Jiangsu Hengrui Pharma 
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 196 Products   52 Diseases   196 Products   3529 Trials   15381 News 


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  • ||||||||||  remimazolam tosylate (HR-7056) / Jiangsu Hengrui Pharma
    Trial completion, Trial completion date, Trial primary completion date:  A Study of Remimazolam Tosilate for Prolonged Sedation in the ICU (clinicaltrials.gov) -  Sep 4, 2025   
    P1/2,  N=24, Completed, 
    Compared with DEB-TACE alone, this combination therapy results in higher CD3+, CD4+, and CD4+/CD8+ levels, as well as reduced CD8+, AFP, and PIVKA-II levels. Recruiting --> Completed | Trial completion date: Nov 2023 --> Mar 2025 | Trial primary completion date: Nov 2023 --> Mar 2025
  • ||||||||||  Hengqu (hetrombopag) / Jiangsu Hengrui Pharma
    Journal, HEOR, Cost-effectiveness:  Herombopag Versus rhTPO in Stem Cell Transplantation: A Comparative Study of Efficacy, Safety, and Cost-Effectiveness. (Pubmed Central) -  Aug 28, 2025   
    Its demonstrated benefits in accelerating platelet recovery, reducing hemorrhagic complications, and lowering healthcare costs suggest it should be considered as a preferred therapeutic option, especially for allo-PBSCT recipients. These findings have important implications for optimizing supportive care in hematopoietic stem cell transplantation.
  • ||||||||||  AiTan (rivoceranib) / HLB Bio Group
    Journal:  Targeting tumor vascular endothelial cells for hepatocellular carcinoma treatment. (Pubmed Central) -  Aug 26, 2025   
    Recently, Wu et al reported that apatinib, an inhibitor of vascular endothelial growth factor receptor 2, can inhibit tumor VEC glycolysis by regulating phosphatidylinositol 3-kinase/protein kinase B/6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 signaling pathway to suppress HCC progression. With great interest, this editorial paper aims to review the function and key molecular signaling pathways of tumor VECs in HCC initiation and progression and summarize potential treatment options in clinical trials.
  • ||||||||||  HRS-5965 / Jiangsu Hengrui Pharma
    Journal, Monotherapy:  Efficacy and safety of HRS-5965 monotherapy in complement inhibitor-na (Pubmed Central) -  Aug 26, 2025   
    The most common treatment-related adverse events were mild lab abnormalities, including increased alkaline phosphatase and alanine aminotransferase. In conclusion, HRS-5965 monotherapy at either 50 or 75?mg BID resulted in substantial Hb improvements and reduced haemolysis with an acceptable safety profile, suggesting its potential as a promising oral therapy for complement inhibitor-na
  • ||||||||||  ketamine / Generic mfg., AiTan (rivoceranib) / HLB Bio Group
    Journal:  Inhibition Mechanism of Ketamine-Apatinib by CYP2C9 and 3A4: A Prediction of Possible Drug-Drug Interaction. (Pubmed Central) -  Aug 26, 2025   
    In conclusion, HRS-5965 monotherapy at either 50 or 75?mg BID resulted in substantial Hb improvements and reduced haemolysis with an acceptable safety profile, suggesting its potential as a promising oral therapy for complement inhibitor-na Molecular docking revealed apatinib's stronger binding affinity (-10.4
  • ||||||||||  Tyvyt (sintilimab) / Innovent Biologics, Eli Lilly, AiTan (rivoceranib) / HLB Bio Group, Teysuno (gimeracil/oteracil/tegafur) / Nordic Group, Otsuka
    Journal:  Conversion therapy with sintilimab combined with chemotherapy and apatinib in stage IV gastric cancer. (Pubmed Central) -  Aug 25, 2025   
    We explored the feasibility and efficacy of sintilimab plus two-drug chemotherapy (S-1 plus nab-paclitaxel) and apatinib as conversion therapy in patients with stage IV gastric cancer in China...The safety profile was manageable. Sintilimab plus chemotherapy and apatinib followed by conversional resection may be a new feasible and safe option for initially unresectable gastric cancer, potentially leading to long-term survival or even cure.
  • ||||||||||  Irene (pyrotinib) / Jiangsu Hengrui Pharma, Enhertu (fam-trastuzumab deruxtecan-nxki) / Daiichi Sankyo, AstraZeneca
    Journal:  Revolutionizing HER2-Positive Breast Cancer Treatment: Insights from the 47th San Antonio Breast Cancer Symposium on Trastuzumab Deruxtecan. (Pubmed Central) -  Aug 24, 2025   
    The editorial also highlights the importance of real-world applications, ongoing research into biomarkers, and the potential of combination therapies, such as T-DXd with pyrotinib. The findings suggest that T-DXd not only extends survival but also enhances health-related quality of life for patients, promising a transformative shift in treatment paradigms for HER2-positive breast cancer.
  • ||||||||||  SHR-1802 / Jiangsu Hengrui Pharma, AiRuiKa (camrelizumab) / HLB Bio Group, famitinib (SHR 1020) / Jiangsu Hengrui Pharma
    Enrollment change, Trial termination:  A Study of SHR-1802 in Patients With Advanced Solid Tumor (clinicaltrials.gov) -  Aug 23, 2025   
    P2,  N=25, Terminated, 
    The findings suggest that T-DXd not only extends survival but also enhances health-related quality of life for patients, promising a transformative shift in treatment paradigms for HER2-positive breast cancer. N=124 --> 25 | Recruiting --> Terminated; Adjustment of R&D strategy