- |||||||||| Hengqu (hetrombopag) / Jiangsu Hengrui Pharma
Enrollment open, Phase classification, Trial completion date, Trial primary completion date: A Study to Evaluate the Safety and Efficacy of Hetrombopag Olamine in Severe Aplastic Anemia ?SAA? Patient (clinicaltrials.gov) - Apr 29, 2020 P2, N=55, Recruiting, Research Funding: Jiangsu Hengrui Medicine Co., Ltd Not yet recruiting --> Recruiting | Phase classification: P1/2 --> P2 | Trial completion date: Jun 2021 --> Jun 2020 | Trial primary completion date: Jan 2021 --> Oct 2019
- |||||||||| Hengqu (hetrombopag) / Jiangsu Hengrui Pharma
Enrollment open: Hetrombopag or Placebo in Treatment-Naive Severe Aplastic Anemia (clinicaltrials.gov) - Apr 28, 2020 P3, N=180, Recruiting, Not yet recruiting --> Recruiting | Phase classification: P1/2 --> P2 | Trial completion date: Jun 2021 --> Jun 2020 | Trial primary completion date: Jan 2021 --> Oct 2019 Not yet recruiting --> Recruiting
- |||||||||| AiRuiKa (camrelizumab) / Incyte
Camrelizumab? (Twitter) - Apr 27, 2020
- |||||||||| AiTan (rivoceranib) / HLB Bio Group
Trial completion date, Trial primary completion date, Real-world evidence, Real-world: A Real World Study of Apatinib in Treatment of Patients With Gastric Carcinoma (clinicaltrials.gov) - Apr 27, 2020 P=N/A, N=270, Active, not recruiting, Not yet recruiting --> Recruiting Trial completion date: Dec 2019 --> Aug 2020 | Trial primary completion date: Jan 2019 --> Aug 2020
- |||||||||| Irene (pyrotinib) / Jiangsu Hengrui Pharma
Enrollment open, Trial initiation date, Real-world evidence, Real-world: HR-BLTN-016: Real World Study of Pyrotinib in Human Epidermal Growth Factor Receptor-2 (HER2) Positive Breast Cancer (clinicaltrials.gov) - Apr 23, 2020 P=N/A, N=3000, Recruiting, The combination use could achieve good efficacy and prolong patients' PFS time; however, apatinib also reduced the patients' quality of life and enhanced the nutrition risk and adverse drug reactions. Not yet recruiting --> Recruiting | Initiation date: Nov 2019 --> Feb 2020
- |||||||||| AiTan (rivoceranib) / HLB Bio Group, AiRuiKa (camrelizumab) / HLB Bio Group
Enrollment closed, Trial primary completion date: Camrelizumab Combined With Apatinib for Recurrent Resistant GTN (clinicaltrials.gov) - Apr 20, 2020 P2, N=20, Active, not recruiting, No abstract available Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2020 --> Aug 2021
- |||||||||| Teysuno (gimeracil/oteracil/tegafur) / Nordic Group, Otsuka, AiRuiKa (camrelizumab) / HLB Bio Group
Enrollment open, Enrollment change, Trial completion date, Trial initiation date, Trial primary completion date, MSI-H, dMMR: A Study to Evaluate Camrelizumab in Combination With Docetaxel +S-1 as Adjuvant Treatment Therapy in Stage III Gastric Cancer (clinicaltrials.gov) - Apr 19, 2020 P2, N=20, Recruiting, Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2020 --> Aug 2021 Not yet recruiting --> Recruiting | N=70 --> 20 | Trial completion date: Jan 2025 --> Dec 2022 | Initiation date: Jan 2020 --> Apr 2020 | Trial primary completion date: Jan 2022 --> Apr 2022
- |||||||||| AiTan (rivoceranib) / HLB Bio Group, Teysuno (gimeracil/oteracil/tegafur) / Nordic Group, Otsuka
Trial completion date, Trial primary completion date: Study of Apatinib Plus S-1 as the Therapy of Advanced Colorectal Cancer (clinicaltrials.gov) - Apr 15, 2020 P2, N=120, Recruiting, Not yet recruiting --> Recruiting Trial completion date: Dec 2019 --> Mar 2021 | Trial primary completion date: Dec 2018 --> Oct 2020
- |||||||||| VT-1598 / Mycovia Pharma, otesaconazole (VT-1161) / Mycovia Pharma, fluconazole / Generic mfg.
Journal: In vitro activities of the novel investigational tetrazoles VT-1161 and VT-1598 compared to the triazole antifungals against azole-resistant strains and clinical isolates of Candida albicans. (Pubmed Central) - Apr 14, 2020 To evaluate their in vitro activities compared to other azoles, MICs were determined by Clinical and Laboratory Standards Institute (CLSI) method for VT-1161, VT-1598, fluconazole, voriconazole, itraconazole, and posaconazole against 68 C...VT-1161 MICs were elevated compared to the control strain SC5314 for hyperactive Tac1 strains and two strains with Erg11 substitutions (Y132F and Y132F&K143R), but showed activity against hyperactive Mrr1 and Upc2 strains. While mutations affecting Erg3 activity appear to greatly reduce susceptibility to VT-1161 and VT-1598, the elevated MICs of both tetrazoles for four isolates could not be explained by known azole resistance mechanisms, suggesting the presence of undescribed resistance mechanisms to triazole- and tetrazole-based sterol demethylase inhibitors.
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