Jiangsu Hengrui Pharma 
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  • ||||||||||  SHR-1501 / Jiangsu Hengrui Pharma
    Enrollment open:  Phase I/II Clinical Study of SHR-1501 Combined With Adbelizumab in Patients With Malignant Tumors (clinicaltrials.gov) -  Jan 22, 2026   
    P1/2,  N=203, Recruiting, 
    Both CYP genetic polymorphisms and drug interactions significantly influence apatinib metabolism, highlighting the importance of personalized dosing strategies for optimizing therapy. Not yet recruiting --> Recruiting
  • ||||||||||  trastuzumab rezetecan (SHR-A1811) / Jiangsu Hengrui Pharma, Avastin (bevacizumab) / Roche
    New P2 trial:  MA-CRC-II-016 SHR-1811 (clinicaltrials.gov) -  Jan 21, 2026   
    P2,  N=80, Not yet recruiting, 
  • ||||||||||  AiTan (rivoceranib) / HLB Bio Group
    Journal:  Case Report: A case of lymph node metastatic cancer of unknown primary with elevated alpha-fetoprotein achieving long-term survival. (Pubmed Central) -  Jan 21, 2026   
    Although subsequent immunohistochemistry classified the case into the unfavorable prognostic subgroup, an individualized treatment strategy including three-drug combination chemotherapy based on the clinical suspicion of gastric cancer, targeted therapy with Apatinib, and localized radiotherapy, resulted in a remarkably long overall survival of 58 months...This case demonstrates that for CUP confined to lymph nodes, active and precisely reasoned individualized treatment can significantly improve prognosis, even in cases categorized as having an unfavorable prognosis. Furthermore, it underscores the necessity of immunohistochemistry for the accurate diagnosis of CUP and suggests that promoting precision medicine strategies may improve outcomes for these patients.
  • ||||||||||  AiTan (rivoceranib) / HLB Bio Group, AiRuiKa (camrelizumab) / HLB Bio Group
    Trial completion date, Trial primary completion date:  Study to Evaluate the Efficacy and Safety of Camrelizumab and Apatinib in Patients With GC/GEJC (clinicaltrials.gov) -  Jan 21, 2026   
    P3,  N=550, Recruiting, 
    identifier CRD420251243032. Trial completion date: Sep 2022 --> Sep 2026 | Trial primary completion date: Apr 2022 --> Apr 2026
  • ||||||||||  AiTan (rivoceranib) / HLB Bio Group, fludarabine IV / Generic mfg.
    Journal, PD(L)-1 Biomarker, IO biomarker:  Apatinib-Induced STAT1/NK axis activation augments PD-1 inhibitor efficacy in advanced Hepatocellular Carcinoma. (Pubmed Central) -  Jan 20, 2026   
    Furthermore, combination therapy remodeled the tumor microenvironment by reducing CA IX (hypoxia marker), CD31 (angiogenesis marker), and ?-SMA (stromal activation marker) expression (p?<?0.05). Apatinib enhances the efficacy and responsiveness of PD-1 inhibition via the STAT1/NK axis, while the combination therapy remodels the tumor microenvironment to potentiate anti-tumor effects.
  • ||||||||||  AiRuiKa (camrelizumab) / HLB Bio Group, Lenvima (lenvatinib) / Eisai, Merck (MSD)
    Biomarker, Journal, PD(L)-1 Biomarker, IO biomarker:  The triglyceride-glucose index shows promise as a novel prognostic marker for advanced hepatocellular carcinoma. (Pubmed Central) -  Jan 19, 2026   
    We further critically examine the methodological limitations, including the retrospective design, the population-specific TyG cut-off value, and unaddressed metabolic confounders. We highlight the imperative for future research to validate its utility across diverse etiologies and treatment settings, and to unravel the underlying immunometabolic pathways.
  • ||||||||||  trastuzumab envedotin (DP303c) / CSPC Pharma, AiTan (rivoceranib) / HLB Bio Group
    Journal, Heterogeneity:  Case report: Spatiotemporal HER2 heterogeneity in AFP-producing gastric cancer: navigating long-term survival with molecularly-guided therapy in a refractory case. (Pubmed Central) -  Jan 19, 2026   
    Following progression on first-line FLOT chemotherapy, the 65-year-old male received second-line apatinib plus programmed death-1 (PD-1) inhibitor...Third-line anti-HER2 antibody-drug conjugate (ADC) DP303c rapidly achieved partial response with normalized AFP...Overall survival reached 79 months. This case highlights: 1) efficacy of anti-angiogenic and immunotherapy in AFPGC; 2) necessity of re-biopsy for detecting HER2 heterogeneity; and 3) potent activity of ADCs against HER2-converted metastases, enabling remarkable survival through sequential precision therapy.
  • ||||||||||  Tarpeyo (budesonide) / Calliditas, Stada, HR19042 / Jiangsu Hengrui Pharma, Budenofalk (budesonide gastro-resistant) / Dr Falk
    PK/PD data, Journal:  Comparison of the Pharmacokinetics of Three Budesonide Formulations in Healthy Chinese Subjects. (Pubmed Central) -  Jan 19, 2026   
    In vitro, the dissolution of HR19042 occurred 30 min earlier than that of Nefecon in the intestinal buffer medium. In conclusion, both in vivo and in vitro findings suggest that HR19042 exhibits a faster absorption rate and higher oral bioavailability.
  • ||||||||||  trastuzumab rezetecan (SHR-A1811) / Jiangsu Hengrui Pharma, Herceptin (trastuzumab) / Roche
    Journal:  Trastuzumab Rezetecan: First Approval. (Pubmed Central) -  Jan 13, 2026   
    Active, not recruiting --> Completed In May 2025, it was approved by the National Medical Products Administration of China
  • ||||||||||  HR17031 / Jiangsu Hengrui Pharma, long acting basal insulin (INS068) / Jiangsu Hengrui Pharma, noiiglutide (SHR20004) / Jiangsu Hengrui Pharma
    PK/PD data, Journal:  Pharmacokinetics and safety of HR17031, a fixed-ratio of INS068/Noiiglutide combination, in Chinese patients with hepatic impairment. (Pubmed Central) -  Jan 13, 2026   
    HR17031 demonstrated PK profiles of INS068 and Noiiglutide comparable between subjects with mild or moderate hepatic impairment and those with normal hepatic function, with modest reductions in moderate impairment. The treatment was well tolerated with a favourable safety profile, and no significant differences in C-peptide concentrations were observed across groups.
  • ||||||||||  Irene (pyrotinib) / Jiangsu Hengrui Pharma, Herceptin (trastuzumab) / Roche, Perjeta (pertuzumab) / Roche
    New P2 trial, Circulating tumor DNA:  ctDNA in HER2+ EBC Neoadjuvant Treatment (clinicaltrials.gov) -  Jan 12, 2026   
    P2,  N=60, Recruiting,