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- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Placebo seems to win in a lot of trials, not only repurposed meds, but including the Paxlovid EPIC-SR trial (SR = Standard Risk). In a vaccinated population, most people will get better and changing disease trajectory is difficult. I expect to see many more negative RCTs. (Twitter) - Apr 1, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Re: "You would also get the same result if you used paxlovid" Let me know when you have a shred of actual evidence for that claim. Because so far all you've only offered excuses to suit your pre-determine conclusion on ivermectin working early. https://t.co/n9v42Osqma (Twitter) - Apr 1, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
You would also get the same result if you used paxlovid, yet I believe paxlovid works. (Twitter) - Apr 1, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Review, Journal: Drug interaction risk between cardioprotective drugs and drugs used in treatment of COVID-19: A evidence-based review from six databases. (Pubmed Central) - Apr 1, 2022
These enhance the view on safety concerns about the drug interaction risk in managing COVID-19 infection in patients with comorbid conditions. This primary evidence may concern preventing potential or unintentional effects resulting from Drug-drug interaction, Improving patient quality of life.
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Like you, I'm constantly analyzing the odds. Lack of govt guarantees for future vaccine doses (existing or updated vax) or paxlovid eligibility puts us all in the situation of trying to calculate timing so that we aren't too waned + with high exposure at the same time. (Twitter) - Apr 1, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Funny. Molnupiravir/Paxlovid trials treat within a day or two of symptoms. We all know viral replication wanes at days 5-7 after symptoms, so generally no treatment benefit after this time. Avg time to treat in this study was 5.2 days. Seriously, you consider this study valid? (Twitter) - Apr 1, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
And we end up wasting Paxlovid on people who didn't need it. Meanwhile, someone with severe HKU1 who might not test positive could benefit from Paxlovid. (Twitter) - Apr 1, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid seems likely to work for most coronaviruses including the endemic ones, other protease inhibitors on the horizon appear to work for an even wider class (Twitter) - Apr 1, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Yet another flaw with the "test to treat" approach. Need to prescribe Paxlovid based on symptoms and community prevalence, especially when tests are scarce, as they tend to be during surges. Time is of the essence (Twitter) - Apr 1, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Paxlovid: Participants who were randomized within 3 days of symptom onset were included (Twitter) - Mar 31, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid trial. No missing data in MAIN variables for subgroup analysis. Sorry, but looks like R parsing error. I use it almost every day and it wouldn't surprise me at all. https://t.co/hp7OdiOt6h (Twitter) - Mar 31, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Sorry to hear. I am not hearing that Paxlovid and other early treatments don’t work on GI stuff but I would def ask a few experts. Maybe @NjbBari3 @boulware_dr @ImmunoFever could weigh in? (Twitter) - Mar 31, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I've heard some horror stories about folks trying to access Paxlovid & being unable to. This definitely needs to be address and righted ASAP. Encouraging that we're not seeing a BA.2-related "spike" yet. (Twitter) - Mar 31, 2022
- || Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Review, Journal: A Systematic Review of the Global Intervention for SARS-CoV-2 Combating: From Drugs Repurposing to Molnupiravir Approval. (Pubmed Central) - Mar 31, 2022
For the treatment of COVID-19, the PF-07321332/ritonavir combination medication is used in Phase III studies and was marketed as Paxlovid. Herein, we represented the almost history of combating COVID-19 from repurposing to the recently available oral anti-SARS-CoV-2 candidates, as a new hope to end the current pandemic.
