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- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Your poll makes the assumption that anyone could find Paxlovid in their county. (Twitter) - Feb 17, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: I just finished my last blister pack last night of Paxlovid. Pulmonologist put me on it last week due to hospitalization and Respiratory failure with a previous variant. I will say it stopped COVID in its tracks and I’m feeling decent. Only effect I noticed was Mild GI upset.👍 (Twitter) - Feb 17, 2022
- || Paxlovid (nirmatrelvir/ritonavir) / Pfizer
Trial completion: Food Effect Study to Evaluate the Effect of High-Fat Meal on the Relative Bioavailability of PF-07321332 Boosted With Ritonavir in Healthy Adult Participants (clinicaltrials.gov) - Feb 17, 2022
P1, N=12, Completed, Sponsor: Pfizer
Recruiting --> Completed
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Cheap and safer IVM has more mechanisms of action than Paxlovid: https://t.co/bqrRgRjQiW (Twitter) - Feb 17, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: In #NYC, if we are positive & symptomatic, we can call hotline to be evaluated for Paxlovid. If approved, we receive it free of charge & it is immediately messengered to our home from a local pharmacy in Midtown Manhattan. cc: @NYCHealthSystem #Paxlovid #COVID #COVIDNYC (Twitter) - Feb 17, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Paxlovid will most likely used as PrEP and PEP once there is enough and hopefully is going to get cheaper (indeed, vaccines must have been so profitable that maybe the Paxlovid patent could be graciously gifted to humanity?) (Twitter) - Feb 17, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: ..2/n PF-07321332, which has a Ki of 3.11 *nano* M (10e6 times more potent than NLC-EXT-1) and is still given with a CYP3A4 inhibitor to prevent its breakdown by the body (the combo, PAXLOVID, has excellent efficacy against hospitalisation and death https://t.co/BZ8u2wxdO2) (Twitter) - Feb 17, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I though Paxlovid is still hard to get? How much did you pay? (Twitter) - Feb 17, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Clinical: All end points like fda definition of hypoxia and composit end point like hospitalisation or ER stay more than 24 hrs ( similar to molnupiravir and paxlovid trials ) are significant. #fluvoxamine (Twitter) - Feb 16, 2022
- |||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: EPIC-HR Trial Tx of symptomatic #Covid-19 with #Nirmatrelvir + #Ritonavir resulted in a risk of progression to severe Covid-19 that was 89% ⬇️ than the risk with placebo https://t.co/weQXv4ewZK @NEJM @pfizer @EricTopol @PeterHotez @DrJennHaythe @CMichaelGibson @hvanspall (Twitter) - Feb 16, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Funziona contro #COVID19 il nuovo #antivirale denominato PF-07321332 (PF-332): testato nei criceti contro le varianti #Beta e #Delta è in grado di bloccare l'infezione e ridurre il rischio di contagio #ansascienza @AnsaScienza @KU_Leuven @pfizeritalia https://t.co/DcG7K3qEDE (Twitter) - Feb 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Amazing data on Paxlovid, but #MedTwitter needs to be aware that this is a combination pill with #ritonavir. The cyp3A4 inhibition is significant, and doctors must pay attention to concomitant medications when prescribing. (Twitter) - Feb 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Not-so-bold prediction -- when supplies of nirmatrelvir/rtv (Paxlovid) increase so that it can be given to anyone with symptoms (< 5 days) of Covid19, widespread prescribing will occur. And that will overall be great! ⬇️ severe dz, ⬇️ transmissions, likely faster ⬇️ symptoms (Twitter) - Feb 16, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: The Paxlovid NEJM RCT excluded people who had been vaccinated for SARS-CoV-2. Should the results be extrapolated to vaccinated people? One more q in 🧵 (Twitter) - Feb 16, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: With today's publication of the Paxlovid data @NEJM, please see this piece we wrote some weeks ago: Outpatient therapies for COVID-19: How do we choose? https://t.co/4OsfbpsMbd @DrEmilyMcD @DrToddLee @ASPphysician (Twitter) - Feb 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: NO CVS IN OHIO HAS PAXLOVID YET (according to the web site!) We can get it at the hospital pharmacy but tightly regulated- this needs to move.......... NOW for the #immunocompromised @edyong209 @PaulSaxMD @CarlosdelRio7 (Twitter) - Feb 16, 2022
- ||| 2/ Currently available COVID treatments: Sotrovimab Bebtelovimab Paxlovid Remdesivir Molnupivavir (Twitter) - Feb 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, oseltamivir / Generic mfg.
