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- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Pfizer Starts Testing Its Covid-19 Pill in Children Drugmaker expects results from its study of Paxlovid in high-risk children by end of year https://t.co/ogLpdc6Kwx (Twitter) - Mar 13, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
yeah if you mean by 'normalizing' them? schools have started using better ventilation if that's something but dropping masks from tomorrow ... friends in EU don't seem alarmed, even if entirely for different reasons PAXLOVID can help you think? (Twitter) - Mar 13, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Where’s our paxlovid? (Twitter) - Mar 13, 2022
- ||| Clinical: What’s Known About the BA.2 Variant: 1) Vaccines work against variants (T/B cell immunity); 2) Antibodies if you had BA1 work against BA2; 3) Not more severe than BA1; 4) Evusheld protects against it & antivirals (remdesivir, molnupiravir, Paxlovid) work https://t.co/bBuADFcNdL (Twitter) - Mar 13, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
What are your thoughts on Paxlovid so far? (Twitter) - Mar 12, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Combination therapy: NEW PODCAST 🎙️ https://t.co/9ScAUSod7u #COVID19Guidelines co-authors @RMKGandhi & @adarsh_bhimraj discuss the latest COVID-19 treatment info, incl. the role of combination therapies, new therapies such as #nirmatrelvir & #strovimab, & @POTUS's "Test to Treat" initiative. (Twitter) - Mar 12, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
vs pt gets 90+% meds filled at chain pharmacy. rph can pull pt med history of fills and actually asks about the OTC meds taken. pt tests pos, rph completes a DUR, *this is where I think rph could fax over rx request for paxlovid for pt's dr to approve or deny...md is in the loop (Twitter) - Mar 11, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
new pt sees random telemed/urgent care clinic dr/NP/PA, tests positive for covid. random telemed/urgent care provider maybe gets a 75-80% complete list of rx and otc drugs taken by pt (verbally provided) and writes an rx for paxlovid, never sees or hears from pt again. (Twitter) - Mar 11, 2022
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Journal: Achieving end-to-end success in the clinic: Pfizer's learnings on R&D productivity. (Pubmed Central) - Mar 11, 2022
Pfizer's Signs of Clinical Activity (SOCA) paradigm enabled better decision-making and, along with other drivers (biology and modality), contributed to this productivity improvement. These laid a strong foundation for the rapid and effective development of the Coronavirus 2019 (COVID-19) vaccine with BioNTech, as well as the antiviral candidate Paxlovid™, under the company's 'lightspeed' paradigm.
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Preclinical, Journal: Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 M inhibitor in animal models. (Pubmed Central) - Mar 11, 2022
The lack of adverse findings reported here in nonclinical species is consistent with the intended therapeutic target of NMV (a virus specific protein not present in mammalian cells), the favorable off-target selectivity profile, and lack of genetic toxicity. The results of these nonclinical studies with NMV along with existing ritonavir safety information indicate that there are no clinically relevant risks associated with PAXLOVID administration during pregnancy and in males and females of reproductive age.
- ||| Clinical: So far we have Paxlovid (89%), Sotrovimab (85%), Remdesivir (81%) & Molnupiravir (30%). Given Paxlovid's impressive 89% reduction, does it still seem likely to you that we'll have newer meds? Any promising ones in clinical trials? Thanks. (Twitter) - Mar 11, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
So what do ppl think of this beef with AMA and pharmacists re: test and treat with Paxlovid? Poorly worded AMA statement. Absurd to suggest pharmDs dont know interactions. But also reaction from PharmD community seems to imply they should be able to essentially practice medicine? (Twitter) - Mar 11, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
EVERY Nurse needs hands-on training with Level 1 Rapid Infuser Sorry for sarcasm. Long day fighting with Nurse Practitioner of my 89 y/o Mother-in-Law who tested COVID positive, symptomatic, refused to give PAXLOVID because "she is vaxx x 3" Her mistake. I reported it to Board (Twitter) - Mar 11, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Have any transplant programs had success using Paxlovid in the context of tacro with monitoring? Any good protocols out there? Or is everyone just avoiding the interaction in favor of other COVID drugs? @MichaelGIsonMD (Twitter) - Mar 11, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
https://t.co/hmvEeVfN1c… Molnupiravir requires atleast 3 months of condom use after 5 days of treatment in heterosexual males. Paxlovid interacts with 32 classes of drugs. Not 32 drugs….32 classes. Both are apparently less toxic than ivermectin...per the FDA. (Twitter) - Mar 10, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
