- |||||||||| Irene (pyrotinib) / Jiangsu Hengrui Pharma, Enhertu (fam-trastuzumab deruxtecan-nxki) / Daiichi Sankyo, AstraZeneca
Review, Journal: Advances and Future Perspectives of HER2 Mutations in Non-Small Lung Cancer (NSCLC), Especially in China. (Pubmed Central) - Jun 5, 2025 In general, the incidence of HER2-mutated NSCLC in the Chinese population seems to be higher than the world average, and there is a large number of missed HER2-mutated NSCLC patients in China. In this field, ADCs and novel TKIs are being developed and researched in spurts, and new drugs are moving from back-line therapy to front-line therapy, and from single-drug regimens to combination regimens.
- |||||||||| Kailimei (satricabtagene autoleucel) / CARsgen
Enrollment closed, Trial primary completion date: CT041-ST-01: Study to Evaluate the Efficacy, Safety and Pharmacokinetics of CT041 Autologous CAR T-cell Injection (clinicaltrials.gov) - Jun 5, 2025 P1/2, N=192, Active, not recruiting, The combination of blinatumomab, olverembatinib, and concurrent intrathecal chemotherapy may be an effective treatment strategy for CML progression, particularly in cases with CNS involvement. Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2024 --> Oct 2024
- |||||||||| vunakizumab (SHR-1314) / Jiangsu Hengrui Pharma
Journal: First successful treatment of epidermolytic Ichthyosis with Vunakizumab: A Case Report. (Pubmed Central) - Jun 2, 2025 After a three-month treatment with Vunakizumab, symptoms alleviated significantly and inflammatory factor levels normalized. This not only shows the great potential of Vunakizumab in treating ichthyosis but also paves the way for further research on anti-IL-17A therapies for skin cornification disorders, offering treatment options for ichthyosis patients.
- |||||||||| ivarmacitinib (SHR0302) / Jiangsu Hengrui Pharma, Arcutis
EFFICACY OF IVARMACITINIB IN BIOLOGICAL DMARDS-NA () - May 28, 2025 - Abstract #EULAR2025EULAR_3953; P3 These findings highlight the potential of vunakizumab as an effective treatment option for AS patients, regardless of gender. Ivarmacitinib effectively reduces disease activity and improves health-related quality of life in bDMARDs-na
- |||||||||| Review, Journal: The Importance of Timing in Immunotherapy: A Systematic Review. (Pubmed Central) - May 26, 2025
These results suggest that the timing of immunotherapy administration may significantly impact treatment efficacy, potentially due to interactions with circadian rhythms. Further research is needed to establish standardized guidelines for optimizing infusion timing to enhance patient outcomes.
- |||||||||| trastuzumab rezetecan (SHR-A1811) / Jiangsu Hengrui Pharma, AiRuiEn (rezvilutamide) / Jiangsu Hengrui Pharma, tizetatug rezetecan (SHR-A1921) / Jiangsu Hengrui Pharma
Trial completion date, Trial primary completion date: A Phase II Study of Advanced Salivary Gland Carcinoma Based on Molecular Typing (clinicaltrials.gov) - May 23, 2025 P2, N=88, Recruiting, We also suggest that pyrotinib combined with vinorelbine has a therapeutic potential. Trial completion date: Sep 2026 --> Dec 2026 | Trial primary completion date: Sep 2025 --> Dec 2025
- |||||||||| Preclinical, Review, Journal, Adverse events: T-DM1 with concurrent radiotherapy in HER2-positive breast cancer: preclinical evaluation and mechanisms, prediction, and exploration of adverse effects. (Pubmed Central) - May 22, 2025
Nevertheless, limited research exists regarding the adverse effects and mechanisms of T-DM1 in combination with radiotherapy. This review investigates preclinical studies on the interactions between T-DM1 and radiotherapy, investigates associated adverse effects and their underlying mechanisms, identifies predictive factors and prognostic implications, and explores potential therapeutic strategies involving the concurrent T-DM1 with radiotherapy.
- |||||||||| ribupatide oral (HRS9531 tablet) / Kailera Therapeutics
Trial completion: A Study of Single and Multiple Doses HRS9531 Tablets in Healthy Subjects (clinicaltrials.gov) - May 21, 2025 P1, N=72, Completed, These findings suggest that the peptide-based radiotracer [68Ga]Ga-DOTA-WC8 represents a promising tool for accurately monitoring of HER2 expression after treatment with HER2-targeting drugs. Recruiting --> Completed
|