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Clinical, Review, Journal: Adipose-Derived Stem Cells in the Treatment of Perianal Fistulas in Crohn's Disease: Rationale, Clinical Results and Perspectives. (Pubmed Central) - Oct 22, 2021
A pivotal phase III-controlled trial using allogenic ADSCs (Alofisel) demonstrated that prolonged clinical and radiological remission can be obtained in nearly 60% of cases with a good safety profile. Future studies should be conducted for a better knowledge of the local effect of ADSCs as well as for a standardization in terms of the number of injections and associated procedures.
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Clinical, Review, Journal: Surfing the clinical trials of mesenchymal stem cell therapy in ischemic cardiomyopathy. (Pubmed Central) - Jul 14, 2021
Lastly, pre-conditioning of MSCs and using of exosomes mediated MSCs or genetically modified MSCs may improve the overall therapeutic effect. Future prospective studies establishing a constant procedure for MSCs transplantation are required in order to apply MSC therapy in our daily clinical practice and subsequently improving the overall prognosis of ischemic heart failure patients.
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