- |||||||||| Lumitin (conbercept) / Chengdu Kanghong Pharma
Journal: INTRAVITREAL INJECTION CONBERCEPT IMPROVES THE BEST-CORRECTED VISUAL ACUITY IN PATIENTS WITH WET AGE-RELATED MACULAR EDEMA. (Pubmed Central) - Oct 23, 2024 Furthermore, microvascular irregularities were correlated with central foveal thickness. The BCVA values of the effective group were lower than those of the ineffective group, and the BCVA changes of the effective group before and after treatment were greater than those of the ineffective group, suggesting that conbercept can improve the visual acuity of patients with macular edema caused by wet age-related macular degeneration.
- |||||||||| Clinical, Retrospective data: Efficacy of four anti-vascular endothelial growth factor agents and laser treatment for retinopathy of prematurity: A network meta-analysis. (Pubmed Central) - Jul 30, 2024
The aim of this study was to compare the efficacy of intravitreal aflibercept (IVA), intravitreal bevacizumab (IVB), intravitreal conbercept (IVC), intravitreal ranibizumab (IVR), and laser therapy in treating these conditions...Our analysis concludes that intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) drug monotherapy generally offer better outcomes than laser treatment for ROP. Nonetheless, additional RCTs are necessary to further evaluate the safety of anti-VEGF agents.
- |||||||||| Lumitin (conbercept) / Chengdu Kanghong Pharma
Retrospective data, Journal: Clinical and genetic features in autosomal recessive bestrophinopathy in Chinese cohort. (Pubmed Central) - Jul 26, 2024 This study provides a comprehensive characterization of anterior segment and genetic features in ARB, with a wide array of morphological abnormalities. Findings are relevant for refining clinical practices and genetic counseling and advancing pathogenesis research.
- |||||||||| Avastin (bevacizumab) / Roche, Lucentis (ranibizumab) / Roche, Novartis, Lumitin (conbercept) / Chengdu Kanghong Pharma
Clinical, Retrospective data, Review: Association of the Complement Factor H Y402H Polymorphism and Response to Anti-Vascular Endothelial Growth Factor Treatment in Age-related Macular Degeneration: An Updated Meta-analysis. (Pubmed Central) - Jun 20, 2024 Key factors influencing visual recovery post-treatment include older age, poorer baseline BCVA, the presence of subfoveal CNV, and organized interlacing patterns of CNV morphology. In patients with AMD, the CFH Y402H is a predictor of the response to anti-VEGF agents and should be considered in the treatment plan.
- |||||||||| Avastin (bevacizumab) / Roche, Lucentis (ranibizumab) / Roche, Novartis, Lumitin (conbercept) / Chengdu Kanghong Pharma
Retrospective data, Review, Journal: Comparison of different agents and doses of anti-vascular endothelial growth factors (aflibercept, bevacizumab, conbercept, ranibizumab) versus laser for retinopathy of prematurity: A network meta-analysis. (Pubmed Central) - Jun 9, 2024 In the SUCRA plots, LPC had a markedly different position with a higher probability for myopia. Further clinical trials comparing different intravitreal doses of anti-VEGF agents are needed, but our findings suggest that low doses of these drugs retain efficacy and may reduce ocular and systemic undesired events.
- |||||||||| Avastin (bevacizumab) / Roche, Lucentis (ranibizumab) / Roche, Novartis, Lumitin (conbercept) / Chengdu Kanghong Pharma
Clinical, Retrospective data, Review, Journal: Comparative efficacy of anti-vascular endothelial growth factor on diabetic macular edema diagnosed with different patterns of optical coherence tomography: A network meta-analysis. (Pubmed Central) - Jun 7, 2024 And, conbercept exhibited the highest reduction in CMT in the DRT, CME, and SRD groups. In conclusion, our study highlights the efficacy of anti-VEGF agents in the management of DME and provides valuable insights into the selection of anti-VEGF agents tailored to the individual needs of patients.
- |||||||||| Eylea (aflibercept intravitreal) / Bayer, Regeneron, Lumitin (conbercept) / Chengdu Kanghong Pharma
Clinical, Journal: Comparative study on the efficacy of Conbercept and Aflibercept in the treatment of neovascular age-related macular degeneration. (Pubmed Central) - May 26, 2024 P2/3 Both Conbercept and Aflibercept are clinically similar in efficacy for nAMD, with the T&E regimen proving therapeutically effective and potentially reducing patient costs. Anti-VEGF treatment efficacy varies across nAMD subtypes, indicating a potential benefit in tailored treatments for specific subtypes.Clinical trial registration number NCT05539235 (Protocol Registration and Results System).
- |||||||||| Lucentis (ranibizumab) / Roche, Novartis, Lumitin (conbercept) / Chengdu Kanghong Pharma
Journal: Clinical evaluation of ranibizumab and conbercept for the treatment of macular oedema secondary to central retinal vein occlusion. (Pubmed Central) - Mar 6, 2024 This NMA showed intravitreal faricimab regimens resulted in statistically beneficial effects on BCVA improvement and CMT reduction, also had the highest probability of being the most effective options in VFQ-25 scores, number of injections and a higher proportion of patients with a gain of at least 15 ETDRS letters compared to ranibizumab, conbercept, aflibercept or laser group after one-year treatment in China. No abstract available
- |||||||||| Lumitin (conbercept) / Chengdu Kanghong Pharma
Journal: Intravitreal injection of conbercept for diabetic macular edema complicated with diabetic nephropathy. (Pubmed Central) - Feb 19, 2024 Intravitreal conbercept is safe and effective for the treatment of ICNV. Conbercept has a significant effect in short-term treatment of DME patients with or without DN, and can significantly ameliorate BCVA, CMT and the number of HF, treatment efficacy of DME patients without DN is better than that of DME patients with DN.
- |||||||||| Retrospective data, Review, Journal: Anti-vascular endothelial growth factor for diabetic macular oedema: a network meta-analysis. (Pubmed Central) - Jan 30, 2024
We found no evidence that any drug increases all-cause mortality compared to control, but estimates were very imprecise. Evidence from RCTs may not apply to real-world practice, where people in need of antiangiogenic treatment are often under-treated, and the individuals exposed to these drugs may be less healthy than trial participants.
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