Jiangsu Hengrui Pharma 
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  • ||||||||||  AiTan (rivoceranib) / HLB Bio Group, AiRuiKa (camrelizumab) / HLB Bio Group
    P2 data, Journal, Metastases:  Camrelizumab plus apatinib for previously treated advanced adrenocortical carcinoma: a single-arm phase 2 trial. (Pubmed Central) -  Nov 29, 2024   
    P2
    The most common grade 3-4 treatment-related adverse events were alanine aminotransferase elevation, aspartate aminotransferase elevation, and lymphopenia. Predefined exploratory analyses indicated that patients with higher peripheral blood CXCR3?+?CD8?+?T cell abundance, lower immunosuppressive CD4?+?T cell abundance, and higher overlap of clonotypes between tumor-infiltrating T cells and circulating T cells, were more likely to respond favorably to the combined therapy.
  • ||||||||||  Review, Journal:  Systemic Therapy for Hepatocellular Carcinoma. (Pubmed Central) -  Nov 29, 2024   
    Areas of development include testing immune checkpoint-based regimens in the adjuvant setting after surgery, ablation, or transarterial embolization. Also of interest are studies for patients with Child-Pugh B liver function and adding new checkpoint molecules to the current standard platforms.
  • ||||||||||  vunakizumab (SHR-1314) / Jiangsu Hengrui Pharma
    Review, Journal:  Vunakizumab: First Approval. (Pubmed Central) -  Nov 28, 2024   
    In August 2024, vunakizumab was approved in China for the treatment of adult patients with moderate-to-severe plaque psoriasis who are suitable for systemic treatment or phototherapy. This article summarizes the milestones in the development of vunakizumab leading to this first approval for the systemic treatment of moderate-to-severe plaque psoriasis.
  • ||||||||||  AiTan (rivoceranib) / HLB Bio Group, AiRuiKa (camrelizumab) / HLB Bio Group
    Journal, HEOR, Cost-effectiveness, Cost effectiveness, Metastases:  First-Line Camrelizumab Plus Rivoceranib in Advanced Hepatocellular Carcinoma: A China-Based Cost-Effectiveness Analysis. (Pubmed Central) -  Nov 25, 2024   
    The results of the subgroup analysis demonstrated camrelizumab plus rivoceranib was the most cost-effective in the subgroup with albumin-bilirubin grade 2. At a willingness-to-pay threshold of US$36?780/QALY, camrelizumab plus rivoceranib is likely to be a cost-effective option compared with sorafenib as first-line treatment for advanced hepatocellular carcinoma in China.
  • ||||||||||  New trial, Adverse events, IO biomarker:  The Effect of Serum Ferritin in irAE (clinicaltrials.gov) -  Nov 25, 2024   
    P=N/A,  N=1500, Recruiting, 
  • ||||||||||  ribupatide injection (HRS9531 injection) / Kailera Therapeutics
    Enrollment open:  Influence of HRS9531 on Pharmacokinetics of Metformin in Healthy Subjects (clinicaltrials.gov) -  Nov 24, 2024   
    P1,  N=20, Recruiting, 
    At a willingness-to-pay threshold of US$36?780/QALY, camrelizumab plus rivoceranib is likely to be a cost-effective option compared with sorafenib as first-line treatment for advanced hepatocellular carcinoma in China. Not yet recruiting --> Recruiting
  • ||||||||||  AiTan (rivoceranib) / HLB Bio Group, AiRuiKa (camrelizumab) / HLB Bio Group
    Trial completion date, Trial primary completion date:  Camrelizumab in Combination With Apatinib Mesylate Plus Short-course Chemotherapy for Advanced ESCC (clinicaltrials.gov) -  Nov 21, 2024   
    P2,  N=188, Recruiting, 
    Not yet recruiting --> Recruiting Trial completion date: Nov 2026 --> Mar 2027 | Trial primary completion date: Jul 2024 --> Sep 2025
  • ||||||||||  AiTan (rivoceranib) / HLB Bio Group, AiRuiKa (camrelizumab) / HLB Bio Group
    New P2 trial:  First-line Treatment of Advanced/unresectable DDLPS (clinicaltrials.gov) -  Nov 18, 2024   
    P2,  N=49, Not yet recruiting, 
  • ||||||||||  SHR-A2102 / Jiangsu Hengrui Pharma
    Enrollment open:  A Trial of SHR-A2102 With Antitumor Therapy in Advanced Urothelial Carcinoma (clinicaltrials.gov) -  Nov 18, 2024   
    P1/2,  N=90, Recruiting, 
    Dalpiciclib, buparlisib, fulvestrant, and ribociclib cause neutropenia, severe depression, adverse gastroenterological effects, and adverse hepatological effects, respectively. Not yet recruiting --> Recruiting
  • ||||||||||  Irene (pyrotinib) / Jiangsu Hengrui Pharma, Herceptin (trastuzumab) / Roche, docetaxel / Generic mfg.
    Journal:  Pyrotinib and trastuzumab combination treatment synergistically overcomes HER2 dependency in HER2-positive breast cancer: insights from the PHILA trial. (Pubmed Central) -  Nov 16, 2024   
    It can increase the one-year survival rate, and elevate the levels of immunoglobulins and immune molecules while reducing the levels of tumor markers and incidence of side effects. Our findings underscore the robust synergy between pyrotinib and trastuzumab in overcoming HER2 dependency and provide a rationale for pyrotinib, trastuzumab, and docetaxel as one of the optimal choices for patients with untreated HER2-positive metastatic breast cancer, who are dependent on the HER2 signalling cascade.
  • ||||||||||  Ibrance (palbociclib) / Pfizer, AiRuiKa (camrelizumab) / Elevar Therapeutics
    Trial primary completion date:  Neoadjuvant Camrelizumab With Palbociclib for Resectable Esophageal Squamous Cell Carcinomas (clinicaltrials.gov) -  Nov 15, 2024   
    P1,  N=6, Recruiting, 
    Therefore, this combination offers a promising therapeutic option for the clinical treatment of patients with breast cancer and BMs. Trial primary completion date: Oct 2024 --> Oct 2025