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  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Journal:  Effects of tetrandrine on proliferation, migration, and invasion of glioblastoma cells (Pubmed Central) -  Jan 14, 2022   
    The plate cloning assay and soft agar colony formation assay showed that Tet weakened the colony formation of LN229 cells in vitro; cytometry assay showed that Tet blocked cells in the G_1 phase and promoted cell apoptosis; scratch and Transwell assays proved that Tet inhibited the migration and invasion of LN229 cells; Western blot results showed that Tet down-regulated the expression levels of CDK2, CDK6, cyclin D1, cyclin E1, snail, slug, vimentin, and N-cadherin, while up-regulated the level of E-cadherin. The results indicate that Tet has a certain inhibitory effect on the proliferation, migration, and invasion of LN229 glioblastoma cells, and such effect may be related to the participation of Tet in the regulation of c-Myc/p27 axis and snail signaling pathway.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Journal:  Tetrandrine suppresses the growth of human osteosarcoma cells by regulating multiple signaling pathways. (Pubmed Central) -  Jan 4, 2022   
    Furthermore, the regulatory effect of TET on OS cells and related signaling pathways was verified again in vivo. Our findings suggest that the anticancer function of TET on human OS may be mediated by its targeting of multiple signaling pathways and that TET may be used as a single drug or in combination with other drugs during the treatment of OS.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Review, Journal:  Phytochemicals as regulators of Th17/Treg balance in inflammatory bowel diseases. (Pubmed Central) -  Dec 17, 2021   
    Recently, a growing body of studies has indicated that phytochemicals derived from natural products are potent regulators of Th17/Treg, and exert preferable protective benefits against colonic inflammation. In this review, the great potential of anti-colitis agents derived from natural products through targeting Th17/Treg cells and their action mechanisms for the treatment or prevention of IBD in recent research is summarized, which may help further the development of new drugs for IBD treatment.
  • ||||||||||  palmatine / LKT Labs, CBT-1 (tetrandrine) / CBA Pharma
    Journal:  An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures. (Pubmed Central) -  Dec 16, 2021   
    A set of 332 plant samples used in traditional Chinese medicine was screened for DNA-binding activity with LLAMAS, resulting in the identification of seven DNA-binding molecules, including berberine (12), palmatine (13), coptisine (14), fangchinoline (15), tetrandrine (16), daurisoline (17), and dauricine (18). These results demonstrate that LLAMAS is an effective natural product discovery platform for the efficient identification and dereplication of DNA-binding molecules from complex mixtures.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Journal, IO biomarker:  Mechanism of Tetrandrine Against Endometrial Cancer Based on Network Pharmacology. (Pubmed Central) -  Dec 16, 2021   
    The results were further confirmed by immunofluorescence assays. Based on bioinformatic analysis and experimental verification, our findings demonstrated that tetrandrine exerted tumour-suppressive effects on EC by regulating the PI3K/Akt signalling pathway.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Journal:  Personalised Medicine for Colorectal Cancer Using Mechanism-Based Machine Learning Models. (Pubmed Central) -  Oct 22, 2021   
    Several significant genes that should be integrated into future mechanistic models of the WNT pathway are DVL3, FZD5, RAC1, ROCK2, GSK3B, CTB2, CBT1, and PRKCA. Thus, the study demonstrates that using mechanistic information in combination with machine learning can identify novel features (genes and proteins) that are important for explaining the STN heterogeneity between patients and their association to clinical outcomes.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Journal:  Dual variable of drug loaded micelles in both particle and electrical charge on gastric cancer treatment. (Pubmed Central) -  Oct 14, 2021   
    In vivo assays indicated that HA/CPP modified paclitaxel plus tetrandrine micelles could be selectively accumulated into tumor sites and exhibited the strong antitumor activity with negligible toxicity. These results suggested that HA/CPP modified paclitaxel plus tetrandrine micelles might provide a new strategy for treating gastric cancer.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Preclinical, Journal:  Design, synthesis and in vitro anticancer research of novel tetrandrine and fangchinoline derivatives. (Pubmed Central) -  Oct 10, 2021   
    In addition, compound 4g inhibited the phosphorylation of PI3K, Akt and mTOR, suggesting a correlation between blocking the PI3K/Akt/mTOR pathway and the above antitumor activities. These results suggest that compound 4g may be a future drug for the development of new potential drug candidates against lung cancer.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Journal:  Autophagy inhibition enhances anti-pituitary adenoma effect of tetrandrine. (Pubmed Central) -  Sep 29, 2021   
    Autophagy inhibitors enhanced Tet-induced caspase activity and apoptotic cell death. These findings demonstrated that Tet has anti-PA effect by inducing autophagy and apoptosis through MAPK/STAT3 signaling pathway attenuation and autophagy inhibition might enhance its anti-PA effect, indicating that Tet (or combined with autophagy inhibitor) is a potential therapeutic regimen for PAs.
