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- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
If you mean stock mkt irrationality wrt covid in China then I agree, and raise you one worse: China Meheco in A share. Import partner of Pfizer Paxlovid in China (Twitter) - Apr 4, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Across the border, pharmacists now able to prescribe paxlovid for those at risk of complications of Covid, which, technically, is anyone. (I believe the official authorization in Canada is for those at risk of progressing to serious disease, which is different) (Twitter) - Apr 4, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: I understand your scarcity argument, but your conclusion went one step too far here. Paxlovid likely cuts risks of hospitalization and death for healthy folks too, it just hasn’t been studied for them yet. Absence of evidence is not evidence of absence. (Twitter) - Apr 4, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer, oseltamivir / Generic mfg.
Weren’t eligibility categories created due to shortage of Paxlovid? Now that in some areas it’s more abundant why wouldn’t it be avail to all? Taking it at onset of symptoms can prevent severe reaction. Anyone’s at risk. Hope some day soon it can be used like tamiflu for the flu (Twitter) - Apr 4, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Biden can’t control how long it takes Pfizer to create Paxlovid. This article explains why it is not available for the general population yet. https://t.co/BXpRl36OLm (Twitter) - Apr 4, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Adverse events: I don’t understand this well. How can you tell from the onset if COVID will take a bad turn, young healthy and then blood clots or heart attack. Paxlovid could prevent that. If it stops replication of the virus doesn’t that decrease load which could prevent organ damage? (Twitter) - Apr 4, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Since the approval for Paxlovid, I’ve had many in my inbox believe that if they get sick with COVID they’ll have access to Paxlovid and everything will be fine. Untrue, as seen here by @Craig_A_Spencer, who inspired me to go back to medicine & #PublicHealth advocacy. ✨🙏🏼 (Twitter) - Apr 4, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
In case anyone wanted an update, I did end up getting pretty sick, I'm better now except for a lingering cough. Paxlovid is in Ireland but distribution is still being worked out, so I didn't get it. I think rollout for it is mid April, so it will be an option soon. (Twitter) - Apr 4, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Read tweet, thread, and replies. Paxlovid is not authorized for those at low risk of progression to severe disease. Clearly not everyone agrees about who should receive it. (Twitter) - Apr 4, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Hubby got an email from @MayoClinic Jacksonville. Paxlovid not for transplant patients taking certain meds. Even for high risk patients- Paxlovid not a choice. He is double boosted - masks indoors and goes out rarely. (Twitter) - Apr 4, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Just b/c we haven't MFG'd & supplied enough Paxlovid doesn't justify backing that failure as though it's medically legitimate. To let anyone suffer more severely/longer, or possibly Long Covid, 'just because we're unethical & didn't stock up' is really 😭 coming from a doctor. (Twitter) - Apr 4, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Just b/c we haven't MFG'd & supplied enough Paxlovid doesn't justify backing that failure as though it's medically legitimate. To let anyone suffer more severely/longer, or possibly Long Covid, 'just because we're unethical & didn't stock up' is really 😭 coming from a doctor. (Twitter) - Apr 4, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Many apparently low risk individuals could be at high risk of LC, and that should be considered a severe manifestation of the disease. Also, if replication is mitigated, Paxlovid can prevent transmission. The supply of this therapeutic needs to be ramped up ASAP. (Twitter) - Apr 4, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Why would you think Paxlovid reduces transmission? (Twitter) - Apr 4, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical, Adverse events: Paxlovid has not shown any efficacy in standard risk patients and has a significant risk of serious side effects. So it would be below the standard of care to prescribe it outside the EUA (Twitter) - Apr 4, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
And I am speaking as a high-risk, front-of-the-line person, to whom Paxlovid rationing would be favorable. We all are at risk of #LongCovid and late side fx like pulmonary embolisms/cardiac/breathing issues. (Twitter) - Apr 4, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: These people (your PATIENTS) with Covid aren’t the problem. The limited supply of Paxlovid is the problem. Use your bully pulpit to decry scarcity, not to condescend to people seeking relief from something very unpleasant and probably at least a little bit terrifying. (Twitter) - Apr 4, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
