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- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Nice re Biden’s ‘Test to Treat” program. Go to pharmacy, get tested and if positive, a free Paxlovid Rx! Not sure however I want a lot of potentially sick folks in the pharmacy though - maybe test w/app or EMR connecting positive test patients to pharmacy would be better/safer (Twitter) - Mar 2, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Many anti-cancer drugs and supportive care therapeutics are metabolized by CYP so please consider when prescribing #paxlovid for our patients with #cancer (Twitter) - Mar 2, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Todd is right; we cannot have it both ways Vaccination transforms risk of bad covid outcomes You cannot cite a trial of Paxlovid in Unvax'd to infer efficacy for vax'd. Doing so is tantamount to claiming vax does nothing to illness course, which is obv. false. (Twitter) - Mar 2, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Now that Biden announced we will be giving out Paxlovid at the time of a positive test result.. Dare I ask: Does anyone know if it works in vaccinated people? Package label is only the trial that EXCLUDED vaccinated Does anyone have data in vaxd? https://t.co/rRFbt9QHUv (Twitter) - Mar 2, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Effect of nirmatrelvir/ritonavir on calcineurin inhibitor levels: Early experience in four SARS‐CoV‐2 infected kidney transplant recipients - Wang - need to hold tacrolimus for the 5 days of using Paxlovid. @jsmadero @CarlosdelRio7 https://t.co/U9kQGNNiMP (Twitter) - Mar 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Important point. Hopefully the drug interactions with paxlovid are being considered with this new initiative. Luckily, pharmacists are pretty expert in this area… @shane6cross (Twitter) - Mar 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Also a good time to promote this FREE CE on molnupiravir and paxlovid. @ASHPOfficial https://t.co/mDLYuvnlhu (Twitter) - Mar 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I have RA and no doctor, and have wondered how I could get paxlovid if I needed it! This is great!!! omg (Twitter) - Mar 2, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Vaccine is best, polyclonal. Paxlovid won’t stand up against variants. (Twitter) - Mar 2, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Biden will definitely get covid if he stops masking in indoor settings like this, even if testing requirement. He should be tested almost daily with paxlovid on hand for early treatment. (Twitter) - Mar 2, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Let's not forget that Paxlovid is not an option for young kids who still can't get vaxxed. Masks are still an important tool for those of us who don't want COVID...And our kids. (Twitter) - Mar 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid? As in pax= peaceful ovid= sheep ??? As if we need that! (Twitter) - Mar 2, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
2. is understandable. But I wonder WHY there are supply issues - is it because Pfizer doesn't have the manufacturing capacity (in which case allowing other companies to make it would help)... or is there a shortage of raw materials required to manufacture Paxlovid? /end. (Twitter) - Mar 2, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
1. That's great news for Americans. I wonder how long it'll take before Canadians have the same access to Paxlovid. I worry it'll take a long time due to supply issues. The U.S. has the advantage of Pfizer being a U.S. company, so I'm sure the U.S. is being prioritized, which... (Twitter) - Mar 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Will we have enough supply of paxlovid? I thought not before June. (Twitter) - Mar 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
How effective is paxlovid for those with pre-existing conditions? (Twitter) - Mar 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Which is more effective when used early, Paxlovid or ivermectin? (Twitter) - Mar 2, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: The general public should "manage their expectations" re use & availability of Paxlovid et cetera💊 they are not OTC pharmaceuticals as some anecdotally appear to believe🙄, NPIs (along with vaccination) pref, or, as the old adage goes, prevention is better than cure ... (Twitter) - Mar 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Nel frattempo, nell’Occidente occidentale, il #Paxlovid arriva nelle farmacie… @claudeger55 @manuelaiati @iuvinale_n (Twitter) - Mar 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid has dozens of contraindications. I cannot take it because I can't stop taking what I can't take it with ... If that makes sense. And pharma makes a boatload and everyone still has to go to work sick or not - capitalist wet dream. (Twitter) - Mar 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Is there enough Paxlovid to pull this off? (Twitter) - Mar 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
#Paxlovid Interactons Checker here: https://t.co/YXy5eomuqt (Twitter) - Mar 2, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: People who'll be counting on Paxlovid to help them recover from Covid, would do well to find out if they're even good candidates for that treatment... #PaxlovidInteractionsChecker: https://t.co/YXy5eomuqt (Twitter) - Mar 2, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: I think we'll be waiting until June to have Paxlovid well-distributed in hospitals, pharmacies. (Twitter) - Mar 2, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Video: Mayor of NYC says: all Paxlovid goes to one specialty pharmacy; if you test positive even on HOME antigen test, you get telehealth appt with Bd Of Health, SHOW them your pos. test on video OR on your phone (!) & doc will write the rx & pharmacy DELIVERS it at no cost to pt's home (Twitter) - Mar 2, 2022
- |||||||| Paxlovid (nirmatrelvir/ritonavir) / Pfizer
New P2/3 trial, New P3 trial: EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease (clinicaltrials.gov) - Mar 2, 2022
P3, N=140, Not yet recruiting, Sponsor: Pfizer
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: The most vulnerable people who get COVID will likely be on many medications. The number of drug interactions with Paxlovid is nearly prohibitive. (Twitter) - Mar 1, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
The new in-pharmacy Covid rapid test and free treatment (Paxlovid) initiative announced by @POTUS tonight is important. We need a much better supply of anti-Covid pills, accurate tests, and solid coordination with pharmacists to pull this off (Twitter) - Mar 1, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: 4 POINT COVID PLAN @POTUS State of Union 1) Vaccines 2) Therapeutics for immunocompromised: Immediate test & Paxlovid in pharmacies bought by government (Test & Treat; very good) 3) Return to offices, revitalize downtowns & schools; surveillance (wastewater) 4) Vaccinate world (Twitter) - Mar 1, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
LOVE the “test to treat” initiative - test positive, get Paxlovid on the spot for free (I assume, of course, that they will check for contraindications 😉) #SOTU2022 (Twitter) - Mar 1, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
It would be nice if we had enough supply of Paxlovid to give EUA allowing availability to everyone infected. (Twitter) - Mar 1, 2022
- | hydroxychloroquine / Generic mfg.