Hoping you can help guide me. If you tested positive for coronavirus or influenza, are medically higher risk, and wanted to start Paxlovid or Tamiflu, respectively, what would matter most to you? ASAP therapy or convo with PCP first, even if that could delay time to therapy? (Twitter) - Feb 16, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 https://t.co/9UMpBEgtNL Finally the Paxlovid study published in @NEJM TRx of symptomatic Covid-19 with nirmatrelvir/ritonavir resulted in a⬇️risk of progression to severe Covid-19 that was 89% ⬇️than placebo. (Twitter) - Feb 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Let’s talk about the strengths/weaknesses of this paper. But first, for some context, here’s a deep dive 🧵from November about Mpro protease inhibitors & paxlovid. 2/ (Twitter) - Feb 16, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, P2 data: 🚨Phase 2–3 double-blind, randomized, controlled trial in which symptomatic, “UNVACCINATED”, nonhospitalized adults at high risk for progression to severe Covid-19 were assigned in a 1:1 ratio to receive either 300 mg Paxlovid or placebo Q 12 hr x 5 days. (Twitter) - Feb 16, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Paxlovid (Nirmatrelvir) study is now published in @NEJM: -89% efficacy vs #COVID hospitalizations/deaths. -Fast reduction of viral load. -Excellent safety profile (even against placebo)! Link: https://t.co/UDhzP2vjZt (Twitter) - Feb 16, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: 🚨Paxlovid study results 💥👉🏼Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 @NEJM https://t.co/QlkGk8OG2w (Twitter) - Feb 16, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: #Paxlovid data now in @NEJM & the results are impressive: - n=2246 high risk outpts randomized to paxlovid vs placebo - 0.77% hospitalization with paxlovid vs 7.0% in placebo (NNT 16); 0 deaths in paxlovid group vs 7 w/ placebo - this is a big deal! 📄 https://t.co/nx2qZnBZ4H 1/ (Twitter) - Feb 16, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: With time vaccines, monoclonals, and now paxlovid have reduced the risk of harm. So a high risk person getting Covid now has a much better odds of survival than before. The outcomes improve slowly but surely. (Twitter) - Feb 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Also note the trial was done in unvaccinated. The risks of severe disease in fully vaccinated and boosted is much lower. So what effect paxlovid will have in this group and whether it will have the same relative magnitude of benefit is not clear. (Twitter) - Feb 16, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Paxlovid results out in @NEJM 89% reduction in risk of hospitalization or death. Oral therapy for 5 days in people at high risk of severe Covid. The graphs look impressive. https://t.co/mxEajqanvp (Twitter) - Feb 16, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Adverse events, Serious adverse event: The Paxlovid pill (Nirmatrelvir) randomized, placebo-controlled trial published @NEJM: 89% efficacy vs Covid hospitalizations or deaths, and quick reduction of viral load. The active pills had less serious adverse events or discontinuations than placebo https://t.co/HBMRZt4wBo (Twitter) - Feb 16, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 | NEJM https://t.co/PwNd1mjuxo (Twitter) - Feb 16, 2022
- | Journal: Outpatient Therapies for COVID-19: How Do We Choose? (Pubmed Central) - Feb 16, 2022
Many countries are fortunate to have access to several effective outpatient therapies to prevent COVID-19 hospitalization. Given differences in efficacy, toxicity, cost, and administration complexity, this assessment serves as one means to frame treatment selection.
