Pharmaleads 
Welcome,         Profile    Billing    Logout  
 1 Product   0 Diseases   1 Product   1 Trial   23 News 
  • ||||||||||  Review, Journal:  Novel Opioids in the Setting of Acute Postoperative Pain: A Narrative Review. (Pubmed Central) -  Jan 23, 2024   
    On the other hand, dinalbuphine sebacate (DNS; semi-synthetic mu partial antagonist and kappa agonist), dual enkephalinase inhibitors (STR-324, PL37, and PL265), and endomorphin-1 analog (CYT-1010) have shown good efficacy in preclinical studies with future plans for clinical trials. Rather than relying solely on mu-opioid receptor agonism to relieve pain and risk opioid-related adverse events (ORAEs), novel opioids make use of alternative mechanisms of action to treat pain while maintaining a safer side-effect profile, such as lower incidence of nausea, vomiting, sedation, and respiratory depression as well as reduced abuse potential.
  • ||||||||||  PL37 / Debiopharm
    Efficacy of a Dual ENKephalinase Inhibitor in a preclinical stress-induced migraine model (Virtual Only) -  Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_4207;    
    To determine whether the endogenous opioid system could potentially be utilized as a migraine therapeutic approach, we tested the efficacy of an Dual ENKephalinase Inhibitor (DENKI) (PL37) in a preclinical model of migraine...These data demonstrate that inhibiting enkephalinase in the periphery is effective in treating migraine-like behavior via activation of opioid receptors. Peripheral targeting of endogenous opioid signaling may be an effective novel therapeutic strategy for migraine that lack the negative effects commonly associated with centrally-acting opioids.; Grant Support: NIH Grant NS104200
  • ||||||||||  PL37 / Debiopharm
    Journal:  Insights into ulvan lyase: review of source, biochemical characteristics, structure and catalytic mechanism. (Pubmed Central) -  Nov 3, 2020   
    Various ulvan lyases have been cloned and characterized from marine bacteria and grouped into five polysaccharide lyase (PL) families, namely: PL24, PL25, PL28, PL37 and PL40 families...Additionally, the structural characteristics and catalytic mechanisms have been introduced in detail. This comprehensive information should be helpful regarding the application of ulvan lyases.