Jiangsu Hengrui Pharma 
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  • ||||||||||  famitinib (SHR 1020) / Jiangsu Hengrui Pharma
    Trial completion:  Safety and Efficacy Study of Famitinib in Patients With Advanced Colorectal Adenocarcinoma?FACT? (clinicaltrials.gov) -  Dec 21, 2020   
    P3,  N=543, Completed, 
    TACE-apatinib was an efficacious and safe treatment for patients with advanced HCC with APS, and apatinib improved the efficacy of TACE in the treatment of these patients. Active, not recruiting --> Completed
  • ||||||||||  Opdivo (nivolumab) / Ono Pharma, BMS
    Clinical, Journal, Adverse events, Checkpoint inhibition:  Landscape of immune checkpoint inhibitor-related adverse events in Chinese population. (Pubmed Central) -  Dec 20, 2020   
    ICI-related AEs were generally mild and tolerable for a predominantly Chinese cohort. However, we should pay attention to the combination of ICI with chemotherapy as it could increase grade 3-5 TRAEs and irAEs.
  • ||||||||||  Kadcyla (ado-trastuzumab emtansine) / Roche, pyrotinib (SHR-1258) / Jiangsu Hengrui Medicine, Gilotrif (afatinib) / Boehringer Ingelheim
    [VIRTUAL] Clinical Management of Lung Adenocarcinoma Patients With HER2 V659E Mutation (Scientific Program Auditorium) -  Dec 17, 2020 - Abstract #IASLCWCLC2020IASLC_WCLC_1861;    
    We revealed the prevalence of ERBB2 V659E in Chinese LUAD patients and elucidated the genomic profile of ERBB2 V659E mutant. This study paves avenue for the utilization of the novel HER2 inhibitors pyrotinib in ERBB2 V659E mutant LUAD patients.
  • ||||||||||  AiTan (rivoceranib) / HLB Bio Group
    [VIRTUAL] Continuous Administration of Low-Dose Apatinib Combined With WBRT for Non-Small Cell Lung Cancer With Symptomatic Brain Metastases (ePoster Hall) -  Dec 17, 2020 - Abstract #IASLCWCLC2020IASLC_WCLC_1603;    
    Conclusion This retrospective study suggests that NSCLC patients with multiple brain metastases treated with apatinib combined with WBRT, achieved encouraging therapeutic effects, showed a significant reduction in tumor size and peritumoral edema, enjoyed an improved KPS score and experienced prolonged survival time. Apatinib combined with WBRT is well tolerated and may be a potential choice for relapsed or drug-resistant advanced NSCLC patients with symptomatic multiple brain metastases.
  • ||||||||||  AiTan (rivoceranib) / HLB Bio Group, AiRuiKa (camrelizumab) / Incyte
    [VIRTUAL] Efficacy of Camrelizumab (SHR-1210) Plus Apatinib in Advanced NSCLC with EGFR Mutation (ePoster Hall) -  Dec 17, 2020 - Abstract #IASLCWCLC2020IASLC_WCLC_1534;    
    P2
    Table 1. Efficacy of camrelizumab and apatinib combination treatment in advanced NSCLC pts with EGFR mutation Conclusion Camrelizumab plus apatinib showed a moderate benefit in pts with EGFR mutated NSCLC and showed better efficacy in pts with EGFR 20ins or L858R mutation sub-types, warrant further investigation.
  • ||||||||||  AiTan (rivoceranib) / HLB Bio Group, AiRuiKa (camrelizumab) / Incyte
    [VIRTUAL] Updated Survival and Biomarker Analysis of Camrelizumab and Apatinib in Previously Treated pts of Advanced Non-Squamous NSCLC (ePoster Hall) -  Dec 17, 2020 - Abstract #IASLCWCLC2020IASLC_WCLC_1530;    
    P2, P3
    The most common treatment-related adverse events of grade 3 or higher were hypertension (18 [17.1%]), palmar-plantar erythrodysesthesia syndrome (14 [13.3%]), and increased gamma-glutamyltransferase (10 [9.5%]). Conclusion Combined camrelizumab and apatinib had promising antitumor activity and acceptable safety in previously treated patients with advanced non-squamous NSCLC, especially in these with STK11 or KEAP1 mutation, phase III trial is ongoing for further validation (NCT04203485).
  • ||||||||||  Irene (pyrotinib) / Jiangsu Hengrui Pharma, Herceptin (trastuzumab) / Roche
    Trial completion date, Trial primary completion date:  Pyrotinib Combined With Trastuzumab And Chemotherapy in HER2-positive MBC (clinicaltrials.gov) -  Dec 16, 2020   
    P=N/A,  N=200, Not yet recruiting, 
    Our clinical study has proven its safety and efficacy. Trial completion date: Oct 2021 --> Jun 2022 | Trial primary completion date: Aug 2021 --> Dec 2021