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- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
I’ve spoken to several dr’s who have seen great results though. At least as good as Sotrovimab and better than Paxlovid. (Twitter) - Mar 19, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
I'd love to hear your preferences listed in order between: sotrovimab, peg interferon-lambda, fluvoxamine, paxlovid....or all of the above! (Twitter) - Mar 19, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I am a researcher (kind of) in a totally different area and I know how the team feels excited about their success. However, unless this research opens new doors, it is far from what we need. We can not settle for 50% reduction. We do need paxlovid kind of success, nothing less. (Twitter) - Mar 19, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Folks seen any real—world data on Paxlovid? Just treated a patient Monday, she’s already 100% asymptomatic and become rapid Ag negative today. @apoorva_nyc @CarlosdelRio7 @mmPharmD #treatmentworks @Bob_Wachter @ashishkjha (Twitter) - Mar 18, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Will this have less drug interactions than Paxlovid? (Twitter) - Mar 18, 2022
- || Review, Journal: Pharmacological treatment of COVID-19: an opinion paper. (Pubmed Central) - Mar 18, 2022
The development of vaccines has not prevented, during the whole period of the pandemic, the constant search for therapeutic medicines, both among existing drugs with different indications and in the development of new drugs. The Scientific Committee of the COVID-19 of the Illustrious College of Physicians of Madrid wanted to offer an early, simplified and critical approach to these new drugs, to new developments in immunotherapy and to what has been learned from the immune response modulators already known and which have proven effective against the virus, in order to help understand the current situation.
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Question for @michaelmina_lab @Bob_Wachter #medtwitter What’s the data for decreased viral shedding with paxlovid? I’m COVID day 3, started paxlovid today. New grandbaby born yesterday 😩. Any chance I can start testing day 5 instead of 6-7? Looking for two neg tests. (Twitter) - Mar 18, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I read that the government is running out of money and that includes money for Paxlovid & other pandemic related expenses. (Twitter) - Mar 18, 2022
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Dentro de los fármacos autorizados no veo el (nirmatrelvir + ritonavir =Paxlovid), tampoco a cuántos inmunodeprimidos se les ha administrado estos tratamientos autorizados (no en fase de pruebas). En casi todos veo una disponibilidad limitada o no autorizado. En fin… (Twitter) - Mar 18, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Why early COVID treatments like Paxlovid are going unused : Shots - Health NewsNPR. "There's an assumption that there's not enough of [these drugs] around but it does seem when you look at the numbers that there is a lot around — it's just not being used," https://t.co/RKODhQqhY0 (Twitter) - Mar 18, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: They literally just said the path forward is vaccination and treatment with mAbs and paxlovid and then revealed they actually have no more funding for these things. Very short sighted. (Twitter) - Mar 18, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Still reading…@ASlavitt @ashishkjha CDC says OK no masks…giving up? No Covid funding Uninsured no testing, vax or treatment? Cut back research, surveillance, paxlovid, treatments, vaxing other countries? Political game w GOP to help only rich and connected? Help big pharma? (Twitter) - Mar 18, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Thirty five generic drugmakers around the world will make inexpensive versions of Pfizer's highly effective COVID-19 oral antiviral Paxlovid to supply the treatment to 95 countries. https://t.co/iud9cM1vAr (Twitter) - Mar 17, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I don't live in an America with a 'robust supply of COVID treatments.' Hardly anyone can get Paxlovid or monoclonal antibodies within the effective time period after testing positive. https://t.co/cGOZZduAwQ @WHCOVIDResponse (Twitter) - Mar 17, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Especially if Congress refuses to fund any more treatments. Paxlovid and monoclonal antibodies are going to disappear. (Twitter) - Mar 17, 2022
- || Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Evusheld/sotrovimab/paxlovid are completely inaccessible to the vast majority of immunocompromised people in this country. Our only reliable tool is total isolation. (Twitter) - Mar 17, 2022
- | etesevimab (JS016) / Chinese Academy of Sciences, Shanghai Junshi Biosci, Eli Lilly, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Journal: An updated practical guideline on use of molnupiravir and comparison with agents having emergency use authorization for treatment of COVID-19. (Pubmed Central) - Mar 17, 2022
However, it is effective only when used within 5-days of onset of symptoms. A 5-days course seems to be safe without any obvious short-term side effects.
