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- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
It’s a combination of 2 drugs nirmatrelvir & ritonavir - the 1st is the new med w/a protease inhibitor that requires the 2nd so that enough of the 1st makes it “effective”. MIT said “The human trial that led to its authorization was relatively small..” https://t.co/luhrKZcKvM (Twitter) - Feb 19, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Nope. Paxlovid is a combination of two drugs and it was tested and proven to work as such. Ivermectin has never been shown to work alone, in combination, in a boat, with a goat, in a train, on a plane... (Twitter) - Feb 19, 2022
- |||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Covid-OUT Trial will follow patients to see if LongCovid is reduced by interventions (fluvoxamine or IVM). At this point we are never going to see a positive IVM trial. It was never meant to be a silver bullet anyway. Exception might be Paxlovid until it becomes ineffective. (Twitter) - Feb 19, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Doesn’t“Paxlovid” have to be paired w/another active drug? Something about the need to increase the time the “active” dose is doing its thing? IVM apparently has a similar protease function? Be a better scientist, doc. (Twitter) - Feb 19, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Paxlovid and Molnupiravir would have both most likely failed in this trial setup just as much, isn't that the case? (Twitter) - Feb 19, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
And what about Fluvoxamine, any news? (I guess, my country won't make Paxlovid accessible.) (Twitter) - Feb 19, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Regional differences are always amazing. Kudos to you for spreading the word on Paxlovid. (Twitter) - Feb 19, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Wouldn't paxlovid interact with inhaled steroid? As per Paul's (excellent blog). Seen a few cases of inhaled steroid + HIV med interactions over the years... (Twitter) - Feb 19, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Exactly. We need to be able to match the strain to the mAb. This has huge practical life-death implications but no one seems to be addressing it in a systematic way. Paxlovid won't be for everyone. (Twitter) - Feb 19, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
It’s okay if paxlovid supply exceeds demand for now in some places. It should be reserved for those at high risk, and supply should be managed presuming that another wave is a certainty. https://t.co/JvmZRTG9Wp (Twitter) - Feb 19, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Good News: Pfizer's (PFE) #Paxlovid Antiviral Covid Pill Is Now Easier to Get https://t.co/Ugjwru3bto (Twitter) - Feb 19, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Nein das kann eben so nicht schreiben, sondern dass sie jetzt nicht verfügbar sind. Zudem schützt auch Paxlovid. Solche Statements sind unnötig angstmachend. (Twitter) - Feb 19, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Wie ist der aktuelle Stand zu die Schweiz, Gesundheitspolitik der Schweiz und #Paxlovid? @BAG_OFSP_UFSP : KEINE Bestellung getätigt @Swissmedic_: KEINE Zulassung ausgesprochen EU/USA dagegen sind EUA ausgesprochen /1 (Twitter) - Feb 19, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
EPIC-SR interim analysis didn't show reduction in symptoms. As the trial is done, and no further updates released -- so assume bad news still likely true as good news is shared rapidly. Combo with steroid inhaler vs. Paxlovid alone would be an interesting RCT. (Twitter) - Feb 19, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Interesting difference between Ivermectin use here and Paxlovid: while Paxlovid is started in first 5 days of symptom onset, in this study the median of symp dur at enroll was 5.1 days meaning half of treatment group was treated in a more advanced disease stage than Pfizer trial. (Twitter) - Feb 19, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: lets see, paxlovid trial was N=1219, double blind, against a placebo pill. this ivm trial was N=490, open label, against an unspecified "standard of care" that included "infection control and symptomatic treatment" which for all we know could've been an effective steroid (Twitter) - Feb 19, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Like I said, Pfizer's Paxlovid is the same. Tested on 300 patients and authorized in a blink of an eye, because well... expensive. (Twitter) - Feb 19, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Seems like you a describing the vaccin cult. 1 shot every 3 month, Huston, we have a timing issue. Not to mention, like IVM Pfizer's Paxlovid has to be taken not later than 2 days after symptoms, because that's the way an anti viral is effective, by reducing viral load. Cheers. (Twitter) - Feb 19, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, oseltamivir / Generic mfg.
Clinical, Adverse events: In pediatrics, anecdotally many community pediatricians are wary of oseltamivir due to significant GI side effects. Paxlovid is largely a moot point for pediatrics as you can't crush pills/no dosing and, regardless, unclear how many would use in otherwise healthy children. (Twitter) - Feb 18, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
22 on paxlovid since Tuesday fever better in simbicort has borderline asthma (Twitter) - Feb 18, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: If it were the first 2 weeks following vaccination, then the patients would be severely compromised from being vaccinated. This data would be critical to know. Anything short of targeted monoclonal or Paxlovid would be a weak tea at best. (Twitter) - Feb 18, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
.@meganranney It’s so exciting to see our numbers going down in Rhode Island - but still wondering if paxlovid is starting to be more readily available? (Twitter) - Feb 18, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
What about Paxlovid? (Twitter) - Feb 18, 2022
- |||| digoxin / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid drug interactions: antiarrhythmics, statins, calcium channel blockers, anticoagulants, antiplatelet agents, beta blockers, diuretics, vasodilators, fibrinolytics, digoxin, oncology drugs, antigout, anti-HIV, antibiotics, antipsychotics, Hep C drugs, opiods, sedatives... (Twitter) - Feb 18, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
"we have the tools".... no we don't. How can i get paxlovid in san diego tomorrow if I test positive? (Twitter) - Feb 18, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, oseltamivir / Generic mfg.