  • ||||||||||  donepezil / Generic mfg.
    Journal:  The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix. (Pubmed Central) -  Sep 15, 2021   
    Here, the main components of STR extracts with different extracting solvents were identified, including three major alkaloids, i.e., cyclanoline, fangchinoline, and tetrandrine...The synergism of STR alkaloids with huperzine A or donepezil was calculated by the median-effect principle...The results support that fangchinoline and cyclanoline, alkaloids derived from STR, could account for the anti-AChE function of STR. Thus, STR extract or its alkaloids may potentially be developed as a therapeutic strategy for Alzheimer's patients.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Journal:  Tetrandrine Inhibits Titanium Particle-Induced Inflammatory Osteolysis through the Nuclear Factor-κB Pathway. (Pubmed Central) -  Sep 11, 2021   
    Mechanistic studies using Western blotting demonstrated that Tet inhibited the nuclear factor (NF)-κB signaling pathway by decreasing the phosphorylation of inhibitor of NF-κB α (IκBα) and p65, which play important roles in osteoclast formation. Collectively, our data indicate that Tet suppressed Ti-induced inflammatory osteolysis and osteoclast formation in mice, suggesting that Tet has the potential to be developed to treat and prevent wear particle-induced inflammatory osteolysis.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Journal:  Identification of Novel Antiviral Compounds Targeting Entry of Hantaviruses. (Pubmed Central) -  Aug 20, 2021   
    Two selected inhibitors, emetine dihydrochloride and tetrandrine, were validated with infectious pathogenic HTNV in a BSL-3 laboratory. This study provides potential therapeutics against emerging virus infection, and highlights the importance of drug repurposing.
  • ||||||||||  galantamine hydrobromide / Generic mfg.
    Journal:  Natural Anti-inflammatory compounds as Drug candidates in Alzheimer's disease. (Pubmed Central) -  Aug 18, 2021   
    In conclusion, natural products from plants represent interesting candidates for the treatment of AD. This review highlights the potential of specific compounds from natural products along with their synthetic derivatives to counteract AD in the CNS.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Journal:  Stephtetrandrine A-D, bisbenzylisoquinoline alkaloids from Stephania tetrandra. (Pubmed Central) -  Aug 6, 2021   
    Stephtetrandrine C showed obvious inhibitory effect on human hepatoma HepG2, with IC value of 16.2 μM. Limacine and 2'-N-chloromethyltetrandrine showed moderate monoamine oxidase inhibitory effect with the IC values of 37.7 and 29.2 μM, respectively.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Clinical, PK/PD data, Review, Journal:  Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems. (Pubmed Central) -  Aug 6, 2021   
    However, the safety, bioavailability and pharmacokinetic parameter studies on tetrandrine are very limited in animal models, especially in clinical settings. Our present review on anticancer potentials of tetrandrine would be necessary and highly beneficial for providing guidelines and directions for further research of tetrandrine.