- |||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Evusheld is used as PrEP, which means it is used preventatively for immunocompromised, much like vaccines. Sotovimab and Paxlovid are two treatments that would be used after somebody got Covid. (Twitter) - Feb 16, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Clinical, Relative risk: If the same composite endpoint (hospitalisation or emergency care >24 hr) used in the #paxlovid and #molnupiravir trials, effect size for fluvoxamine 100mg 2x/d is similar as before: (relative risk 0·74 [95% CI 0·56–0·98]) as now published at #IDtwitter https://t.co/csg1Nz3PlP (Twitter) - Feb 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Let’s hope. We need a human study. Fast. As a new deadlier virus may come soon. Also, a study: does #paxlovid help #longhaulers ? @AlbertBourla @pfizer @DrEricDing @WmHaseltine @ScottGottliebMD @DrLeanaWen @dianaberrent (Twitter) - Feb 16, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Preclinical: The benefit of Paxlovid (the oral anti-Covid pill) may actually extend to preventing infection and its transmission, as seen in this new report in the Syrian hamster model https://t.co/DtuZpqwBSr @NatureComms @KU_Leuven (Twitter) - Feb 15, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
The ones at the top are preparing but just for themselves. Paxlovid, mAbs, maybe something else. (Twitter) - Feb 15, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: It’s frightening that there are a lot of transplant patients walking around, thinking that the vaccines keep them safe. Very few have been full informed of serious risks. They also don’t know the Paxlovid is not a good solution for them. Communication failure. (Twitter) - Feb 15, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I thot so originally, until I found out thatthere are a # of commonly rx'd drugs which paxlovid, say, interacts with. DC'ing them or replacing them is kinda out of the purview of a pharmacist, as much as I respect their training & skill. (Twitter) - Feb 15, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
do look at the contraindications. Paxlovid interacts w/ a # of commonly prescribed & important drugs: https://t.co/aqubBrcGi5 (Twitter) - Feb 15, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I plan to keep wearing mine at LEAST till paxlovid is available to “higher but not critically highest” risk people like me, too. At this point though? Even after that there’ll be a couple boxes of N95s in my house for rest of my life, just in case. “Once burned…” and all that. (Twitter) - Feb 15, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Special Considerations for Paxlovid Treatment Among Transplant Recipients With SARS-CoV-2 Infection https://t.co/pfCGGl2jDl (FREE) @sfishbane @jam_hirsch @vinaynairdo @HofstraKidney #COVID19 #kidneytransplant (Twitter) - Feb 14, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
I wouldn’t touch Paxlovid or Molnupiravir. (Twitter) - Feb 14, 2022
- |||| Clinical, HEOR: Charted: How cost-effective are 4 major Covid-19 treatments?: “When balancing these treatment costs and QALY, ICER found that fluvoxamine offered the best value for patients, followed by Paxlovid, molnupiravir, and sotrovimab.” https://t.co/RjVG6u1sRE (Twitter) - Feb 14, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Unfortunately paxlovid is contraindicated in renal failure, hepatic failure, and it can’t be given with heart medications commonly prescribed for arrhythmia. Transplant patients have pretty much no chance of receiving it, even if it is available. They’ve been failed by the US (Twitter) - Feb 13, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
personally I would take fluvox over paxlovid and definitely over molnupirivir because the AE are very well known (and has less interactions than paxlovid) (Twitter) - Feb 13, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Though monoclonals/Paxlovid currently hard to get, this CDC "change" has one significance: @SabinehazanMD @MdBreathe @AngelaReiersen @Kamalapearl @EmpressNorton @drsayedtahir @drakchaurasia @ArvindK26905698 @drakchaurasia @OutOfTheDarkAge @Thinkerks @amareshskumar (Twitter) - Feb 13, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
#China #pfizer #paxlovid approved 🇨🇳 @pfizeraustria @pfizer_de (Twitter) - Feb 13, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Welcomed attention to the frustrating obstacles to outpatient C-19 therapies. Scarcity of Paxlovid and Sotro is preplexing. There is potential for serious Paxlovid drug interactions. Govt-funded virtual clinic visits could be a solution. @aaronecarroll https://t.co/Woquc0pSFU (Twitter) - Feb 13, 2022
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid/Ritonavir? (Twitter) - Feb 13, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I honestly don’t know. I think they only treat symptoms and no one can get their hands on paxlovid. Meanwhile everyone is normalizing covid. Mask regulations dropped indoor restaurants reopening at a time when we will be hit by more variants. (Twitter) - Feb 13, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@ericTopol great summary of prior covid.. unlike other viruses like measles and even the flu, covid now has good antivirals in paxlovid; i suspect that will solidify “three spikes, youre out” and not require yearly boosters…hmm (Twitter) - Feb 13, 2022