjwL8 (Twitter) - Feb 1, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Preclinical: That's true, I compared to the paxlovid just in regard to Mpro inhibition but there are many other pathways at play, but cellculture and modelling can only go so far. (Twitter) - Feb 1, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Yes, generates trust to end a state of emergency when public health has the tools: the vaccines are incredibly effective against severe disease & are authorized down to 5; therapeutics (monoclonal antibodies, Paxlovid) for those who decline & at risk of severe breakthroughs (Twitter) - Feb 1, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
That's ridiculous. It's not the flu. If you're going to get it, better at least wait until it's possible to get Paxlovid when you get it. It's not possible now. (Twitter) - Feb 1, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Why aren’t you screaming from the rooftops trying to find out why Paxlovid isn’t available everywhere by now? Why no Defense Protection Act to make Paxlovid available at will? Wouldn’t that save lives right now? WHY IS IT NOT AVAILABLE?!?!? Don’t you care to save lives??? (Twitter) - Feb 1, 2022
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer
EMA: Paxlovid®-Zulassung in Sicht; neue Gentherapie bei Leukämie https://t.co/7aPtE42cZy via @medscape (Twitter) - Feb 1, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Clinical: & beyond implication=further mutations all down line they explain patient=Not follow HIV/AIDS treatment course Certainly,we'll see same behaviors w/Molnupiravir Paxlovid resulting in further CVar. mutagens Prolly,much similar as resistant malaria's @fitterhappierAJ @RickABright (Twitter) - Jan 31, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Likewise, Paxlovid is also scarce, & accessing it is also not straightforward (nor is distribution equitable): https://t.co/8mBYagkPED. So once again, we choose to sacrifice the same people we’ve repeatedly sacrificed in this #pandemic: the #immunocompromised, Black people, etc. (Twitter) - Jan 31, 2022