  • ||||||||||  Nexavar (sorafenib) / Bayer, Amgen
    Preclinical, Journal:  Murine Precision-cut Intestinal Slices as a Potential Screening Tool for Antifibrotic Drugs. (Pubmed Central) -  Jul 10, 2021   
    Precision-cut intestinal slices can successfully be used as a potential preclinical screening tool for antifibrotic drugs. We demonstrated that sunitinib reduced the expression of several fibrosis markers, warranting further evaluation of this compound for the treatment of intestinal fibrosis.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Journal, PARP Biomarker, IO biomarker:  Tetrandrine Enhances HO-Induced Apoptotic Cell Death Through Caspase-dependent Pathway in Human Keratinocytes. (Pubmed Central) -  Jun 29, 2021   
    We demonstrated that sunitinib reduced the expression of several fibrosis markers, warranting further evaluation of this compound for the treatment of intestinal fibrosis. These are the first and novel findings showing tetrandrine enhances HO-induced apoptotic cell death of HaCaT cells and may provide a potent approach for the treatment of proliferated malignant keratinocytes.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Preclinical, Journal:  Combination Nanotherapeutics for Dry Eye Disease Treatment in a Rabbit Model. (Pubmed Central) -  Jun 12, 2021   
    Thus, we have prepared a liposome loading 1-bromoheptadecafluorooctane and tetrandrine (PFOB@LIP-Tet) to treat DED via anti-inflammation that hardly affects intraocular pressure in this study, which provided another therapy strategy for dry eye disease...The intraocular pressure changes of DED rabbits before and after treatment by PFOB@LIP-Tet showed no statistical significance. We successfully synthesized PFOB@LIP-Tet, and it could effectively treat dry eye disease via anti-inflammation but hardly affected the intraocular pressure.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Journal:  Bisbenzylisoquinoline alkaloids and P-glycoprotein function: A structure activity relationship study. (Pubmed Central) -  Jun 3, 2021   
    Moreover, stereo-configuration of bisbenzylisoquinoline 3D structures determined their inhibitory activities, which provided a new viewpoint to recognize the specificity of binding pocket in P-glycoprotein. Our data also indicated that 3D chemical structure was more sensitive than 2D to predict the P-glycoprotein inhibitory-potencies of bisbenzylisoqunoline alkaloids.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma, Humira (adalimumab) / Eisai, AbbVie
    Review, Journal:  The role of CD4FoxP3 regulatory T cells in the immunopathogenesis of COVID-19: implications for treatment. (Pubmed Central) -  May 21, 2021   
    Furthermore, the potential Treg-boosting effect of therapeutic agents used in the treatment of COVID-19, including dexamethasone, vitamin D, tocilizumab and sarilumab, chloroquine, hydroxychloroquine, azithromycin, adalimumab and tetrandrine, is discussed. The problems in the current study of Treg cells in COVID-19 and future perspectives are also addressed.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Journal:  Tetrandrine partially reverses multidrug resistance of human laryngeal cancer cells. (Pubmed Central) -  May 15, 2021   
    Because dynamics of methyl groups are essential for biochemical activity, screening studies based on the computed potential energy profiles may help identify promising candidates within a given class of drugs. We showed that tetrandrine exerts anti-MDR activity in Hep-2/v cells, possibly by inhibiting MDR1 overexpression-mediated drug efflux and by altering expression of HTRA1 and RGS10.
  • ||||||||||  CBT-1 (tetrandrine) / CBA Pharma
    Journal:  Synthesis, biological evaluation and toxicity of novel tetrandrine analogues. (Pubmed Central) -  Apr 21, 2021   
    Those enhanced anticancer properties were linked to influences on activation of the kinase Akt and mitochondrial events. In sum, our study clarifies the role of CYP3A4-mediated toxicity of the bisbenzylisoquinoline alkaloid tetrandrine and provides the basis for the exploitation of novel synthetic analogues for their antitumoral potential.
  • ||||||||||  verapamil / Generic mfg.
    Journal:  Identification of Potassium and Calcium Channel Inhibitors as Modulators of Polyomavirus Endosomal Trafficking. (Pubmed Central) -  Apr 7, 2021   
    Using a panel of more specific Ca blockers, we show that both MCPyV and SV40 are dependent on the activity of two-pore Ca channels (TPCs), as the TPC-specific blocker tetrandrine could prevent the capsid disassembly and nuclear transport required for virus entry. We therefore reveal a novel target to restrict the entry of polyomaviruses, which given the known role of TPCs during endolysosomal-ER fusion, is likely to be applicable to other viruses that transit this pathway.