- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal, IO biomarker: Tetrandrine promotes the survival of the random skin flap via the PI3K/AKT signaling pathway. (Pubmed Central) - Nov 4, 2023
Additionally, tetrandrine decreased the expression of Bax, which is associated with the induction of apoptosis, and also decreased inflammation in the flap tissue. Tetrandrine improved the survival rate of random flaps by promoting angiogenesis, inhibiting apoptosis, and reducing inflammation in the flap tissue through the modulation of the PI3K/AKT signaling pathway.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal: Preliminary Study on the Effect and Molecular Mechanism of Tetrandrine in Alleviating Pulmonary Inflammation and Fibrosis Induced by Silicon Dioxide. (Pubmed Central) - Sep 27, 2023
Molecular mechanism research indicated that, compared with SiO expose group, Tet intervention could significantly reduce the expression levels of inflammatory cytokines and fibrosis markers (TNF-?, IL-1?, MCP-1, TGF-?1, HYP, Col-I, and Fn), and regulate the expression of key molecules ATG7, microtubule-associated protein 1 light chain 3B (LC3B), and P62 in the autophagy pathway to improve the blocking of autophagic flux, promote the recovery of autophagic lysosomal system function, and inhibit apoptosis. In summary, Tet can alleviate silica-induced lung inflammation and fibrosis, which may be achieved by regulating the expression of key molecules in the autophagy process and associated apoptotic pathway.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal: QSAR Research of Novel Tetrandrine Derivatives against Human Hepatocellular Carcinoma. (Pubmed Central) - Sep 1, 2023
We highlighted that miR-638 suppresses cervical cancer progression by inhibiting NCAPG2 under tetrandrine treatment. The computer-constructed drug molecular model reveals the factors affecting the activity of human hepatocellular carcinoma cells, which provides directions and guidance for the development of highly effective anti-human-hepatocellular-carcinoma drugs in the future.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal: Tetrandrine Derivatives as Promising Antibacterial Agents. (Pubmed Central) - Aug 14, 2023
The results indicate that MAnT can induce a general state of oxidative stress in S. aureus and Escherichia coli, while MAcT induces an oxidative response in S. aureus. Complementary electrochemical studies were included.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal: Long-Term Outcomes of Depression Treatment With Hypnotherapy or Cognitive Behavioral Therapy. (Pubmed Central) - Jul 3, 2023
In the present article, we extended the results in a secondary analysis and investigated how HT compares with CBT 1) during the course of the self-rated depressive symptoms throughout the 12-month follow-ups, 2) with regard to the rates of full remission, and 3) for the time to remission after treatment...Overall, both treatments achieved comparably high long-term remission rates of 73% after a median of 30 weeks. Outpatient psychotherapy with HT achieved good long-term results mostly comparable to CBT.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal: In Silico Method for the Screening of Phytochemicals against Methicillin-Resistant Staphylococcus Aureus. (Pubmed Central) - Jun 3, 2023
Out of the multiple phytochemicals screened, nine were found as good inhibitors to be PBP2a, among which cyanidin, tetrandrine, cyclomorusin, lipomycin, and morusin showed strong binding potential with the receptor protein...Our findings suggest that cyanidin can be used as a drug against MRSA infection either in purified form or that its structure can lead to the development of more potent anti-MRSA medicines. However, experimental studies are required to evaluate the inhibitory potential of these phytochemicals against MRSA.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal: Osmotically Rupturing Phagosomes in Macrophages Using PNIPAM Microparticles. (Pubmed Central) - May 25, 2023
The results further support that the osmotic pressure generated by the dissolved microparticles causes phagosomal rupture and demonstrated usefulness of this method for studying phagosomal rupture. This method can be further developed, ultimately leading to a deeper understanding of phagosomal rupture.
