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- | VE-821 / EMD Serono, Vertex, AB-110 / Angiocrine
Journal: Pharmacological degradation of ATR induces antiproliferative DNA replication stress in leukemic cells. (Pubmed Central) - Mar 23, 2024
It is derived from the ATR inhibitor VE-821 and recruits the E3 ubiquitin-ligase component cereblon to ATR...This mechanism provokes DNA replication catastrophe and augments anti-leukemic effects of the clinically used ribonucleotide reductase-2 inhibitor hydroxyurea...Treatment of wild-type but not of cereblon knockout cells with Abd110 stalls their proliferation which verifies that ATR elimination is the primary mechanism of Abd110. Altogether, our findings demonstrate specific anti-leukemic effects of an ATR PROTAC.
- || AB-110 / Angiocrine
Trial completion, Trial completion date: Trial of AB-110 in Adults With Hematologic Malignancies Undergoing Cord Blood Transplantation (clinicaltrials.gov) - May 31, 2022
P1, N=10, Completed, Sponsor: Angiocrine Bioscience
Altogether, our findings demonstrate specific anti-leukemic effects of an ATR PROTAC. Active, not recruiting --> Completed | Trial completion date: Nov 2022 --> Jan 2022
- | AB-110 / Angiocrine
Trial completion date: Trial of AB-110 in Adults With Hematologic Malignancies Undergoing Cord Blood Transplantation (clinicaltrials.gov) - Dec 28, 2021
P1, N=10, Active, not recruiting, Sponsor: Angiocrine Bioscience
Active, not recruiting --> Completed | Trial completion date: Nov 2022 --> Jan 2022 Trial completion date: Mar 2023 --> Nov 2022
- | AB-110 / Angiocrine
Enrollment closed, Trial completion date, Trial primary completion date: Trial of AB-110 in Adults With Hematologic Malignancies Undergoing Cord Blood Transplantation (clinicaltrials.gov) - Mar 15, 2021
P1, N=10, Active, not recruiting, Sponsor: Angiocrine Bioscience
Trial completion date: Mar 2023 --> Nov 2022 Recruiting --> Active, not recruiting | Trial completion date: Mar 2022 --> Mar 2023 | Trial primary completion date: Jun 2020 --> Jun 2021
- | AB-110 / Angiocrine
Journal: Effect of airborne particle abrasion and sintering order on the surface roughness and shear bond strength between Y-TZP ceramic and resin cement. (Pubmed Central) - Oct 24, 2019
The controls displayed lower SBS values than the treated groups (p<0.05), which had statistically similar results to each other. Airborne particle abrasion of pre-sintered Y-TZP, followed by sintering, increased the tetragonal structure contents.
- | AB-110 / Angiocrine
New P1 trial: Trial of AB-110 in Adults With Hematologic Malignancies Undergoing Cord Blood Transplantation (clinicaltrials.gov) - Mar 30, 2018
P1, N=9, Not yet recruiting, Sponsor: Angiocrine Bioscience