It's not like there is an abundance of Paxlovid either! If there were it wouldn't seem so harmful. Wonder why nobody pursued TMPRSS2 receptor blockers either. I followed doctors in India who were light on their feet & skillfully treating w/an assortment of repurposed drugs. (Twitter) - Apr 3, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Adverse events: Even higher risk if PAXLOVID is provided before steroid, due to DDI with ritonavir which increases steroids side effects. (Twitter) - Apr 3, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I have a friend who qualifies for paxlovid, but is afraid to take it because it’s “a new drug“ and long term risk is unknown. What are your thoughts about that? And what are your thoughts about paxlovid‘s ability to reduce the risk of long Covid? (Twitter) - Apr 3, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: The main takeaway is that if you’re young, healthy, and vaccinated, you might not need nor be eligible for oral antiviral pills like Paxlovid. And they aren’t used to shorten the amount of time you’re sick or have a cough. They’re meant to prevent hospitalizations and death… (Twitter) - Apr 3, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Worked a telehealth shift today. Most of my patients were young, vaccinated & very healthy w/ Covid, requesting Paxlovid ‘to feel better faster’. A reminder that oral antivirals are for preventing severe disease—especially in high-risk populations—not for symptom improvement. 🧵 (Twitter) - Apr 3, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
If you plan to use #Paxlovid , 1st line treatment for #COVID19 per NIH recs: 1.Dose adjust with eGFR< 60; contraindicated with eGFR < 30. 2.Strong CYP3A4 inhibitor, so check for drug interactions. Good site: https://t.co/Iwx6gLD9Ec #MedTwitter #MedEd @NACECMEOnline (Twitter) - Apr 3, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Sometimes the only difference between a person who is ambulatory and one who is admitted for COVID-19 is that a clinician decided to admit them to the hospital. Still, I have heard of situations where patients are discharged so they can get paxlovid or a mAb and then readmitted. (Twitter) - Apr 3, 2022
- ||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Adverse events: If you look at the full prescribing information for just about any drug, there will be a long list of potential adverse effects. Compared to the average prescription drug, fluvoxamine is very safe. There are of course some contraindications, as with paxlovid and other drugs. (Twitter) - Apr 3, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Would you expect that taking paxlovid early in an infection would reduce the chances of long Covid? (Twitter) - Apr 3, 2022
- |||| ivermectin oral / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: If they can deliberately infect healthy people with covid then they can test ivermectin vs. paxlovid. There would be many volunteers. https://t.co/2kjjGQM7UL (Twitter) - Apr 3, 2022
- |||| fluvoxamine / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: But the goal should surely be to prescribe effective meds before patients land in hospital with ARDS?? We need early intervention. Paxlovid looks like a winner but is awfully scarce - and costly AF. Need safe, cheap alternatives before ppl are hospitalized! Fluvoxamine may serve. (Twitter) - Apr 3, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Clinical: I believe that is what you believe. Can you please provide evidence to document ur statement? That's equivalent of suggesting advocacy of Monoclonal antibodies, Paxlovid & Molnupiravir somehow promoted people to not get vaccinated. I wasn't trying to be cute-I was dead serious (Twitter) - Apr 3, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Sorry to hear that you got sick Sigal and are not feeling well. Happy you got paxlovid option and hope you can rest and recover quickly. (Twitter) - Apr 3, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: We rely too heavily on the US for pharmaceuticals. Paxlovid should have been readily available pre-omicron in both countries… always chasing the ball… The US is always closer though… what about the vaccines in <5?… i’m just venting lol… hope you get well! (Twitter) - Apr 3, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
What is the criteria to receive paxlovid? Here in Canada only a select few of seriously compromised individuals can receive it. I think everyone would benefit. Am I wrong? (Twitter) - Apr 3, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
It is good u got your hands on Paxlovid, wish they were more available in Ontario Canada (Twitter) - Apr 3, 2022
- |||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: ". . . in a local hospital but they would never know. These coronaviruses are not a major cause of mortality, but elderly people can die from them." Of course, we don't have a Paxlovid for OC43, either, so . . . (Twitter) - Apr 3, 2022
- | Paxlovid (nirmatrelvir and ritonavir) / Pfizer
We need to push the paxlovid on to millions to see if it can help us all. Please help us all (Twitter) - Apr 3, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I keep a close eye on Paxlovid availability near me. The CVS within walking distance is a test to treat location. (Twitter) - Apr 2, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I’ve got the home tests. I’m vaxxed and boosted. I’m as ready as I’ll ever be. Your know who isn’t vaxxed and doesn’t have access to Paxlovid? My two kids <5. You know why? @CDCDirector and @DrCaliff_FDA won’t allow off-label vax. My kids are sitting ducks for covid. 2 years out. (Twitter) - Apr 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Si jamais @OrdrepharmaQc et ses professionnelles/ls veulent en apprendre plus sur déprescription/Paxlovid: https://t.co/wrC2z2TEFd @DrEmilyMcD @DrToddLee @MedSaferTool @McGill_DOM @RIMUHC1 (Twitter) - Apr 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I thought this had some useful practical common sense advice from @taraparkerpope @KnvulS @nytimes in order to prepare for BA.2 or other future variants. This includes having home testing available, a plan for securing Paxlovid, etc https://t.co/j4JAtGAb2s (Twitter) - Apr 2, 2022
- | hydroxychloroquine / Generic mfg.