- |||||||||| salinomycin (HSB-1216) / Hillstream BioPharma, CBT-1 (tetrandrine) / CBA Pharma, apilimod (STA-5326) / Madrigal Pharma
Preclinical, Journal: Lessons Learned From Limited Overlap of 15 In Vitro COVID-19 Drug Repurposing Screens. (Pubmed Central) - May 17, 2023
Of those 304 drugs, 30 were identified in 2 or more screens, while only 3 drugs (apilimod, tetrandrine, and salinomycin) were identified in 4 screens. The lack of concordance in high-confidence hits and variations in protocols makes it challenging to use the collective data as down-selection criteria for identifying repurposing candidates to move into a clinical trial.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Preclinical, Journal: Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents. (Pubmed Central) - May 1, 2023
Gene expression profiling during virus infection suggested that alkaloid fraction and tetrandrine displayed similar effects on cellular gene expression and pathways, while fangchinoline showed distinct effects on cells. Our study demonstrates a multifaceted approach to systematically investigate the diverse activities conferred by complex botanical mixtures, their cell-context specificity, and their pleiotropic effects on biological systems.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Review, Journal: Understanding the Potential Role of Nanotechnology in Liver Fibrosis: A Paradigm in Therapeutics. (Pubmed Central) - Mar 30, 2023
The purpose of this review is to educate a concise discussion of the epidemiology of chronic liver disease, the pathogenesis and pathophysiology of liver fibrosis, the symptoms of liver fibrosis progression and regression, the clinical evaluation of liver fibrosis and the research into nanotechnology-based synthetic and herbal treatments for the liver fibrosis is summarized in this article. The herbal remedies summarized in this review article include epigallocathechin-3-gallate, silymarin, oxymatrine, curcumin, tetrandrine, glycyrrhetinic acid, salvianolic acid, plumbagin, Scutellaria baicalnsis Georgi, astragalosides, hawthorn extract, and andrographolides.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal: Traditional herbal compounds as candidates to inhibit the SARS-CoV-2 main protease: an in silico study. (Pubmed Central) - Feb 1, 2023
Among them, six molecules (physalin B 5,6-epoxide (PHY), methyl amentoflavone (MAM), withaphysalin C (WPC), daphnoline or trilobamine (TRI), cepharanoline (CEP) and tetrandrine (TET)) were selected based on Lipinski's rule and ADMET analysis as criteria...Overall, we found six potential candidates to inhibit the SARS-CoV-2 M and highlighted key residues from the binding pocket that can be used for future drug design. Communicated by Ramaswamy H. Sarma.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal: A novel class of C14-sulfonate-tetrandrine derivatives as potential chemotherapeutic agents for hepatocellular carcinoma. (Pubmed Central) - Jan 28, 2023
Moreover, 33 was found to induce apoptosis via a mitochondria-mediated intrinsic pathway via flow cytometry and western blotting analysis. In addition, colony formation, wound healing, and transwell assays demonstrated that 33 significantly inhibited HepG-2 and SMMC-7721 cell proliferation, migration, and invasion, indicating that it might potentially be a candidate for an anti-HCC therapy in the future.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Preclinical, Review, Journal: Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and In Vivo Effects. (Pubmed Central) - Jan 22, 2023
Fifty-six phytochemicals were included in this study, such as curcumin, resveratrol, kaempferol, sesamol, pinocembrin, astragalin, oxyberberine, berberine hydrochloride, botulin, taxifolin, naringin, thymol, isobavachalcone, lancemaside A, aesculin, tetrandrine, Ginsenoside Rk3, mangiferin, diosgenin, theanine, tryptanthrin, lycopene, gyngerol, alantolactone, mangostin, ophiopogonin D, fisetin, sinomenine, piperine, oxymatrine, euphol, artesunate, galangin, and nobiletin...Moreover, phytochemicals can improve weight loss, stool consistency, and rectal bleeding in IBD. Therefore, phytochemicals can constitute a powerful treatment option for IBD in humans.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal: Plant-food-derived bioactives in managing hypertension: From current findings to upcoming effective pharmacotherapies. (Pubmed Central) - Jan 10, 2023
Some of the activities presented by these bioactive compounds are reducing oxidative stress, renin-angiotensin system control, SIRT1 activation, regulating platelet aggregation and COX activity, anti-atherogenic effects, anti-inflammatory properties, vasorelaxation and other results that translate into the prevention or control of hypertension. The knowledge of these bioactive compounds is important in developing countries where traditional medicine is the majority, but it can also give rise to new approaches in hypertension therapy.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Review, Journal: Phytochemicals and mitochondria: Therapeutic allies against gastric cancer. (Pubmed Central) - Jan 1, 2023
