Accure Therap 
Welcome,         Profile    Billing    Logout  
  Products    Diseases    Trials    News 
  • ||||||||||  ACT-01 / Accure Therap
    [VIRTUAL] Extended neuroprotective efficacy of ACT-01 in the animal model of lysolecithin induced demyelination in optic nerve (ECTRIMS 2021) -  Sep 23, 2021 - Abstract #P711; Author: Prof. Pablo Villoslada; S. Paris; Presentation Time: October 14, 2021; 12:00-21:00   
    Reduced levels of demyelination and axonal loss of the ACT-01 groups were continuous and sustained and significantly lower than placebo until the end of the follow-up period (day 28). ACT-01 provides continuous and sustained neuroprotective effects after a short course administration in the animal model of lysolecithin-induced demyelination, thus suggesting long-term benefits after an inflammatory insult of the CNS.
  • ||||||||||  ACT-01 / Accure Therap
    [VIRTUAL] Extended neuroprotective efficacy of ACT-01 in the animal model of lysolecithin induced demyelination in optic nerve (ECTRIMS 2021) -  Aug 3, 2021 - Abstract #P711; Author: Prof. Pablo Villoslada; S. Paris; Presentation Time: October 13, 2021; 12:00-21:00   
    Reduced levels of demyelination and axonal loss of the ACT-01 groups were continuous and sustained and significantly lower than placebo until the end of the follow-up period (day 28). ACT-01 provides continuous and sustained neuroprotective effects after a short course administration in the animal model of lysolecithin-induced demyelination, thus suggesting long-term benefits after an inflammatory insult of the CNS.
  • ||||||||||  ACT-01 / Accure Therap
    Trial completion:  BN201 SAD MAD Study in Healthy Subjects (clinicaltrials.gov) -  Apr 9, 2019   
    P1,  N=48, Completed, 
    Recruiting -> Completed
  • ||||||||||  ACT-01 / Accure Therap
    Journal:  Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation. (Pubmed Central) -  Mar 1, 2019   
    In vivo, BN201 prevents axonal and neuronal loss, and it promotes remyelination in models of multiple sclerosis, chemically induced demyelination, and glaucoma. In summary, we provide a new promising strategy to promote neuroaxonal survival and remyelination, potentially preventing disability in brain diseases.
  • ||||||||||  ACT-01 / Accure Therap
    Journal:  Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancer. (Pubmed Central) -  Sep 22, 2017   
    Since knockdown of HNF4A caused a reduction in ApoB and HNF1A expression, possibly loss of HNF4 reduces the expression of these genes and subsequently tumor growth is triggered. Therefore, we propose that HNF4A mutations G79C, F83C, and M125I are functional mutations found in liver cancers and that loss of HNF4A function, through its mutation, leads to a reduction in HNF1A and ApoB gene expression with a concomitant increased risk of liver tumorigenesis.
  • ||||||||||  ACT-01 / Accure Therap
    Journal:  Genome Sequence of a Novel Reassortant and Very Virulent Strain of Infectious Bursal Disease Virus. (Pubmed Central) -  Aug 26, 2017   
    Here, we report the complete coding genome sequence of a novel reassortant and very virulent infectious bursal disease virus (IBDV), designated JBN2011. Characterization of the JBN2011 genome suggests that it is a rare recombinant virus having a very virulent IBDV segment A and a Bursine-2-like attenuated IBDV segment B.
  • ||||||||||  ACT-01 / Accure Therap
    A Qualitative Study of The Enhancers and Barriers to Pain Self-Management (BPS 2017) -  May 23, 2017 - Abstract #79; Author: Joanna Elizabeth Quinlan - Affiliated with Pain SIG, Wolfson Institute of Health and Wellbeing Durham University, Dr Frances Cole - Pain Plan Workshops Pain Toolkit, Antony Chuter - Pain UK Pain UK, Ian Semmons - Action on Pain Action on Pain, Angela Walker - Fibromyalgia UK Fibromyalgia UK, Dr Paul Chazot - Wolfson Institute of Health and Wellbeing Durham University,;    
    Our approach has meant further research is focused on public set agendas. This follow-up study is likely to be specific to one significant impact enhancer/ barrier for one pain condition in one locality.
  • ||||||||||  ACT-01 / Accure Therap
    New cancer prevention model using imaging for early detection of mesothelin-expressing cancers (AACR 2017) -  Mar 31, 2017 - Abstract #LB-135 / 7; Author: Khushboo Sharma, Catherine Yin, Kalika Kamat, Claire Repellin, Lidia C. Sambucetti, Nathalie Scholler.; Presentation Time: April 03, 2017; 13:00-17:00   
    In summary, our results indicate that G3a nanobody is a valuable reagent for early detection of mesothelin-expressing cancer, and that DKO mice induced for Pten and Dicer double knockout by intra ovarian injection of CRE adenovirus develop serous ovarian cancer that express CA125 and mesothelin. We propose this model for in vivo monitoring of cancer development, as a novel system model for ovarian cancer prevention studies.
  • ||||||||||  ACT-01 / Accure Therap
    Journal:  Neuropeptidergic Regulation of Pair-bonding and Stress Buffering: Lessons from Voles. (Pubmed Central) -  Apr 26, 2015   
    In the present review, we highlight the work from this burgeoning field and focus on the role(s) of the neuropeptides oxytocin (OT), vasopressin (AVP), and corticotrophin releasing hormone (CRH) mediating stress buffering. Together, the data suggest that OT underlies social bonding to reduce stress-induced psychological illness while AVP and CRH facilitate arousal to enhance autonomic reactivity, increasing susceptibility to adverse mental and physical health.