This is a summary of the two antiviral pills for COVID-19; I kind of think of the nuceloside analog (molnupiravir) as AZT for HIV (helped but not as powerful) and Paxlovid as a 1st generation protease inhibitor (very powerful) https://t.co/NxPQfmdVVl (Twitter) - Mar 10, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: PAXLOVID: Pfizer said on Wednesday it has begun a mid-to-late-stage study of its antiviral COVID-19 pill for non-hospitalized children aged 6-17 years who are at high risk of developing severe illness https://t.co/JZ4Xm576Pl (Twitter) - Mar 10, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Are any of the anti virals approved for use in younger children? I understand paxlovid has a lot of contraindications. I will feel much better when anti virals are available to anyone with covid… (Twitter) - Mar 10, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
The trial was designed well. In a low risk population, they wanted to see if paxlovid reduced symptoms faster. Good idea, good endpoint. It just failed and did not change symptom duration, so now it's how to salvage in order to have a postive secondary endpoint. (Twitter) - Mar 10, 2022
- |||| remdesivir / Generic mfg., fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: As possible BA.2 surge looms, keep the following in mind, esp for nonboosted or immunocompromised: -Remdesivir actually works for outpatients -Alternatively, Paxlovid very obtainable -consider the 2 Fs: Fluvoxamine, Flexhaler (Pulmicort) -metabolic intervention if obese (FF, MET) (Twitter) - Mar 10, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
i would take the people with depleted subsets and treat with paxlovid a la feline infectious peritonitis and see if the subsets reconstitute. (Twitter) - Mar 10, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@POTUS @vivek_murthy @GovInslee @ScottGottliebMD @EricTopol @ashishkjha We shouldn't have lifted all the restrictions before we were in a position to provide Paxlovid to anyone and everyone in need. (Twitter) - Mar 10, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Cancer treatments do not seem to impair COVID-19 survival after vaccination (tweeted CID paper before that B cell depleting therapies & solid organ transplant recipients less responsive to vax so need 4th shot/Paxlovid ready) https://t.co/HjFUsvgZan) https://t.co/oAlqHD0eQD (Twitter) - Mar 9, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Details of the pediatric trial are available. https://t.co/EKFGyowCI4 While there is not wide spread need for paxlovid in children, there are immunocompromised children for whom knowing appropriate dosing is potentially life saving. (Twitter) - Mar 9, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: In #Paxlovid #COVID19 news, @Pfizer announced they have started a pediatric study -- testing safety and PK. https://t.co/41QYxu1VPw Most interesting tid bit in press releae is EPIC-SR sample size is being expanded by +800 people, so I take it they reached no positive endpoint. (Twitter) - Mar 9, 2022
- ||||| remdesivir / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Clinical: Efficacy of Antiviral Agents against the SARS-CoV-2 Omicron Subvariant BA.2 https://t.co/4BHONRnN00 Susceptibility to remdesivir, molnupiravir, & nirmatrelvir similar to that of ancestral strain & other VOC @NicoleKuderer @PergamIC @JoshuaHillMD @OncoAlert @fredhutch @SeattleCCA (Twitter) - Mar 9, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: TEST & TREAT: MDs who work with PharmDs know that they are AWESOME & can test, check patient's whole med list, check for drug-drug interactions, and enact @POTUS Test-and-Treat Plan with Paxlovid; @AmeshAA explains; but we need investment in this #2 of President's 4-point plan (Twitter) - Mar 9, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: TEST & TREAT: MDs who work with PharmDs now that they are AWESOME & can read the test, checking for drug-drug interactions, checking the patient's whole med list and enacting @POTUS Test-and-Treat Plan with Paxlovid; Plan below & need investment in #2 of President 4-point plan (Twitter) - Mar 9, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: And while one can say, it's time to transition from free everything to people paying for therapies -- we live in a global world. Thus, if the US gov does not exercise its Pfizer contract options for paxlovid, the meds produced will just go elsewhere in the world. (Twitter) - Mar 9, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
GOP Senators block further US gov funding to buy more #COVID19 therapeutics, such as paxlovid or monoclonal antibodies. Other countries chear as they will have access to Paxlovid. https://t.co/z4v3S89OKd. (Twitter) - Mar 9, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
With the idea that Paxlovid needs to be given early, so the majority of rapid tests "missing" infections occurs on the viral load downslope, when it's too late for much benefit from the drug anyway. (Twitter) - Mar 9, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
It really does. The vast majority of times a rapid test returns negative while PCR returns positive is in the period *after* infection starts to rapidly clear (yellow area in graph). Missing these is not a big deal, as Paxlovid needs to be given early (w/in 5 days of symptoms). (Twitter) - Mar 9, 2022
- Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Threshold Price in the US to Achieve Cost-Effective Use of Molnupiravir and PF-07321332/Ritonavir for the Prevention of Severe COVID-19 in High-Risk Adults (In-person & Virtual) - Mar 8, 2022 - Abstract #ISPOR2022ISPOR_1757;
Cost-effective use is estimated at $2,643 per PF-07321332/ritonavir treatment course at a threshold of $100,000/QALY. The gap between this estimated threshold price and current negotiated price agreements highlights the public health importance of affordability of these antivirals.