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
que no sabíais cual es uno de los efectos secundarios de PAXLOVID💊 de Pfizer....? (Twitter) - Mar 31, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Hoping you have the speediest recovery. Recovered 2 weeks ago, found Paxlovid to be incredibly helpful. (Twitter) - Mar 31, 2022
- |||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Without more COVID funding from Congress, the US will run out of / face shortages of: May: COVID monoclonal antibody treatments June: at-home rapid antigen tests July: Evusheld to protect immunocompromised people against COVID September: Paxlovid to treat COVID (Twitter) - Mar 31, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Need to know where to get outpatient #COVID19 treatment? Here is an amazing new resource. Note, #Paxlovid is the treatment of choice but has many drug interactions. https://t.co/dmUIbX1hvA. https://t.co/oef9bElAJK @AADmember #epitwitter #Dermtwitter #MedTwitter (Twitter) - Mar 31, 2022
- |||| Paxlovid (nirmatrelvir/ritonavir) / Pfizer
Enrollment open, Phase classification: EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease (clinicaltrials.gov) - Mar 31, 2022
P2/3, N=140, Recruiting, Sponsor: Pfizer
Herein, we represented the almost history of combating COVID-19 from repurposing to the recently available oral anti-SARS-CoV-2 candidates, as a new hope to end the current pandemic. Not yet recruiting --> Recruiting | Phase classification: P3 --> P2/3
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I would think she would just test at any signs of symptoms, so not that expensive. I think it can still take 2 days sometimes for rapid like binax to turn positive. Starting Paxlovid 2 days earlier probably huge difference. Maybe I’m missing something? (Twitter) - Mar 31, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Does anyone know what treatment there is for children under 12 years old or under 88 lbs since they cannot take Paxlovid, the most effective antiviral. If even able to be vaxxed, their dose is waning or has already waned and schools are unmasked. What option do they have? (Twitter) - Mar 31, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid not easy to get. Would you use fluxovamine if you couldn’t get paxlovid? (Twitter) - Mar 30, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Thank you @WesElyMD! Is anyone trialing Paxlovid with #LongCovid patients? (Twitter) - Mar 30, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
There is NO access to Paxlovid for the general public. When are the Twitter blue checks going to realize this. (Twitter) - Mar 30, 2022
- |||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Yes! And virtually NO ONE can get Paxlovid (except CEOs, public officials, celebrities). Even worse, our academic med ctr, (which has zero Paxlovid) won’t allow its MDs to even prescribe fluvoxamine b/c “not in their protocol”& “most ppl don’t need treatment for acute Covid” (Twitter) - Mar 30, 2022
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Wow. Sounds awful. I didn’t know other names for Paxlovid (Twitter) - Mar 30, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: #Paxlovid4LongCovid @ncats_nih_gov @NIHDirector @POTUS @DanielGriffinMD @LekshmiMD #LongCovid @Bob_Wachter @LckUsa @loscharlos @PCH_SF @nathavindra @TheExtraFiles @profvrr @ahandvanish @searose2012 @microbeminded2 @StanfordMed @UCSFHospitals @AlisaValdesRod1 @annieluet (Twitter) - Mar 30, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Is there a #directopatient plan to same day ship #paxlovid to homes like #nyc has? @WHCOS @WHCOVIDResponse @POTUS @benwakana46 @ashishkjha #Immunocompromised ppl arent going into maskless pharmacty for #rapidtests they can do at home & we must #reportrapids-add this tool to site? (Twitter) - Mar 30, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Is this worth investing in as a gift for high risk friend who has to go to work now, can no longer isolate? Would seem to me, this would give best chance of starting Paxlovid or mABS the earliest possible moment? (Twitter) - Mar 30, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Thanks again for your amazing wealth of knowledge btw. I'm still curious to hear if you think high-dose melatonin = Paxlovid given its protease inhibitor features. (Twitter) - Mar 30, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Zero effect on replication/fusion etc. Zero effect on viral load. Science has moved past our previous guesses. We stopped a long time ago with IVM for the use of MAB's and Fluvoxamine and now Paxlovid. Of course if you are vaccinated virtually no need for anything else. (Twitter) - Mar 30, 2022
- || fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Cd147? The Asian studies - since 2005 - have identified this path. It was reiterated by Asian researchers in 2020 & 2021 -- Why does the USA not approve Fluvoxamine. Cheap. Supported by local, independent studies while Paxlovid has had no independent Trial (Twitter) - Mar 30, 2022