  • ||||||||||  ACT-01 / Accure Therap
    Journal:  Luteinizing Hormone: Evidence for direct action in the CNS. (Pubmed Central) -  Mar 20, 2015   
    However, few studies have researched the direct actions of LH on neurons and glial cells. Here we summarize the role of luteinizing hormone in modulating cognition, and we propose a mechanism that underlies a role for brain LH in this process.
  • ||||||||||  ACT-01 / Accure Therap
    Journal:  Luteinizing Hormone as a key player in the cognitive decline of Alzheimer's disease. (Pubmed Central) -  Feb 9, 2015   
    Mounting evidence in basic research and epidemiological studies supports the role of elevated luteinizing hormone in exacerbating age-related cognitive decline in both males and females. This review summarizes the recent developments involving luteinizing hormone in increasing the cognitive deficits and molecular pathology characteristic of Alzheimer's disease.
  • ||||||||||  ACT-01 / Accure Therap
    Journal:  The Impact of Luteinizing hormone and Testosterone on beta amyloid (Aβ) accumulation: animal and human clinical studies. (Pubmed Central) -  Jan 28, 2015   
    The underlying mechanisms by which these hormones modulate Aβ accumulation and contribute to neurodegeneration are not completely understood, however they have been shown to regulate Aβ metabolism, enhance its clearance and alter the processing of its parent molecule, the amyloid precursor protein. This review will discuss underlying mechanisms by which testosterone and LH modulate Aβ and provide an update on therapeutic approaches targeting these hormones.
  • ||||||||||  ACT-01 / Accure Therap
    Journal:  Surprising Origins of Sex Differences in the Brain. (Pubmed Central) -  Jan 23, 2015   
    We propose that some neuroanatomical endpoints are canalized to enhance sex differences in the brain by reducing variability within one sex while also preventing the sexes from diverging too greatly. We further propose mechanisms by which such canalization could occur and discuss what relevance this may have to sex differences in behavior.
  • ||||||||||  ACT-01 / Accure Therap
    Journal:  Sex Differences in Anxiety Disorders: Interactions between Fear, Stress, and Gonadal Hormones. (Pubmed Central) -  Dec 21, 2014   
    In this review, we discuss the intersect between stress and fear mechanisms and their modulation by gonadal hormones and discuss the relevance of this information to sex differences in anxiety and fear-based disorders. Understanding these converging influences is imperative to the development of more effective, individualized treatments that take sex and hormones into account.
  • ||||||||||  ACT-01 / Accure Therap
    Journal:  Neuroendocrine regulation of long-term pair maintenance in the monogamous zebra finch. (Pubmed Central) -  Dec 18, 2014   
    Here, we review the endocrinology of opportunistic breeding in zebra finches, the sex steroid profiles of breeding and non-breeding zebra finches (domesticated and wild), and the roles of sex steroids and other signaling molecules in pair-maintenance behaviors in the zebra finch and other monogamous species. Studies of zebra finches and other songbirds will be useful for broadly understanding the neuroendocrine regulation of affiliative behaviors, including pair bonding and monogamy.
  • ||||||||||  ACT-01 / Accure Therap
    Journal:  The influence of stress and gonadal hormones on neuronal structure and function. (Pubmed Central) -  Dec 16, 2014   
    Moreover, little work has been done to probe the causal relationship between dendritic morphology and neuronal excitability, leaving only speculation about the adaptive versus maladaptive nature of experience-dependent dendritic remodeling. We propose that future studies combine electrophysiology with a circuit-level approach to better understand how dendritic structure contributes to neuronal functional properties and behavioral outcomes.
  • ||||||||||  ACT-01 / Accure Therap
    Journal:  The value of eutherian-marsupial comparisons for understanding the function of glucocorticoids in female mammal reproduction. (Pubmed Central) -  Dec 9, 2014   
    Much of our current thinking about GCs and reproduction comes from research involving stress-induced levels of GCs and has led to broad assumptions about the effects of GCs on reproduction. Unfortunately, this has left a gaping hole in our knowledge about basal GC levels and how they may influence reproductive function, thereby preventing a broader understanding of adrenal physiology and obscuring potential solutions for reproductive dysfunction.
  • ||||||||||  ACT-01 / Accure Therap
    Journal:  Maternal High-Fat Diet Programming of the Neuroendocrine System and Behavior. (Pubmed Central) -  Dec 3, 2014   
    This leads to increased risk of placental dysfunction, and altered fetal neuroendocrine development. Changes in brain development that likely contribute to the increased risk of behavioral and mental health disorders include increased inflammation in the brain, as well as alterations in the serotonergic system, dopaminergic system and hypothalamic pituitary adrenal (HPA) axis.
  • ||||||||||  ACT-01 / Accure Therap
    Preclinical:  Cognitive Disruptions in Stress-Related Psychiatric Disorders: A Role for Corticotropin Releasing Factor (CRF). (Pubmed Central) -  Nov 6, 2014   
    We also describe preclinical behavioral studies that demonstrate CRF's ability to alter fear conditioning, impair memory consolidation, and alter a number of executive functions, including attention and cognitive flexibility. The implications of these findings for the etiology and treatment of the cognitive impairments observed in stress-related psychiatric disorders are described.