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
And there is a very long list of common medications taken for many different conditions that contravene using something like paxlovid: https://t.co/taFmSv7MIm (Twitter) - Mar 17, 2022
- || Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
have you found places offering paxlovid and evusheld local to you? most rural areas have no access to those. (Twitter) - Mar 17, 2022
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Journal: Novel Nitrile Peptidomimetics for Treating COVID-19. (Pubmed Central) - Mar 17, 2022
On December 22, 2021, the U.S. FDA granted Emergency Use Authorization for the oral viral main protease inhibitor, Nirmatrelvir, to treat patients with mild-to-moderate COVID-19. This patent review reveals the structure-activity relationship of key inhibitors described in the patent WO 2021/250648 A1.
- |||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Covaxin (BBV152 COVID Vaccine) / Bharat Biotech, Indian Council of Medical Research, Ocugen, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Congratulations @ashishkjha, new role White House COVID coordinator, 4 point COVID-19 preparedness plan! 1. Vaccines; 2. Test&Treat with Paxlovid, Evusheld for immunocompromised; 3. Wastewater surveillance; 4. Vax world. Consider whole virus vax like Covaxin as booster; Congrats! (Twitter) - Mar 17, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Why aren’t you focusing more on paxlovid and fluvoxamine? (Twitter) - Mar 17, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
1mo ago, my son came 🏡 from the school with Covid. When my symptoms started: urgent care, fast test negative, next day positive, less than 5 days, on PAXLOVID. It helped a lot. I still have a lingering cough and using 2 inhalers daily. Get better SOON!!! (Twitter) - Mar 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Ocrevus (ocrelizumab) / Roche, Biogen
I just did 5 days on Paxlovid and it was excellent. I take Ocrevus. I have a lingering little cough, but nothing major. Paxlovid leaves a metal taste..just chew a lot of gum. (Twitter) - Mar 16, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
My dr prescribed me Paxlovid immediately (Twitter) - Mar 16, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Thanks so much. Since he would need IV transfusion, I'm guessing Sotrovimab would be our best bet. But really disappointing Paxlovid isn't available for those who can't take oral meds. Another strike against the disability community. (Twitter) - Mar 16, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Pricing, Reimbursement: >>> Know where you’d get Paxlovid & Sotrovimab. The government is bailing. You are on your own now to pay Covid's big pharma bills. Talk to your insurance company, not sure about the pricing. No one has a number yet. (Twitter) - Mar 16, 2022
- ||| remdesivir / Generic mfg., Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
71 yrs old, 2nd booster, I wear n95 masks and limit trips out of the house. The problem is I’m not eligible for Paxlovid and Evusheld. Also cannot have Remdesivir. I’m am seriously hoping I don’t come down with covid. As a very high risk person I am very concerned. (Twitter) - Mar 16, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
So far it looks like about 150,000 courses of Paxlovid and Molnupiravir have been used? https://t.co/YE15CepftQ Or https://t.co/zNCieTOtVZ (Twitter) - Mar 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
He's also on Paxlovid now as well so I'm very hopeful for his survival. My concern is the long term effects of multiple infections of COVID-19 & whether that is going to diminish his overall expected lifespan. Bigger point is that, for some, vaxx + boost + prior /= immunity. (Twitter) - Mar 16, 2022
- ||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Xevudy (sotrovimab) / GSK, National Institutes of Health, Vir Biotech, National Institute of Allergy and Infectious Diseases
Clinical: I don’t know what BA.2 will mean for the US. I do know this: It hinges on vaccination/booster rates *now*. So: 👆+ 4th doses & Evusheld for immunocompromised ASAP, if not done. Know where you’d get Paxlovid & Sotrovimab. Order rapids now. Get N95s or best possible now. (Twitter) - Mar 16, 2022
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Journal: Association nirmatrelvir/ritonavir contre la COVID-19. (Pubmed Central) - Mar 16, 2022
This patent review reveals the structure-activity relationship of key inhibitors described in the patent WO 2021/250648 A1. No abstract available