Phytochemicals could target the mitochondria in the treatment of gastric cancer, providing potential directions and evidence for clinical translation. Drug discovery focused on phytochemicals has great potential to break barriers in cancer treatment.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal: Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting the degradation of TRAIL. (Pubmed Central) - Nov 27, 2022
Drug discovery focused on phytochemicals has great potential to break barriers in cancer treatment. Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting TRAIL degradation and promotes osteoblast differentiation, suggesting its potential in antiosteopenia pharmacotherapy.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Preclinical, Journal: Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies. (Pubmed Central) - Oct 30, 2022
This impairment results in a vicious cycle that accelerates disease pathogenesis. The success of tetrandrine in reducing tau aggregation suggests first, that tetrandrine could be an effective drug for tauopathies and second, that rescuing lysosomal Ca homeostasis, thereby restoring ALP function, could be an effective general strategy for the development of novel therapies for tauopathies.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal: Synergistic Activity of Tetrandrine and Colistin against mcr-1-Harboring Escherichia coli. (Pubmed Central) - Oct 29, 2022
Similarly, molecular docking showed that tetrandrine interacted with the three crucial amino acids of the MCR-1 protein in the active site, which might inhibit MCR-1 from binding to its substrates, cause MCR-1 to lose its ability to confer resistance. This study confirmed that tetrandrine and colistin have the ability to synergistically overcome the issue of colistin resistance in mcr-1-harboring E. coli.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal: Antiviral effects of natural small molecules on aquatic rhabdovirus by interfering with early viral replication. (Pubmed Central) - Oct 26, 2022
Notably, dihydroartemisinin (DHA) (100 µmol/L) and (S, S)-(+)-tetrandrine (TET) (16 µmol/L) exhibited high antiviral effects in epithelioma papulosum cyprinid (EPC) cells, with inhibitory rates of 70.11% and 73.54%, respectively...For in vivo study, both agents enhanced the survival rate of SVCV-infected zebrafish by 53.3%, significantly decreased viral load, and modulated the expression of antiviral-related genes, indicating that DHA and TET may stimulate the host innate immune response to prevent viral infection. Overall, our findings indicated that DHA and TET had positive effects on suppressing SVCV infection by affecting early-stage viral replication, thus holding great potential as immunostimulants to reduce the risk of aquatic rhabdovirus disease outbreaks.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal: Tetrandrine Attenuates Podocyte Injury by Inhibiting TRPC6-Mediated RhoA/ROCK1 Pathway. (Pubmed Central) - Oct 18, 2022
Tet downregulated the expression of renal TRPC6, RhoA, and ROCK1 and upregulated the expression of synaptopodin; meanwhile, it reduced calcineurin activity in vivo and in vitro. In conclusion, Tet protects against podocyte by affecting TRPC6 and its downstream RhoA/ROCK1 signaling pathway.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal: Rapid Quantitative Analysis of 19 Bioactive Components in Fangji Huangqi Decoction Based on UHPLC-MS/MS. (Pubmed Central) - Oct 18, 2022
The correlation analysis indicated that astragalus flavonoids were negatively correlated with astragalosides, tetrandrine and their corresponding flavonoid glycosides, and atractylenolides were positively correlated with astragalosides and fangchinoline. This method proved to be reliable and effective, which would give a helpful basis for the quality control, pharmacological and pharmacokinetic of FHD.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Clinical data, Journal: Tetrandrine Treatment May Improve Clinical Outcome in Patients with COVID-19. (Pubmed Central) - Sep 30, 2022
In all-type and moderate-type patients, tetrandrine improved the rate of improvement in cough and fatigue on day 7 (p < 0.05). Tetrandrine may improve clinical outcome in COVID-19 patientsand could be a promising potential natural antiviral agent for the prevention and treatment of COVID-19.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Review, Journal: Progress on structural modification of Tetrandrine with wide range of pharmacological activities. (Pubmed Central) - Sep 3, 2022
The results of many researchers have confirmed that chemical structural modifications and nanocarrier delivery can address the limited application of Tet and improve its efficacy. In this paper, we summarize the anti-tumor efficacy and mechanism of action, anti-inflammatory efficacy and mechanism of action, and clinical applications of Tet, and describe the progress of Tet based on chemical structure modification and nanocarrier delivery, aiming to explore more diverse structures to improve the pharmacological activity of Tet and provide ideas to meet clinical needs.
|