- ||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Can anyone tell my why Public Health is obsessed with promoting masks, a primitive mitigation tool that has NEVER reduced cases by any significant degree, and not about Paxlovid/EvuSheld for high risk people? @VPrasadMDMPH @davidzweig @DrJBhattacharya (Twitter) - Mar 30, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Journal: Special Considerations for Paxlovid Treatment Among Transplant Recipients With SARS-CoV-2 Infection. (Pubmed Central) - Mar 30, 2022
Not yet recruiting --> Recruiting | Phase classification: P3 --> P2/3 No abstract available
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
We won't have enough Paxlovid. We have no way to pay for it. (Twitter) - Mar 30, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
COVID Test-to-Treat site locator here: https://t.co/9DUryciK5W Find locations where you can walk-in, get a test & get treated for COVID. Paxlovid & monulpiravir are provided at no cost. But some sites may charge for testing/diagnosis. (Twitter) - Mar 30, 2022
- |||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
P3 data: #Fluvoxamine doesn’t get support “for or against” #COVID because data are flimsy. A large phase 3 study (best design to date) was stopped because of futility (⬇️ effect). Only a large platform study was mildly positive & that’s much weaker. Paxlovid data are better. @DrEricDing (Twitter) - Mar 30, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Adverse events: Its because its efficacy is lagging in preventing hospitalization in comparison to paxlovid (33% < 90%) also, bc its an SSRI, it interacts wa bunch of diff meds & can have permanent side effects after prolonged use. (Twitter) - Mar 30, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
PROTEASE INHIBITORS FOR COVID-19. Exciting to have Paxlovid but it is like the first generation PIs for HIV (200mg of ritonavir); more PIs are coming for SARS-CoV-2 which we can use to protect those with COVID at risk of severe disease from progressing https://t.co/rxGoQcanhf (Twitter) - Mar 29, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
You can track how much Paxlovid is available in your area here: https://t.co/AbNmYTZvEd We’re doing well right now, but could face problems with another big peak. (Twitter) - Mar 29, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: I think that will need to be answered by clinical trials. For now, we have 5 days from symptom onset to initiate treatment w Paxlovid… (Twitter) - Mar 29, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Useful article from Nature on both Mpro and RdRp inhibitors and describes speed of Paxlovid from a compound in a freezer. "600 compounds, 80 co-crystals, structure-based drug discovery, and a candidate 8 months later,” https://t.co/8k7voOBcSC (Twitter) - Mar 29, 2022
- |||| brivudine (RP 101) / RESprotect, RedHill, SciClone, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: It might be interesting to try an anti EBV drug like Brivudine first and if that is unsuccessful try Paxlovid. With people having a history of EBV reactivations, an anti EBV drug might be considered as soon as they test positive for SARS-CoV-2 or maybe also before a vaccination. (Twitter) - Mar 29, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid is really all we have left now early treatment (Twitter) - Mar 28, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Why early COVID treatments like Paxlovid are going unused : Shots - Health News : NPR https://t.co/JDyUBUuf1l (Twitter) - Mar 28, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: How would you trust a CEO this naive! It is a shame that $pfe keeps lying even with Paxlovid which does not work on vaccinated people! #lambda #interferon $eigr $pfe @boulware_dr @PaulSaxMD @AlbertBourla (Twitter) - Mar 28, 2022
- |||| Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: 10 points for COVID management which need ongoing investment- mainly vaccines (including novel), prophylaxis for vulnerable (Evusheld), oral antivirals for treatment, vulnerable (Paxlovid), don't see mask mandates coming back but choice of good 1-way masks https://t.co/8n1EUcZFGV (Twitter) - Mar 28, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid is looking quite promising for those who can take it. (I was testing negative by day 3 on Paxlovid) (Twitter) - Mar 28, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Paxlovid is a virus-directed pill, highly effective independent of variants. Now a pill that is host-directed, against the TMPRSS 2 receptor, also pan-#SARSCov2, with much potential, including as a preventive Rx, @Nature today https://t.co/YY5moHoXPx (Twitter) - Mar 28, 2022