- |||||||||| remimazolam tosylate (HR-7056) / Jiangsu Hengrui Pharma
Trial completion, Trial completion date, Trial primary completion date: A Study of Remimazolam Tosilate for Prolonged Sedation in the ICU (clinicaltrials.gov) - Sep 4, 2025 P1/2, N=24, Completed, Compared with DEB-TACE alone, this combination therapy results in higher CD3+, CD4+, and CD4+/CD8+ levels, as well as reduced CD8+, AFP, and PIVKA-II levels. Recruiting --> Completed | Trial completion date: Nov 2023 --> Mar 2025 | Trial primary completion date: Nov 2023 --> Mar 2025
- |||||||||| Hengqu (hetrombopag) / Jiangsu Hengrui Pharma
Journal, HEOR, Cost-effectiveness: Herombopag Versus rhTPO in Stem Cell Transplantation: A Comparative Study of Efficacy, Safety, and Cost-Effectiveness. (Pubmed Central) - Aug 28, 2025 Its demonstrated benefits in accelerating platelet recovery, reducing hemorrhagic complications, and lowering healthcare costs suggest it should be considered as a preferred therapeutic option, especially for allo-PBSCT recipients. These findings have important implications for optimizing supportive care in hematopoietic stem cell transplantation.
- |||||||||| AiTan (rivoceranib) / HLB Bio Group
Journal: Targeting tumor vascular endothelial cells for hepatocellular carcinoma treatment. (Pubmed Central) - Aug 26, 2025 Recently, Wu et al reported that apatinib, an inhibitor of vascular endothelial growth factor receptor 2, can inhibit tumor VEC glycolysis by regulating phosphatidylinositol 3-kinase/protein kinase B/6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 signaling pathway to suppress HCC progression. With great interest, this editorial paper aims to review the function and key molecular signaling pathways of tumor VECs in HCC initiation and progression and summarize potential treatment options in clinical trials.
- |||||||||| HRS-5965 / Jiangsu Hengrui Pharma
Journal, Monotherapy: Efficacy and safety of HRS-5965 monotherapy in complement inhibitor-na (Pubmed Central) - Aug 26, 2025 The most common treatment-related adverse events were mild lab abnormalities, including increased alkaline phosphatase and alanine aminotransferase. In conclusion, HRS-5965 monotherapy at either 50 or 75?mg BID resulted in substantial Hb improvements and reduced haemolysis with an acceptable safety profile, suggesting its potential as a promising oral therapy for complement inhibitor-na
- |||||||||| Tyvyt (sintilimab) / Innovent Biologics, Eli Lilly, AiTan (rivoceranib) / HLB Bio Group, Teysuno (gimeracil/oteracil/tegafur) / Nordic Group, Otsuka
Journal: Conversion therapy with sintilimab combined with chemotherapy and apatinib in stage IV gastric cancer. (Pubmed Central) - Aug 25, 2025 We explored the feasibility and efficacy of sintilimab plus two-drug chemotherapy (S-1 plus nab-paclitaxel) and apatinib as conversion therapy in patients with stage IV gastric cancer in China...The safety profile was manageable. Sintilimab plus chemotherapy and apatinib followed by conversional resection may be a new feasible and safe option for initially unresectable gastric cancer, potentially leading to long-term survival or even cure.
- |||||||||| SHR-1802 / Jiangsu Hengrui Pharma, AiRuiKa (camrelizumab) / HLB Bio Group, famitinib (SHR 1020) / Jiangsu Hengrui Pharma
Enrollment change, Trial termination: A Study of SHR-1802 in Patients With Advanced Solid Tumor (clinicaltrials.gov) - Aug 23, 2025 P2, N=25, Terminated, The findings suggest that T-DXd not only extends survival but also enhances health-related quality of life for patients, promising a transformative shift in treatment paradigms for HER2-positive breast cancer. N=124 --> 25 | Recruiting --> Terminated; Adjustment of R&D strategy
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