Journal: Computational Screening of Phenylamino-Phenoxy-Quinoline Derivatives against the Main Protease of SARS-CoV-2 Using Molecular Docking and the ONIOM Method. (Pubmed Central) - Apr 2, 2022
These amino acids are related to the proteolytic cleavage process of the catalytic triad mechanisms. Therefore, this study provides important information for further studies on synthetic quinoline derivatives as antiviral candidates in the treatment of SARS-CoV-2.
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Did this guy switch to Gidmk fanboy save his career? Sure seems like it. The together trial is the worst designed trial on ivermectin done to date. They should run the same trial on Paxlovid. (Twitter) - Apr 2, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
After decades of prescribing #Ritonavir , finally got to try it: 5 bubble packs titled #Paxlovid (yes, I qualify). It is indeed bitter. But it will likely shorten the illness, prevent complications, maybe even shorten period of infectiousness 1/4 https://t.co/oJcunCnU3s (Twitter) - Apr 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
I wonder if RAT is neg in a symptomatic boosted person and pcr + if Paxlovid would actually be worth taking. I guess virus could be cranking in the gut and it would be worth shutting it down fast. (Twitter) - Apr 2, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: Then why are studies done against placebo? Do a test of ivermectin, paxlovid and placebo. If paxloxid is effective and ivermectin not then it will prove to naysayers that the study was not simply designed to make the test drug outcome insignificant. (Twitter) - Apr 2, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Hope you get better soon! Some said their LC condition improved by Paxlovid. Don’t know whether docs can prescribe or there’s any trial on this. https://t.co/FidEiihIwZ (Twitter) - Apr 2, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: I agree. If you're almost better, the paxlovid won't add much at that point except in edge cases like people who have no capacity to make antibody (and even then, who knows) (Twitter) - Apr 2, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@EdoajoEric what are your thoughts on Paxlovid to treat long COVID (Twitter) - Apr 1, 2022
- || Paxlovid (nirmatrelvir and ritonavir) / Pfizer
As long as you knew it and could get on an antiviral asap. Test every 2 days if you’re going to go out & resume activities. Make a plan w/your doctor. Keep up on @DanielGriffinMD’s latest treatment hierarchy & make sure drs know it. Need kidney function test for full Paxlovid. (Twitter) - Apr 1, 2022
- ||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Clinical: UK hospitals are totally overwhelmed. 1 in 13 have COVID. It’s over. @CDCDirector @US_FDA @ashishkjha @JoeBiden We will see the same in USA by May unless we have enough #Paxlovid Please Order more. Much more. @DrEricDing @ashishkjha @AlbertBourla @pfizer @ASlavitt (Twitter) - Apr 1, 2022
- ||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Sorry. That 25 million is per week 10 weeks x 25 = 250 million How many will be 65 or with preconditions? If 30% = 75 million @JoeBiden @ashishkjha @CDCDirector @US_FDA @AlbertBourla @pfizer @DrEricDing @EricTopol @WmHaseltine @DrLeanaWen @drdanchoi ORDER MORE #Paxlovid (Twitter) - Apr 1, 2022