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Republicans in the Senate forced a vote with a couple absent Democrats and removed $15.1billion in covid funding out of the bill! This was $$ for rapid tests, and Paxlovid. House will try to refund it. Biden can veto but then they must start over again. Republican sabotage! (Twitter) - Mar 16, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Worldwide new normal: readily-available free vaccines, rapid testing, & paxlovid-type medications. More worldwide vax will cut down on variants. One can test before going to an event or upon any symptoms. If positive, meds can cut risk of long covid. (Twitter) - Mar 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Nobody needs that expensive nonsense. Do believe Paxlovid works? By 3CL protease inhibition? Then ivermectin works, and would save millions of lives if our government didn’t want to murder us (Twitter) - Mar 16, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Reimbursement: Is the government the only source of Paxlovid or will pharmacies eventually be able to buy it themselves, and have it covered by private insurance? (Twitter) - Mar 16, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I called my MS infusion team & they sorted paxlovid anti virals that day. The courier delivered them before the PCR result was back. (Twitter) - Mar 16, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
But shouldn't supply of paxlovid be sufficient by then to address that risk in that population? (Twitter) - Mar 16, 2022
- || Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
And when @CDCgov changed its metrics on community spread, part of my comfort was the knowledge that we'd have testing, and that we had TREATMENTS/protection - things like Paxlovid & Evusheld - for our highest-risk citizens. https://t.co/KWLzrq4xAM (Twitter) - Mar 15, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: 5) Without more funding, the government cannot buy more oral antiviral treatments like Paxlovid beyond the 20 million treatments already secured and needs to scale back planned purchases of preventive treatments for immunocompromised people, the White House said. (Twitter) - Mar 15, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: HORRIFYING—White House warns that US has run out of money for: 📌test, treat & vaccinate uninsured 📌Monoclonal antibody drugs cut 30% 📌Paxlovid (that reduces severe COVID risk by 90%) now cut—only 20 mil available. Congress dropped the ball on funding!https://t.co/notIJAOjUZ (Twitter) - Mar 15, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Now is not the time to bicker about who pays for the salad nicoise and who pays for the turkey club. If BA.2 and cases climb, if the House/Senate turn their backs and cross their arms, and we can’t get Paxlovid, mabs, or boosters, this will be very destabilizing for the nation (Twitter) - Mar 15, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Adverse events: This is a problem. Use of a drug with very low efficacy (30%) and worrisome side effects due to inadequate supply of Paxlovid pills https://t.co/5xilTwxRnJ by @JaredSHopkins (Twitter) - Mar 15, 2022
- ||||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Video: [Recd 10/03/2022] #Podcast #Video #TWiV 874: #COVID19 #ClinicalUpdate #105 with @DanielGriffinMD | This Week in #Virology @profvrr https://t.co/9Koot99gVa #SARSCoV2 #PublicHealth #GlobalHealth #Vaccines #Children #Paxlovid #Testing #Masks #Schools #Evusheld #Monoclonals #5Stars (Twitter) - Mar 15, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Probably hoarding N95s and Paxlovid (Twitter) - Mar 15, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: “Once the public emergency ends, the free lunch ends." Now, anything medical to do with COVID-19-vaccines, tests, drugs can be had on demand at no cost. Without the emergency declaration, a shot of vaccine or a course of Paxlovid could bring a sizable bill https://t.co/wE0QH1zo6L (Twitter) - Mar 14, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
paxlovid not mentionned. (Twitter) - Mar 14, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: How to be complacent and unprepared. If this stands..... Cancels order for 9.2 million doses of Paxlovid, blatant lack of support improved data/ wastewater surveillance and testing, pan-β-coronavirus vaccine, and other critical public health measures (Twitter) - Mar 14, 2022
- | Selzentry (maraviroc) / ViiV Healthcare, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
No Im not referring to maraviroc. Talking about paxlovid (Twitter) - Mar 14, 2022