Journal: Effectiveness of Antiviral Therapy in Highly-Transmissible Variants of SARS-CoV-2: A Modeling and Simulation Study. (Pubmed Central) - Mar 1, 2022
As of October 2021, neither established agents (e.g., hydroxychloroquine) nor experimental drugs have lived up to their initial promise as antiviral treatment against SARS-CoV-2 infection...Here we describe a model to understand the effect of changes in within-host reproduction number R, as proxy for transmissibility, of VOCs on the effectiveness of antiviral therapy with molnupiravir through modeling and simulation...Our findings suggest there may be a role for pre- or post-exposure prophylactic antiviral treatment in areas with presence of highly transmissible SARS-CoV-2 variants. Furthermore, clinical trials with borderline efficacious results should consider identifying VOCs and examine their impact in post-hoc analysis.
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Prescribing Nirmatrelvir–Ritonavir: How to Recognize and Manage Drug–Drug Interactions | Annals of Internal Medicine https://t.co/dkjMSjAm5V (Twitter) - Mar 1, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
They will have a lower death rate than Australia however, as they are more highly boostered than when Australia had its wave. Additionally paxlovid will be available for more immunocompromised in April, around the peak of this wave. Although given they have BA2 also it may differ (Twitter) - Mar 1, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Is paxlovid for long COVID as well? (Twitter) - Feb 28, 2022
- |||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
COVID treatment guidelines @IDSA. We need more & more treatments and prophylactics but remember: 1) Evusheld double dose now for immunocompromised (protects 6 months); 2) Paxlovid oral 89% reduction in severe disease; 3) Molnupiravir 30% reduction https://t.co/245609xo4F (Twitter) - Feb 28, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, clopidogrel / Generic mfg.
Avoiding the drug-drug interactions (DDIs) when prescribing Paxlovid (Nirmatrelvir-Ritonavir) for Covid https://t.co/uwto4TStqc @AnnalsofIM Common drugs like statins can be paused, other DDIs can be avoided by switching (e.g clopidogrel) or withdrawn (Twitter) - Feb 28, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid. That way, if symptoms then improve, it would suggest that there's an active but hidden viral infection at play, possibly (likely?) Sars cov 2, that Paxlovid is treating. (Twitter) - Feb 28, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: And if it's inactive virus, why would an antiviral be showing efficacy? One possibility is that Paxlovid is treating an existing infection other than Sars cov 2. IMO patients need to be tested with a fully detailed viral panel to exclude that possibility, before beginning (Twitter) - Feb 28, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I've seen "experts" suggest Paxlovid should be given to LHers. This would be like trying to eliminate the stench of a dead body by shooting it. (Twitter) - Feb 28, 2022
- ||| Decadron (dexamethasone) / Merck (MSD), colchicine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
So, a guy who apparently had patent for an ocular treatment, is now peddling B Shit about COVID. What studies have shown combination early treatment works (perhaps colchicine and decadron, Antibodies, and now Paxlovid Re do your medical degree then tweet after? (Twitter) - Feb 28, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
With our medical colleagues in Ukraine battling the impacts of War, low O2 supply, and a resurgent pandemic, would be great to see: 1. *Some* of the pre-allocated @Pfizer Paxlovid supply donated directly to Ukraine. 2. Safe passage for airlift and delivery of nearby O2 supply (Twitter) - Feb 27, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Apparently, one can buy this in Amazon https://t.co/QDaqYiIu4H @james1chas3 @boback @mattjbrunner @mikejohansenmd @ZiikZiiii @barttels2 @RadCentrism @Eric_Carroll @paxlovidforall @greg_travis (you can provide aerial support) @gmsamaras @Incindery1 @Gab_H_R (Twitter) - Feb 27, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I don’t think that we will never see my sister again. Even in this last year so much has changed. When paxlovid comes it will help (but not for children, yet). (Twitter) - Feb 27, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Talk to your PCP. Don’t just look at the website. Your 90 year old mother can access paxlovid. (Twitter) - Feb 27, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
No. Incorrect. Call your PCP. You can get paxlovid. (Twitter) - Feb 27, 2022
- ||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Messaging tells immune compromised people that therapeutics are available so we’re safe. But Paxlovid has a long list of contraindicated drugs (steroids which can’t be abruptly discontinued) and Evusheld has a very narrow eligibility requirement. We’re not protected at all. (Twitter) - Feb 27, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Pricing: The controversy surrounding pricing of Paxlovid is neither unexpected nor surprising. Of particular use in those unvaccinated and develop symptoms. Would be interesting to see how L /MIC quota is operated and disbursed. Effective new drug is welcome. Murar Y. (Twitter) - Feb 26, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
He asked about sotrovimab and paxlovid but they said he wasn’t sick enough. They just cut his immunosuppressant and told him to rest. (Twitter) - Feb 26, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Review, Journal: Molecular Insights of SARS-CoV-2 Antivirals Administration: A Balance between Safety Profiles and Impact on Cardiovascular Phenotypes. (Pubmed Central) - Feb 26, 2022
Our advice is to continuously adhere to the strict indications of FDA documents, monitor the possible side effects of antivirals, and increase physicians' awareness on the co-administration of antivirals and cardiovascular-relevant medications. This review dissects the global and local tendency to structure patient-based treatment plans, for a glance towards practical application of precision medicine.