7/ Some examples: - Masks - Rapid at-home tests (we also have rapid antigen tests for flu and could develop for a range of viral respiratory infections) - Treatment (Paxlovid for COVID, Tamiflu for influenza) - Indoor ventilation & air filtration (Twitter) - Feb 18, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Federal government ordered 20 million doses Paxlovid with the intention to make it widely available for rapid treatment. I don't know when it will show up though. (But hey, I just got my free test kits & masks in the mail this week. So at least something is working (Twitter) - Feb 18, 2022
- || Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid is effective against Omicron. It was most monoclonal antibodies that were ineffective against Omicron, all but two (sotruvimab and Evusheld), which have just been shown to be ineffective against the BA.2 subtype of Omicron which is currently rising in prevalence. (Twitter) - Feb 18, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Nobody cares about it anymore. Nobody used fluvoxamine too, that has RCT DB with strong results in the Lancet. Everything against this started with underpowered HCQ studies. But there is a science party with Paxlovid. (Twitter) - Feb 17, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical, Gold standard: Also in the gold standard life virus PrNT50 essay our lab confirmed no remaining neutralizing activity of sotrovimab against BA2 (in contrast to Ba1/delta) at 1 micg/ml. This is bad news for our immunocompr patients where it remains to be seen if 5d of Paxlovid will help… (Twitter) - Feb 17, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
This is not good — more focus will be put on new mabs and $PFE Paxlovid. (Twitter) - Feb 17, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Yes. Certainly, in high risk folks even more reason to use on top of preventing hospitalization and death. In standard risk, not so much. I am struck by how many people we offer Paxlovid to are turning it down. Maybe just needs a good TV ad campaign. (Twitter) - Feb 17, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, oseltamivir / Generic mfg.
Right but Tamiflu (I’ve become even more shameless when it comes to not using generic names since I got my Pfizer vax) offers the promise of feeling better sooner. Paxlovid can’t really claim that. (Twitter) - Feb 17, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, oseltamivir / Generic mfg.
Clinical: Basing this on the current practice with oseltamivir -- which is to treat a high proportion of those who are sick enough to get diagnosed with flu, even though the data are not nearly as strong from placebo-controlled RCTs as they are for nirmatrelvir (Twitter) - Feb 17, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Took 30 days to get my 4 free rapid tests. 2 of my 80yo immune-compromised mom's medications interact with Paxlovid. These things you talk about "needing to do"- when do we do them? What's the relative cost of masking while we wait? 100,000 dead this year. 30,000 dead this month. (Twitter) - Feb 17, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Are vaccinated generally needing treatment with Paxlovid? (Twitter) - Feb 17, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Pfizer IS conducting a randomized clinical trial of Paxlovid including vaccinated people. Why are you implying otherwise. EPIC-SR: https://t.co/tUaGpaiWnE (Twitter) - Feb 17, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Value goes completely out the window if paxlovid starts being used syndromically and not only for test positives. Of course that's the twenty billion dollar dream if you're the company. (Twitter) - Feb 17, 2022
- |||| remdesivir / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Clinical: None of the trials for the 4 outpatient covid therapeutics (Paxlovid, molnupiravir, remdesevir, sortrovimab) included people who had been vaccinated (except for EPIC SR, but the data haven’t been released) (Twitter) - Feb 17, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: i prefer never to be infected however if I am fully vaccinated and later (how much later?) get infected then what can be some of the potential long term health effects? Would Paxlovid help at all?😵💫 (Twitter) - Feb 17, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: South Florida it’s the hunger games. Hardly any inventory even now when cases are going down. Paxlovid was intended for those at high risk, the immunocompromised. Maybe healthy people were able to have Doctor’s write scripts, which contributed to people scrambling for it. (Twitter) - Feb 17, 2022
- |||| remdesivir / Generic mfg., Tollovir (NLC-V-01) / Todos Medical, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Israel study shows Todos Medical’s botanical Tollovir, a safer alternative to Paxlovid and superior to Remdesivir, takes dying off the table. The also have a 3CL protease inhibitor supplement available called Tolllvid (with a D). $TOMDF . https://t.co/QbFQenQInt (Twitter) - Feb 17, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Also a problem is doctors being hesitant to prescribe them to patients on maintenance meds (who need this treatment & often high-risk). My 83 yo mom had COVID 20 days ago. . .primary knew nothing of paxlovid. Had supply in her town, unwilling to investigate or talk to pharmacist (Twitter) - Feb 17, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@marshall_steven so why didn’t we wait for Paxlovid to arrive before opening up? (Twitter) - Feb 17, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
If they spend the first half of year downplaying paxlovid, don’t be surprised when they keep downplaying it later on. See should people wear high quality masks (Twitter) - Feb 17, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: How do you explain this figure? It seems that viral load reduction is faster with paxlovid but eventually similar to placebo. (Twitter) - Feb 17, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Adverse events: The main side effect of Paxlovid was dysgeusia (in 5.6%), a distorted sense of taste, mechanism unclear. It's interesting since the drug takes down the virus's main protease, and this symptom is shared with some people who get Covid. (Twitter) - Feb 17, 2022
- ||| remdesivir / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: I've heard of no one finding paxlovid or monulpavir. Did someone that got remdesivir. More hospital to hospice at home discharges last month than previous waves. (Twitter) - Feb 17, 2022