- Informing a Conceptual Framework for a Patient-Centered Value Assessment of Emerging Therapies for Mild/Moderate COVID-19 (In-person & Virtual) - Mar 8, 2022 - Abstract #ISPOR2022ISPOR_894;
We searched PubMed [December 21, 2021] to identify relevant publications using the string: “(mild OR moderate) AND (COVID OR coronavirus 2019 OR COVID19) AND (bamlanivimab OR estesevimab OR sotrovimab OR casirivimab OR imdevimab OR REGN-COV2) OR (paxlovid) OR (molnupiravir) ” . Potential impacts on productivity and patient costs suggest that therapies for mild/moderate COVID-19 should be assessed with evaluations that include the patient-informed value elements .
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Journal: SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combination. (Pubmed Central) - Mar 8, 2022
Potential impacts on productivity and patient costs suggest that therapies for mild/moderate COVID-19 should be assessed with evaluations that include the patient-informed value elements . No abstract available
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Thank you for the info. This makes the trial results even that more impressive. I wonder if the Paxlovid study recruited people with underlying conditions as well or if it was a healthier cohort 🤔 (Twitter) - Mar 8, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
A problem with Paxlovid is it must be started within first 5 days of symptoms. Many people don’t bother to get tested/treated until it is too late for Paxlovid to be effective. Fluvoxamine may work best if given early, but it still expected to have benefit if stated later. (Twitter) - Mar 8, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Preclinical: Here, you need a PCR to access paxlovid or sotrovimab. A RAT won't cut it. Not sure the logic behind that, since it adds barriers to access and at least a day turnaround #IDJClub (Twitter) - Mar 8, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Review, Journal: Emerging small molecule antivirals may fit neatly into COVID-19 treatment. (Pubmed Central) - Mar 8, 2022
Many other antiviral small molecules that may have therapeutic potential are under investigation in clinical trials. This article provides a summary of key molecular targets, pharmacology and preliminary data on the efficacy and safety of small molecule antiviral agents being investigated for the treatment of COVID-19.
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Right. The real-life benefit of Paxlovid could be inferior. (Twitter) - Mar 8, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Fluvoxamine and pharma drugs can hardly be compared in terms of performance, because the design of their studies is different. Fluvoxamine was tested in a real life setting, meaning people could drop the treatment ; Paxlovid patients took 100% of doses and were payed for that. (Twitter) - Mar 8, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Why Paxlovid is a Just-in-Time Breakthrough, by @EricTopol https://t.co/opcYzMeygy (Twitter) - Mar 8, 2022
- ||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Would have been nice if they'd used access to Evusheld/Paxlovid/etc. as a metric as well...these 3 metrics basically leave the #immunocompromised at the mercy of community spread. In fact, we will probably be the ones who drive up hospitalizations in these metrics. (Twitter) - Mar 7, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
True we don’t know if paxlovid may have benefit in preventing PASC and if viremia does not only correlates with PASC but drives it, it might #idjclub (Twitter) - Mar 7, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
The comparison was with Molnupiravir. Paxlovid is supposed to be far better. (Twitter) - Mar 7, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
So if I’m understanding it, Fluvoxamine and Paxlovid have about the same results which is incredible! (Twitter) - Mar 7, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
During Feb, MA had 2X the death rate as Maryland, while MD administered 6X more Paxlovid VT/ME/RI have all administered Paxlovid at 5X the rate of MA MA has largest unused supply of #Paxlovid per capita, 3X more than FL (Twitter) - Mar 7, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Concerning though that already the White House is behind on its paxlovid purchasing - lots of positive WH messaging without on the ground capability and your plan has many elements they sadly ignore (Twitter) - Mar 7, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Really like comprehensive 96-page plan by White House for next phase. Pharmacists well equipped to both perform the test & dispense the 5 days of Paxlovid therapy with standing orders; they know patient med profiles & drug-drug interactions; for vulnerable https://t.co/F3OGQwsRVt (Twitter) - Mar 7, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
The ‘Paxlovid challenge’ is to take a deep breath and list as many drugs that interact with Paxlovid in that single breath and see how far you get. (Twitter) - Mar 7, 2022